期刊
ENVIRONMENTAL POLLUTION
卷 210, 期 -, 页码 388-396出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2015.12.008
关键词
Perfluorooctane sulfonate; Acute toxicity; Subchronic toxicity; Apoptosis
资金
- National High Technology Research and Development Program of China (863 Program) [2013BAD18B01, 2013BAD18B02, 2012BAD28B07, 2012BAD12B08]
- National Natural Science Foundation of China [31301407, 31200691]
- Graduate Student Innovation Project of Jiangsu Province [KYLX15_1135]
- National Basic Research Program of China (973 Program) [2012CB720802]
- Key Projects in the National Science and Technology Pillar Program during the 12th Five-Year Plan [2012BAD28B07, 2012BAD12B08]
- Programme of Introducing Talents of Discipline to Universities [B07029]
- Fundamental Research Funds for the Central Universities [JUSRP51501]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Industry Development Program in Collaborative Innovation Center for Food safety and quality control, Jiangsu province
Perfluorooctane sulfonate (PFOS) is a principal representative and the final degradation product of several commercially produced perfluorinated compounds. However, PFOS has a high bioaccumulation potential and therefore can exert toxicity on aquatic organisms, animals, and cells. Considering the widespread concern this phenomenon has attracted, we examined the acute and subchronic toxic effects of varying doses of PFOS on adult male C57BL/6 mice. The acute oral LD50 value of PFOS in male C57BL/6J mice was 0.579 g/kg body weight (BW). Exposure to the subchronic oral toxicity of PFOS at 2.5, 5, and 10 mg PFOS/kg BW/day for 30 days disrupted the homeostasis of antioxidative systems, induced hepatocellular apoptosis (as revealed by the terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay), triggered liver injury (as evidenced by the increased serum levels of aspartate aminotransferase, alanine amino transferase, alkaline phosphatase, and gamma-glutamyl transpeptidase and by the altered histology), and ultimately increased the liver size and relative weight of the mice. PFOS treatment caused liver damage but only slightly affected the kidneys and spleen of the mice. This study provided insights into the toxicological effects of PFOS. (C) 2015 Elsevier Ltd. All rights reserved.
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