期刊
APPLIED SCIENCES-BASEL
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/app11052173
关键词
erythrocyte; nanoparticles; carrier into carrier
类别
资金
- Tecnopolo di Nanotecnologia e Fotonica per la medicina di precisione (TECNOMED)-FISR/MIUR-CNR: delibera CIPE [3449, CUP: B83B17000010001]
- Tecnopolo per la medicina di precisione (TecnoMed Puglia)-Regione Puglia: DGR [2117, CUP: B84I18000540002]
- Global Thesis-Prize 2019 of University of Bari-Aldo Moro-for student exchange
Nano-delivery systems, which combine synthetic nanoparticles and erythrocytes, offer a hybrid approach strategy that utilizes the advantages of both natural and synthetic materials. These systems have the ability to target cells effectively and carry a wide range of therapeutic molecules, making them versatile tools for therapy and disease diagnosis.
Nano-delivery systems represent one of the most studied fields, thanks to the associated improvement in the treatment of human diseases. The functionality of nanostructures is a crucial point, which the effectiveness of nanodrugs depends on. A hybrid approach strategy using synthetic nanoparticles (NPs) and erythrocytes offers an optimal blend of natural and synthetic materials. This, in turn, allows medical practitioners to exploit the combined advantages of erythrocytes and NPs. Erythrocyte-based drug delivery systems have been investigated for their biocompatibility, as well as the long circulation time allowed by specific surface receptors that inhibit immune clearance. In this review, we will discuss several methods-whole erythrocytes as drug carriers, red blood cell membrane-camouflaged nanoparticles and nano-erythrosomes (NERs)-while paying attention to their application and specific preparation methods. The ability to target cells makes erythrocytes excellent drug delivery systems. They can carry a wide range of therapeutic molecules while also acting as bioreactors; thus, they have many applications in therapy and in the diagnosis of many diseases.
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