Article
Agriculture, Dairy & Animal Science
Saif Ullah, Wael Ennab, Quanwei Wei, Changfa Wang, Abdul Quddus, Sheeraz Mustafa, Tavakolikazerooni Hadi, Dagan Mao, Fangxiong Shi
Summary: This study examines the negative effects of lead (Pb) and cadmium (Cd) exposure on the testicular function of bull camels. It reveals the bioaccumulation of these toxic metals, leading to subcellular alterations, reduced testes, and altered hormone synthesis. The findings highlight the significance of understanding and addressing the effects of Pb and Cd exposure on camel reproductive health.
Review
Biochemistry & Molecular Biology
Massimiliano Peana, Alessio Pelucelli, Christos T. Chasapis, Spyros P. Perlepes, Vlasoula Bekiari, Serenella Medici, Maria Antonietta Zoroddu
Summary: Cadmium (Cd) is a toxic metal that can cause chronic exposure and increase the risk of various cancers. It is mainly released into the environment through human activities such as industrial processes, pollution, waste incineration, and electronic waste recycling. Cd-induced carcinogenesis mechanisms include oxidative stress, inhibition of antioxidant enzymes, lipid peroxidation, and interference with DNA repair systems. Proper treatments for Cd poisoning and preventive measures to counteract chronic exposure are summarized in this paper.
Article
Public, Environmental & Occupational Health
Rodrigo X. Armijos, M. Margaret Weigel, Emmanuel Obeng-Gyasi, Marcia Racines-Orbe
Summary: The study identified elevated levels of lead and other metals/metalloids in mothers and children from low-resource households in Quito, Ecuador, indicating urgent public health concern. Traffic-related exposures and other environmental sources were found to contribute significantly to metal/metalloid exposures in urban Ecuadorian populations. Future biomonitoring studies are needed to confirm these findings and develop effective intervention strategies.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Zhijun Zeng, Xijin Xu, Yongzhan Zhu, Qihua Wang, Yuling Zhang, Xia Huo
Summary: This study investigates the effects and interaction between Pb, Cd exposure from e-waste and interleukin gene polymorphisms on interleukin expressions in children. The results suggest that high blood Pb and urine Cd levels are associated with low IL-13 and IL-10 levels, and the interaction between Pb exposure and Il-13 gene polymorphisms negatively regulates IL-13 expression. This may pose a risk to abnormal asthma-relevant immunomodulation in preschool children.
Article
Environmental Sciences
Hui Zhang, Hailong Li, Amanda Phipps Green, Ming Wang, Fei Yan, Maichao Li, Yuwei He, Wenyan Sun, Xuan Yuan, Jie Lu, Mingshu Sun, Tony R. Merriman, Changgui Li
Summary: This study investigated the association between low-level environmental exposure to Cd/Pb and gout status, and found that Cd and Pb levels were significantly higher in the gout flare group compared to control or intercritical groups. The results suggest that Cd and Pb may be risk factors for gout flare status.
Article
Engineering, Environmental
Miaomiao Wang, Xinru Wang, Wenjing Cui, Guoying Zhu, Yihuai Liang, Xiao Chen, Taiyi Jin
Summary: The study indicates that anemia may be associated with incident of osteoporosis in men rather than women environmentally exposed to lead and cadmium.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Environmental Sciences
Chi-Sian Kao, Yen-Tzu Fan, Ying-Lin Wang, Yi-Hua Chen, Hsing-Jasmine Chao, Yu-Chun Lo, Chuen-Bin Jiang, Ling-Chu Chien
Summary: This study evaluated the relationships between parental and postnatal exposure to metals (arsenic, cadmium, and lead) and developmental delays in preschool children. The findings showed that higher concentrations of these metals in the parents' toenails were associated with an increased risk of developmental delays in their children. Specifically, the concentration of arsenic in the father's toenail and cadmium in the mother's toenail were positively correlated with the risk of developmental delays in offspring.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Zhi Qu, Jianli Zhou, Peisen Guo, Jingrui Wang, Panpan Wang, Limin Liu, Mengdi Wu, Peixi Wang, Nan Liu
Summary: This study aims to explore the association between co-exposure to typical heavy metals in drinking water and soil and type 2 diabetes mellitus (T2DM) and obesity indices in southern China. The results show that there were no significant correlations between lead (Pb) and cadmium (Cd) exposure and T2DM, and lead exposure was negatively associated with obesity indices.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Hongwu Wang, Peng Huang, Ruibiao Zhang, Xueyong Feng, Qiulin Tang, Sixi Liu, Feiqiu Wen, Li Zeng, Yufeng Liu, Tianyou Wang, Lian Ma
Summary: This study found that children living in Guiyu are significantly affected by e-waste exposure, with lead exposure more significantly inhibiting Hb synthesis, leading to a higher prevalence of anemia. Further research is needed to develop relevant protective measures.
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
(2021)
Article
Engineering, Environmental
Cong Wan, Shangxia Pan, Lifeng Lin, Jun Li, Guanghui Dong, Kevin C. Jones, Fei Liu, Daochuan Li, Jing Liu, Zhiqiang Yu, Gan Zhang, Huimin Ma
Summary: This study identified 43 differentially methylated regions (DMRs) in children aged 9-11 related to the relationship between lead exposure and intelligence decline. Two fragments, FAM50B1 and PTCHD3, significantly mediated this relationship with contribution rates of 30.36% (p = 0.010) and 60.36% (p < 0.001), respectively, suggesting potential biomarkers for neurological diseases.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Psychology, Multidisciplinary
Mohamed A. A. Zoromba, Doaa Abdelgawad, Sahar Hashem, Heba El-Gazar, Magda Ahmed Abd El Aziz
Summary: A survey study found a significant association between media exposure and behavioral problems among preschool children. The duration of media exposure was correlated to various subscales of the Conners Comprehensive Behavior Rating Scales (CBRS-48).
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Environmental Sciences
Xiaoming Zhou, Yijun Feng, Zonglin Gong
Summary: This study found associations between blood levels of heavy metal elements cadmium, lead, mercury, urinary total arsenic, dimethylarsinic acid and elevation of ALT in adults. The associations between blood lead and mercury with ALT elevation were only observed in women.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xiang Zeng, Cheng Xu, Xijin Xu, Yu Zhang, Yu Huang, Xia Huo
Summary: The study revealed that in e-waste-exposed areas, there is a correlation between children's blood lead levels and behavioral health, with higher blood lead levels linked to increased risk of behavioral problems, and lower NPY levels associated with higher risk of behavioral difficulties.
Editorial Material
Ecology
Corinna Ponti, Giuseppe Nasti, Diego Di Girolamo, Irene Cantone, Fahad A. Alharthi, Antonio Abate
Summary: Lead, known as one of the most toxic elements, has been prohibited due to its severe environmental and health impacts. However, as we enter the perovskite era, the widespread application of lead may be necessary once again.
TRENDS IN ECOLOGY & EVOLUTION
(2022)
Review
Food Science & Technology
Johnson Mwove, Samuel Imathiu, Irene Orina, Paul Karanja
Summary: This study assessed the levels of lead (Pb) and cadmium (Cd) contamination in ready-to-eat street vended foods (SVFs) sold in Thika town, Kenya. The results showed that at least one food sample was contaminated with Pb, exceeding the recommended limits. Therefore, there is a need for policies to reduce heavy metal contamination in SVFs.
FOOD SCIENCE & NUTRITION
(2023)
Article
Cell Biology
Caroline M. S. Marques, Rafael N. Gomes, Tatiana Pedron, Bruno L. Batista, Giselle Cerchiaro
Summary: The study investigates the involvement of cellular prion protein (PrPC) in neuroprotection under oxidative stress. The presence of PrPC showed resistance to oxidative stress in astrocytes, and PrPC plays a role in metal homeostasis and prevents protein aggregation. Additionally, PrPC can translocate SOD1 to cell nuclei under oxidative stress, potentially controlling DNA damage. Overall, the study suggests that PrPC activates cellular response and defense against oxidative stress, protecting neurons and ensuring astrocyte functionality.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Plant Sciences
M. P. Saraiva, C. F. Maia, B. L. Batista, A. K. da S. Lobato
Summary: This study aimed to determine whether 24-epibrassinolide (EBR) can improve the nutritional, physiological, biochemical and morphological responses of soybean plants subjected to nickel (Ni) excess. The results showed that the application of EBR significantly increased biomass, which can be explained by improved nutrient content and ionic homeostasis.
Article
Environmental Sciences
Fernanda Junqueira Salles, Fernanda Pollo Paniz, Bruno Lemos Batista, Adelaide Cassia Nardocci, Kelly Polido Kaneshiro Olympio
Summary: This study investigated the levels of toxic elements in costume cosmetics and their potential risks to human health. The results indicated the presence of potentially toxic elements in these products, highlighting the need for regulation and protection, particularly for occupational exposure and use by children.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Agronomy
Breno Ricardo Serrao da Silva, Elaine Maria Silva Guedes Lobato, Leidy Alves dos Santos, Rodrigo Mendes Pereira, Bruno Lemos Batista, Mohammed Nasser Alyemeni, Parvaiz Ahmad, Allan Klynger da Silva Lobato
Summary: The purpose of this research was to investigate the negative effects of salt stress on soybean plants in terms of anatomical, morphological, nutritional, physiological, and biochemical parameters. The study found that concentrations of 50 to 200 mM Na+ significantly reduced the levels of K, Ca, and Mg in the plants, and had negative effects on photosynthesis, gas exchange, and photosynthetic pigments, which were likely caused by oxidative stress. Interestingly, at concentrations below 100 mM Na+, there were changes in epicuticular wax deposition, stomatal quantity and morphology, and leaf epidermis thickness in soybean plants. Overall, significant deleterious effects were observed in soybean plants under salt stress conditions above 100 mM Na+.
Article
Public, Environmental & Occupational Health
Alda Neis Miranda Araujo, Isabelle Nogueira Leroux, Danielle Zildeana Sousa Furtado, Ana Paula Sacone da Silva Ferreira, Bruno Lemos Batista, Heron Dominguez Torres Silva, Evangelos Handakas, Nilson Antonio Assuncao, Kelly Polido Kaneshiro Olympio
Summary: Occupational exposure to potentially toxic elements in informal jewelry production can have adverse health effects on workers. This study used proteomic and metabolomic analyses to assess the impact of these exposures on workers' exposome in Limeira city, Brazil. The results showed high levels of Sn and Cu in welders' blood, as well as correlations between certain proteins and blood PTE levels. Additionally, pathway analysis revealed seven metabolic pathways potentially disturbed by the informal work. These findings highlight the harmful effects of PTE exposure in the jewelry production industry.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Kamila de Almeida Piai, Thiago Nogueira, Kelly Polido Kaneshiro Olympio, Adelaide Cassia Nardocci
Summary: This study assessed the risk of human health from exposure to arsenic, nickel, and lead in airborne particulate matter (PM10-2.5) in Sao Paulo, Brazil. The results showed that the annual mean concentrations of these elements were within the limits set by international agencies, with higher concentrations observed during winter. However, there was a greater health risk for the adult population and during the winter season.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Fernanda Junqueira Salles, Isabelle Nogueira Leroux, Alda Neis Miranda de Araujo, Nilson Antonio Assuncao, Maciel Santos Luz, Glaucia Raquel Luciano da Veiga, Fernando Luiz Affonso Fonseca, Fredi Alexander Diaz-Quijano, Kelly Polido Kaneshiro Olympio
Summary: This study compared the incidence of Covid-19 symptoms between informal home-based workers and a control group, and assessed the association of these cases with blood elements concentrations and other relevant risk factors for Sars-Cov-2 infection. The results showed that the control group had lower adherence to social distancing, while the welders, who worked from home, maintained greater social distancing and may have been better protected against Covid-19.
REVISTA DE SAUDE PUBLICA
(2023)
Article
Environmental Sciences
Fernanda Pollo Paniz, Tatiana Pedron, Vitoria Aparecida Procopio, Camila Neves Lange, Bruna Moreira Freire, Bruno Lemos Batista
Summary: The study found that selenium has the potential to regulate the toxicity of arsenic and cadmium in rice plants, reducing their accumulation in grains and the risks associated with human consumption. However, different rice cultivars may show different responses to arsenic and selenium exposure under the same growing conditions.
Article
Environmental Sciences
Kamila de Almeida Piai, Kelly Polido Kaneshiro Olympio
Summary: This review presents recent evidence on blood lead levels of children in Latin America and the Caribbean, and highlights the latest recommendations to address this public health issue. Most of the reviewed articles focus on evaluating BLL in areas at risk of lead contamination, with only a few investigating associations with health outcomes. The findings indicate that nearly half of the studies evaluating BLL reported average concentrations exceeding recommended limits. The recommendations provided in this review represent the current best practices for preventing childhood lead contamination. However, the main challenge lies in prioritizing actions in political processes.
CURRENT OPINION IN ENVIRONMENTAL SCIENCE & HEALTH
(2023)
Article
Biochemistry & Molecular Biology
Miguel Tabanez, Ilma R. Santos, Juliane M. Ikebara, Mariana L. M. Camargo, Bianca A. Dos Santos, Bruna M. Freire, Bruno L. Batista, Silvia H. Takada, Rosanna Squitti, Alexandre H. Kihara, Giselle Cerchiaro
Summary: As people age, they become more susceptible to neurodegenerative illnesses such as Alzheimer's disease. This study found that the antioxidant hydroxytyrosol can regulate metal levels and improve learning performance in a rat model of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Fernanda V. Cabral, Bianca de Melo Santana, Camila N. Lange, Bruno L. Batista, Amedea B. Seabra, Martha S. Ribeiro
Summary: This study investigated the potential of polymeric hydrogels in the treatment of melanoma. The researchers found that hydrogels containing both a nitric oxide donor and copper oxide nanoparticles significantly reduced cell viability and increased reactive oxygen species levels. They also observed changes in cell nuclei, loss of mitochondrial membrane potential, and lipid peroxidation, leading to cell death.
Article
Biochemistry & Molecular Biology
Isabella Martins Lourenco, Bruna Moreira Freire, Joana Claudio Pieretti, Roberta Albino dos Reis, Nicolas Martins Soares, Marcelo da Luz Santos, Bruno Lemos Batista, Amedea Barozzi Seabra, Camila Neves Lange
Summary: This study investigated the effects of zinc oxide nanoparticles, nitric oxide donor, and their combination on the enzymatic and photosynthetic profile, as well as element accumulation, in rice plants. The results showed that these treatments increased the concentration of zinc and iron, and caused a mild disturbance in the antioxidant system. However, these disturbances did not significantly affect the yield, growth, or photosynthetic pigment production of rice plants.
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
