Implications for an Imidazole-2-yl Carbene Intermediate in the Rhodanase-Catalyzed C–S Bond Formation Reaction of Anaerobic Ergothioneine Biosynthesis

Inverse Solvent Isotope Effects in Enzyme-Catalyzed Reactions

(2020) Patrick L. Fernandez et al.   MOLECULES

Stable Carbenes, Nitrenes, Phosphinidenes, and Borylenes: Past and Future

(2020) Michele Soleilhavoup et al.   Chem

Single-Step Replacement of an Unreactive C–H Bond by a C–S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis

(2020) Ronghai Cheng et al.   ACS Catalysis

An Alternative Active Site Architecture for O2 Activation in the Ergothioneine Biosynthetic EgtB from Chloracidobacterium thermophilum

(2019) Anja R. Stampfli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and Mechanistic Basis for Anaerobic Ergothioneine Biosynthesis

(2019) Florian Leisinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal Structure of the Ergothioneine Sulfoxide Synthase from Candidatus Chloracidobacterium thermophilum and Structure-Guided Engineering To Modulate Its Substrate Selectivity

(2019) Nathchar Naowarojna et al.   ACS Catalysis

Selenocysteine as a substrate, an inhibitor and a mechanistic probe for bacterial and fungal iron‐dependent sulfoxide synthases.

(2019) Kristina V. Goncharenko et al.   CHEMISTRY-A EUROPEAN JOURNAL

Design and Preparation of Poly-Selenides: Easily Fabricated and Efficient Organoselenium Materials for Heavy Metal Removing and Recycling

(2018) Xiaobi Jing et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Mini-Review: Ergothioneine and Ovothiol Biosyntheses, an Unprecedented Trans-Sulfur Strategy in Natural Product Biosynthesis

(2018) Nathchar Naowarojna et al.   BIOCHEMISTRY

Use of a Tyrosine Analogue To Modulate the Two Activities of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis, Cysteine Oxidation versus Oxidative C–S Bond Formation

(2018) Li Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Catalytic iron-carbene intermediate revealed in a cytochromeccarbene transferase

(2018) Russell D. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biosynthesis and isolation of selenoneine from genetically modified fission yeast

(2018) Nikolaus G. Turrini et al.   Metallomics

In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C–S Lyase and Methyltransferase Reactions

(2018) Nathchar Naowarojna et al.   ORGANIC LETTERS

Prolonging healthy aging: Longevity vitamins and proteins

(2018) Bruce N. Ames   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanistic Studies of a Nonheme Iron Enzyme OvoA in Ovothiol Biosynthesis Using a Tyrosine Analogue, 2-Amino-3-(4-hydroxy-3-(methoxyl) phenyl) Propanoic Acid (MeOTyr)

(2018) Li Chen et al.   ACS Catalysis

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Antibacterial sulfur-containing platensimycin and platencin congeners from Streptomyces platensis SB12029

(2016) Liao-Bin Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example

(2016) Paul H. Oyala et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction of Hydrogen Sulfide with Disulfide and Sulfenic Acid to Form the Strongly Nucleophilic Persulfide

(2015) Ernesto Cuevasanta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Role of Tyrosine and Rational Tuning of Oxidase Activity by Genetic Incorporation of Unnatural Tyrosine Analogs

(2015) Yang Yu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis and Reactivity of Cysteine Persulfides in Signaling

(2015) Pramod K. Yadav et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate

(2015) Heng Song et al.   Scientific Reports

Bioinformatic and Biochemical Characterizations of C–S Bond Formation and Cleavage Enzymes in the Fungus Neurospora crassa Ergothioneine Biosynthetic Pathway

(2014) Wen Hu et al.   ORGANIC LETTERS

Genetic and Metabolomic Dissection of the Ergothioneine and Selenoneine Biosynthetic Pathway in the Fission Yeast, S. pombe, and Construction of an Overproduction System

(2014) Tomáš Pluskal et al.   PLoS One

Hemoglobin as a major binding protein for methylmercury in white-sided dolphin liver

(2013) Zoyne Pedrero Zayas et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Role of a Guanidinium Cation–Phosphodianion Pair in Stabilizing the Vinyl Carbanion Intermediate of Orotidine 5′-Phosphate Decarboxylase-Catalyzed Reactions

(2013) Bogdana Goryanova et al.   BIOCHEMISTRY

Identification and Determination of Selenoneine, 2-Selenyl-N α , N α , N α -Trimethyl-l-Histidine, as the Major Organic Selenium in Blood Cells in a Fish-Eating Population on Remote Japanese Islands

(2013) Michiaki Yamashita et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars

(2013) Chia-I. Lin et al.   CHEMICAL SOCIETY REVIEWS

Identification of an Intermediate Methyl Carrier in the Radical S-Adenosylmethionine Methylthiotransferases RimO and MiaB

(2013) Bradley J. Landgraf et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selenoneine, a Novel Selenium-Containing Compound, Mediates Detoxification Mechanisms against Methylmercury Accumulation and Toxicity in Zebrafish Embryo

(2013) Michiaki Yamashita et al.   MARINE BIOTECHNOLOGY

Observation of a stable carbene at the active site of a thiamin enzyme

(2013) Danilo Meyer et al.   Nature Chemical Biology

Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases

(2013) Farhad Forouhar et al.   Nature Chemical Biology

Regioselectivity of the Oxidative C–S Bond Formation in Ergothioneine and Ovothiol Biosyntheses

(2013) Heng Song et al.   ORGANIC LETTERS

Proton Transfer from C-6 of Uridine 5′-Monophosphate Catalyzed by Orotidine 5′-Monophosphate Decarboxylase: Formation and Stability of a Vinyl Carbanion Intermediate and the Effect of a 5-Fluoro Substituent

(2012) Wing-Yin Tsang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Importance of Residues in the Orotate Binding Site

(2011) Vanessa Iiams et al.   BIOCHEMISTRY

Ergothioneine; antioxidant potential, physiological function and role in disease

(2011) Irwin K. Cheah et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

OMP Decarboxylase: Phosphodianion Binding Energy Is Used To Stabilize a Vinyl Carbanion Intermediate

(2011) Bogdana Goryanova et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and Characterization of the First Ovothiol Biosynthetic Enzyme

(2011) Andrea Braunshausen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Incorporation of Fluorotyrosines into Ribonucleotide Reductase Using an Evolved, Polyspecific Aminoacyl-tRNA Synthetase

(2011) Ellen C. Minnihan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification in human urine and blood of a novel selenium metabolite, Se-methylselenoneine, a potential biomarker of metabolization in mammals of the naturally occurring selenoneine, by HPLC coupled to electrospray hybrid linear ion trap-orbital ion trap MS

(2011) Marlène Klein et al.   Metallomics

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: “Remote” Residues That Stabilize the Active Conformation

(2010) B. McKay Wood et al.   BIOCHEMISTRY

Activation of R235A Mutant Orotidine 5′-Monophosphate Decarboxylase by the Guanidinium Cation: Effective Molarity of the Cationic Side Chain of Arg-235

(2010) Shonoi A. Barnett et al.   BIOCHEMISTRY

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Product Deuterium Isotope Effects for Orotidine 5′-Monophosphate Decarboxylase: Effect of Changing Substrate and Enzyme Structure on the Partitioning of the Vinyl Carbanion Reaction Intermediate

(2010) Krisztina Toth et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In Vitro Reconstitution of Mycobacterial Ergothioneine Biosynthesis

(2010) Florian P. Seebeck   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Examination of the Relationship between Active Site Loop Size and Thermodynamic Activation Parameters for Orotidine 5′-Monophosphate Decarboxylase from Mesophilic and Thermophilic Organisms

(2009) Krisztina Toth et al.   BIOCHEMISTRY

Orotic Acid Decarboxylation in Water and Nonpolar Solvents: A Potential Role for Desolvation in the Action of OMP Decarboxylase

(2009) Charles A. Lewis et al.   BIOCHEMISTRY

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization,

(2009) Kui K. Chan et al.   BIOCHEMISTRY

Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Effect of Solvent Viscosity on Kinetic Constants

(2009) B. McKay Wood et al.   BIOCHEMISTRY

Formation and Stability of a Vinyl Carbanion at the Active Site of Orotidine 5‘-Monophosphate Decarboxylase:  pKaof the C-6 Proton of Enzyme-Bound UMP

(2008) Tina L. Amyes et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structures of the Human Orotidine-5′-Monophosphate Decarboxylase Support a Covalent Mechanism and Provide a Framework for Drug Design

(2008) Julia G. Wittmann et al.   STRUCTURE