Article
Nutrition & Dietetics
Alessia Alunno, Francesco Carubbi, Francesco Maria Mariani, Cecilia Martini, Elena Campanozzi, Claudio Ferri
Summary: This study found a strong association between disease activity, interstitial lung disease (ILD), and cardiovascular events in primary Sjögren's syndrome (pSS) patients. The association between ILD and cardiovascular events was dependent on higher serum uric acid levels and independent of other traditional cardiovascular risk factors. Assessing serum uric acid levels in pSS patients and considering the application of correction factors in cardiovascular risk assessment tools can achieve better stratification of cardiovascular risk.
Review
Immunology
Lilian Gomes de Oliveira, Yan de Souza Angelo, Antonio H. Iglesias, Jean Pierre Schatzmann Peron
Summary: Neuroinflammatory and neurodegenerative diseases are major public health issues worldwide, with mitochondrial dysfunction playing a significant role. Regulation of mitochondrial dynamics is essential for CNS health maintenance, impacting the development and progression of neuroinflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biology
Gordon L. Klein
Summary: Chronic inflammatory conditions with bone resorption are associated with an increased risk of heart disease. Studies have shown that anti-resorptive agents can reduce overall mortality and mortality from cardiovascular disorders. Children and adolescents have a protective mechanism against calcium entering the circulation following inflammatory bone resorption, which may reduce cardiovascular morbidity and mortality. In adults with chronic inflammatory conditions, the lack of response from the calcium-sensing receptor may contribute to the development of cardiovascular disease.
Article
Cardiac & Cardiovascular Systems
Myuri Ruthirakuhan, Hugo Cogo-Moreira, Walter Swardfager, Nathan Herrmann, Krista L. Lanctot, Sandra E. Black
Summary: This study identified three groups of cardiovascular risk factors in cognitively normal elderly individuals, and only the vascular-dominant group was significantly associated with incidence of Alzheimer's disease. Selective mortality may contribute to the attenuated association between the vascular-metabolic group and incident AD.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ravi Retnakaran, Baiju R. Shah
Summary: Women with gestational diabetes have an increased risk of cardiovascular disease, and adverse glycemic and lipid measures contribute to this elevated risk. Monitoring and intervention targeting these risk factors may help prevent cardiovascular disease in this population.
Review
Neurosciences
Oualid Sbai, Veronica Bazzani, Shreya Tapaswi, Joshua McHale, Carlo Vascotto, Lorena Perrone
Summary: Recent research suggests that inflammation plays a critical role in Alzheimer's Disease (AD) pathogenesis. Diseases characterized by inflammation, such as type 2 diabetes, obesity, hypertension, and traumatic brain injury, are considered risk factors for AD. Genetic variations in inflammatory pathway genes are also risk factors for AD. Mitochondrial dysfunction, which affects energy balance in the brain, is another characteristic of AD. This dysfunction has been observed in neuronal cells and inflammatory cells, leading to inflammation and neurodegeneration.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Meneerah Abdulrahman Aljafary, Ebtesam Abdullah Al-Suhaimi
Summary: Adiponectin plays a key role in regulating energy generation and storage as well as functioning as an endocrine tissue in the body. It has both pro-inflammatory and anti-inflammatory effects on the cardiovascular system, making it an important biomarker and potential therapeutic tool for metabolic syndromes and cardiovascular diseases. Adiponectin is known for its cardioprotective impact and its ability to regulate various metabolic processes.
Review
Medicine, Research & Experimental
Mehmet Ozansoy, Houda Mikati, Halil Aziz Velioglu, Burak Yulug
Summary: This review investigates the role of exosomes as possible mediators between chronic systemic inflammatory diseases and Alzheimer's disease. Exosomes carry pro-inflammatory molecules generated in the periphery and target glial and neuronal cells in the central nervous system, initiating chronic neuroinflammation and contributing to Alzheimer's disease pathology.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Dimitri Patriki, Seyed Soheil Saeedi Saravi, Giovanni G. Camici, Luca Liberale, Juerg H. Beer
Summary: PCSK 9 plays a key role in lipid metabolism and is associated with the development and progression of atherosclerosis. It increases circulating LDL by binding to LDL receptors. Recent research suggests that PCSK 9 may also contribute to atherosclerosis through its effects on inflammation. However, it is difficult to differentiate between the lipid-dependent and -independent inflammatory properties of PCSK 9 due to the influence of lipid metabolism on inflammatory processes.
CURRENT MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Haydar M. Al-kuraishy, Majid S. Jabir, Ali K. Albuhadily, Ali I. Al-Gareeb, Mayyadah F. Rafeeq
Summary: It has been shown that metabolic syndrome is associated with the neuropathology of Alzheimer's disease. The components of metabolic syndrome, including central obesity, hypertension, insulin resistance, and dyslipidemia, have negative effects on the pathogenesis of Alzheimer's disease through different mechanisms such as activation of the renin-angiotensin system, inflammatory signaling pathways, neuroinflammation, brain insulin resistance, mitochondrial dysfunction, and oxidative stress. Targeting these molecular pathways in metabolic syndrome could be a potential therapeutic strategy for managing Alzheimer's disease in high risk individuals, although the underlying mechanisms are not fully understood.
AGEING RESEARCH REVIEWS
(2023)
Article
Economics
Nathalie Mathieu-Bolh
Summary: Obesity has been a significant public health and policy issue for several decades, with literature pointing to both non-economic and economic factors as contributors. While poverty appears connected to obesity in affluent countries, empirical studies suggest a more complex relationship between income and obesity, which may vary as countries develop over time. Recent theoretical explanations have emerged to better understand this intricate link, aiming to provide a solid foundation for informed policy-making.
JOURNAL OF ECONOMIC SURVEYS
(2022)
Article
Cardiac & Cardiovascular Systems
Yang Yang, Nianchun Peng, Gang Chen, Qin Wan, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo, Ruying Hu, Zhen Ye, Guijun Qin, Zhengnan Gao, Qing Su, Yiming Mu, Jiajun Zhao, Lulu Chen, Tianshu Zeng, Xuefeng Yu, Qiang Li, Feixia Shen, Li Chen, Yinfei Zhang, Youmin Wang, Huacong Deng, Chao Liu, Shengli Wu, Tao Yang, Mian Li, Yu Xu, Min Xu, Zhiyun Zhao, Tiange Wang, Jieli Lu, Yufang Bi, Weiqing Wang, Guang Ning, Qiao Zhang, Lixin Shi
Summary: Smoking and diabetes interact with each other in relation to increased risk of cardiovascular disease events, and the beneficial effect of risk factor management on cardiovascular disease risk among participants with diabetes is attenuated by smoking.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Pharmacology & Pharmacy
Borden A. Emily, Furey Matthew, Gattone J. Nicholas, Hambardikar D. Vedangi, Liang Xiao Hua, Scoma R. Ernest, Abou Samra Antonella, D-Gary R. Lakeshia, Dennis J. Dayshaun, Fricker Daniel, Garcia Cindy, Jiang ZeCheng, Khan A. Shariq, Kumarasamy Dheenadhayalan, Kuppala Hasmitha, Ringrose Savannah, Rosenheim J. Evan, Van Exel Kimberly, Vudhayagiri Hemanth Sai, Zhang Jiarui, Zhang Zhaowen, Guitart-Mampel Mariona, Urquiza Pedro, Solesio E. Maria
Summary: Mitochondrial dysfunction is a common feature in neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, with inorganic polyphosphate (polyP) potentially being a promising pharmacological target against these conditions. Further research is needed to fully understand the role of polyP in neurodegeneration and its effects on cellular and mitochondrial physiology.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Randa M. Breikaa, Brenda Lilly
Summary: COVID-19 is closely linked to a variety of cardiovascular complications, with the Notch signaling pathway potentially serving as a key driver in these complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Editorial Material
Neurosciences
Francesco Mattace-Raso, Jeannette A. Goudzwaard, Harmke A. Polinder-Bos, Lisanne Tap
Summary: Current guidelines on cardiovascular risk management may not be applicable for older adults with dementia, as previous studies have not specifically included this population. Considering the potential risks and benefits, individualized treatment strategies and regular monitoring are necessary in managing cardiovascular risk in older patients with dementia. The focus should be on maintaining quality of life, preventing cognitive and functional deterioration, and promoting independence.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
