Article
Food Science & Technology
Pasquale Filannino, Raffaella Di Cagno, Giuseppe Gambacorta, Ali Zein Alabiden Tlais, Vincenzo Cantatore, Marco Gobbetti
Summary: The study utilized an integrated metabolomic approach to investigate the impact of starter cultures on the volatilome and bioaccessible phenolics profile of fermented bee-collected pollen. Fermentation increased volatile compounds and altered their proportions, with the profile depending on the type of fermentation. Started-BCP had higher levels of esters and alcohols, while both types of fermented BCP showed increased bioaccessible phenolics compared to unprocessed raw BCP.
Article
Entomology
Amalie Elton Baisgaard, Kristina Magaard Koldby, Torsten Nygard Kristensen, Mette Nyegaard, Palle Duun Rohde
Summary: Parkinson's disease (PD) is a neurodegenerative disorder with a complex etiology, and genetic studies have identified over 100 genomic regions associated with the risk of developing PD. This study aimed to validate PD-associated genes in fruit flies and found 11 highly conserved genes between humans and fruit flies. Knockdown of these genes resulted in disrupted escape response in fruit flies, supporting their potential involvement in PD pathology.
Review
Neurosciences
Zhe Li, Hongfeng Liang, Yingyu Hu, Lin Lu, Chunye Zheng, Yuzhen Fan, Bin Wu, Tao Zou, Xiaodong Luo, Xinchun Zhang, Yan Zeng, Ziyan Liu, Zhicheng Zhou, Zhenyu Yue, Yi Ren, Zhuo Li, Qiaozhen Su, Pingyi Xu
Summary: Recent advances have revealed a relationship between gut dysbiosis and Parkinson's disease (PD). Microbiota transplantation from PD patients to mice can induce increased alpha-synuclein-mediated motor deficits. Human studies have shown differences in the gut microbiota of PD patients compared to healthy controls. This systematic review identified alterations in short-chain fatty acids-producing bacteria and an increase in putative gut pathobionts in the gut microbiome of PD patients. Increased levels of certain bacterial genera may be associated with PD medications and aging.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Automation & Control Systems
Mayank Jain, Tarek AlSkaif, Soumyabrata Dev
Summary: This article introduces a novel scheme to objectively validate and compare the clustering results of residential electric demand profiles, considering all steps prior to the clustering algorithm. Compared to traditional clustering validity indices, the proposed scheme provides better, unbiased, and uniform recommendations.
IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS
(2021)
Article
Clinical Neurology
Philip von Rosen, Maria Hagstromer, Erika Franzen, Breiffni Leavy
Summary: Distinct physical activity profiles were identified among people with mild-moderate Parkinson's Disease, including Sedentary, Light Movers, and Steady Movers. Sedentary individuals showed poorer balance, functional mobility, and higher likelihood of previous falls compared to Light Movers. The Timed Up and Go test was the only measure that could differentiate between the three profiles.
Article
Clinical Neurology
Katherine Longardner, Aristide Merola, Irene Litvan, Alberto Maria De Stefano, Simona Maule, Fabrizio Vallelonga, Leonardo Lopiano, Alberto Romagnolo
Summary: Cardiovascular dysautonomia was associated with a sevenfold higher risk of developing dementia and a fivefold higher risk of falls in PD patients, as well as significantly higher impairment in ADLs and HRQoL. No relevant associations were found between the other autonomic domains and these outcomes.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Seong Ho Jeong, Su Hong Kim, Chan Wook Park, Hye Sun Lee, Phil Hyu Lee, Yun Joong Kim, Young H. Sohn, Yong Jeong, Seok Jong Chung
Summary: This study investigated the differential effects of hypoperfusion and hyperperfusion in cerebral regions on motor and cognitive symptoms in patients with Parkinson's disease. The results showed that hypoperfusion was associated with motor symptoms and cognitive performance levels, while hyperperfusion was associated with future dementia conversion. These findings suggest that hypoperfusion and hyperperfusion have different effects on motor and cognitive functions in patients with Parkinson's disease.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Anna Kurz, Rohit Kumar, Bernd H. Northoff, Catharina Wenk, Joerg Schirra, Sainitin Donakonda, Guenter U. Hoeglinger, Johannes Schwarz, Verena Rozanski, Rainer Huebner, Kai Botzel, Lesca Miriam Holdt, Thomas Koeglsperger
Summary: This study identified an enrichment of miR-486-5p in routine colonic biopsies from PD patients, with its expression correlating with age and disease severity. Analysis revealed 301 gene targets affected by miR-486-5p, indicating their role in biological processes in the enteric nervous system (ENS). These findings suggest the potential of miR-486-5p as a biomarker for PD and provide insights into the molecular mechanisms of GI dysfunction in PD.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Neurosciences
Junling Wang, Junyan Sun, Linlin Gao, Dongling Zhang, Lili Chen, Tao Wu
Summary: This study used rs-fMRI to investigate the functional connectivity profiles of the dorsal raphe and median raphe in PD patients and found associations between dysconnectivity of these nuclei and clinical phenotypes of PD. The results revealed decreased connectivity of the raphe nuclei with various brain regions in PD, and this dysconnectivity was correlated with symptoms such as depression, drowsiness, anxiety, cognitive deficits, sleep disturbances, and pain.
HUMAN BRAIN MAPPING
(2023)
Article
Cell Biology
Lung Chan, Chen-Chih Chung, Ruan-Ching Yu, Chien-Tai Hong
Summary: In this study, the role of plasma extracellular vesicle (EV)-derived cytokines in the pathogenesis of Parkinson's disease (PD) was investigated. The results indicate that these cytokines can be used as potential biomarkers for predicting the progression of PD and its motor symptoms. These findings are valuable for the diagnosis and treatment of PD.
Article
Plant Sciences
Limin Chen, Xiaowei Li, Jinming Zhang, Tianjun He, Jun Huang, Zhijun Zhang, Yeyang Wang, Muhammad Hafeez, Shuxing Zhou, Xiaoyun Ren, Youming Hou, Yaobin Lu
Summary: The study found differential accumulation of volatile organic compounds and metabolites in eggplants and tomatoes in response to Tuta absoluta infestation, with terpenes playing a key role in the differences observed. These differentially accumulated metabolites and volatile compounds are crucial in eggplant resistance to T. absoluta, indicating their significant impact on the behavior of this pest.
FRONTIERS IN PLANT SCIENCE
(2021)
Review
Chemistry, Analytical
P. Rodriguez-Hernandez, M. J. Cardador, L. Arce, V. Rodriguez-Estevez
Summary: Volatilome analysis is gaining attention for disease diagnosis in animals and humans. Fecal samples are being proposed as a fast, easy, and noninvasive method for disease diagnosis. However, fecal samples are complex and require special consideration and preparation. This review evaluates the analytical methods, advantages, and limitations in studies focused on the diagnosis of animal diseases through fecal volatilome.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Josefine Schardey, Can Lu, Jens Neumann, Ulrich Wirth, Qiang Li, Tianxiao Jiang, Petra Zimmermann, Joachim Andrassy, Alexandr V. Bazhin, Jens Werner, Florian Kuehn
Summary: Chronic inflammation plays a significant role in the development of colorectal cancer, particularly in colitis-associated colorectal cancer. This study examined the differences in immune infiltration patterns between colitis-associated colorectal cancer and sporadic colorectal cancer and their impact on prognosis.
Article
Clinical Neurology
Megan C. Bakeberg, Anastazja M. Gorecki, Jade E. Kenna, Alexa Jefferson, Michelle Byrnes, Soumya Ghosh, Malcolm K. Horne, Sarah McGregor, Rick Stell, Sue Walters, Paola Chivers, Samantha J. Winter, Frank L. Mastaglia, Ryan S. Anderton
Summary: Sex was found to significantly impact cognitive performance in Parkinson's disease patients, with males performing worse in global cognition, memory, and fluency, while females showed greater decline in attention/orientation, memory, and visuospatial domains. These sex-specific findings indicate a differential pattern of cognitive decline in male and female participants, highlighting the need for further investigation into the underlying mechanisms of this sexual dimorphism.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Raphael Scherbaum, Eun Hae Kwon, Daniel Richter, Dirk Bartig, Ralf Gold, Christos Krogias, Lars Toenges
Summary: The study found that hospitalizations for PD transiently decreased in 2020 compared to 2019, and the frequency of COVID-19 was significantly higher in PD patients, especially in older age groups. COVID-19(+) inpatients with PD showed higher incidences of established risk comorbidities than non-PD COVID-19(+) subjects, particularly hypertension and chronic kidney disease.
MOVEMENT DISORDERS
(2021)
Article
Medicine, Research & Experimental
Varvara Mathiopoulou, Niels Rijks, Matthan W. A. Caan, Luka C. Liebrand, Francisca Ferreira, Rob M. A. de Bie, Pepijn van den Munckhof, P. Richard Schuurman, Maarten Bot
Summary: This study segmented the motor part of the subthalamic nucleus (STN) in patients with Parkinson's disease using 7.0-Tesla T2 and DWI sequences. The results showed that patients with active electrode contacts located in the predominantly motor-connected segment of the STN had significantly higher motor improvement. This method can optimize deep brain stimulation for Parkinson's disease.
Article
Chemistry, Multidisciplinary
Tobias Preitschopf, Floriane Sturm, Iuliia Stroganova, Alexander K. Lemmens, Anouk M. Rijs, Ingo Fischer
Summary: Isolated 2-phenylallyl radicals (2-PA) generated from a nitrite precursor were studied using IR/UV ion dip spectroscopy with free electron laser radiation. 2-PA is a resonance-stabilized radical involved in the formation of polycyclic aromatic hydrocarbons (PAH) in combustion and interstellar space. Gas-phase IR spectrum was used to identify the radical, and several bimolecular reaction products were identified, indicating efficient formation of PAH through self-reaction and reactions with decomposition products of 2-PA. Possible mechanisms were discussed and the chemistry of 2-PA was compared with related radicals.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Physical
Alexander K. Lemmens, Cameron J. Mackie, Alessandra Candian, Timothy M. J. Lee, Alexander G. G. M. Tielens, Anouk M. Rijs, Wybren Jan Buma
Summary: This study validates the reliability of polycyclic aromatic hydrocarbons (PAHs) size distribution in the interstellar medium (ISM) using the calculated intrinsic infrared (IR) spectra. By comparing calculations from the NASA Ames PAH IR spectroscopic database to gas-phase experimental absorption IR spectra, it was found that the 11.2/3.3 mu m intensity ratio is consistently underestimated by 34%. However, higher level anharmonic calculations show good agreement with the experiments. Based on these findings, the intrinsic ratio of these modes was adjusted and incorporated into an interstellar PAH emission model, suggesting that typical PAH sizes in reflection nebulae are actually in the range of 40 to 55 carbon atoms.
FARADAY DISCUSSIONS
(2023)
Article
Chemistry, Physical
Ake Andersson, Vasyl Yatsyna, Mathieu Linares, Anouk Rijs, Vitali Zhaunerchyk
Summary: We investigate the gas-phase structure of the neutral pentaalanine peptide using supersonic jet cooling, infrared multiphoton dissociation, and vacuum-ultraviolet action spectroscopy. The molecule assumes multiple stable conformations, mainly of two structure types, with the most stable conformation featuring a C5 ring at the N-terminus and a 310-helix backbone with two beta-turns. The conformational preferences of pentaalanine are also evaluated using Born-Oppenheimer molecular dynamics, revealing a systematic frequency shift caused by a nonzero simulation time step.
JOURNAL OF PHYSICAL CHEMISTRY A
(2023)
Article
Biochemical Research Methods
Anouk M. Rijs, Agathe Depraz Depland, Iuliia Stroganova, Christopher A. Wootton
Summary: Ion mobility mass spectrometry (IM-MS) is an excellent method to study the structure of amyloidogenic protein and peptide aggregates. However, it is challenging to obtain detailed structural information on the early-stage intermediates due to their complex environment. Trapped ion mobility spectrometry (TIMS) is a high-resolution technique that can be used to analyze protein conformations. By optimizing the instrumental parameters of TIMS-qToF-MS, researchers can investigate the aggregation process of peptide aggregates.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Clinical Neurology
R. van Veen, G. Pallada, L. Wieske, S. E. M. Ten Holter, A. F. van Rootselaar, C. Verhamme, R. M. A. de Bie, I. N. van Schaik, I. S. J. Merkies, J. M. Dijk, Filip Eftimov
Summary: This study aimed to investigate whether tremor in CIDP is associated with disability. The presence of a clinically relevant tremor and tremor severity were significantly associated with disability in CIDP patients, independent of other impairments. To assess disease activity in CIDP patients with tremor, both impairment and disability outcomes should be assessed, as disability is partly caused by tremor while the effect of immunotherapy on tremor seems limited.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM
(2023)
Article
Clinical Neurology
V. Sisodia, B. E. K. S. Swinnen, J. M. Dijk, E. Verwijk, G. van Rooijen, A. W. Lemstra, P. R. Schuurman, R. M. A. de Bie
Summary: This clinical trial aims to determine the effectiveness and safety of deep brain stimulation (DBS) compared to best medical treatment (BMT) for patients with Parkinson's disease dementia (PDD). The trial will randomly assign 44 patients to either receive STN-DBS with BMT or BMT alone and assess their symptoms and cognitive abilities over a 30-week period, along with other secondary outcome measures.
Review
Chemistry, Multidisciplinary
Emilia Christofi, Perdita Barran
Summary: The investigation of macromolecular biomolecules with ion mobility mass spectrometry (IM-MS) techniques has provided substantial insights into the field of structural biology. An IM-MS workflow can provide mass, charge, and conformation information of a given target analyte, which is crucial for studying protein structures. This review focuses on the analysis of proteins and their complexes using IM-MS, discussing the typical features of an IM-MS experiment and how the data can be interpreted and compared with computational tools. The review also highlights the benefits of coupling mobility analysis to activation methods and its application to the study of conformationally dynamic and intrinsically disordered proteins.
Article
Chemistry, Analytical
Ruben F. Kranenburg, Henk-Jan Ramaker, Yannick Weesepoel, Peter W. F. Arisz, Peter H. J. Keizers, Annette van Esch, Cathelijne Zieltjens-van Uxem, Jorrit D. J. van den Berg, Janneke W. Hulshof, Sjors Bakels, Anouk M. Rijs, Arian C. van Asten
Summary: The need for on-site testing of MDMA formulations encountered by law enforcement and border security has led to the exploration of near-infrared spectroscopy. This technique shows promise in terms of rapid analysis, non-invasive detection, and suitability for portable operation. The NIR spectrum of MDMA, specifically a peak at around 2000 nm, is attributed to water molecules of crystallization in the MDMA lattice. Understanding the different forms of MDMA and their detection challenges will enhance the effectiveness of on-site NIR-based drug detection.
FORENSIC CHEMISTRY
(2023)
Article
Clinical Neurology
Bart E. K. S. Swinnen, Rob M. A. de Bie, Mark Hallett, Rick C. Helmich, Arthur W. G. Buijink
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Chemistry, Multidisciplinary
Daniel J. Bell, Tongtong Zhang, Niklas Geue, Ciaran J. Rogers, Perdita E. Barran, Alice M. Bowen, Louise S. Natrajan, Imogen A. Riddell
Summary: Multinuclear, self-assembled lanthanide complexes have potential as sensors and imaging agents, but synthetic and characterization challenges hinder their systematic study. This study evaluates the effect of ligand backbone symmetry on self-assembly of multinuclear lanthanide complexes, presenting an unusual Ln(6)L(6) architecture.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Antonio Valle, Maria Elena de la Calle, Howbeer Muhamadali, Katherine A. Hollywood, Yun Xu, Jonathan R. Lloyd, Royston Goodacre, Domingo Cantero, Jorge Bolivar
Summary: Metabolic engineering can enhance the production of hydrogen and ethanol by modifying Escherichia coli. Metabolomics platforms can identify metabolic bottlenecks, and various strategies can increase hydrogen production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
C. Gehin, J. Tokarska, S. J. Fowler, P. E. Barran, D. K. Trivedi
Article
Chemistry, Multidisciplinary
Manuel David Peris-Diaz, Alexey Barkhanskiy, Ellen Liggett, Perdita Barran, Artur Krezel
Summary: Ion mobility-mass spectrometry (IM-MS) revealed different conformational stability in Zn4-7-metallothionein-2. A new molecular dynamics simulation approach was introduced, which explored all conformational space, confirmed experimental data, and revealed that both Zn-S bonds and alpha-beta domain interactions modulate protein unfolding.
CHEMICAL COMMUNICATIONS
(2023)
