Article
Endocrinology & Metabolism
Liming Chen, Qiuling Xing, Jing Li, Jianxin Zhou, Yi Yuan, Ying Wan, Brian K. Pflug, Kenneth W. Strauss, Laurence J. Hirsch
Summary: This randomized controlled trial aimed to assess the impact of providing intensive injection technique education to patients routinely injecting insulin into sites of lipohypertrophy. The results showed that proper injection technique education enables a safe reduction of total daily dose of insulin while maintaining overall glycemic control.
Review
Endocrinology & Metabolism
Sanjay Kalra, Faruque Pathan, Ida Ayu Made Kshanti, Nguyen Quang Bay, Terumasa Nagase, Teresa Oliveria, Shailendra Bajpai
Summary: The correct use of insulin injection technique is crucial for the effectiveness of therapy in diabetes patients. Despite established recommendations and evidence highlighting the importance of effective insulin injection technique, impediments to its use among patients need to be identified, and awareness among patients and healthcare professionals needs to be raised. This review focuses on recent advancements in delivery devices, teaching methods, monitoring, and complication management to optimize injection techniques and improve diabetes outcomes.
Review
Dermatology
Michael H. Gold
Summary: This review describes available techniques for hastening bruise resolution and their application in resolving bruises associated with a CCH injectable.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Agostino Consoli, Gloria Formoso
Summary: This study aimed to evaluate patient perceptions of insulin therapy management and their impressions of connected insulin pens compared to standard insulin pens. Findings showed that patients had a high need to overcome the cognitive burden associated with insulin therapy, and only 25% of patients had high adherence. Patients rated connected insulin pens as very useful, suggesting that reducing the cognitive burden can influence preferences for insulin delivery systems.
ACTA DIABETOLOGICA
(2023)
Article
Agronomy
Changsu Xu, Dong Wang, Fudong Xu, Han Tang, Jiale Zhao, Jinwu Wang
Summary: This research evaluated the bruise susceptibility of newly harvested white radishes in various impact scenarios using finite element analysis and response surface methodology. The accurate form of the white radish was obtained through reverse engineering, and a two-layer material finite element model was created to simulate the collisions. The empirical model established through response surface analysis can predict the bruising susceptibility of white radish. The findings suggest that this model can describe the susceptibility of white radish to bruising under specific impact scenarios.
POSTHARVEST BIOLOGY AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Sachiko Honjo, Yukako Koshii, Shusaku Tozaka, Hiroko Tateno, Yamato Keidai, Yohei Seno, Yorihiro Iwasaki, Kanako Iwasaki, Shiho Ayano, Akihiro Hamasaki
Summary: A study was conducted to investigate the improvement of glycemic control through appropriate re-education on insulin self-injection technique (SIT) in patients with diabetes mellitus undergoing insulin therapy. The subjects' SIT was checked and HbA1c levels were measured during a six-month observation period. The results showed that re-education on SIT effectively reduced HbA1c levels and improved adherence to proper SIT.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Endocrinology & Metabolism
Jarl Hellman, Niels Vaever Hartvig, Anne Kaas, Jonas Bech Moller, Mads Reinholdt Sorensen, Johan Jendle
Summary: This study evaluates the association between bolus insulin injection frequency, smart pen engagement, and changes in glycaemic control for individuals with type 1 diabetes. The results indicate that the number of daily bolus injections is significantly correlated with time in the target glucose range. Additionally, effective use of a smart pen is associated with improved glycaemic control.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Quanying Wu, Mingqun Deng, Weihao Wang, Shuyi Yu, Miao Wang, Chao Sun, Qi Pan, Lixin Guo
Summary: This study found that needle-free insulin injections can better control blood glucose levels and reduce pain in patients with diabetes who require intensive glycemic control.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Han-Chow E. Koh, Chao Cao, Bettina Mittendorfer
Summary: Plasma insulin clearance plays an important role in determining plasma insulin concentration and is closely related to excess adiposity, insulin sensitivity, and type 2 diabetes. The lower insulin clearance rate observed in people with obesity is not a compensatory response to insulin resistance, but directly linked to insulin sensitivity. Additionally, postprandial insulin clearance decreases due to increased delivery of insulin to tissues that clear insulin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Hematology
Thomas W. King, Blake J. Cochran, Kerry-Anne Rye
Summary: ApoA-I, the main component of HDL, has multiple cardioprotective and antidiabetic functions. This review summarizes the current knowledge of apoA-I's antidiabetic effects, the mechanism behind these effects, and the potential of small peptides that mimic apoA-I to be used as innovative treatments for diabetes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Dandan Xiao, Wenguang Chang
Summary: This article discusses the role of phospholipids in cell membrane structure as well as various cellular processes. Studies have found a relationship between certain phospholipids and insulin sensitivity. Additionally, phospholipids play a significant role in controlling insulin secretion, regulating insulin signaling transduction, and contributing to the progression of diabetic complications. PS supplements and PS-containing liposomes have shown protective effects against diabetes in animal studies.
MOLECULAR PHARMACEUTICS
(2023)
Article
Medicine, General & Internal
Mousa Abujbara, Eiman A. Khreisat, Yousef Khader, Kamel M. Ajlouni
Summary: This study assessed the practices of insulin injection techniques among diabetes patients and found that rotation of injection sites, lipohypertrophy, and lower daily insulin dose were significantly associated with better glycemic control.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Sanjay Kalra, Ambika G. Unnikrishnan, K. M. Prasanna Kumar, Rakesh Sahay, Hemraj B. Chandalia, Banshi Saboo, Sundaram Annamalai, Jothydev Kesavadev, Rishi Shukla, S. K. Wangnoo, Manash P. Baruah, Jubbin Jacob, Saurabh Arora, Rajiv Singla, Suresh K. Sharma, Suresh Damodaran, Ganapathi Bantwal
Summary: With the emerging complexities in chronic diseases and people's lifestyles, healthcare professionals need to update their methods to better manage and educate patients with diabetes. The Forum for Injection Technique and Therapy Expert Recommendations in India has updated its recommendations to improve insulin injection technique, including newer ways of detecting hypoglycemia and lipohypertrophy, preventing needlestick injuries, encouraging proper disposal of insulin needles, and introducing recommendations for calculating insulin bolus dose.
Article
Endocrinology & Metabolism
Yeye Zhuo, Ying Pan, Kun Lin, Guoshu Yin, Yixi Wu, Jing Xu, De Cai, Lixuan Xu
Summary: The study investigates the efficacy of a clinical pharmacist-led smartphone application on medication adherence, insulin injection technique, and diabetes-related outcomes among women with gestational diabetes mellitus. The results show that the app, combined with usual care, can improve medication adherence and various aspects of diabetes management.
PRIMARY CARE DIABETES
(2022)
Editorial Material
Biochemistry & Molecular Biology
Roy W. Beck
Summary: Automated insulin delivery systems, used in type 1 diabetes, hold promise for patients with type 2 diabetes and are expected to have a significant impact on public health.
Article
Dermatology
Enrico Brocco, Vincenzo Curci, Roberto Da Ros, Cesare Miranda, Giovanni Boschetti, Sara Barone, Anna Tedeschi, Elisabetta Salutini, Roberto Anichini
Summary: Diabetic foot ulcers are common and complex complications with high costs. This study presents a new treatment method based on photomedicine principles, which can effectively kill microbial agents in foot ulcers and promote ulcer healing, thus reducing amputation rate.
INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS
(2022)
Article
Endocrinology & Metabolism
Luciano Zenari, Andrea Da Porto, Lorena De Moliner, Francesca Lugli, Valeria Guazzoni, Gloria Groppelli, Laura Molteni, Massimo Bracaccia, Vera Frison, Natalino Simioni, Barbara Bonsembiante, Cesare Miranda, Annunziata Lapolla
Summary: The study demonstrates that switching to IDegLira treatment is a valid option for Italian patients with uncontrolled type 2 diabetes mellitus who are struggling with glycemic control and/or experiencing side effects of other insulin therapies. Significant improvements in glycemic control, including reductions in glycated hemoglobin levels, were observed in both the BOT and BB groups following the switch to IDegLira treatment. Additionally, these improvements were achieved with moderate doses of IDegLira.
Review
Endocrinology & Metabolism
Sandro Gentile, Giuseppina Guarino, Teresa Della Corte, Giampiero Marino, Alessandra Fusco, Gerardo Corigliano, Sara Colarusso, Marco Piscopo, Maria Rosaria Improta, Marco Corigliano, Emilia Martedi, Domenica Oliva, Viviana Russo, Rosa Simonetti, Ersilia Satta, Carmine Romano, Sebastiano Vaia, Felice Strollo
Summary: The study investigated the relationship between age and insulin injection technique errors leading to subcutaneous fat hypertrophy, showing a higher prevalence of LH in the elderly group. Older patients exhibited more injection habit issues and painful injections.
Article
Endocrinology & Metabolism
Sandro Gentile, Giuseppina Guarino, Teresa Della Corte, Giampiero Marino, Ersilia Satta, Maria Pasquarella, Carmine Romano, Carmelo Alfrone, Felice Strollo
Summary: Structured education was found to effectively reduce the rate of intra-lipohypertrophy injections, leading to significant improvements in HbA1c levels, glycemic variability, insulin requirements, and hypoglycemia prevalence. This resulted in a decrease in overall healthcare costs, indicating the economic advantage of intensive educational interventions in improving injection technique.
Review
Medicine, Research & Experimental
Vincenzo Maria Monda, Francesca Porcellati, Felice Strollo, Alessandro Fucili, Marcello Monesi, Ersilia Satta, Sandro Gentile
Summary: This review examines the relationship between obstructive sleep apnoea (OSA) and type 2 diabetes mellitus (T2DM), suggesting the potential use of sodium-glucose co-transporter-2 inhibitors (SGLT-2i) as a treatment target. It also proposes that SGLT-2i indications could expand beyond current ones, including glucose, lipids, uric acid, blood pressure, and body weight control, as well as chronic heart failure and kidney disease prevention.
ADVANCES IN THERAPY
(2021)
Article
Endocrinology & Metabolism
Sandro Gentile, Giuseppina Guarino, Teresa Della Corte, Giampiero Marino, Ersilia Satta, Maria Pasquarella, Carmine Romano, Carmelo Alfrone, Laura Giordano, Fabrizio Loiacono, Maurizio Capace, Rossella Lamberti, Felice Strollo
Summary: The study found that an intensive, structured education-based rehabilitation protocol has a positive and lasting impact on insulin injection practice in people with type 2 diabetes mellitus. Continuous education refresher courses help maintain and improve injection habits, prevent hypoglycemic events, and assist in controlling blood glucose levels effectively.
Editorial Material
Medicine, Research & Experimental
Vincenzo Maria Monda, Sandro Gentile, Francesca Porcellati, Ersilia Satta, Alessandro Fucili, Marcello Monesi, Felice Strollo
Summary: In this mini-review, the complex interplay between heart failure, nonalcoholic fatty liver disease, and obstructive sleep apnea syndrome was examined. The study described the potential favorable effects of sodium-glucose cotransporter 2 inhibitors in heart failure with preserved ejection fraction through improved cardiorenal function and redistribution of body fat. These inhibitors may have promising roles in preventing, rehabilitating, and treating patients with obstructive sleep apnea, regardless of the presence of type 2 diabetes.
ADVANCES IN THERAPY
(2022)
Review
Endocrinology & Metabolism
Andrea Da Porto, Cesare Miranda, Gabriele Brosolo, Giorgio Zanette, Andrea Michelli, Roberto Da Ros
Summary: Nutritional status plays a crucial role in wound healing for patients with diabetic foot ulcers, but malnutrition is often overlooked. Currently, there is no clear recommendation or evidence regarding the use of nutritional supplements to improve wound healing in patients with diabetic foot ulcers.
WORLD JOURNAL OF DIABETES
(2022)
Review
Endocrinology & Metabolism
Jingtong Huang, Andrea M. Yeung, David Kerr, Sandro Gentile, Lutz Heinemann, Mohammed E. Al-Sofiani, Jeffrey I. Joseph, Jane Jeffrie Seley, David C. Klonoff
Summary: This article reviews the current status of practical knowledge related to insulin-associated lipohypertrophy (LH), a commonly caused accumulation of fatty subcutaneous nodules resulting from repeated injections and/or infusions of insulin into the same site. Injecting insulin into areas with lipohypertrophy is associated with reduced pain but may interfere with insulin absorption and increase the risk of glucose variability, hypo- and hyperglycemia. Early diagnosis of lipohypertrophy can be achieved using modern visualization technology such as ultrasound. Education on insulin injection techniques can prevent and treat the physiological and psychological consequences of developing insulin lipohypertrophy.
ENDOCRINE PRACTICE
(2023)
Article
Endocrinology & Metabolism
Viviana Castaldo, Daniela Domenici, Mauro Valentino Biscosi, Paolo Ubiali, Cesare Miranda, Giorgio Zanette, Cinzia Mazzon, Maurizio Tonizzo
Summary: Doege-Potter syndrome is a rare paraneoplastic entity that is mostly associated with solitary fibrous tumors. If the cause of hypoglycemia is unexplained, this syndrome should be suspected, and further investigation for unknown tumors should be conducted.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2023)
Article
Endocrinology & Metabolism
Giuseppina Guarino, Felice Strollo, Teresa Della Corte, Ersilia Satta, Sandro Gentile
Summary: This study demonstrates that PGR, when combined with lifestyle changes, improves lipid and glucose metabolism-related parameters in adults with MAFLD. Additionally, it reduces visceral fat, liver fat content, and severity of liver fibrosis. The effect of PGR may be attributed to reduced post-meal blood glucose and insulin peaks, as well as potential changes in intestinal microbiota.
Editorial Material
Endocrinology & Metabolism
Tiffany Tian, Rachel E. Aaron, Jingtong Huang, Andrea M. Yeung, Jannet Svensson, Sandro Gentile, Angus Forbes, Lutz Heinemann, Jane Jeffrie Seley, David Kerr, David C. Klonoff
Summary: Lipohypertrophy is a common skin complication in insulin-treated diabetes that is often underestimated as a contributing factor to suboptimal blood sugar control, glucose variability, and hypoglycemia. In a recent Webinar by the Diabetes Technology Society, international experts provided updates on the latest knowledge related to lipohypertrophy for clinicians, educators, researchers, and insulin delivery industries. The recorded session of the Webinar is freely available on the Diabetes Technology Society Web site (https://www.diabetestechnology.org/).
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Matteo Monami, Alessia Scatena, Cesare Miranda, Luca Monge, Alessandro De Cassai, Antonio Volpe, Rodolfo Tramonta, Gerardo Medea, Corrado Bordieri, Marco Falcone, Laura Stefanon, Andrea Bernetti, Cristina Cappella, Mauro Gargiulo, Valentina Lorenzoni, Germano Scevola, Eugenio Stabile, Benedetta Ragghianti, Giovanni Antonio Silverii, Roberto da Ros, Marco Meloni, Laura Giurato, Giuseppe Murdolo, Eleonora Bianchini, Francesco Gaggia, Carlotta Gauna, Francesco Romeo, Matteo Apicella, Michele Mantuano, Luigi Uccioli, Cristiana Vermigli
Summary: The Italian Society of Diabetology and other scientific societies are developing the first Italian guidelines for the treatment of diabetic foot syndrome (DFS), covering diagnosis, treatment, prevention, and organization management.
ACTA DIABETOLOGICA
(2023)
Review
Endocrinology & Metabolism
Alessia Scatena, Matteo Apicella, Michele Mantuano, Francesco Liistro, Giorgio Ventoruzzo, Pasquale Petruzzi, Cesare Miranda, Luca Monge, Benedetta Ragghianti, Antonio Silverii, Isabella Ferraro, Luigi Uccioli, Cristiana Vermigli, Edoardo Mannucci, Germano Scevola, Eugenio Stabile, Mauro Gargiulo, Matteo Monami
Summary: This study reports on a review and meta-analysis of randomized controlled trials comparing bypass surgery and endovascular treatment for infrainguinal peripheral arterial disease. The results show no clear superiority between the two treatments, with similar rates of major amputation and ulcer healing. However, endovascular treatment had shorter operative duration and hospital stay but higher risk of reintervention.
ACTA DIABETOLOGICA
(2023)
