Review
Biochemistry & Molecular Biology
Junhu Tai, Jiwon Kwak, Munsoo Han, Tae Hoon Kim
Summary: This review discusses the role of dendritic cells (DCs) in chronic rhinosinusitis (CRS) and their function in the nasal sinus mucosa. Studies have shown that DCs may play an important role in the pathogenesis of CRS and can be targeted for therapeutic intervention. Future research directions need to be further explored.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Toxicology
Silvia Vivarelli, Chiara Costa, Michele Teodoro, Federica Giambo, Aristidis Michael Tsatsakis, Concettina Fenga
Summary: Non-communicable diseases (NCDs) are major global causes of mortality and morbidity. Unhealthy lifestyle habits are closely associated with NCDs, and improving these habits may help alleviate symptoms and prolong the life expectancy of affected individuals. Polyphenols (PPLs) derived from plants have shown positive results in preventing and treating NCDs and are considered safe.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Otorhinolaryngology
Amr F. Hamour, John J. W. Lee, Ewa Wasilewski, Eric Monteiro, John M. Lee, Allan Vescan, Lakshmi P. Kotra
Summary: This study established a murine model of eosinophilic CRS and found that the nasal mucosa of the model showed significant eosinophilic infiltration and inflammatory changes, which could be reversed by treatment with mometasone. This model can be used to evaluate the efficacy of therapeutics for chronic rhinosinusitis.
JOURNAL OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Immunology
Hua Sun, Ashish Damania, Megan L. Mair, Eniola Otukoya, Yi-Dong Li, Katherine Polsky, Yuying Zeng, Jeremiah A. Alt, Martin J. Citardi, David B. Corry, Amber U. Luong, John Morgan Knight
Summary: This study established a murine model of chronic unified eosinophilic airway inflammation and identified gene networks and pathways associated with human disease. The researchers demonstrated the important role of STAT6 in fungal-induced sinus inflammation using a specific inhibitor and gene-deficient mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biology
Romica Cergan, Ovidiu Nicolae Berghi, Mihai Dumitru, Daniela Vrinceanu, Felicia Manole, Crenguta Sorina Serboiu
Summary: Chronic rhinosinusitis is a common ENT pathology, affecting 5-12% of the population. Treatment options include pharmacological, surgical, and immunological approaches. Biologics have emerged as a new type of treatment for some CRS cases.
Review
Allergy
Stephanie Shintani Smith, Raymond Kim, Richard Douglas
Summary: This review article examines the rationale for and against the use of antibiotics for treating chronic rhinosinusitis, based on current evidence and understanding of pathophysiology. It also summarizes the current guidelines.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Shyam Ajay Gokani, Matthew Jefferson, Jelena Gavrilovic, Allan Clark, Falk Hildebrand, Tom Wileman, Claire Hopkins, Carl Philpott
Summary: This study aims to correlate clinical parameters and treatment response with CRS endotypes by analyzing biomarkers in nasal tissue and bacterial swabs. It could provide the foundation for patient classification and predicting treatment outcomes.
Article
Otorhinolaryngology
Vidit M. Talati, Hannah J. Brown, Young-Jae Kim, Mary K. Allen-Proctor, Paolo Gattuso, Mahboobeh Mahdavinia, Peter Papagiannopoulos, Pete Batra, Bobby A. Tajudeen
Summary: This retrospective study examined the impact of diabetes mellitus on chronic rhinosinusitis clinically and on structured histopathology. The findings suggest that diabetic patients with chronic rhinosinusitis have increased fungal elements on histopathology. This has important implications for the management of diabetic patients with chronic rhinosinusitis.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Otorhinolaryngology
Lauren T. Roland, Alan Regenberg, Amber U. Luong, Sarah K. Wise, Elina Toskala, Kent K. Lam, Joshua M. Levy, Christine B. Franzese, Kristine Smith, Jean Kim
Summary: Biologics have been approved for use in chronic rhinosinusitis with nasal polyps patients, showing effectiveness in controlling the disease in both subjective and objective short-term outcomes. However, the high costs of biologics may pose a burden for the healthcare system with widespread and prolonged use. Cost-effectiveness analyses are needed to determine appropriate usage, along with addressing patient preferences, counseling on side effects, and healthcare economics.
INTERNATIONAL FORUM OF ALLERGY & RHINOLOGY
(2021)
Editorial Material
Multidisciplinary Sciences
Nic Fleming
Summary: Team science can suffer when junior researchers feel that their career-defining contributions to a paper are being downplayed. Here are some ways to tackle these disputes.
Review
Allergy
Concepcio Marin, Thomas Hummel, Zheng Liu, Joaquim Mullol
Summary: The COVID-19 pandemic has increased awareness of olfactory dysfunction, with chronic rhinosinusitis being one of the common causes. However, there is still limited scientific information about chronic rhinosinusitis in the context of COVID-19. This review focuses on the potential effects of COVID-19 on chronic rhinosinusitis symptoms, diagnosis, and treatment options.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Tim Delemarre, Bruce S. Bochner, Hans-Uwe Simon, Claus Bachert
Summary: Chronic rhinosinusitis is often characterized by eosinophilic inflammation, but a third of patients have mucosal inflammation dominated by neutrophils. Understanding the interactions between eosinophilic and neutrophilic inflammation in pathophysiology, as well as the mixed presentation in patients with severe type 2 CRS with nasal polyps, is crucial for treatment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Otorhinolaryngology
David W. Jang, Hui-Jie Lee, Philip G. Chen, Seth M. Cohen, Charles D. Scales
Summary: This retrospective study analyzed data from a national claims database and found wide variations in the management of CRS prior to referral to otolaryngologists. The delayed referral group showed significantly higher healthcare expenditure and resource utilization.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Ifeanyi Jude Ezeonwumelu, Edurne Garcia-Vidal, Eva Riveira-Munoz, Eudald Felip, Lucia Gutierrez-Chamorro, Ignasi Calba, Marta Massanella, Guillem Sirera, Bonaventura Clotet, Ester Ballana, Roger Badia
Summary: This study evaluated the use of compounds targeting IKK complex subunits and related kinases as a novel pathway to reverse HIV-1 latency. The results showed that these compounds could induce HIV reactivation without affecting antiretroviral therapy. Additionally, these compounds have immunomodulatory effects and can control the inflammatory responses caused by HIV infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Psychiatry
Noa Reuveni, Cole A. Carlson, Sarah Schwartz, Diana Meter, Tyson S. Barrett, Sara M. Freeman
Summary: This systematic review and meta-analysis of preclinical literature on the effects of cannabinoids in the chronic unpredictable stress model of depression found that cannabinoid administration moderately improved the negative effects of stress on depressive-like behavior, suggesting that cannabinoids may be a viable long-term treatment for stress-related psychopathologies such as depression.
TRANSLATIONAL PSYCHIATRY
(2022)
