Phytonutrient and Nutraceutical Action against COVID-19: Current Review of Characteristics and Benefits

The trend toward using phytonutrients and/or nutraceuticals (P/Ns) with the aim of impacting immune health has increased in recent years. The main reason is that properties of P/Ns are associated with possible immunomodulating effects in the prevention and complementary treatment of viral diseases, including COVID-19 and other respiratory infections. In the present review, we assess the scientific plausibility of specific P/Ns for this purpose of preventative and therapeutic interventions against COVID-19, with an emphasis on safety, validity, and evidence of efficacy against other viruses. Five potential candidates have been identified after reviewing available studies (in silico, in vitro, and in vivo) in which certain flavonoids have demonstrated a potential for use as adjuvant therapeutic agents against viral infections, including COVID-19. As these are often better tolerated than pharmacological treatments, their use could be more widely considered if additional detailed studies can validate the existing evidence.

Automated summary

The trend of using phytonutrients and nutraceuticals to impact immune health has increased recently, as these substances may have immunomodulating effects that can be used for prevention and treatment of viral diseases, including COVID-19. Research has identified certain flavonoids as potential adjuvant therapeutic agents against viral infections, particularly COVID-19.