Review
Biochemistry & Molecular Biology
Lixia Zhang, Chenchen Ai, Ming Bai, Jinglei Niu, Zheng Zhang
Summary: This article summarizes the role of pyroptosis in diabetic cardiomyopathy (DCM) and potential therapeutic targets in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Mei-Zi Wang, Jie Wang, Dong-Wei Cao, Yue Tu, Bu-Hui Liu, Can-Can Yuan, Huan Li, Qi-Jun Fang, Jia-Xin Chen, Yan Fu, Bing-Ying Wan, Zi-Yue Wan, Yi-Gang Wan, Guo-Wen Wu
Summary: The study confirmed that FPS, similar to RAP, can alleviate RF in DKD by inhibiting NLRP3 inflammasome-mediated podocyte pyroptosis, regulating the AMPK/mTORC1/NLRP3 signaling axis. These findings provide an in-depth understanding of the pathogenesis of RF, aiding in identifying precise targets for DKD treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Huijie Zhao, Yiming Zhang, Yanting Zhang, Chaoran Chen, Huiyang Liu, Yihan Yang, Honggang Wang
Summary: Inflammasomes are important in innate immunity, dealing with pathogens and cellular products related to stress and injury. The NLRP3 inflammasome, consisting of NLRP3, ASC, and procaspase-1, is the best studied and most characteristic inflammasome. Activation of the NLRP3 inflammasome leads to caspase-1 activation, interleukin (IL)-1 beta and IL-18 maturation, and pyroptosis. While the NLRP3 inflammasome is involved in tumorigenesis, it also plays a protective role in some cancers. This article focuses on the role of the NLRP3 inflammasome in hepatocellular carcinoma (HCC) and analyzes the underlying mechanisms, aiming to provide insights for future research.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yulin Wang, Li Ding, Ruiqiang Wang, Yanhong Guo, ZiJun Yang, Lu Yu, LiuWei Wang, Yan Liang, Lin Tang
Summary: Diabetic kidney disease (DKD) has become the leading cause of chronic kidney disease (CKD) in many countries. Recent studies have shown that circular RNA and pyroptosis play an important role in the pathogenesis of DKD. This study found that circular RNA circ_0004951 promotes pyroptosis of renal tubular epithelial cells in DKD via the miR-93-5p/NLRP3 inflammasome pathway.
FRONTIERS IN MEDICINE
(2022)
Review
Immunology
Yan Wang, Zhun Sui, Mi Wang, Peng Liu
Summary: Diabetic kidney disease (DKD) is a major complication of diabetes and a leading cause of end-stage kidney disease (ESKD) globally. Renal inflammation driven by the NLRP3 inflammasome has been shown to play a critical role in the pathogenesis of DKD. Natural products, with their pharmacological and biological activities, have been found to alleviate DKD by targeting the NLRP3 inflammasome. This review highlights the role of the NLRP3 inflammasome in DKD and the pathways through which natural products inhibit its activation, providing novel insights for the treatment of DKD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yuxuan Yang, Gengchen Jiang, Runchun Huang, Yi Liu, Xingyu Chang, Songbo Fu
Summary: Diabetic retinopathy (DR) is a common complication of diabetes and a major cause of vision loss. The NLRP3 inflammasome, an intracellular complex involved in innate immunity, plays a significant role in DR progression. Studies have shown increased expression of NLRP3 and related inflammatory mediators in vitreous samples from DR patients, and targeting the NLRP3 inflammasome has shown potential in DR therapeutics.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Kai Liu, Dongmei Yue, Xinru Mao, Hu Li, Jie Qu, Shuiping Liu, Viktor Korolchuk, Yunhuan Liu, Fang Gan, Cuiling Pan, Kehe Huang, Xingxiang Chen
Summary: This study revealed that ROS/NLRP3-inflammasome-mediated pyroptosis may be involved in the nephrotoxicity induced by low levels of OTA, which is negatively regulated by autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Qing Sun, Rui Zhang, Xiaowei Xue, Qunli Wu, Dan Yang, Chao Wang, Bin Yan, Xiaochun Liang
Summary: The study found that JMT effectively relieved diabetic neuropathic pain by reducing the activation of NLRP3 inflammasome and pyroptosis. This provides new evidence supporting JMT as an alternative treatment for DNP.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Khurrum Shahzad, Sameen Fatima, Hamzah Khawaja, Ahmed Elwakiel, Ihsan Gadi, Saira Ambreen, Silke Zimmermann, Peter R. Mertens, Ronald Biemann, Berend Isermann
Summary: This study found that activation of the NLRP3 inflammasome in podocytes is both necessary and sufficient for diabetic kidney disease (DKD), indicating that podocytes have immune cell-like functions. Targeting NLRP3 may be a promising therapeutic approach for DKD.
KIDNEY INTERNATIONAL
(2022)
Article
Environmental Sciences
Hongyuan Jing, Fuhan Wang, Xue-jiao Gao
Summary: This study investigated the mechanism of renal inflammatory reaction induced by excessive intake of lithium. The results showed that high concentrations of lithium caused inflammatory damage and apoptosis in kidney tissue cells, as well as reduced antioxidant enzyme capacity and increased production of reactive oxygen species. Moreover, excessive lithium activated the NF-kappa B signaling pathway and NLRP3 inflammasome, resulting in the activation of inflammatory factors.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Immunology
Yi Huang, Wen Xu, Rongbin Zhou
Summary: The NLRP3 inflammasome is a cytosolic multiprotein complex that responds to microbial infection, endogenous danger signals, and environmental stimuli. Its activation can induce pyroptosis and release of inflammatory cytokines, contributing to innate immune defense. However, aberrant activation of the NLRP3 inflammasome is associated with inflammatory diseases, and there is a close relationship between cell death pathways and NLRP3 inflammasome activation.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiangri Kong, Yunyun Zhao, Xingye Wang, Yongjiang Yu, Ying Meng, Guanchi Yan, Miao Yu, Lihong Jiang, Wu Song, Bingmei Wang, Xiuge Wang
Summary: The study found that loganin has a protective effect on diabetic kidney disease, reducing renal damage and downregulating the expression of related proteins and cytokines.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Immunology
Jun Zhou, Shan Yan, Xu Guo, Yanguo Gao, Shiqi Chen, Xiaohan Li, Yonghong Zhang, Qibin Wang, Tao Zheng, Li Chen
Summary: This study investigated the effects of salidroside (SAL) on pancreatic beta-cell pyroptosis in diabetic mice. The results showed that SAL can protect beta-cells against pyroptosis by activating AMPK and inhibiting NLRP3/GSDMD signaling.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Yingying Hu, Shuqian Zhang, Han Lou, Monayo Seth Mikaye, Run Xu, Ziyu Meng, Menghan Du, Pingping Tang, Zhouxiu Chen, Yongchao Chen, Xin Liu, Zhimin Du, Yong Zhang
Summary: This study demonstrates the therapeutic effects of aloe-emodin derivative (AED) in treating diabetic cardiomyopathy (DCM). AED inhibits myocardial pyroptosis in DCM by suppressing the pyroptosis pathway mediated by the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain 3 (NLRP3) inflammasome.
Article
Medicine, Research & Experimental
ShiChun Shen, Fei He, Cheng Cheng, BangLong Xu, JianLong Sheng
Summary: This study revealed that uric acid exacerbates MI/R injury by promoting ROS generation, while NLRP3 inflammasome inhibitors and ROS scavengers partially reverse this injury.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Construction & Building Technology
Yang Zhou, Yuan Chen, Ming Jin, Jiaping Liu, Changwen Miao
Summary: In this study, molecular dynamics simulations were used to investigate the effects of irradiation on cementitious materials. The results showed that irradiation led to a transformation in structure and a reduction in mechanical performance of calcium silicate hydrates. Additionally, an increase in ductility was observed, which could be beneficial for designing more radiation-resistant cement materials.
JOURNAL OF SUSTAINABLE CEMENT-BASED MATERIALS
(2023)
Article
Clinical Neurology
Shuiwei Xia, Yajie Wang, Xianli Lv, Chunmiao Chen, Junguo Hui, Xulu Wu, Zufei Wang, Huijun Chen, Jiansong Ji
Summary: This study compared the abilities of vessel wall magnetic resonance imaging techniques, SNAP sequence and T1-weighted volumetric isotropic turbo spin echo acquisition (T1-w VISTA) sequence, in evaluating cervical artery dissection (CAD). The results showed that both SNAP and T1-w VISTA sequences had the same diagnostic performance in CAD diagnosis, and their consistencies with the final diagnosis were good. Additionally, SNAP showed better intramural hematoma (IMH)-wall contrast than T1-w VISTA.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Computer Science, Information Systems
Jao-Hong Cheng, Li-Wei Lin
Summary: This study examines the relationship between situational factors, social support, and purchase intention in social commerce. The results show that control senses and raise mediation trust belief have a significant impact on purchase intention. Sellers should pay attention to consumer's trust belief to enhance purchase intention in social commerce.
ASLIB JOURNAL OF INFORMATION MANAGEMENT
(2023)
Article
Environmental Sciences
Nianping Chi, Jiajun Liu, Minghua Lei, Li Feng
Summary: The introduction of amphiphilic CPAM TP-ADB with cationic microblock structure and hydrophobic association improves the dewatering performance of PD sludge.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Jiawei Li, Guoqiang Song, Zhenzhen Mu, Xiaoou Lan, Fan Yang, Lin Li, Xiuping Han
Summary: Several studies have shown a relationship between short-term exposure to air pollution and worsening of certain skin conditions. This study in Shenyang, China, from 2016 to 2018, expands on these findings by exploring the potential association between exposure to air pollutants including particulate matter, sulfur dioxide, and ozone and the incidence of acute and chronic urticaria. The results suggest that short-term exposure to ozone, PM2.5, and PM10 can increase the risk of acute and chronic urticaria.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Lili Lin, Saili Xie, Yingzheng Zhao, Zenghui Liang, Qilong Wu, Mingling Fang, Xiaolu Teng, Binbin Shi, Yunjun Yang, Bin Chen
Summary: Heparin-loaded microbubbles (HPMB) combined with ultrasound (UHPMB) exhibit therapeutic effects by reducing oxidative stress and inflammation in acute pancreatitis (AP) models. The study demonstrated that UHPMB can selectively target pancreatic lesions, release heparin, and inhibit oxidative stress and inflammation effectively. Additionally, US-targeted microbubble destruction (UTMD) enhances the therapeutic effect without causing harm to vital organs.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Fisheries
Yawen Lan, Rui Shao, Jinjin Zhang, Jiayu Liu, Xinmeng Liao, Shufei Liang, Kangsen Mai, Qinghui Ai, Min Wan
Summary: Vitamin D3 enhances bactericidal ability in turbot by increasing the expression of C-type lectin receptors, leading to improved immune functions and bacterial clearance.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Engineering, Multidisciplinary
Jun Li, Jia Wei Li, Jia Rui Zhang, Kuo Li, Tian Ma, Wei Feng Wang, Xiao Wei Zhai, William N. MacPherson, Robert R. J. Maier, Duncan P. Hand
Summary: In this paper, we demonstrate the design and fabrication of 45 degrees micro-mirrors using focused ion beam (FIB) processing. The mirrors are accurately aligned with optical fibre cores, eliminating the need for alignment of external turning mirror components. Experimental results show that the fabricated structure is capable of measuring two-axis acceleration with a linear response range of 0.2 to 4 g and an rms. error of 0.03 g. Frequency response up to 700 Hz and cross-sensitivity of approximately 4.3% are also demonstrated.
MEASUREMENT SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Weiyuan Ding, Ali Saad, Yuchen Wu, Zhiwei Wang, Xiuting Li
Summary: In this study, FeCo nanoparticles, MNx (M = Fe, Co), and FePx were embedded in porous and graphitized carbon nanotubes (CNTs)/carbon nanofiber (CNF) using electrospinning and chemical vapor deposition (CVD) techniques. The prepared FeCo@CoNx@FePx/C exhibited a high half-wave potential of 0.86 V in oxygen reduction reaction (ORR) and a low oxygen evolution reaction (OER) overpotential of 368 mV at 10 mAmiddotcm(-2). The assembled Zn-air battery (ZAB) showed a high energy efficiency of 65% at 20 mAmiddotcm(-2) and remained stable for 700 charge-discharge cycles. This work has important implications for the design of bifunctional electrocatalysts.
Article
Spectroscopy
Ling Lin, Meiling Fan, Muhammad Ijaz, Leiyang Cheng, Gang Li
Summary: In the LED multi-spectral imaging (LEDMSI) system, modulation using square wave frequency division with a frequency ratio of 2 can improve image quality and acquisition speed, but it occupies a wide frequency band. This paper proposes a modulation method using multiple square wave signals with different phases as carrier signals to solve the above problems. Experimental results show that the proposed method improves the quality of multi-spectral images, indicating its significance in improving the performance of the LEDMSI system.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Materials Science, Textiles
Lei Nie, Jiawei Li, Xiaofei Yan, Chenkai Zhu, Xiaoming Yang, Yaobang Li, Dongming Qi
Summary: This study presents a flame-retardant structure design for high-performance fiber-reinforced composites, which involves the coating of functional glass fiber layers treated with flame-retardant agents and silicone-modified waterborne polyurethane. This design successfully achieves a balance between fire resistance and structural performance. The composites treated with 8% silicone-modified waterborne polyurethane exhibited a significant decrease in total heat release and total smoke release, while their tensile and flexural strength were significantly increased. This new strategy provides potential applications in aircraft and aerospace.
TEXTILE RESEARCH JOURNAL
(2023)
Article
Computer Science, Artificial Intelligence
Yiyang Liu, Hua Dai, Jiawei Li, Yu Chen, Geng Yang, Jun Wang
Summary: This paper proposes a BP-Model-based convoy mining algorithm that optimizes mining by adopting the divide-and-conquer methodology. The performance of the algorithms is evaluated on real-world datasets, showing that they are more efficient than existing convoy mining algorithms.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Geosciences, Multidisciplinary
Li Luo, Tingting Liao, Xiaoling Zhang, Yunfei Wu, Jiawei Li, Renjian Zhang, Zhenzhen Zheng, Shuh-Ji Kao
Summary: By coupling nitrate dual isotopes with aerosol chemical compositions, this study investigated the size-segregated formation mechanisms of nitrate (NO3-) during winter haze pollution events in Chengdu, China. Different formation pathways were identified for fine particles and coarse particles, with N2O5 hydrolysis, NO3 + VOCs, and NO2 + OH homogeneous reactions being major contributors for fine particle NO3- production, and the reaction between gas-phase HNO3 and CaCO3 dominating coarse particle NO3- formation. This research provides quantitative insights and a better understanding of NO3- formation during haze pollution.
Article
Nanoscience & Nanotechnology
Jia-Wei Li, Jian-Gang Guo, Li-Jun Zhou
Summary: Many studies have shown that the nanotwinned structure and graphene reinforcing phase can improve the mechanical properties of aluminum. However, the synergistic effect of the two on the strengthening and toughening mechanisms of aluminum matrix composites has rarely been reported. In this work, molecular dynamics simulations are used to study the mechanical properties and microscopic deformation mechanisms of graphene/nanotwinned aluminum matrix composites. The effects of graphene distribution patterns, twin boundaries (TBs), their angles, and the number of graphene layers on the mechanical behaviors of the composites are analyzed.
PHYSICA E-LOW-DIMENSIONAL SYSTEMS & NANOSTRUCTURES
(2023)
Article
Computer Science, Artificial Intelligence
Xiang Shi, Yinpeng Liu, Jiawei Liu, Qikai Cheng, Wei Lu
Summary: Scientific papers are crucial for academic communication, but many of them lack in-depth research and present core content ambiguously, hindering the progression of science and technology. To address this challenge, the INTEGrity vERification (INTEGER) task is introduced to help researchers assess the integrity of their papers and verify the clarity of each knowledge unit. A multi-task learning model utilizing Tucker decomposition and span-level attention mechanism is proposed to accurately identify terms and their integrity. Experimental results show the effectiveness of the model.
EXPERT SYSTEMS WITH APPLICATIONS
(2024)