Article
Environmental Sciences
Jun Zeng, Junli Li, Sishangyu Liu, Zhiqiang Yang, Yue Zhong, Xiaomei Chen, Guiling Li, Jia Li
Summary: The lipidomic study revealed comprehensive lipidome disturbance induced by both BPA and BPS exposure, with a significant similarity between the two. Lipid remodeling in response to exposure involved cardiolipins, phosphatidylglycerols, and fatty acids metabolic pathways, providing novel clues on the potential mechanism linking BPA/BPS exposure to increased risk of insulin resistance. The substitution of BPA by BPS should be performed with caution, as BPA-free products are not necessarily safer.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Chemistry, Analytical
Maria A. Woerheide, Jan Krumsiek, Gabi Kastenmueller, Matthias Arnold
Summary: Recent advances in high-throughput technologies have enabled the profiling of multiple layers of a biological system, generating vast amounts of data that can be integrated in multi-omics studies. Integrative analysis of such datasets is complicated by the high dimensionality, heterogeneity, and lack of universal protocols. While previous reviews focused on integrating two omics layers with a phenotype, this review highlights methods to combine metabolomics data with two or more omics layers without focusing on a specific phenotype.
ANALYTICA CHIMICA ACTA
(2021)
Article
Environmental Sciences
Eric Gyimah, Hai Xu, Xing Dong, Xuchun Qiu, Zhen Zhang, Yuanqing Bu, Osei Akoto
Summary: Exposure to low concentrations of BPA and BPS during embryonic development can have deleterious effects on the central nervous system development and induce behavioral abnormalities in zebrafish, potentially by interfering with the normal expression of development-related genes.
Article
Engineering, Environmental
Xu Hong, Gengfu Wang, Xingcun Liu, Ming Wu, Xindong Zhang, Xiaohui Hua, Pengpeng Jiang, Sheng Wang, Song Tang, Xiaoming Shi, Yichao Huang, Tong Shen
Summary: This study found a higher level of bisphenol A (BPA) in the urine of colorectal cancer (CRC) patients compared to controls, and a positive correlation between BPA and CRC biomarkers. Lipidomic screening revealed significant perturbation in the glycerophospholipid metabolism pathway, which contributed to the association between BPA exposure and CRC. These findings contribute to a better understanding of the etiology of CRC induced by environmental stressors.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Food Science & Technology
Liping Hao, Shaoguo Ru, Jingyu Qin, Weiwei Wang, Jie Zhang, Shuhui Wei, Jun Wang, Xiaona Zhang
Summary: This study suggests that parental exposure to BPS interferes with the reproductive development of unexposed offspring through DNA methylation. BPS-induced epigenetic modification inheritance has a long-term effect on the fitness and sustainability of fish populations.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Review
Biochemical Research Methods
Haiyan Lu, Hua Zhang, Lingjun Li
Summary: Single-cell analysis provides new insights into the study of fundamental biological phenomena and cellular heterogeneity. Mass spectrometry has emerged as a leading technology for molecular profiling of single-cell omics, but it faces challenges such as ionization suppression and low concentration. Chemical tagging/derivatization has proven to be an effective solution to overcome these challenges in single-cell mass spectrometry analysis.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Review
Environmental Sciences
David J. Beale, Georgia M. Sinclair, Rohan Shah, Amy M. Paten, Anupama Kumar, Sara M. Long, Suzanne Vardy, Oliver A. H. Jones
Summary: Per and Polyfluoroalkyl Substances (PFAS) are a group of man-made chemicals with high concern due to their potential toxicity and persistence. While high levels of PFAS exposure have been implicated in harmful effects on human and environmental health, further research is needed to understand their impacts at environmentally relevant exposure levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Zhiying Liang, Yafen Guo, Duan Pi, Xiang Li, Bingying Li, Yongsi Huang, Xiaohong Song, Ramji Kumar Bhandari, Xuegeng Wang
Summary: Recent studies have shown that the concentration of bisphenol F (BPF) in water has dramatically increased, raising concerns about its adverse effects on aquatic organisms and humans. This study conducted acute toxic exposure and developmental exposure experiments using Chinese medaka, and found that BPF at a concentration of 2000 ng/L significantly affected the development of Chinese medaka and caused endocrine-related abnormalities in the transcriptional network of genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Geng Ding, Yosia Mugume, Maria Emilia Duenas, Young Jin Lee, Meiling Liu, Daniel S. Nettleton, Xuefeng Zhao, Ling Li, Diane C. C. Bassham, Basil J. J. Nikolau
Summary: A systems biology strategy, combining multi-omics data, was evaluated in this study to discover gene functions. Lipidomics, metabolite mass-spectral imaging, and transcriptomics data were combined to evaluate the response of Arabidopsis leaves and roots to mutations in AuTophaGy-related (ATG) genes. The multi-omics data provided a detailed molecular understanding of the effects of each mutation, and the exact biochemical function of ATG7 and ATG9 proteins greatly facilitated the comprehensive physiological modeling of genetic and environmental changes in autophagy.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Food Science & Technology
Iliya Dauda Kwoji, Olayinka Ayobami Aiyegoro, Moses Okpeku, Matthew Adekunle Adeleke
Summary: The concept of probiotics has gained attention for its benefits in influencing the host microbiome and host immunity. The use of 'omics' technologies has resulted in extensive characterization of probiotics and the generation of a large amount of data. The recent development of system biology approaches allows for the integration of data from different omics techniques to understand molecular information flow and regulatory features. This review discusses the use of different omics techniques for studying probiotics and their influence on the host and microbiome.
NPJ SCIENCE OF FOOD
(2023)
Article
Environmental Sciences
Sheng-Han Lee, Wei-Chen Tseng, Zhi-Yi Du, Wan-Yu Lin, Mei-Huei Chen, Ching-Chun Lin, Guang-Wen Lien, Hao-Jan Liang, Hui-Ju Wen, Yue-Leon Guo, Pau-Chung Chen, Ching-Yu Lin
Summary: This study evaluated the impact of PFASs exposure on lipid changes in children, finding that children exposed to different levels of specific PFASs exhibited different lipid patterns, potentially related to hepatic lipid metabolism, metabolic disorders, and PFASs-membrane interactions.
ENVIRONMENTAL POLLUTION
(2021)
Article
Cell Biology
Sora Q. Kim, Rodrigo Mohallem, Jackeline Franco, Kimberly K. Buhman, Kee-Hong Kim, Uma K. Aryal
Summary: This study utilized a multi-omics approach to investigate the effects of high fat and low fat diets on the livers of mice, revealing that high fat diet led to a decrease in protein phosphorylation levels and impacted lipolysis and lipid-mediated signaling pathways.
Article
Toxicology
Laia Guardia-Escote, Judit Biosca-Brull, Maria Cabre, Jordi Blanco, Mikaela Mladenova-Koleva, Pia Basaure, Cristian Perez-Fernandez, Fernando Sanchez-Santed, Jose L. Domingo, Maria Teresa Colomina
Summary: Lipids are important for brain function and development, and the APOE genotype and CPF exposure impact the lipid composition of the brain. Differences in lipid concentrations may be associated with brain development and function.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kim T. Hellgren, Hajani Premanandhan, Callum J. Quinn, Andrew W. Trafford, Gina L. J. Galli
Summary: The study found that male offspring from hypoxic pregnancies had mitochondria with increased H2O2 production and lower respiratory capacity, while females had higher respiratory capacity and lower H2O2 production. These results suggest that early exposure to hypoxia has long-term, sex-dependent effects on cardiac metabolic function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Bo Shan, Clive S. Barker, Mengle Shao, Qianbin Zhang, Rana K. Gupta, Yibo Wu
Summary: This study used a multilayered omics approach to investigate heterogeneity of adipose progenitor cells, including progenitor subpopulation, sex, and anatomical localization. By using mass spectrometry and RNA-seq, the study identified different protein and gene expression levels in adipose progenitor cells, and discovered sex differences and regulatory pathways. This research provides important insights into adipose tissue plasticity and highlights the complementarity of proteomics in scRNA-seq studies.
Article
Infectious Diseases
Cyrus Ghaznavi, Masahiro Ishikane, Daisuke Yoneoka, Yuta Tanoue, Takayuki Kawashima, Akifumi Eguchi, Shuhei Nomura
Summary: During the COVID-19 pandemic, the incidence of droplet-transmitted infections decreased due to mask-wearing and social distancing, but there is concern that countermeasures like lockdowns may increase legionellosis due to water stagnation. This study analyzed data from Japan to compare the incidence of legionellosis and IPD during the pandemic and found that while both decreased, the relative incidence of legionellosis increased. There was no evidence to suggest an increase in legionellosis cases after state of emergency declarations.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Veterinary Sciences
Kodai Motohira, Yared Beyene Yohannes, Yoshinori Ikenaka, Akifumi Eguchi, Shouta M. M. Nakayama, Victor Wepener, Nico J. Smit, Johan H. J. V. A. N. Vuren, Mayumi Ishizuka
Summary: This study investigated the effects of DDT on wild rats in DDT-sprayed areas of South Africa. The researchers used LC-Q-TOF-MS to quantify plasma metabolites and examined gene expression levels in rat liver samples. The results showed that DDT had an impact on bile acid biosynthesis and gene expression of enzymes related to constitutive androstane receptor. However, no significant correlation was found between DDT concentration and gene expression involved in steroid hormone synthesis in the testis.
JOURNAL OF VETERINARY MEDICAL SCIENCE
(2023)
Article
Neurosciences
Xingming Wang, Akifumi Eguchi, Yong Yang, Lijia Chang, Xiayun Wan, Jiajing Shan, Youge Qu, Li Ma, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: Multiple sclerosis (MS) is a common demyelinating disease that affects the central nervous system. This study investigated the effects of subdiaphragmatic vagotomy (SDV) on demyelination in cuprizone (CPZ)-treated mice and found that SDV significantly improved demyelination and microglial activation in the brain. Analysis of gut microbiota composition and blood metabolites revealed that SDV also improved the abnormal levels in CPZ-treated mice. These findings suggest a link between the gut microbiota-brain axis and demyelination in the brain.
NEUROBIOLOGY OF DISEASE
(2023)
Correction
Neurosciences
X. Wang, A. Eguchi, Y. Yang, L. Chang, X. Wan, J. Shan, Y. Qu, L. Ma, C. Mori, J. Yang, K. Hashimoto
NEUROBIOLOGY OF DISEASE
(2023)
Article
Clinical Neurology
Yong Yang, Akifumi Eguchi, Xiayun Wan, Lijia Chang, Xingming Wang, Youge Qu, Chisato Mori, Kenji Hashimoto
Summary: This study suggests that Chrna7 knockout mice exhibit depression-like behaviors and reduced expression of synaptic proteins in the medial prefrontal cortex through the gut-microbiota-brain axis via the subdiaphragmatic vagus nerve. Subdiaphragmatic vagotomy can block these depression-like behaviors and alter the composition of gut microbiota and microbiota-derived metabolites.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Youge Qu, Akifumi Eguchi, Xiayun Wan, Li Ma, Lijia Chang, Jiajing Shan, Yong Yang, Chisato Mori, Kenji Hashimoto
Summary: 3,4-Methylenedioxymethamphetamine (MDMA), the most widely used illicit compound worldwide, may contribute to stress resilience in mice subjected to chronic social defeat stress (CSDS) through the gut-microbiota-brain axis. The study found that MDMA treatment prevented the negative effects of CSDS, such as splenomegaly, anhedonia-like phenotype, and increased interleukin-6 (IL-6) levels in the mice. Gut microbiome analysis revealed differences between the saline + CSDS group and the MDMA + CSDS group, while metabolomics analysis showed altered plasma levels of N-epsilon-methyl-L-lysine in the saline + CSDS group compared to the control and MDMA + CSDS groups.
PSYCHIATRY RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Shuhei Nomura, Shiori Tanaka, Akifumi Eguchi, Takayuki Kawashima, Haruyo Nakamura, Kaung Suu Lwin, Lisa Yamasaki, Daisuke Yoneoka, Yuta Tanoe, Megumi Adachi, Hitomi Hayabuchi, Shosei Koganemaru, Toshihide Nishimura, Byron Sigel, Hisayuki Uneyama, Kenji Shibuya
Summary: This study shows that replacing salt with umami substances can help US adults reduce their salt intake without compromising taste. Approximately 21.21-26.04% of US adults can keep their salt intake below 5 g/d in the absence of low-Na products.
PUBLIC HEALTH NUTRITION
(2023)
Letter
Allergy
Yuzaburo Inoue, Yu Yamamoto, Shigenori Suzuki, Shingo Ochiai, Akifumi Eguchi, Taiji Nakano, Fumiya Yamaide, Satomi Hasegawa, Hiroyuki Kojima, Chisato Mori, Yoichi Kohno, Hiroyuki Suganuma, Naoki Shimojo
Article
Chemistry, Analytical
Kohki Takaguchi, Norimichi Suzuki, Hiroko Nakaoka, Kayo Tsumura, Akifumi Eguchi, Yoshitake Nakayama, Fumitoshi Ogino, Fumito Baba, Tomohiro Nagame, Chisato Mori
Summary: This study aimed to develop a low-cost, easy-to-distribute sampling method using a mop to collect house dust and analyze OPFRs, phthalate esters, and alternative plasticizers. The findings showed that the proposed mop sampling method can be easily distributable and lower contamination from a sampling tool. Moreover, the proposed house dust sampling method is extremely useful for a large-scale survey such as a cohort study.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY
(2023)
Article
Clinical Neurology
Xingming Wang, Akifumi Eguchi, Yuko Fujita, Xiayun Wan, Lijia Chang, Yong Yang, Jiajing Shan, Youge Qu, Li Ma, Yukihiko Shirayama, Chisato Mori, Jianjun Yang, Kenji Hashimoto
Summary: This study found that gut microbiota and microbiome-derived metabolites play important roles in susceptibility versus resilience in rats exposed to inescapable electric stress. The relative abundances of Asaccharobacter, Eisenbergiella, and Klebsiella in the gut microbiota of susceptible rats were significantly higher than that of resilient rats. Additionally, several microbiome and metabolites were found to be significantly altered between susceptible and resilient rats.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Xiayun Wan, Akifumi Eguchi, Lijia Chang, Chisato Mori, Kenji Hashimoto
Summary: Patients with depression often have reduced bone mineral density. The new antidepressant arketamine has been shown to improve this reduction in mice. This study investigates the potential role of the gut microbiota and its metabolites in the beneficial effects of arketamine on behavioral and bone density changes in mice with chronic social defeat stress.
Article
Public, Environmental & Occupational Health
S. Nomura, A. Eguchi, C. Ghaznavi, L. Yamasaki, S. K. Rauniyar, Y. Tanoue, T. Kawashima, D. Yoneoka, S. Kohsaka, M. Suzuki, M. Hashizume
Summary: This study investigated cerebrovascular excess deaths in Japan, finding that there was a significant increase in excess deaths from June 2021 onwards. This increase was particularly notable among the elderly population and those who died in hospitals.
Article
Immunology
Cyrus Ghaznavi, Akifumi Eguchi, Kaung Suu Lwin, Daisuke Yoneoka, Yuta Tanoue, Santosh Kumar Rauniyar, Sayaka Horiuchi, Masahiro Hashizume, Shuhei Nomura
Summary: The COVID-19 pandemic has severely disrupted routine immunizations globally, leading to lower-than-predicted vaccine coverage for various antigens, especially in South America, Africa, Eastern Europe, and Southeast Asia. The coverage drop for subsequent doses compared to first doses was observed for diphtheria-tetanus-pertussis, pneumococcus, and rotavirus vaccines in both 2020 and 2021. Efforts are needed to recover from the vaccination coverage losses and improve vaccine access in areas with inadequate coverage.
Article
Immunology
Xiayun Wan, Akifumi Eguchi, Akemi Sakamoto, Yuko Fujita, Yong Yang, Youge Qu, Masahiko Hatano, Chisato Mori, Kenji Hashimoto
Summary: Depletion of gut microbiota induced by antibiotic administration affects spleen and brain function, leading to decreased spleen weight and altered immune cell populations. Depletion of gut microbiota also leads to changes in metabolite levels, affecting spleen and brain function.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Article
Environmental Sciences
Hoa Thanh Nguyen, Yuka Yoshinouchi, Masashi Hirano, Kei Nomiyama, Haruhiko Nakata, Eun-Young Kim, Hisato Iwata
Summary: In this study, we evaluated the activation potency of bisphenols (BPs) and hydroxylated polychlorinated biphenyls (OH-PCBs) on Baikal seal estrogen receptors and constructed quantitative structure-activity relationship (QSAR) models to predict the in vitro transactivation potencies.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)