Cardiac ryanodine receptor calcium release deficiency syndrome

Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes

(2020) Iuliia Polina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ElectroMap: High-throughput open-source software for analysis and mapping of cardiac electrophysiology

(2019) Christopher O’Shea et al.   Scientific Reports

Suppression-of-function mutations in the cardiac ryanodine receptor: Emerging evidence for a novel arrhythmia syndrome?

(2017) Thomas M. Roston et al.   HEART RHYTHM

A type 2 ryanodine receptor variant associated with reduced Ca2+ release and short-coupled torsades de pointes ventricular arrhythmia

(2017) Yusuke Fujii et al.   HEART RHYTHM

A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia

(2017) Thomas M. Roston et al.   JOURNAL OF ELECTROCARDIOLOGY

Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts

(2016) X. Zhong et al.   BIOCHEMICAL JOURNAL

Catecholaminergic Polymorphic Ventricular Tachycardia

(2016) Krystien V. Lieve et al.   CIRCULATION JOURNAL

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

High-resolution Optical Mapping of the Mouse Sino-atrial Node

(2016) Di Lang et al.   Jove-Journal of Visualized Experiments

Catecholaminergic Polymorphic Ventricular Tachycardia in Children

(2015) Thomas M. Roston et al.   Circulation-Arrhythmia and Electrophysiology

Arrhythmogenesis in a catecholaminergic polymorphic ventricular tachycardia mutation that depresses ryanodine receptor function

(2015) Yan-Ting Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optical Mapping of Sarcoplasmic Reticulum Ca 2+ in the Intact Heart

(2014) Lianguo Wang et al.   CIRCULATION RESEARCH

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias

(2014) Wenqian Chen et al.   NATURE MEDICINE

Ryanodine Receptor Mutations Presenting as Idiopathic Ventricular Fibrillation: A Report on Two Novel Familial Compound Mutations, c.6224T>C and c.13781A>G, With the Clinical Presentation of Idiopathic Ventricular Fibrillation

(2014) Christian Paech et al.   PEDIATRIC CARDIOLOGY

Phospholamban Knockout Breaks Arrhythmogenic Ca 2+ Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice

(2013) Yunlong Bai et al.   CIRCULATION RESEARCH

In Situ Confocal Imaging in Intact Heart Reveals Stress-Induced Ca 2+ Release Variability in a Murine Catecholaminergic Polymorphic Ventricular Tachycardia Model of Type 2 Ryanodine Receptor R4496C+/− Mutation

(2012) Biyi Chen et al.   Circulation-Arrhythmia and Electrophysiology

Inherited Dysfunction of Sarcoplasmic Reticulum Ca 2+ Handling and Arrhythmogenesis

(2011) Silvia G. Priori et al.   CIRCULATION RESEARCH

Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release

(2011) Qiang Zhou et al.   NATURE MEDICINE

Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation

(2010) Simon Sedej et al.   CARDIOVASCULAR RESEARCH

Incidence and Risk Factors of Arrhythmic Events in Catecholaminergic Polymorphic Ventricular Tachycardia

(2009) Meiso Hayashi et al.   CIRCULATION

The RYR2-Encoded Ryanodine Receptor/Calcium Release Channel in Patients Diagnosed Previously With Either Catecholaminergic Polymorphic Ventricular Tachycardia or Genotype Negative, Exercise-Induced Long QT Syndrome

(2009) Argelia Medeiros-Domingo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans

(2009) Hiroshi Watanabe et al.   NATURE MEDICINE

Endoplasmic reticulum Ca2+measurements reveal that the cardiac ryanodine receptor mutations linked to cardiac arrhythmia and sudden death alter the threshold for store-overload-induced Ca2+release

(2008) Peter P. Jones et al.   BIOCHEMICAL JOURNAL