Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells
出版年份 2021 全文链接
标题
Neoadjuvant anti-OX40 (MEDI6469) therapy in patients with head and neck squamous cell carcinoma activates and expands antigen-specific tumor-infiltrating T cells
作者
关键词
-
出版物
Nature Communications
Volume 12, Issue 1, Pages -
出版商
Springer Science and Business Media LLC
发表日期
2021-02-18
DOI
10.1038/s41467-021-21383-1
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in resectable melanoma
- (2019) Alexander C. Huang et al. NATURE MEDICINE
- Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
- (2019) Junfei Zhao et al. NATURE MEDICINE
- Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma
- (2019) Timothy F. Cloughesy et al. NATURE MEDICINE
- Neoadjuvant nivolumab modifies the tumor immune microenvironment in resectable glioblastoma
- (2019) Kurt A. Schalper et al. NATURE MEDICINE
- Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4
- (2019) Jitske van den Bulk et al. Genome Medicine
- Cancer statistics, 2018
- (2018) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Data maturity and follow-up in time-to-event analyses
- (2018) Val Gebski et al. INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
- CheckMate 141: 1‐Year Update and Subgroup Analysis of Nivolumab as First‐Line Therapy in Patients with Recurrent/Metastatic Head and Neck Cancer
- (2018) Maura L. Gillison et al. ONCOLOGIST
- Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors
- (2018) Thomas Duhen et al. Nature Communications
- Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity
- (2018) Marka R. Crittenden et al. Scientific Reports
- Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates
- (2018) Yannick Simoni et al. NATURE
- Neoadjuvant PD-1 Blockade in Resectable Lung Cancer
- (2018) NEW ENGLAND JOURNAL OF MEDICINE
- An R package for model fitting, model selection and the simulation for longitudinal data with dropout missingness
- (2018) Cong Xu et al. COMMUNICATIONS IN STATISTICS-SIMULATION AND COMPUTATION
- Neoadjuvant immune checkpoint blockade in high-risk resectable melanoma
- (2018) Rodabe N. Amaria et al. NATURE MEDICINE
- Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
- (2018) Wouter Scheper et al. NATURE MEDICINE
- Neoadjuvant versus adjuvant ipilimumab plus nivolumab in macroscopic stage III melanoma
- (2018) Christian U. Blank et al. NATURE MEDICINE
- Noncoding regions are the main source of targetable tumor-specific antigens
- (2018) Céline M. Laumont et al. Science Translational Medicine
- Late-Stage Tumor Regression after PD-L1 Blockade Plus a Concurrent OX40 Agonist
- (2018) Fanny Polesso et al. Cancer Immunology Research
- Concurrent PD-1 Blockade Negates the Effects of OX40 Agonist Antibody in Combination Immunotherapy through Inducing T-cell Apoptosis
- (2017) Rajeev K. Shrimali et al. Cancer Immunology Research
- Evidence-Based Treatment Options in Recurrent and/or Metastatic Squamous Cell Carcinoma of the Head and Neck
- (2017) Athanassios Argiris et al. Frontiers in Oncology
- ICOS Promotes the Function of CD4+Effector T Cells during Anti-OX40–Mediated Tumor Rejection
- (2016) Todd C. Metzger et al. CANCER RESEARCH
- Antitumor Activity of Pembrolizumab in Biomarker-Unselected Patients With Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Results From the Phase Ib KEYNOTE-012 Expansion Cohort
- (2016) Laura Q.M. Chow et al. JOURNAL OF CLINICAL ONCOLOGY
- Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ
- (2016) Amy E. Moran et al. JOURNAL OF IMMUNOLOGY
- Safety and clinical activity of pembrolizumab for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-012): an open-label, multicentre, phase 1b trial
- (2016) Tanguy Y Seiwert et al. LANCET ONCOLOGY
- Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck
- (2016) Robert L. Ferris et al. NEW ENGLAND JOURNAL OF MEDICINE
- OX40 signaling in head and neck squamous cell carcinoma: Overcoming immunosuppression in the tumor microenvironment
- (2016) R. Bryan Bell et al. ORAL ONCOLOGY
- Improved Efficacy of Neoadjuvant Compared to Adjuvant Immunotherapy to Eradicate Metastatic Disease
- (2016) J. Liu et al. Cancer Discovery
- Human Papillomavirus and Overall Survival After Progression of Oropharyngeal Squamous Cell Carcinoma
- (2014) Carole Fakhry et al. JOURNAL OF CLINICAL ONCOLOGY
- OX40 Is a Potent Immune-Stimulating Target in Late-Stage Cancer Patients
- (2013) B. D. Curti et al. CANCER RESEARCH
- Increased Frequency of ICOS+ CD4 T Cells as a Pharmacodynamic Biomarker for Anti-CTLA-4 Therapy
- (2013) D. Ng Tang et al. Cancer Immunology Research
- Science gone translational: the OX40 agonist story
- (2011) Andrew D. Weinberg et al. IMMUNOLOGICAL REVIEWS
- The American Joint Committee on Cancer: the 7th Edition of the AJCC Cancer Staging Manual and the Future of TNM
- (2010) Stephen B. Edge et al. ANNALS OF SURGICAL ONCOLOGY
- Preoperative CTLA-4 Blockade: Tolerability and Immune Monitoring in the Setting of a Presurgical Clinical Trial
- (2010) B. C. Carthon et al. CLINICAL CANCER RESEARCH
- Adjuvant Therapy With Agonistic Antibodies to CD134 (OX40) Increases Local Control After Surgical or Radiation Therapy of Cancer in Mice
- (2010) Michael J. Gough et al. JOURNAL OF IMMUNOTHERAPY
- Human Papillomavirus and Survival of Patients with Oropharyngeal Cancer
- (2010) K. Kian Ang et al. NEW ENGLAND JOURNAL OF MEDICINE
- Signaling Through OX40 Enhances Antitumor Immunity
- (2010) Shawn M. Jensen et al. SEMINARS IN ONCOLOGY
- Anti-CTLA-4 therapy results in higher CD4+ICOShiT cell frequency and IFN-γ levels in both nonmalignant and malignant prostate tissues
- (2009) Hong Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- OX40 Agonist Therapy Enhances CD8 Infiltration and Decreases Immune Suppression in the Tumor
- (2008) M. J. Gough et al. CANCER RESEARCH
- CTLA-4 blockade increases IFN -producing CD4+ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
- (2008) C. I. Liakou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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