期刊
FRONTIERS IN MICROBIOLOGY
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2021.596002
关键词
antimicrobial; fecal microbiome; swine; gut dysfunction; meta-analysis
类别
资金
- World Institute of Kimchi [KE2001-1]
- Ministry of Science and ICT
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry, and Fisheries (IPET) through Agricultural Microbiome RD Program
- Ministry of Agriculture, Food and Rural Affairs (MAFRA), South Korea [918018-04-3-HD040]
The study found that finishing swine administered with lincomycin exhibited gut dysbiosis, increased abundance of detrimental microbes, and decreased levels of fiber-degrading bacteria. Lincomycin treatment also led to enrichment of metabolic pathways related to pathogenicity and deficiency of polysaccharide degradation in finishing swine, indicating severe disruption of the commensal microbiota.
Subclinical doses of antimicrobials are commonly used in the swine industry to control infectious diseases and growth performance. Accumulating evidence suggests that swine administered with antibiotics are susceptible to disease development due to disruption of the beneficial gut microbial community, which is associated with host immune regulation, nutrient digestion, and colonization resistance against pathogens. In this study, we found that finishing swine administered with lincomycin showed gut dysbiosis and increased diarrhea incidence compared with control swine. 16S rRNA amplicon sequencing was used to analyze the gut microbiota in finishing swine administered with lincomycin. The relative abundance of detrimental microbes, such as species of Clostridium, Aerococcus, Escherichia-Shigella, and Corynebacterium was increased in the feces of lincomycin-administered finishing swine, but that of bacteria associated with fiber degradation, such as species of Treponema, Succinivibrio, Fibrobacter, and Cellulosilyticum was decreased. Moreover, administration of lincomycin significantly increased the enrichment of metabolic pathways related to pathogenicity and deficiency of polysaccharide degradation. These results suggest that lincomycin treatment could cause severe disruption of the commensal microbiota in finishing swine.
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