Article
Oncology
Amel Baghdadli, Giovanni G. G. Arcuri, Clarence G. G. Green, Lynn R. R. Gauthier, Pierre Gagnon, Bruno Gagnon
Summary: Cancer-related cognitive impairment (CRCI) significantly affects the quality of life of cancer patients. Existing cognitive assessment tools are time-consuming and fail to detect subtle cognitive changes expected in patients with CRCI. This study introduces a new tool called Fast Cognitive Evaluation (FaCE) that is rapid, reliable, and sensitive to detect even minimal cognitive changes over time.
Article
Clinical Neurology
Loretta Norton, Karnig Kazazian, Teneille Gofton, Derek B. Debicki, Davinia Fernandez-Espejo, Jonathan E. Peelle, Eyad Al Thenayan, G. Bryan Young, Adrian M. Owen
Summary: This study aimed to investigate the efficacy of functional neuroimaging in assessing cognitive function in acute disorders of consciousness. The results showed that functional neuroimaging could detect preserved auditory function and language comprehension, and even reveal covert conscious awareness in patients. Furthermore, there was a positive relationship between fMRI responsivity and the level of functional recovery.
ANNALS OF NEUROLOGY
(2023)
Review
Health Care Sciences & Services
Dorota Siwicka-Gieroba, Chiara Robba, Jakub Golacki, Rafael Badenes, Wojciech Dabrowski
Summary: Organism survival relies on the balance of oxygen delivery and utilization, especially crucial for the brain after acute injuries. Clinical protocols play an important role in improving oxygen delivery and reducing mortality in brain-injured patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Pediatrics
Niklas Breindahl, Martin G. Tolsgaard, Tine B. Henriksen, Charles C. Roehr, Tomasz Szczapa, Luigi Gagliardi, Maximo Vento, Ragnhild Stoen, Kajsa Bohlin, Anton H. van Kaam, Daniel Klotz, Xavier Durrmeyer, Tongyan Han, Anup C. Katheria, Peter A. Dargaville, Lise Aunsholt
Summary: This study established an international consensus on the training curriculum and assessment tool for the less invasive surfactant administration procedure (LISA). The consensus-based expert statement provides content that can optimize and standardize LISA training in the future.
PEDIATRIC RESEARCH
(2023)
Article
Clinical Neurology
Lorina Naci, Adrian M. Owen
Summary: The use of functional neuroimaging and electroencephalography-based techniques has been helpful in detecting covert awareness in behaviorally unresponsive patients with severe brain injuries. The studies have shown that some chronic behaviorally unresponsive patients have covert consciousness and preserved mental life. Research on covert consciousness in acutely brain-injured patients could have significant implications for patient prognosis, treatment, and decisions regarding withdrawal of care.
SEMINARS IN NEUROLOGY
(2022)
Article
Pharmacology & Pharmacy
Keli Jaqueline Staudt, Bruna Bernar Dias, Izabel Almeida Alves, Benedicte Lelievre, Jean-Philippe Bouchara, Bibiana Verlindo de Araujo
Summary: This study developed a population pharmacokinetic model to describe the exposure of voriconazole in the plasma, interstitial cerebral fluid, and cerebrospinal fluid of rats. The model showed that voriconazole has sufficient tissue exposure in the interstitial fluid and cerebrospinal fluid for the treatment of fungal infections in these tissues.
Article
Medicine, General & Internal
Sung Ho Jang, Seong Ho Kim, Jeong Pyo Seo
Summary: This report describes a patient with hypoxic-ischemic brain injury who recovered from a minimally conscious state over 6 years, along with recovery of the injured ascending reticular activating system. Results showed an increase in neural connectivity to the basal forebrain and prefrontal cortex in the upper ARAS on 8-year DTT compared to 1.5-year DTT, while no significant change was observed in the lower dorsal and ventral ARAS.
Review
Anesthesiology
Edoardo Picetti, Pierre Bouzat, Luca Cattani, Fabio S. Taccone
Summary: This review mainly discusses the management and care methods for traumatic brain injury (TBI), as well as the treatment strategies for different situations. It emphasizes the importance of the perioperative TBI period and presents recommendations applicable to high-income countries.
MINERVA ANESTESIOLOGICA
(2022)
Review
Clinical Neurology
Yaroslava Longhitano, Francesca Iannuzzi, Giulia Bonatti, Christian Zanza, Antonio Messina, Daniel Godoy, Wojciech Dabrowski, Li Xiuyun, Marek Czosnyka, Paolo Pelosi, Rafael Badenes, Chiara Robba
Summary: Impaired cerebral autoregulation in non-brain injured patients may lead to cognitive dysfunction, neurological damage, worse outcomes, and increased mortality. Monitoring cerebral autoregulation could be a useful tool for bedside optimization and individualized clinical management in this patient population.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Tomohiro Yamaki, Naoya Hatakeyama, Takemi Murayama, Mika Funakura, Takuya Hara, Shinji Onodera, Daisuke Ito, Maidinamu Yakufujiang, Masaru Odaki, Nobuo Oka, Shigeki Kobayashi
Summary: In this pilot study, the researchers investigated whether assessing regional brain glucose metabolism using FDG-PET at rest could predict voluntary movement in severe TBI patients, particularly those with sufficient upper limb capacity. The results showed that glucose uptake in specific areas of the primary motor cortex may reflect contralateral voluntary movement. FDG-PET may be a useful biomarker for predicting long-term recovery of motor function in severe TBI patients with disorders of consciousness.
HUMAN BRAIN MAPPING
(2023)
Article
Critical Care Medicine
Celine Gelinas, Melanie Berube, Kathleen A. Puntillo, Madalina Boitor, Melissa Richard-Lalonde, Francis Bernard, Virginie Williams, Aaron M. Joffe, Craig Steiner, Rebekah Marsh, Louise Rose, Craig M. Dale, Darina M. Tsoller, Manon Choiniere, David L. Streiner
Summary: The study showed that the CPOT-Neuro is valid for brain-injured ICU patients across different levels of consciousness, with no significant differences in CPOT-Neuro scores between LOC groups. Additionally, the tool demonstrated moderate correlations with self-reported pain intensity.
Article
Rehabilitation
Wendy L. Magee, Ajit Narayanan, Rebecca O'Connor, Fiona Haughey, Erin Wegener, Bernice H. L. Chu, Mark Delargy, Dee Gray, Alika D. Seu, Richard J. Siegert, Rosanne J. Tyas, Kudret C. Yelden, Caroline Schnakers
Summary: This study aimed to examine the concurrent validity of the Music Therapy Assessment Tool for Awareness in Disorders of Consciousness (MATADOC) with the criterion standard Coma Recovery Scale-Revised (CRS-R) in patients with prolonged disorders of consciousness (PDoC). The results showed that MATADOC and CRS-R measure similar underlying latent variables of awareness and could complement each other for diagnosis and intervention purposes.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2023)
Article
Medicine, General & Internal
Marco Meloni, Benjamin Bouillet, Raju Ahluwalia, Juan Pedro Sanchez-Rios, Elisabetta Iacopi, Valentina Izzo, Chris Manu, Vouillarmet Julien, Claas Luedmann, Jose Luis Garcia-Klepzig, Jerome Guillaumat, Jose Luis Lazaro-Martinez
Summary: This study aimed to validate the association between the severity grades of diabetic foot ulcers (DFUs) identified by the fast-track model and specific outcomes. The findings showed that the severity of DFUs was associated with healing, amputation, hospitalization, and survival. The fast-track model, which categorizes DFUs into three levels of severity, can be a useful tool in assessing the severity and prognosis of DFUs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
William Torregrossa, Michele Torrisi, Rosaria De Luca, Carmela Casella, Carmela Rifici, Mirjam Bonanno, Rocco Salvatore Calabro
Summary: Traumatic brain injury is damage to the brain occurring after birth, resulting in deterioration of cognitive, behavioural, and emotional functions. Neuropsychological evaluation can assist clinicians in assessing the patient's condition, reaching differential diagnoses, and developing intervention strategies. However, it is difficult to determine the most suitable assessment tool for different brain injury conditions considering the various rating scales available.
Article
Clinical Neurology
Lena Ruehl, Joji B. Kuramatsu, Jochen A. Sembill, Bernd Kallmuenzer, Dominik Madzar, Stefan T. Gerner, Antje Giede-Jeppe, Stefanie Balk, Tamara Mueller, Jakob Jaeger, Stefan Schwab, Hagen B. Huttner, Maximilian Spruegel
Summary: This study found that amantadine treatment can improve consciousness in patients with non-traumatic brain injury. However, there may be an increased risk of epileptic seizures after treatment initiation. Further randomized controlled trials are needed to confirm these findings.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Camilla Ippoliti, Marjorie Fadeur, Christian Malherbe, Jenny De Flines, Anne-Marie Verbrugge, Olivia Gosseries, Didier Ledoux, Benoit Misset, Steven Laureys, Nicolas Paquot, Aurore Thibaut
Summary: This study evaluates the relationship between nutritional status and clinical variables in patients with prolonged disorders of consciousness. The results show that most patients are well nourished and that excessive muscle activity may affect their daily calorie needs.
Article
Biology
Steven Jillings, Ekaterina Pechenkova, Elena Tomilovskaya, Ilya Rukavishnikov, Ben Jeurissen, Angelique Van Ombergen, Inna Nosikova, Alena Rumshiskaya, Liudmila Litvinova, Jitka Annen, Chloe De Laet, Catho Schoenmaekers, Jan Sijbers, Victor Petrovichev, Stefan Sunaert, Paul M. Parizel, Valentin Sinitsyn, Peter zu Eulenburg, Steven Laureys, Athena Demertzi, Floris L. Wuyts
Summary: This study used functional magnetic resonance imaging (fMRI) to investigate the impact of prolonged microgravity on the human brain. The results showed changes in brain functional connectivity, providing insights into the adaptations and modifications occurring during spaceflight and upon return to Earth.
COMMUNICATIONS BIOLOGY
(2023)
Article
Neurosciences
Aminata Bicego, Helena Cassol, Jessica Simon, Pauline Fritz, Simona Abagnale, Audrey Vanhaudenhuyse, Steven Laureys, Charlotte Martial
Summary: This study investigated the potential personality and psychological predictors of near-death experiences (NDEs) and near-death-like experiences (NDEs-like). The results showed that the recall of NDEs-like was associated with endorsement of spiritual beliefs, while the recall of NDEs was associated with Openness and Fantasy proneness.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Neurosciences
Rajanikant Panda, Ane Lopez-Gonzalez, Matthieu Gilson, Olivia Gosseries, Aurore Thibaut, Gianluca Frasso, Benedetta Cecconi, Anira Escrichs, Gustavo Deco, Steven Laureys, Gorka Zamora-Lopez, Jitka Annen
Summary: The study of brain's dynamic activity is helping in the clinical assessment of patients with consciousness disorders. The reduced neural propagation and responsiveness to events in patients with disorders of consciousness is related to severe reduction in glucose metabolism. These findings provide insights into the mechanisms behind consciousness disorders, combining network function with measures of brain integrity and behavior.
HUMAN BRAIN MAPPING
(2023)
Correction
Critical Care Medicine
Emanuele Rezoagli, Matteo Petrosino, Paola Rebora, David Menon, Stefania Mondello, D. James Cooper, Andrew I. R. Maas, Eveline J. A. Wiegers, Stefania Galimberti, Giuseppe Citerio, Cecilia Ackerlund, Krisztina Amrein, Nada Andelic, Lasse Andreassen, Audny Anke, Gerard Audibert, Philippe Azouvi, Maria Luisa Azzolini, Ronald Bartels, Ronny Beer, Bo-Michael Bellander, Habib Benali, Maurizio Berardino, Luigi Beretta, Erta Beqiri, Morten Blaabjerg, Stine Borgen Lund, Camilla Brorsson, Andras M. Buki, Manuel Cabeleira, Alessio Caccioppola, Emiliana Calappi, Maria Rosa Calvi, Peter Cameron, Guillermo Carbayo Lozano, Marco Carbonara, Ana D. Castano-Leon, Simona Cavallo, Giorgio Chevallard, Arturo Chieregato, Hans Clusmann, Mark Steven Coburn, Jonathan Coles, Jamie Cooper, Marta Correia, Endre Czeiter, Marek Czosnyka, Claire Dahyot-Fizelier, Paul Dark, Veronique Keyser, Vincent Degos, Francesco Della Corte, Hugo Boogert, Bart Depreitere, Dula Dilvesi, Abhishek Dixit, Jens Dreier, Guy-Loup Duliere, Ari Ercole, Erzsebet Ezer, Martin Fabricius, Kelly Foks, Shirin A. Frisvold, Alex Furmanov, Damien Galanaud, Dashiell Gantner, Alexandre Ghuysen, Lelde Giga, Jagos Golubovic, Pedro Gomez, Benjamin J. Gravesteijn, Francesca Grossi, Deepak Gupta, Iain Haitsma, Raimund G. Helbok, Eirik Helseth, Jilske Huijben, Peter Hutchinson, Stefan Jankowski, Faye Johnson, Mladen Karan, Angelos Kolias, Daniel Kondziella, Evgenios Kornaropoulos, Lars-Owe Koskinen, Noemi Kovacs, Ana Kowark, Alfonso Lagares, Steven Laureys, Aurelie Lejeune, Fiona Lecky, Didier Ledoux, Roger Lightfoot, Hester Lingsma, Alex Manara, Hugues Marechal, Costanza Martino, Julia Mattern, Catherine McMahon, Tomas Menovsky, Benoit Misset, Visakh Muraleedharan, Lynnette Murray, Ancuta Negru, David Nelson, Virginia Newcombe, Jozsef Nyiradi, Fabrizio Ortolano, Jean-Francois Payen, Vincent Perlbarg, Paolo P. Persona, Wilco Peul, Anna Piippo-Karjalainen, Horia Ples, Inigo Pomposo, Jussi Posti, Louis Puybasset, Andreea Radoi, Arminas Ragauskas, Rahul Raj, Jonathan Rhodes, Sophie Richter, Saulius Rocka, Cecilie Roe, Olav Roise, Jeffrey Rosenfeld, Christina Rosenlund, Guy Rosenthal, Rolf Rossaint, Sandra Rossi, Juan Sahuquillo, Oliver Sakowitz, Renan Sanchez-Porras, Oddrun Sandrod, Kari Schirmer-Mikalsen, Rico Frederik W. Schou, Charlie Sewalt, Peter Smielewski, Abayomi Sorinola, Emmanuel Stamatakis, Ewout Steyerberg, Nino Stocchetti, Nina Sundstroem, Riikka Takala, Viktoria Tamas, Tomas Tamosuitis, Olli Tenovuo, Matt Thomas, Dick Tibboel, Christos Tolias, Tony Trapani, Cristina Maria Tudora, Andreas Unterberg, Peter Vajkoczy, Egils A. Valeinis, Shirley Vallance, Zoltan Vamos, Gregory Steen, T. J. M. van Dijck Jeroen, Thomas Essen, Roel Wijk, Alessia Vargiolu, Emmanuel Vega, Anne Vik, Rimantas Vilcinis, Victor Volovici, Peter Vulekovic, Eveline A. Wiegers, Guy Williams, Stefan Winzeck, Stefan Wolf, Alexander Younsi, Frederick Zeiler, Agate Ziverte, Tommaso V. Zoerle, Russel Gruen, Lynette Murray, Dinesh Varma, Christopher MacIsaac, Andrea Jordan
INTENSIVE CARE MEDICINE
(2023)
Article
Neurosciences
Charlotte Martial, Helena Cassol, Mel Slater, Pierre Bourdin, Armand Mensen, Ramon Oliva, Steven Laureys, Pablo Nunez
Summary: Out-of-body experiences (OBEs) are subjective experiences of seeing one's own body and the environment from a location outside the physical body. They can be induced using technology like virtual reality, and in this experiment, virtual OBE-like experiences were induced in participants using a multisensory method of virtual embodiment. EEG analysis revealed an increase in delta and a decrease in alpha power, as well as a reduction in theta complexity and an increase in beta-2 connectivity, suggesting the involvement of these brain activities in the subjective experience of OBEs.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2023)
Article
Neurosciences
Rajanikant Panda, Audrey Vanhaudenhuyse, Andrea Piarulli, Jitka Annen, Athena Demertzi, Naji Alnagger, Srivas Chennu, Steven Laureys, Marie-Elisabeth Faymonville, Olivia Gosseries
Summary: This study investigates altered brain dynamics during hypnosis, using high-density EEG measurements. The results show modified connectivity in the brain, with increased connectivity between frontal and parietal regions and decreased connectivity in alpha and beta-2 bands. These changes suggest a modification in the internal and external awareness brain networks and may reflect more efficient cognitive-processing and lower incidences of mind-wandering during hypnosis.
JOURNAL OF COGNITIVE NEUROSCIENCE
(2023)
Review
Medicine, General & Internal
Naji Alnagger, Paolo Cardone, Charlotte Martial, Steven Laureys, Jitka Annen, Olivia Gosseries
Summary: Patients with disorders of consciousness (DoC) have varying levels of wakefulness and awareness due to severe brain injury. Standardised behavioural examinations are commonly used to assess these patients, but they are often inaccurate. Neuroimaging has provided insights into the neural alterations associated with DoC, and has led to the development of neuroimaging paradigms for clinical assessment. However, consciousness cannot be solely attributed to the activation of specific brain areas, but rather requires the preservation of thalamo-cortical circuits and connectivity between different brain networks. Computational methodologies applied to DoC research can enhance our understanding and inform clinical practice.
Article
Business
Frederic Ooms, Jitka Annen, Rajanikant Panda, Paul Meunier, Luaba Tshibanda, Steven Laureys, Jeffrey M. M. Pollack, Bernard Surlemont
Summary: Despite the limited use of functional brain imaging (fMRI) in entrepreneurship research, this study showcases the application of resting-state fMRI (rs-fMRI) in neuroentrepreneurship for the first time. Unlike traditional task-based fMRI, rs-fMRI explores the brain in the absence of cognitive tasks or stimulus presentation, providing valuable insights into the entrepreneurial mind. By utilizing seed-based correlation analysis, the study reveals increased functional connectivity between the insula and anterior prefrontal cortex in habitual entrepreneurs compared to managers, suggesting potential benefits for flexible behavior. This exemplar expands our understanding of the brain in entrepreneurship and highlights the need for further research and challenges to incorporate rs-fMRI into neuroentrepreneurship.
ENTREPRENEURSHIP THEORY AND PRACTICE
(2023)
Article
Psychology, Clinical
Marie M. Vitello, Marie-Michele Briand, Didier Ledoux, Jitka Annen, Riem El Tahry, Steven Laureys, Didier Martin, Olivia Gosseries, Aurore Thibaut
Summary: This clinical trial aims to evaluate the therapeutic clinical effects of transcutaneous auricular vagal nerve stimulation (taVNS) in patients with disorders of consciousness (DoC), investigate the neural mechanisms underlying its effects, assess the feasibility and safety of the procedure, define the phenotype of clinical responders, and assess the long-term efficacy of taVNS in terms of functional outcomes. The study will be a prospective parallel randomized controlled double-blind trial, with 44 early post-injury patients randomly receiving either active taVNS or sham stimulation for 5 days. Behavioral and neurophysiological measures will be collected at baseline and the end of the treatment period to analyze changes at the group and individual levels. The results will contribute to understanding the role of taVNS and provide potential therapeutic strategies for DoC patients.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Anesthesiology
Paolo Cardone, Olivier Bodart, Murielle Kirsch, Julien Sanfilippo, Alessandra Virgillito, Charlotte Martial, Jessica Simon, Sarah Wannez, Robert D. Sanders, Steven Laureys, Marcello Massimini, Gilles Vandewalle, Vincent Bonhomme, Olivia Gosseries
Summary: This study investigated the effects of dexmedetomidine on cortical excitability. The results showed that cortical excitability increased in the frontal cortex during light sedation, deep sedation, and recovery. There was also an interaction between dexmedetomidine and brain region on cortical excitability.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Behavioral Sciences
Charlotte Martial, Anne-Lise Poirrier, Laurence Pottier, Helena Cassol, Sepehr Mortaheb, Rajanikant Panda, Mateo Lopez, Thibault Perrin, Antoine Boilevin, Olivia Gosseries, Steven Laureys
Summary: This study aimed to examine the effect of lemon essential oil inhalation on alertness level and brain functional connectivity. The study found that lemon fragrance inhalation increased alertness level but did not significantly differ from the control condition. It also revealed increased global functional connectivity in the thalamus and decreased connectivity in several cortical regions during lemon fragrance inhalation. The findings suggest that lemon essential oil inhalation can enhance alertness.
Article
Psychology, Clinical
Leandro R. D. Sanz, Steven Laureys, Olivia Gosseries
Summary: Understanding the mechanisms of human consciousness is crucial in improving the prognosis and treatment of severely brain-injured patients. Recent advances in neuroscience have allowed scientists to better understand consciousness disorders and have led to significant changes in clinical practice. This review examines the impact of consciousness neurosciences on the management of severe brain injury and highlights the need for a multimodal framework based on precision medicine and evidence-based decisions.
INTERNATIONAL JOURNAL OF CLINICAL AND HEALTH PSYCHOLOGY
(2023)
Article
Clinical Neurology
Michele Farisco, Rita Formisano, Olivia Gosseries, Yoko Kato, Shigeki Koboyashi, Steven Laureys, Nicolas Lejeune, Charlotte Martial, Amal Matar, Ann-Marie Morrisey, Caroline Schnakers, Maidinamu Yakufujiang, Tomohiro Yamaki, Vigneswaran Veeramuthu, Matteo Zandalasini, Nathan Zasler, Alfonso Magliacano, Anna Estraneo, IBIA Special Interest Group DoCs
Summary: Clinical practices for patients with prolonged disorders of consciousness (pDoCs) vary across countries and settings. Two international guidelines have been developed to promote consistent practice. The survey revealed that some recommendations are followed, while others need more clarity and utility.
JOURNAL OF NEUROLOGY
(2023)