Article
Oncology
Arpita Dutta, Priyadarshini Halder, Anakshi Gayen, Avik Mukherjee, Chandrama Mukherjee, Shubhra Majumder
Summary: This study shows that downregulation of VDAC1 in pancreatic cancer and glioblastoma cells increases ciliation and inhibits cell proliferation. VDAC1 depletion also leads to longer primary cilia in quiescent cells. These findings highlight the importance of VDAC1 in regulating tumorigenesis and primary cilium disassembly.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Jing Zhang, Aomei Zhao, Xi Jia, Xinru Li, Yiqian Liang, Yan Liu, Xin Xie, Xijie Qu, Qi Wang, Yuemin Zhang, Rui Gao, Yan Yu, Aimin Yang
Summary: Sinomenine hydrochloride (SH) shows therapeutic potential in the treatment of papillary thyroid cancer (PTC). It inhibits cell proliferation, induces apoptosis, promotes cell redifferentiation, and enhances the efficacy of radioactive iodine (RAI) therapy in PTC cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jingxian Li, Zikun Yang, Yuanjiong Qi, Xun Liu, Yang Liu, Xinyu Gao, Shuai Li, Jianqiang Zhu, Changwen Zhang, E. Du, Zhihong Zhang
Summary: STIL expression is up-regulated in most cancer types and affected by copy number variation, mutation, and DNA methylation. High STIL expression is associated with worse outcomes and promotes cancer progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Conception Paul, Ruizhi Tang, Ciro Longobardi, Rossano Lattanzio, Thibaut Eguether, Hulya Turali, Julie Bremond, Chloe Maurizy, Monica Gabola, Sophie Poupeau, Andrei Turtoi, Emilie Denicolai, Maria Concetta Cufaro, Magali Svrcek, Philippe Seksik, Vincent Castronovo, Philippe Delvenne, Vincenzo de Laurenzi, Quentin Da Costa, Francois Bertucci, Benedicte Lemmers, Damiana Pieragostino, Emilie Mamessier, Carsten Janke, Valerie Pinet, Michael Hahne
Summary: This study found that a decrease in primary cilia numbers in the colon promotes colitis and colorectal cancer, and an activation loop may exist between the inflammatory environment and IL-6 production in relation to primary cilia loss.
Article
Pathology
Ning Bai, Chunyan Liu, Xiaole Zhang, Yang Cheng, Deqiang Hou
Summary: This study found that NOD1 expression is correlated with improved prognosis in papillary thyroid carcinoma and promotes cancer cell apoptosis through the RIP2/TAK1 and MAPK pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Julia Ramirez-Moya, Christos Miliotis, Allison R. Baker, Richard Gregory, Frank J. Slack, Pilar Santisteban
Summary: ADAR1 deregulation leads to increased A-to-I editing in thyroid tumors, with CDK13 being identified as an oncogene that is significantly over-edited in tumor samples. This editing event promotes cancer cell hallmarks and increases the nucleolar abundance of the protein, potentially explaining the global splicing changes induced by ADAR1 deregulation.
Article
Cell Biology
Yu-Chieh Chen, Che-Wei Yang, Te-Fu Chan, Ammad Ahmad Farooqi, Hsun-Shuo Chang, Chia-Hung Yen, Ming-Yii Huang, Hsueh-Wei Chang
Summary: Cryptocaryone (CPC) derived from Cryptocarya plants has shown antiproliferative effects on ovarian cancer (OVCA) cells, particularly TOV-21G and SKOV3 cells. Its mechanisms of action include inducing oxidative stress, promoting mitochondrial dysfunction, triggering apoptosis, and causing DNA damage.
Article
Biochemistry & Molecular Biology
Hyocheol Bae, Sunwoo Park, Jiyeon Ham, Jisoo Song, Taeyeon Hong, Jin-Hee Choi, Gwonhwa Song, Whasun Lim
Summary: Beta-sitosterol, a plant-derived phytosterol, has been found to exhibit anticancer effects against ovarian cancer by inducing apoptosis, suppressing proliferation, inhibiting migration, and showing synergistic effects with standard anticancer drugs.
Article
Biochemistry & Molecular Biology
Yehua Li, Baoqiang Fan, Ning Pu, Xue Ran, Tiancheng Lian, Yifan Cai, Wei Xing, Kun Sun
Summary: The study demonstrates that isorhamnetin (ISO) induces apoptosis in gastric cancer cells through the mitochondria-dependent apoptotic pathway, inhibiting cell proliferation and providing a potential strategy for clinical therapy.
Article
Biochemistry & Molecular Biology
Silvia Martina Ferrari, Giusy Elia, Francesca Ragusa, Sabrina Rosaria Paparo, Valeria Mazzi, Armando Patrizio, Simona Piaggi, Enke Baldini, Marco Centanni, Concettina La Motta, Alessandro Antonelli, Poupak Fallahi
Summary: This study evaluated the antineoplastic effect of multitarget tyrosine kinase inhibitor pazopanib in primary human anaplastic thyroid cancer cells in vitro. The results showed that pazopanib inhibited cell proliferation, migration, and invasion, and increased apoptosis. Moreover, pazopanib significantly decreased the expression of VEGF in the cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Xuguang Jiang, Wenxin Shao, Yongping Chai, Jingying Huang, Mohamed A. A. Mohamed, Zeynep Okten, Wei Li, Zhiwen Zhu, Guangshuo Ou
Summary: This study investigates the unloading process of tubulin in intraflagellar transport (IFT) mechanism and discovers that the ciliary kinase DYF-5/MAK phosphorylates the tubulin-binding module of IFT-74, reducing its tubulin-binding affinity. This phosphorylation plays a fundamental role in ciliogenesis by regulating tubulin unloading and impacting the growth and maintenance of cilia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Jie Xu, Xiaoyan Deng, Xiangmei Wu, Huifang Zhu, Yinghua Zhu, Jie Liu, Qian Chen, Chengfu Yuan, Geli Liu, Changdong Wang
Summary: This study found that gastric cancer may cause bone damage prior to bone metastasis, possibly through cilia-dependent activation of the Wnt/beta-catenin signaling pathway as indicated by clinical evidence and mouse model experiments.
Article
Integrative & Complementary Medicine
Ge Wang, Xiu-Qi Fan, Lu Li, Yan Li, Bian Shi, Ke-Xin Xing, Qi-Long Gao
Summary: Toosendanin (TSN) extracted from Melia toosendan Sieb et Zucc has been demonstrated to possess antitumor activities on ovarian cancer cells, inhibiting cell proliferation, inducing apoptosis, reducing mitochondrial membrane potential, and suppressing invasion and migration. TSN's effects are associated with modulation of expression levels of key proteins related to the caspase-dependent mitochondrial apoptotic pathway.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Plant Sciences
Yiqun Hu, Qingliang Wen, Yefeng Cai, Yunye Liu, Wenli Ma, Qinglin Li, Fahuan Song, Yawen Guo, Lei Zhu, Jingyan Ge, Qian Zeng, Jiahui Wang, Changtian Yin, Guowan Zheng, Minghua Ge
Summary: Alantolactone (ATL), extracted from Inula helenium L., showed significant anti-ATC activity by inhibiting proliferation, inducing apoptosis and pyroptosis, and increasing the release of LDH and IL-1 beta in ATC cells. ATL also activated caspase-dependent pathways through ROS-mediated mitochondria dysfunction. In addition, ATL induced the translocation of calreticulin to the cell membrane, indicating immunogenic cell death. ATL also inhibited the growth of ATC subcutaneous xenograft model with high safety profile.
Article
Cell Biology
Changfeng Li, Jiao Liu, Wen Hou, Rui Kang, Daolin Tang
Summary: Ferroptosis is a type of iron-dependent regulated cell death where the ER protein STING1 promotes cell death by increasing mitochondrial fusion. This discovery establishes a new cell death mechanism and potential strategy for enhancing ferroptosis-based therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Katri Lindfors, Jake Lin, Hye-Seung Lee, Heikki Hyoty, Matti Nykter, Kalle Kurppa, Edwin Liu, Sibylle Koletzko, Marian Rewers, William Hagopian, Jorma Toppari, Annette-Gabriele Ziegler, Beena Akolkar, Jeffrey P. Krischer, Joseph F. Petrosino, Richard E. Lloyd, Daniel Agardh
Article
Endocrinology & Metabolism
Qian Li, Hemang Parikh, Martha D. Butterworth, Ake Lernmark, William Hagopian, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-G. Ziegler, Beena Akolkar, Oliver Fiehn, Sili Fan, Jeffrey P. Krischer
Article
Endocrinology & Metabolism
Kendra Vehik, Ezio Bonifacio, Ake Lernmark, Liping Yu, Alistair Williams, Desmond Schatz, Marian Rewers, Jin-Xiong She, Jorma Toppari, William Hagopian, Beena Akolkar, Anette G. Ziegler, Jeffrey P. Krischer
Article
Biochemistry & Molecular Biology
Lauric A. Ferrat, Kendra Vehik, Seth A. Sharp, Ake Lernmark, Marian J. Rewers, Jin-Xiong She, Anette-G Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey P. Krischer, Michael N. Weedon, Richard A. Oram, William A. Hagopian
Article
Endocrinology & Metabolism
Ezio Bonifacio, Andreas Weiss, Christiane Winkler, Markus Hippich, Marian J. Rewers, Jorma Toppari, Ake Lernmark, Jin-Xiong She, William A. Hagopian, Jeffrey P. Krischer, Kendra Vehik, Desmond A. Schatz, Beena Akolkar, Anette-Gabriele Ziegler
Summary: The risk of developing islet autoimmunity decreases with age, and the impact of major genetic factors is limited to the first few years of life. The best time for screening for type 1 diabetes with multiple autoantibody phenotypes is at 2 years and again at 5-7 years of age.
Article
Cell Biology
Elin Schoultz, Ellen Johansson, Carmen Moccia, Iva Jakubikova, Naveen Ravi, Shawn Liang, Therese Carlsson, Mikael Montelius, Konrad Patyra, Jukka Kero, Kajsa Paulsson, Henrik Fagman, Martin O. Bergo, Mikael Nilsson
Summary: Research has discovered that papillary thyroid carcinomas originate from a single follicle and grow within a confined space. There are also differences in tumor size between male and female mice, mirroring the gender difference observed in human thyroid cancer.
DISEASE MODELS & MECHANISMS
(2022)
Article
Endocrinology & Metabolism
Konrad Patyra, Kristiina Makkonen, Maria Haanpaa, Sinikka Karppinen, Liisa Viikari, Jorma Toppari, Mary Pat Reeve, Jukka Kero
Summary: Central hypothyroidism (CeH) is a rare condition that can affect normal development if not detected and treated promptly. Diagnosing isolated CeH can be challenging, as multiple genetic causes have been identified. This study identified a novel genetic mutation in the X-linked IRS4 gene in two brothers with CeH and confirmed an association of the IRS4 gene locus with thyroid disease risk in a large genetic database.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Laura M. Jacobsen, Kendra Vehik, Riitta Veijola, Katharina Warncke, Jorma Toppari, Andrea K. Steck, Patricia Gesualdo, Beena Akolkar, Markus Lundgren, William A. Hagopian, Jin-Xiong She, Marian Rewers, Anette-G Ziegler, Jeffrey P. Krischer, Helena Elding Larsson, Michael J. Haller
Summary: The TEDDY study examines age-specific differences associated with type 1 diabetes. Younger children with type 1 diabetes tend to have fewer autoantibodies and more symptoms at diagnosis. The incidence of DKA at onset in TEDDY is rare, especially among individuals with a family history of the disease.
Correction
Biochemistry & Molecular Biology
Lauric A. Ferrat, Kendra Vehik, Seth A. Sharp, Ake Lernmark, Marian J. Rewers, Jin-Xiong She, Anette-G. Ziegler, Jorma Toppari, Beena Akolkar, Jeffrey P. Krischer, Michael N. Weedon, Richard A. Oram, William A. Hagopian
Article
Endocrinology & Metabolism
Konrad Patyra, Christoffer Lof, Holger Jaeschke, Hendrik Undeutsch, Huifei Sophia Zheng, Sofia Tyystjarvi, Kamila Pulawska, Milena Doroszko, Marcin Chrusciel, Britt-Marie Loo, Riikka Kurkijarvi, Fu-Ping Zhang, Chen-Che Jeff Huang, Claes Ohlsson, Andreina Kero, Matti Poutanen, Jorma Toppari, Ralf Paschke, Nafis Rahman, Ilpo Huhtaniemi, Jarmo Jaaskelainen, Jukka Kero
Summary: This study found that congenital hypothyroidism and hyperthyroidism have functional effects on adrenal gland development, steroidogenic activity, and adrenal medulla.
Article
Multidisciplinary Sciences
Ingrid Braenne, Suna Onengut-Gumuscu, Ruoxi Chen, Ani W. Manichaikul, Stephen S. Rich, Wei-Min Chen, Charles R. Farber
Summary: By analyzing longitudinal blood transcriptomic profiles in the TEDDY study, researchers found highly dynamic differences in connectivity within immune response gene networks associated with T1D in the approximately 2 years leading up to clinical diagnosis. This suggests that gene co-expression is highly plastic and alterations in connectivity may influence the timing and progression of clinical disease.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Elin M. Hard Af Segerstad, Xiang Liu, Ulla Uusitalo, Daniel Agardh, Carin Andren Aronsson, Teddy Study Group
Summary: High dietary intake of gluten is associated with increased risk of celiac disease (CD) in children at genetic risk. Intake of high amounts of bread and milk cereal drink before the age of 2 is associated with increased risk of both celiac disease autoimmunity (CDA) and CD in genetically at-risk children.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Multidisciplinary Sciences
Carina Torn, Xiang Liu, Suna Onengut-Gumuscu, Kevin M. Counts, Jose Leonardo Moreno, Cassandra L. Remedios, Wei-Min Chen, Jonathon LeFaive, Martha D. Butterworth, Beena Akolkar, Jeffrey P. Krischer, Ake Lernmark, Marian Rewers, Jin-Xiong She, Jorma Toppari, Anette-Gabriele Ziegler, Aakrosh Ratan, Albert Smith, William A. Hagopian, Stephen S. Rich, Hemang M. Parikh
Summary: The TEDDY study found that the age at blood sample collection was negatively correlated with telomere length, European children had shorter telomeres than American children, paternal age was positively associated with telomere length, and maternal age, gestational diabetes, and first-degree relative status did not have a significant impact on telomere length. Additionally, children with HLA-DR4/4 or HLA-DR4/X genotypes had longer telomeres. The study also found that telomere length did not significantly affect the risk for islet autoimmunity or type 1 diabetes, but was shorter in high prevalence populations in Finland and Sweden.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Maria Mansson Martinez, Falastin Salami, Helena Elding Larsson, Jorma Toppari, Ake Lernmark, Jukka Kero, Riitta Veijola, Jaakko J. Koskenniemi, Paivi Tossavainen, Markus Lundgren, Henrik Borg, Anastasia Katsarou, Marlena Maziarz, Carina Torn
Summary: Participants positive for a single islet autoantibody showed normal beta cell function, while those positive for multiple islet autoantibodies appeared to have deteriorated beta cell function.
ENDOCRINOLOGY DIABETES & METABOLISM
(2021)