Unraveling the Developmental Roadmap toward Human Brown Adipose Tissue

Inflammatory Signaling and Brown Fat Activity

(2020) Farah Omran et al.   Frontiers in Endocrinology

Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

(2020) Denis P. Blondin et al.   Cell Metabolism

Heterogeneity in the perirenal region of humans suggests presence of dormant brown adipose tissue that contains brown fat precursor cells

(2019) Naja Z. Jespersen et al.   Molecular Metabolism

Exogenous Cytokine-Free Differentiation of Human Pluripotent Stem Cells into Classical Brown Adipocytes

(2019) Oka et al.   Cells

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

(2019) Marina Badenes et al.   Molecular Metabolism

Recapitulating early development of mouse musculoskeletal precursors of the paraxial mesoderm in vitro

(2018) Jérome Chal et al.   DEVELOPMENT

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

A mesodermal fate map for adipose tissue

(2018) Zachary L. Sebo et al.   DEVELOPMENT

Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis

(2018) Esther Paulo et al.   Scientific Reports

Secretin-Activated Brown Fat Mediates Prandial Thermogenesis to Induce Satiation

(2018) Yongguo Li et al.   CELL

BATLAS: Deconvoluting Brown Adipose Tissue

(2018) Aliki Perdikari et al.   Cell Reports

A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors

(2018) Jianbo Wu et al.   Cell Reports

Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor

(2017) Lasse K. Markussen et al.   PLoS One

Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes

(2016) Ester García-Casarrubios et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

(2016) Lynne E. Ramage et al.   Cell Metabolism

Functional characterization of somatic mutations in cancer using network-based inference of protein activity

(2016) Mariano J Alvarez et al.   NATURE GENETICS

Control of brown and beige fat development

(2016) Wenshan Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Emerging Complexities in Adipocyte Origins and Identity

(2016) Joan Sanchez-Gurmaches et al.   TRENDS IN CELL BIOLOGY

Vitamin C promotes the proliferation of human adipose-derived stem cells via p53-p21 pathway

(2016) Peihua Zhang et al.   Organogenesis

Position-dependent plasticity of distinct progenitor types in the primitive streak

(2016) Filip J Wymeersch et al.   eLife

Brown Adipose Tissue Is Linked to a Distinct Thermoregulatory Response to Mild Cold in People

(2016) Maria Chondronikola et al.   Frontiers in Physiology

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Short-term Cold Acclimation Recruits Brown Adipose Tissue in Obese Humans

(2015) Mark J.W. Hanssen et al.   DIABETES

Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes

(2015) Ruidan Xue et al.   NATURE MEDICINE

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans

(2015) Andrew J. Whittle et al.   Nature Communications

NANOG and CDX2 Pattern Distinct Subtypes of Human Mesoderm during Exit from Pluripotency

(2014) Sasha Mendjan et al.   Cell Stem Cell

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Adipocytes arise from multiple lineages that are heterogeneously and dynamically distributed

(2014) Joan Sanchez-Gurmaches et al.   Nature Communications

Brown adipose tissue: development, metabolism and beyond

(2013) Tim J. Schulz et al.   BIOCHEMICAL JOURNAL

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

Adipogenesis: new insights into brown adipose tissue differentiation

(2013) Stefania Carobbio et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Differentiation of Human Induced Pluripotent Stem Cells into Brown and White Adipocytes: Role of Pax3

(2013) Tala Mohsen-Kanson et al.   STEM CELLS

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Production of Functional Classical Brown Adipocytes from Human Pluripotent Stem Cells using Specific Hemopoietin Cocktail without Gene Transfer

(2012) Miwako Nishio et al.   Cell Metabolism

Programming human pluripotent stem cells into white and brown adipocytes

(2012) Tim Ahfeldt et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

In Vitro Modeling of Paraxial Mesodermal Progenitors Derived from Induced Pluripotent Stem Cells

(2012) Hidetoshi Sakurai et al.   PLoS One

Human BAT Possesses Molecular Signatures That Resemble Beige/Brite Cells

(2012) Louis Z. Sharp et al.   PLoS One

Brachyury establishes the embryonic mesodermal progenitor niche

(2010) B. L. Martin et al.   GENES & DEVELOPMENT

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Signaling Gradients during Paraxial Mesoderm Development

(2009) A. Aulehla et al.   Cold Spring Harbor Perspectives in Biology

PRDM16 controls a brown fat/skeletal muscle switch

(2008) Patrick Seale et al.   NATURE