Fluorination of α-diazo-γ-lactams with the Olah reagent

Direct conversion of diazo compounds to fluoro derivatives

(2020) Valeria Burianova et al.   TETRAHEDRON LETTERS

Synthetic Exploration of α-Diazo γ-Butyrolactams

(2019) Daniil Zhukovsky et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Medicinally Relevant Modification of the Isoquinoline-1,3-dione Scaffold via Metal-Free Arylation and Fluorination of Diazo Homophthalimides­ in Brønsted Acids

(2019) Andrei Golushko et al.   SYNTHESIS-STUTTGART

Practical Application of the Aqueous ‘Sulfonyl-Azide-Free’ (SAFE) Diazo Transfer Protocol to Less α-C–H Acidic Ketones and Esters

(2019) Dmitry Dar’in et al.   SYNTHESIS-STUTTGART

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents

(2018) Paul S. Humphries et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Continuous Production of Anhydrous tert-Butyl Hydroperoxide in Nonane Using Membrane Pervaporation and Its Application in Flow Oxidation of a γ-Butyrolactam

(2018) Bryan Li et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Improvements to Enable the Large Scale Synthesis of 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833)

(2018) Stephen W. Wright et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design

(2017) Katherine L. Lee et al.   JOURNAL OF MEDICINAL CHEMISTRY

Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2

(2015) Thierry Sifferlen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Reduction of thermal radiation by steam in flare stack system

(2012) Heon Seok Lee et al.   KOREAN JOURNAL OF CHEMICAL ENGINEERING