期刊
ENVIRONMENTAL POLLUTION
卷 214, 期 -, 页码 568-574出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2016.04.049
关键词
TBEOP; Organophosphate flame retardants; Endocrine disruption; HPG axis; Zebraflsh
资金
- National Research Foundation of Korea (NRF) [2013R1A1A2012182]
- National Research Foundation of Korea [2013R1A1A2012182, 22A20130012692] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Tris(2-butoxyethyl) phosphate (TBEOP), a widely used organophosphate flame retardant, has frequently been detected both in the environment and the biota. However, limited information is available on the effects of TBEOP on the endocrine system and its underlying mechanisms. We exposed adult zebrafish pairs to TBEOP at concentrations of 0, 2.1,11, and 118 mu g/L for 21 d, and investigated the effects on gene transcription and hormone production related to the hypothalamic-pituitary-gonadal (HPG) axis, and on reproduction. The adverse effects on the F1 generation were further examined. In male fish, plasma concentrations of 17 beta-estradiol were significantly increased along with up-regulation of cyp19a. Exposure to TBEOP at 118 mu g/L to a significant decrease in average egg production. Exposure of the F0 generation to TBEOP delayed hatching and lowered hatching rates in the F1 generation. The results demonstrate that exposure to TBEOP at environmentally relevant concentration levels could affect the sex hormone balance by altering regulatory circuits of the HPG axis, eventually leading to disruption of reproductive performance and the development of offspring. (C) 2016 Elsevier Ltd. All rights reserved.
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