期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41598-020-80923-9
关键词
-
资金
- MBIE Catalyst grant (The New Zealand-Australia Life Course Collaboration on Genes, Environment, Nutrition and Obesity (GENO)) [UOAX1611]
- National Health and Medical Research Council (NHMRC) of Australia [1041352, 1109355]
- Royal Children's Hospital Foundation [2014-241]
- University of Melbourne
- National Heart Foundation of Australia [100660]
- Financial Markets Foundation for Children [2014-055, 2016-310]
- Victorian Deaf Education Institute
- Victorian Government's Operational Infrastructure Support Program
- New Zealand International Doctoral Research Scholarship 2017
- NHMRC [1046518, 1160906, 1064629]
- National Heart Foundation of Australia: Honorary Future Leader Fellowship [100369]
- Cure Kids New Zealand
- the Murdoch Children's Research Institute
- [GTN1175744]
- New Zealand Ministry of Business, Innovation & Employment (MBIE) [UOAX1611] Funding Source: New Zealand Ministry of Business, Innovation & Employment (MBIE)
This study found that amino acid concentrations are influenced by age, sex, and shared familial factors. Most amino acids were higher in adults compared to children, with differences also seen between genders.
Amino acid (AA) concentrations are influenced by both exogenous (e.g. diet, lifestyle) and endogenous factors (e.g. genetic, transcriptomic, epigenetic, and metabolomic). Fasting plasma AA profiles in adulthood are predictive of diabetes risk over periods of up to 12 years. Data on AA profiles in cross-generational cohorts, including individuals from shared gene-environment settings are scarce, but would allow the identification of the contribution of heritable and environmental factors characterising the levels of circulating AAs. This study aimed to investigate parent-child (familial dyad) concordance, absolute differences between generations- (children versus adults), age- (in adults: 28-71 years), and sex-dependent differences in plasma AA concentrations. Plasma AA concentrations were measured by UHPLC/MS-MS in 1166 children [mean (SD) age 11 (0.5) years, 51% female] and 1324 of their parents [44 (5.1) years, 87% female]. AA concentrations were variably concordant between parents and their children (5-41% of variability explained). Most AA concentrations were higher in adults than children, except for the non-essential AAs arginine, aspartic acid, glutamine, hydroxy-proline, proline, and serine. Male adults and children typically had higher AA concentrations than females. The exceptions were alanine, glutamine, glycine, hydroxy-proline, serine, and threonine in girls; and glycine and serine in women. Age, sex, and shared familial factors are important determinants of plasma AA concentrations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据