Article
Medicine, General & Internal
Oscar Demeulenaere, Adrien Bertolo, Sophie Pezet, Nathalie Ialy-Radio, Bruno Osmanski, Clement Papadacci, Mickael Tanter, Thomas Deffieux, Mathieu Pernot
Summary: This study demonstrates the potential of 3D ultrafast ultrasound localization microscopy (ULM) in mapping the whole-brain microvasculature and flow in vivo, providing unprecedented insights into the cerebral vascular system in mice models. The technology has the potential to become a major tool for clinical investigation of the cerebral microcirculation.
Article
Biochemistry & Molecular Biology
Daniel G. Blackmore, Fabrice Turpin, Tishila Palliyaguru, Harrison T. Evans, Antony Chicoteau, Wendy Lee, Matthew Pelekanos, Nghia Nguyen, Jae Song, Robert K. P. Sullivan, Pankaj Sah, Perry F. Bartlett, Jurgen Gotz
Summary: The study reveals that scanning ultrasound combined with microbubbles can fully restore LTP induction in the aged mouse brain, while ultrasound treatment alone can also improve LTP and spatial learning deficits in aged mice. This non-invasive therapeutic approach may enhance cognition in elderly humans.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Sanjay Ghosh, Ashish Raj, Srikantan S. Nagarajan
Summary: This article introduces a computational framework that reconstructs functional connectivity from structural connectivity by identifying a joint subspace of eigenmodes. It is found that a small number of these eigenmodes are sufficient for reconstruction and the proposed algorithm shows competitive performance and better interpretability compared to existing methods.
Article
Neurosciences
Jose Maria Martinez de Paz, Emilie Mace
Summary: Functional ultrasound (fUS) is a hemodynamic-based neuroimaging technique with high spatiotemporal resolution, large field of view, and compatibility with behavior, making it well-suited for studying patterns of correlated activity between brain regions and brain-wide pathways associated with behavior. By combining fUS with optogenetics, its capabilities can be further enhanced, promising a significant impact in multi-modal studies.
Article
Neurosciences
Seoyoung Son, Steffy B. Manjila, Kyra T. Newmaster, Yuan-ting Wu, Daniel J. Vanselow, Matt Ciarletta, Todd E. Anthony, Keith C. Cheng, Yongsoo Kim
Summary: This study provides a comprehensive mapping of Oxt neurons in the whole brain of adult male and female mice, revealing the anatomical connectivity and relationship with Oxtr expression in different hypothalamic regions, shedding light on the distinct functions of Oxt signaling in the brain.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Benjamin A. Seitzman, Francisco J. Reynoso, Timothy J. Mitchell, Annie R. Bice, Anmol Jarang, Xiaodan Wang, Cedric Mpoy, Lori Strong, Buck E. Rogers, Carla M. Yuede, Joshua B. Rubin, Stephanie M. Perkins, Adam Q. Bauer
Summary: Cognitive dysfunction is a common complication following radiotherapy to the brain, but its mechanisms are not well understood. This study used imaging and behavioral tests to examine the effects of radiotherapy on brain activity and found disruptions in cortical activity and cognitive deficits.
Article
Neurosciences
Hyunyeol Lee, Felix W. Wehrli
Summary: Quantitative BOLD (qBOLD) MRI allows evaluation of hemodynamic and metabolic states of the brain, but separating deoxyhemoglobin's contribution remains a challenge. A new 3D MRI oximetry technique was developed in this study to enable robust qBOLD mapping across the entire brain.
Article
Neurosciences
Chae Hyeon Lee, Hyunjin Park, Mi Ji Lee, Bo-yong Park
Summary: Using dimensionality reduction techniques, we found significant differences in whole-brain functional connectivity between patients with migraine and healthy controls, particularly in the sensory/motor and limbic cortices. We also revealed significant alterations in subcortical connectivity with subcortico-cortical connectivity multiplied by cortical eigenvectors. Moreover, using supervised machine learning, we moderately predicted headache frequency using cortical and subcortical functional connectivity features.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Taylor Kuhn, Norman M. Spivak, Bianca H. H. Dang, Sergio Becerra, Sabrina E. Halavi, Natalie Rotstein, Benjamin M. Rosenberg, Sonja Hiller, Andrew Swenson, Luka Cvijanovic, Nolan Dang, Michael Sun, David Kronemyer, Rustin Berlow, Malina R. Revett, Nanthia Suthana, Martin M. Monti, Susan Bookheimer
Summary: This study demonstrated that tFUS can selectively and accurately target and modulate deep brain structures in humans, resulting in increased perfusion, direct modulation of neural activity, and regulation of functional network connectivity in the targeted regions.
FRONTIERS IN NEURAL CIRCUITS
(2023)
Article
Neurosciences
Lindsey M. Brier, Xiaohui Zhang, Annie R. Bice, Seana H. Gaines, Eric C. Landsness, Jin-Moo Lee, Mark A. Anastasio, Joseph P. Culver
Summary: Temporal correlation analysis of spontaneous brain activity provides insights into the functional organization of the human brain. However, traditional bivariate analysis techniques are susceptible to confounding physiological processes. In contrast, a multivariate approach can accurately determine functional connectivity and provide performance advantages. In a study analyzing neural calcium imaging data from mice, the multivariate functional connectivity showed sparser connections and better connectivity deficit detection compared to traditional functional connectivity.
Article
Psychiatry
Sha-sha Yi, Jun-jie Zou, Long Meng, Hou-minji Chen, Zhong-qiu Hong, Xiu-fang Liu, Umar Farooq, Mo-xian Chen, Zheng-rong Lin, Wei Zhou, Li-juan Ao, Xi-quan Hu, Li-li Niu
Summary: Research shows that ultrasound stimulation of the prefrontal cortex can suppress inflammation and improve depressive and anxiety-like behaviors, potentially offering a non-invasive treatment option for neuropsychiatric diseases.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Ke Song, Yong Wang, Mei-Xia Ren, Jiao Li, Ting Su, Si-Yi Chen, Yi Shao, Ya-Li Lv
Summary: Using resting-state functional connectivity, this study found abnormal neural activities in specific brain regions of patients with optic neuritis, with significant changes in rsFC, longFCD, and IFCD values, which may help identify the specific mechanism of change in brain function in ON.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Anatomy & Morphology
Zikuan Chen, Xiulan Zhai, Zeyuan Chen
Summary: We hypothesized that brain normal aging consists of a balanced whole-brain functional connectivity, where some connections decline while others increase or retain, resulting in a summation balance. We validated this hypothesis by using brain intrinsic magnetic susceptibility source reconstructed from fMRI phase data. Our results showed that the chi FC aging upholds a FC balance in life span and is closer to the brain FC aging truth compared to the MRI-borne mFC and pFC agings.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Pharmacology & Pharmacy
Marie-Solenne Felix, Emilie Borloz, Khaled Metwally, Ambre Dauba, Benoit Larrat, Valerie Matagne, Yann Ehinger, Laurent Villard, Anthony Novell, Serge Mensah, Jean-Christophe Roux
Summary: Gene therapy is a powerful tool for treating diseased tissues and providing lasting and effective correction. The combination of focused ultrasound and microbubbles appears to be a technological breakthrough for delivering therapeutic agents to the central nervous system.
Article
Engineering, Biomedical
Ping Xie, Yingying Hao, Xiaoling Chen, Ziqiang Jin, Shengcui Cheng, Xin Li, Lanxiang Liu, Yi Yuan, Xiaoli Li
Summary: This study aimed to explore and evaluate the neuromodulation effects of transcranial ultrasound stimulation (TUS) on mouse motor neural circuits. The results showed that TUS can enhance functional corticomuscular coupling in the motor cortex, especially in the lower frequency bands.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Benoit Beliard, Chaimae Ahmanna, Elodie Tiran, Kadia Kante, Thomas Deffieux, Mickael Tanter, Fatiha Nothias, Sylvia Soares, Sophie Pezet
Summary: Acute spinal cord injury results in severe damage to the microvascular network. This study uses ultrafast Doppler imaging and ultrasound localization microscopy to analyze the structural and functional vascular alterations during chronic SCI. The results show hemodynamic alterations in the spinal cord and correlations between vascular dysfunction biomarkers and SCI severity. This imaging modality can be used to evaluate vascular function recovery and predict treatment outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Maximiliano Anzibar Fialho, Lucia Vazquez Alberdi, Mariana Martinez, Miguel Calero, Jerome Baranger, Mickael Tanter, Juan Pablo Damian, Carlos Negreira, Nicolas Rubido, Alejandra Kun, Javier Brum
Summary: The hippocampus is crucial for learning and memory, requiring adequate blood flow. This study used mu Doppler and scanning laser confocal microscopy to examine the vascular structure in the hippocampus of wild-type mice. The results showed a correlation between cerebral blood volume (CBV) and vessel volume fraction (VVF), and significant changes in CBV and vasculature with ageing. The findings suggest that this combined imaging approach can be a powerful tool for studying various pathological changes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Julien Claron, Julie Royo, Fabrice Arcizet, Thomas Deffieux, Mickael Tanter, Pierre Pouget
Summary: The activity of the medial prefrontal cortex (SEF) is found to be related to pupil dynamics, and manipulating pupil diameter can affect the neurovascular activity in SEF. These findings provide a novel understanding of the physiological links between pupil and SEF.
Article
Medicine, General & Internal
Oscar Demeulenaere, Adrien Bertolo, Sophie Pezet, Nathalie Ialy-Radio, Bruno Osmanski, Clement Papadacci, Mickael Tanter, Thomas Deffieux, Mathieu Pernot
Summary: This study demonstrates the potential of 3D ultrafast ultrasound localization microscopy (ULM) in mapping the whole-brain microvasculature and flow in vivo, providing unprecedented insights into the cerebral vascular system in mice models. The technology has the potential to become a major tool for clinical investigation of the cerebral microcirculation.
Article
Acoustics
Matthieu Blons, Thomas Deffieux, Bruno -Felix Osmanski, Mickael Tanter, Beatrice Berthon
Summary: Ultrafast ultrasound is an emerging imaging modality that provides high spatial and temporal resolution. In this study, a real-time enhancement strategy based on deep-learning techniques was proposed to improve the quality of Doppler imaging. The proposed method outperformed standard filters in reducing noise, increasing contrast, and preserving details.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Engineering, Biomedical
Justine Robin, Charlie Demene, Baptiste Heiles, Victor Blanvillain, Liene Puke, Fabienne Perren, Mickael Tanter
Summary: This study proposes an adaptive aberration correction technique for imaging the human brain vasculature using intravenously injected microbubbles. The technique improves image quality and increases contrast and the number of detected microbubble tracks. It has significant implications for better diagnosis and follow-up of brain pathologies and makes transcranial ultrasound imaging possible in difficult-to-image human adults.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Sara Cadoni, Charlie Demene, Ignacio Alcala, Matthieu Provansal, Diep Nguyen, Dasha Nelidova, Guillaume Labernede, Jules Lubetzki, Ruben Goulet, Emma Burban, Julie Degardin, Manuel Simonutti, Gregory Gauvain, Fabrice Arcizet, Olivier Marre, Deniz Dalkara, Botond Roska, Jose Alain Sahel, Mickael Tanter, Serge Picaud
Summary: Researchers have successfully achieved precise control and activation of retinal and cortical neurons by expressing ultrasound-sensitive proteins and combining unconventional high-frequency ultrasound stimulation. The spatiotemporal resolution and acoustic energy deposit achieved are compatible with the requirements of visual restoration. Sonogenetics provides neuron-specific activation at high spatiotemporal resolution both in retina and in the deep visual cortex, providing a less invasive approach for visual restoration compared to current brain-machine interfaces.
NATURE NANOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
Hugues Favre, Mathieu Pernot, Mickael Tanter, Clement Papadacci
Summary: By using a multi-lens diffracting layer, ultrasound localization microscopy (ULM) can effectively map and quantify blood microflows in the brain. In this study, a 16 elements prototype was developed and in vitro experiments were performed to validate the imaging capabilities of this new probe concept.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Beatrice Berthon, Antoine Bergel, Marta Matei, Mickael Tanter
Summary: Functional Ultrasound (fUS) provides high-resolution and high-sensitivity spatial and temporal frames of vascular activity in the brain. However, the resulting data is currently underused due to the lack of proper visualization and interpretation tools. This study demonstrates that neural networks can utilize the information in fUS datasets to accurately determine behavior after appropriate training.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Julien Claron, Matthieu Provansal, Quentin Salardaine, Pierre Tissier, Alexandre Dizeux, Thomas Deffieux, Serge Picaud, Mickael Tanter, Fabrice Arcizet, Pierre Pouget
Summary: To better understand the brain's role in primate behavior, simultaneous recording of neural activity at different spatiotemporal scales is necessary but challenging. This study uses functional ultrasound imaging and single-unit activity (SUA) recordings in macaque monkeys to show that SUA can estimate neurovascular response below the typical fMRI spatial resolution. The study also finds that SUA and cerebral blood volume (CBV) activities are not correlated during resting state but are correlated during tasks, suggesting implications for interpreting functional imaging findings.
Article
Medicine, General & Internal
Guillaume Goudot, Anatole Jimenez, Nassim Mohamedi, Jonas Sitruk, Lina Khider, Helene Mortelette, Clement Papadacci, Fabien Hyafil, Mickael Tanter, Emmanuel Messas, Mathieu Pernot, Tristan Mirault
Summary: Ultrasound localization microscopy (ULM) based on ultrafast ultrasound imaging of circulating microbubbles can visualize microvascular blood flows in vivo up to the micron scale. This study aimed to perform vasa vasorum ULM of the carotid wall in patients with Takayasu arteritis (TA) and demonstrate that ULM can provide imaging markers to assess TA activity.
Meeting Abstract
Peripheral Vascular Disease
Guillaume Goudot, Anatole Jimenez, Nassim Mohamedi, Jonas Sitruk, Lina Khider, Mickael Tanter, Emmanuel Messas, Mathieu Pernot, Tristan Mirault