Visible-light induced radical aryldifluoromethylation of N-arylacrylamides by [bis(difluoroacetoxy)iodo]benzene

CF3SO2Na Acted as a Bifunctional Reagent: Electrochemical Trifluoromethylation of Alkenes Accompanied by SO2-Insertion to Access Trifluoromethylated Cyclic N-Sulfonylimines

(2020) Wei-Wei Liao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

From C1 to C3: Copper-Catalyzed gem-Bis(trifluoromethyl)olefination of α-Diazo Esters with TMSCF3

(2020) Jinbo Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

NHC-Catalyzed Radical Trifluoromethylation Enabled by Togni Reagent

(2020) Bei Zhang et al.   ORGANIC LETTERS

Electrochemical Intramolecular Oxytrifluoromethylation of N-Tethered Alkenyl Alcohols: Synthesis of Functionalized Morpholines

(2020) Aurélie Claraz et al.   ORGANIC LETTERS

Intermolecular Trifluoromethyl-Hydrazination of Alkenes Enabled by Organic Photoredox Catalysis

(2020) Peng Wang et al.   ORGANIC LETTERS

Cu-Catalyzed Site-Selective C(sp2)–H Radical Trifluoromethylation of Tryptophan-Containing Peptides

(2020) Itziar Guerrero et al.   ORGANIC LETTERS

Direct C–H difluoromethylation of heterocycles via organic photoredox catalysis

(2020) Wei Zhang et al.   Nature Communications

Trifluoromethylation of Alkyl Radicals: Breakthrough and Challenges †

(2020) Lin Zhu et al.   CHINESE JOURNAL OF CHEMISTRY

The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

(2020) Patrick J. Sarver et al.   Nature Chemistry

Copper-Catalyzed Trifluoromethylation of Ynones Coupled with Dearomatizing Spirocyclization of Indoles: Access to CF3-Containing Spiro[cyclopentane-1,3′-indole]

(2020) Chengwen Li et al.   ORGANIC LETTERS

Access to Aryl and Heteroaryl Trifluoromethyl Ketones from Aryl Bromides and Fluorosulfates with Stoichiometric CO

(2020) Martin B. Johansen et al.   ORGANIC LETTERS

AIBN-Induced Remote Trifluoromethyl-Alkynylation of Thioalkynes

(2020) Zhimin Xiong et al.   ORGANIC LETTERS

Catalyst-Free, Direct Electrochemical Tri- and Difluoroalkylation/Cyclization: Access to Functionalized Oxindoles and Quinolinones

(2019) Zhixiong Ruan et al.   ORGANIC LETTERS

Hydrodifluoromethylation of Alkenes with Difluoroacetic Acid

(2019) Claudio F. Meyer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Electrophotocatalytic Undirected C−H Trifluoromethylations of (Het)Arenes

(2019) Youai Qiu et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of CF2H-containing oxindoles via photoredox-catalyzed radical difluoromethylation and cyclization of N-arylacrylamides

(2019) Mei Zhu et al.   JOURNAL OF FLUORINE CHEMISTRY

Fluorine and Fluorinated Motifs in the Design and Application of Bioisosteres for Drug Design

(2018) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Visible-Light Photoredox Decarboxylation of Perfluoroarene Iodine(III) Trifluoroacetates for C–H Trifluoromethylation of (Hetero)arenes

(2018) Bin Yang et al.   ACS Catalysis

Competing Crystallization between Lanthanide and Actinide in Acidic Solution Leading to Their Efficient Separation

(2018) Xuemiao Yin et al.   CHINESE JOURNAL OF CHEMISTRY

Visible-Light- and Oxygen-Promoted Direct Csp2-H Radical Difluoromethylation of Coumarins and Antifungal Activities

(2018) Peng Dai et al.   ORGANIC LETTERS

Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

(2017) Jing-jing Ma et al.   JOURNAL OF FLUORINE CHEMISTRY

Difluoromethyl Bioisostere: Examining the “Lipophilic Hydrogen Bond Donor” Concept

(2017) Yossi Zafrani et al.   JOURNAL OF MEDICINAL CHEMISTRY

CF2H, a Hydrogen Bond Donor

(2017) Chanan D. Sessler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Direct C–H Difluoromethylation of Heteroarenes Based on the Photolysis of Hypervalent Iodine(III) Reagents That Contain Difluoroacetoxy Ligands

(2017) Ryu Sakamoto et al.   ORGANIC LETTERS

China's flourishing synthetic organofluorine chemistry: innovations in the new millennium

(2017) Qinghe Liu et al.   National Science Review

Radical Fluoroalkylation of Isocyanides with Fluorinated Sulfones by Visible-Light Photoredox Catalysis

(2016) Jian Rong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible-light-mediated radical oxydifluoromethylation of olefinic amides for the synthesis of CF2H-containing heterocycles

(2016) Weijun Fu et al.   CHEMICAL COMMUNICATIONS

Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation

(2016) Sarah L. Clarke et al.   CHEMISTRY-A EUROPEAN JOURNAL

Visible Light Induced Oxydifluoromethylation of Styrenes with Difluoromethyltriphenylphosphonium Bromide

(2016) Yang Ran et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox-Catalyzed Intramolecular Difluoromethylation of N-Benzylacrylamides Coupled with a Dearomatizing Spirocyclization: Access to CF2H-Containing 2-Azaspiro[4.5]deca-6,9-diene-3,8-diones

(2016) Zuxiao Zhang et al.   ORGANIC LETTERS

Photoredox-Catalyzed Bromodifluoromethylation of Alkenes with (Difluoromethyl)triphenylphosphonium Bromide

(2016) Qing-Yu Lin et al.   ORGANIC LETTERS

Visible-Light-Induced Hydrodifluoromethylation of Alkenes with a Bromodifluoromethylphosphonium Bromide

(2015) Qing-Yu Lin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Efficient Cu-catalyzed Atom Transfer Radical Addition Reactions of Fluoroalkylsulfonyl Chlorides with Electron-deficient Alkenes Induced by Visible Light

(2015) Xiao-Jun Tang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Photoredox-Catalyzed Reductive Difluoromethylation of Electron-Deficient Alkenes

(2015) Xiao-Jun Tang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Oxydifluoromethylation of Alkenes by Photoredox Catalysis: Simple Synthesis of CF2 H-Containing Alcohols

(2015) Yusuke Arai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluoroalkylative Aryl Migration of Conjugated N-Arylsulfonylated Amides Using Easily Accessible Sodium Di- and Monofluoroalkanesulfinates

(2015) Zhengbiao He et al.   ORGANIC LETTERS

Photoredox-Catalyzed Intramolecular Aminodifluoromethylation of Unactivated Alkenes

(2015) Zuxiao Zhang et al.   ORGANIC LETTERS

Photoredox-Catalyzed Tandem Insertion/Cyclization Reactions of Difluoromethyl and 1,1-Difluoroalkyl Radicals with Biphenyl Isocyanides

(2015) Zuxiao Zhang et al.   ORGANIC LETTERS

Electrophilic Trifluoromethylation by Use of Hypervalent Iodine Reagents

(2014) Julie Charpentier et al.   CHEMICAL REVIEWS

Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents

(2014) Sebastián Barata-Vallejo et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Oxindoles through Silver-Catalyzed Trifluoromethylation-, Difluoromethylation- and Arylsulfonylation-Cyclization Reaction ofN-Arylacrylamides

(2014) Jidan Liu et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Photoredox-Catalyzed Tandem Radical Cyclization of N-Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2-Oxindoles Using Fluoroalkylsulfonyl Chlorides

(2014) Xiao-Jun Tang et al.   ORGANIC LETTERS

Introduction of Fluorine and Fluorine-Containing Functional Groups

(2013) Theresa Liang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

Copper- and Iron-Catalyzed Decarboxylative Tri- and Difluoromethylation of α,β-Unsaturated Carboxylic Acids with CF3SO2Na and (CF2HSO2)2Zn via a Radical Process

(2013) Zejiang Li et al.   ORGANIC LETTERS

A “Renaissance” in Radical Trifluoromethylation

(2012) Armido Studer   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Reagent for Direct Difluoromethylation

(2012) Yuta Fujiwara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical and innate carbon–hydrogen functionalization of heterocycles

(2012) Yuta Fujiwara et al.   NATURE

Aromatic Trifluoromethylation with Metal Complexes

(2011) Olesya A. Tomashenko et al.   CHEMICAL REVIEWS

The fluorous effect in biomolecular applications

(2011) Massimo Cametti et al.   CHEMICAL SOCIETY REVIEWS

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C-3 Position

(2010) Feng Zhou et al.   ADVANCED SYNTHESIS & CATALYSIS

Spiroindolones, a Potent Compound Class for the Treatment of Malaria

(2010) M. Rottmann et al.   SCIENCE

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS