Article
Multidisciplinary Sciences
Christiane Kofink, Nicole Trainor, Barbara Mair, Simon Woehrle, Melanie Wurm, Nikolai Mischerikow, Michael J. Roy, Gerd Bader, Peter Greb, Geraldine Garavel, Emelyne Diers, Ross McLennan, Claire Whitworth, Vesna Vetma, Klaus Rumpel, Maximilian Scharnweber, Julian E. Fuchs, Thomas Gerstberger, Yunhai Cui, Gabriela Gremel, Paolo Chetta, Stefan Hopf, Nicole Budano, Joerg Rinnenthal, Gerhard Gmaschitz, Moriz Mayer, Manfred Koegl, Alessio Ciulli, Harald Weinstabl, William Farnaby
Summary: Targeted protein degradation using bifunctional molecules provides a new therapeutic option for undruggable targets. In this study, the authors developed orally bioavailable VHL-recruiting degraders that selectively degrade SMARCA2, demonstrating the feasibility of broadening the E3 ligase and physicochemical space for achieving oral efficacy with bifunctional molecules.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Plant Sciences
Claudia Cocozza, Maria Laura Traversi, Alessio Giovannelli
Summary: Climate change is predicted to increase the frequency and intensity of extreme events, impacting the harshness of the environment and tree growth under natural conditions. Traditional single dose-effect approach is deemed inadequate in explaining the complex genotype-environment interactions in open field or forest stands. There is a need to develop new approaches and technologies to define suitable threshold responses of trees under suboptimal natural conditions.
Article
Chemistry, Multidisciplinary
Kateryna Kostenkova, Aviva Levina, Drew A. Walters, Heide A. Murakami, Peter A. Lay, Debbie C. Crans
Summary: Two new series of complexes with pyridine-containing Schiff bases were synthesized and their chemical properties and stability were studied. One of the complexes exhibited good anti-proliferative activity in cell culture media, showing high selectivity towards glioblastoma cells and potential for drug treatment.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Giovanni Bella, Jan Holub, Giuseppe Bruno, Francesco Nicolo, Antonio Santoro
Summary: This study investigates the formation of supramolecular architectures from ligands and metal ions, and explores the impact of ligand flexibility and the number of coordinating atoms on the organization of the coordination structure.
Article
Chemistry, Inorganic & Nuclear
Tabea Huss, Isabelle M. Dixon
Summary: Metal complexes with a 3d6 electron count are being considered as alternatives to 4d6-based photosensitizers, emitters, or photoredox catalysts. Fe(II) potential emitters based on strongly donating ligand sets have been proposed, which undergo oxidation to their 3d5 species. The geometry and electronic structure of 2LMCT states are investigated in this study.
INORGANIC CHEMISTRY
(2023)
Article
Environmental Sciences
Markus Dengg, Claudine H. Stirling, Karl Safi, Niklas J. Lehto, Susanna A. Wood, Kyyas Seyitmuhammedov, Malcolm R. Reid, Piet Verburg
Summary: This study evaluates the role of iron in regulating phytoplankton growth in lakes of different nutrient status in New Zealand. The study identifies the thresholds for bioavailable and colloidal iron that control algal bloom formation and carbon sequestration in lakes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Inorganic & Nuclear
Sergej Stipurin, Thomas Strassner
Summary: The combination of strong electron-withdrawing groups in cyclometalated N-heterocyclic carbene ligands with known beneficial auxiliary ligands in phosphorescent platinum(II) complexes results in efficient light-to-deep-blue emission with quantum yields of up to 92%. The compounds were characterized and studied for their photophysical, electrochemical, and thermal properties, with three complexes being characterized by solid-state structures. Density functional theory calculations were performed using PBE0/6-311G* with dispersion correction.
INORGANIC CHEMISTRY
(2021)
Editorial Material
Biology
Paul F. Hill
Summary: Including geometric spatial cues in the environment can alleviate spatial navigation difficulties for children and older adults.
Article
Chemistry, Analytical
Charlotte Catrouillet, Melanie Davranche, Imane Khatib, Corentin Fauny, Aurelie Wahl, Julien Gigault
Summary: Microplastics from the North Atlantic Gyre deposited on Guadeloupe beaches were sampled and characterized, with the study identifying certain elements as additives in the microplastics. While only cadmium was deemed a danger for fish when ingested based on acidic leaching element content, further research is required to determine potential health impacts caused by the ingestion of multiple elements and microplastics.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2021)
Article
Multidisciplinary Sciences
Vignesh N. Hariharan, Minwook Shin, Ching-Wen Chang, Daniel O'Reilly, Annabelle Biscans, Ken Yamada, Zhiru Guo, Mohan Somasundaran, Qi Tang, Kathryn Monopoli, Pranathi Meda Krishnamurthy, Gitali Devi, Nicholas McHugh, David A. Cooper, Dimas Echeverria, John Cruz, Io Long Chan, Ping Liu, Sun-Young Lim, Jill McConnell, Satya Prakash Singh, Samuel Hildebrand, Jacquelyn Sousa, Sarah M. Davis, Zachary Kennedy, Chantal Ferguson, Bruno M. D. C. Godinho, Yann Thillier, Jillian Caiazzi, Socheata Ly, Manish Muhuri, Karen Kelly, Fiachra Humphries, Alyssa Cousineau, Krishna Mohan Parsi, Qi Li, Yang Wang, Rene Maehr, Guangping Gao, Dmitry Korkin, William M. McDougall, Robert W. Finberg, Katherine A. Fitzgerald, Jennifer P. Wang, Jonathan K. Watts, Anastasia Khvorova
Summary: The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid development of pan-viral variant therapeutics. Through the systematic screening of oligonucleotide sequences, fully chemically stabilized siRNAs and ASOs that target conserved regions of the SARS-CoV-2 genome have been identified. A platform for identifying and generating potent, chemically modified multimeric siRNAs bioavailable in the lung has been developed.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Astronomy & Astrophysics
J. Katz
Summary: The text discusses the significance of outliers in measured properties and how to distinguish between qualitative and quantitative differences. By comparing the ratio of the most extreme member to the next-most extreme, the applicability of power law to empirical distributions can be tested.
MONTHLY NOTICES OF THE ROYAL ASTRONOMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Deepak Gupta, Geraldine Chanteux, Gulshan Kumar, Koen Robeyns, Alexandru Vlad
Summary: This study reports the formation of robust supramolecular frameworks using hetero-polytopic metal complexes interacting with different ancillary ions. The choice of ancillary ions was found to have no significant impact on the formation of the frameworks. The resulting porous structure of the frameworks makes them suitable candidates for gas sorption, separation, and chemical sensing applications.
Article
Economics
Kirby Nielsen, John Rehbeck
Summary: Using a laboratory experiment, the study finds that many individuals want to follow canonical choice axioms and are willing to re-evaluate their decisions based on these axioms. In a shorter online experiment, the study shows correlations between mistakes and response times, as well as measures of cognition.
AMERICAN ECONOMIC REVIEW
(2022)
Article
Chemistry, Multidisciplinary
Weinan Zhou, Tridib Sarma, Yonghuan Su, Chuanhu Lei, Jonathan L. Sessler
Summary: The meso-unsubstituted expanded porphyrinoid 3 is an effective ligand for Co(II) and can form metal-to-ligand metallocage complexes or metalloring species. Additionally, studies suggest that the Pd(II) complex is more stable compared to its Co(II) and Zn(II) congeners based on structural, electrochemical, and spectral analyses.
Article
Chemistry, Multidisciplinary
Deepak Gupta, Geraldine Chanteux, Gulshan Kumar, Koen Robeyns, Alexandru Vlad
Summary: This study reports the formation of robust supramolecular frameworks built from hetero-polytopic metal complexes and interacting with different ancillary ions. The functionalized phenanthroline ligands control the overall charge stoichiometry, leading to the formation of 2D porous honeycomb networks without significant alteration in the molecular packing.
Article
Biochemistry & Molecular Biology
J. Auclair, C. Peyrot, K. J. Wilkinson, F. Gagne
Summary: The study found that different geometries of silver nanoparticles have effects on the formation of liquid crystals, fractal kinetics of the PK-LDH system, F-actin levels, and protein damage in the soft tissues of freshwater mussels.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xiaojun Luo, Xingjuan Zhao, Gregory Q. Wallace, Marie-Helene Brunet, Kevin J. Wilkinson, Ping Wu, Chenxin Cai, C. Geraldine Bazuin, Jean-Francois Masson
Summary: The study presents a novel SERS aptasensor for indirect detection of microcystin toxins MC-LR and MC-RR in water and algal cultures. The sensor showed high sensitivity, excellent selectivity, and good recoveries, with significantly improved detection limits compared to other reported methods. These aptasensors were successfully applied to monitor MC-LR production in a realistic environment, demonstrating their potential practical utility.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Environmental
Agil Azimzada, Ibrahim Jreije, Madjid Hadioui, Phil Shaw, Jeffrey M. Farner, Kevin J. Wilkinson
Summary: The study measured NP concentrations and sizes for Ti-, Ce-, and Ag-containing NPs in global surface waters and precipitation samples, providing insights into their compositions and origins. Total Ti- and Ce-NP concentrations were often found to be within 10(4) to 10(7) NP mL(-1), while Ag NPs exhibited sporadic occurrences with low concentrations up to 10(5) NP mL(-1). The observed NP levels so far do not seem to exceed toxicity thresholds for the environment or human health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Elise Morel, Lei Cui, William Zerges, Kevin J. Wilkinson
Summary: Research showed that rare earth elements have common biological effects on microalgae under low concentrations and mixed conditions, affecting functions like protein processing in the endoplasmic reticulum and phosphate transport. When applied as a mixture, the elements may compete with each other for bio-uptake, resulting in antagonistic effects. These findings suggest that regulating rare earth elements based on data from single metal exposures may be overly cautious.
ENVIRONMENTAL POLLUTION
(2021)
Article
Chemistry, Multidisciplinary
Joelle Auclair, Caroline Peyrot, Kevin J. Wilkinson, Francois Gagne
Summary: This study examined the toxicity of different structures (sphere, cube, and prism) of silver nanomaterials (nAg) in Dreissena bugensis mussels. The results showed that spheric and prismatic nAg significantly decreased viscosity in the mussels, while cubic nAg reduced protein aggregation in the cytoplasm. Additionally, the activity of acetylcholinesterase (AChE) was more strongly decreased by prismatic nAg compared to cubic and spheric nAg. It was concluded that the geometries of nanoparticles could influence their toxicity in aquatic organisms.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Peiying Wang, Juliana A. Galhardi, Lan Liu, Vinicius Bueno, Subhasis Ghoshal, Valerie Gravel, Kevin J. Wilkinson, Stephane Bayen
Summary: The goal of this study was to validate a method for analyzing the active ingredients of two pesticides with different physicochemical properties. By using a modified extraction method and mass spectrometry technique, the active ingredients of nanopesticides in strawberry and soil samples were successfully measured, providing a means to study the fate of nanopesticides in food and environmental matrices.
Article
Chemistry, Multidisciplinary
Joelle Auclair, Patrice Turcotte, Christian Gagnon, Caroline Peyrot, Kevin James Wilkinson, Francois Gagne
Summary: The study examined the sub-lethal toxicity of low concentrations of selected nanoparticles alone and in mixtures in juvenile trout. The results showed that the nanoparticles were bioavailable for fish, with different levels of toxicity for different nanoparticles and antagonistic effects in the mixtures. In conclusion, the bioavailability and toxicity of these nanoparticles are influenced by mixtures of nanoparticles, which is likely to occur in contaminated environments.
Article
Biochemistry & Molecular Biology
Alexandre Chalifoux, Madjid Hadioui, Nesrine Amiri, Kevin J. J. Wilkinson
Summary: Regulation and characterization of nanomaterials in foods are of interest due to potential risks and increasing applications in the food industry. Lack of standardized extraction procedures for nanoparticles limits regulation efforts. In this study, enzymatic- and alkaline-based hydrolysis approaches were optimized for extracting 40 nm Ag NPs from a fatty beef matrix. Single particle ICP-MS was used for characterization. Fast sample processing and minimal NP losses were achieved through ultrasonication and optimization of enzymes/chemicals, surfactants, and sonication. The alkaline approach showed higher recoveries (>90%), but lower stability compared to enzymatic digestion using pork pancreatin and lipase (approx. 60% recovery). Enzymatic extraction had lower method detection limits (MDL) of 4.8 x 10(6) particles g(-1) and a size detection limit (SDL) of 10.9 nm, while alkaline hydrolysis had an MDL of 5.7 x 10(7) particles g(-1) and an SDL of 10.5 nm.
Article
Chemistry, Multidisciplinary
Joelle Auclair, Patrice Turcotte, Christian Gagnon, Caroline Peyrot, Kevin James Wilkinson, Francois Gagne
Summary: The toxicity of different forms of silver nanoparticles (nAg) in juvenile rainbow trout was compared in this study. It was found that dissolved Ag had the highest uptake and distribution in the fish gills, followed by spherical, cubic, and prismatic nAg. Dissolution of nAg was observed in all forms, with prismatic nAg releasing higher levels of Ag in the protein pool. Cubic nAg had a higher aggregation tendency compared to other forms. Lipid peroxidation was closely related to protein aggregation and viscosity. Biomarkers indicated changes in lipid/oxidative stress and genotoxicity, which were associated with protein aggregation loss and inflammation (NO2 levels), respectively. In general, the effects were observed in all forms of nAg, with prismatic nAg showing higher toxicity than spherical and cubic nAg. The strong relationship between genotoxicity and inflammation response suggests the involvement of the immune system in the observed responses of juvenile fish gills.
Article
Agriculture, Multidisciplinary
Peiying Wang, Valerie Gravel, Vinicius Bueno, Juliana A. Galhardi, Alexandra Roginski, Subhasis Ghoshal, Kevin J. Wilkinson, Stephane Bayen
Summary: This study compared the impact of two different types of nanocarriers (Allosperse and SiO2 nanoparticles) loaded with two active ingredients (azoxystrobin and bifenthrin) on the phenolic contents and metabolic profiles of strawberries. The results showed slight decreases in total phenolic content and pelargonidin 3-glucoside content, but increases in gallic acid, quercetin, and kaempferol levels in strawberries treated with the nanoencapsulated pesticides. Principal component analysis identified the effects of nanocarriers on metabolites and phenolic profiles. Overall, while the effects of nanopesticides on strawberry plants were not obvious, there were significant molecular-level changes in plant health and fruit quality. Further research is needed to assess the impact of diverse nanopesticides on other plant metabolites.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Chemistry, Multidisciplinary
Zhizhong Li, Madjid Hadioui, Kevin J. J. Wilkinson
Summary: This study investigated the analysis of Si-NPs in soil using single-particle ICP-MS. A size detection limit of 29 +/- 3 nm was achieved in Milli-Q water. Na4P2O7 was found to be the best extractant for Si-NP, preserving their size distribution for at least one month.
Article
Agriculture, Multidisciplinary
Peiying Wang, Valerie Gravel, Vinicius Bueno, Juliana A. Galhardi, Subhasis Ghoshal, Kevin J. Wilkinson, Stephane Bayen
Summary: This study assessed the thermal degradation of nanoencapsulated pesticides during food processing and found that nanocarriers provide protection to the active ingredients against degradation but have no impact on the degradation product types. The degradation rate of the pesticide active ingredients was slightly affected by the nanocarriers.
ACS AGRICULTURAL SCIENCE & TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Juliana A. Galhardi, Peiying Wang, Vinicius Bueno, Subhasis Ghoshal, Valerie Gravel, Kevin J. Wilkinson, Stephane Bayen
Summary: Polymeric and SiO2 nanoparticles can enhance the efficacy of pesticide delivery in agriculture, but have minimal impact on soil and plant health, as well as soil microbial composition and function.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Chemistry, Multidisciplinary
Ibrahim Jreije, Agil Azimzada, Madjid Hadioui, Kevin J. Wilkinson
Summary: This study investigates the release and behavior of cerium oxide nanoparticles (CeO2 NP) from surface coatings in the environment. Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is used to detect very small NP concentrations. The results show that the stability of CeO2 NP is affected by physicochemical properties, and their release under natural weathering conditions is mainly in the form of dissolved cerium.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Biochemistry & Molecular Biology
Elise Morel, Jessica Dozois, Vera Slaveykova, Kevin J. Wilkinson
Summary: This study investigated the biological responses of the freshwater alga Chlamydomonas reinhardtii to exposure to ionic cerium or two different types of cerium engineered nanoparticles (ENPs). The research found that changes in cerium speciation and the dissolution of cerium ENPs significantly influenced cerium bioavailability.