Article
Surgery
S. K. Kamarajah, A. W. Phillips, L. Ferri, W. L. Hofstetter, S. R. Markar
Summary: For patients with esophageal adenocarcinoma (OAC), although neoadjuvant chemoradiotherapy (nCRT) offers pathological benefits, there is no prognostic advantage compared to chemotherapy (nCT); on the contrary, for patients with squamous cell carcinoma (OSCC), nCRT provides both pathological and prognostic benefits.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Surgery
E. L. Vos, R. A. Carr, M. Hsu, M. Nakauchi, T. Nobel, A. Russo, A. Barbetta, K. S. Tan, L. Tang, D. Ilson, G. Y. Ku, A. J. Wu, Y. Y. Janjigian, S. S. Yoon, M. S. Bains, D. R. Jones, D. Coit, D. Molena, V. E. Strong
Summary: In patients undergoing surgical resection for locally advanced adenocarcinoma of the gastro-oesophageal junction, there was no significant difference in overall survival and disease-free survival between those who had neoadjuvant chemoradiation compared with chemotherapy.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Environmental Sciences
Hyung Jun Yang, Youzuo Lin, Brendt Wohlberg, Daniel M. Tartakovsky
Summary: The research develops a CE methodology for spatial delineation of geologic formations, improving image reconstruction quality and demonstrating its effectiveness through a series of numerical experiments.
WATER RESOURCES RESEARCH
(2021)
Article
Oncology
Juan I. Pisula, Rabi R. Datta, Leandra Boerner Valdez, Jan-Robert Avemarg, Jin-On Jung, Patrick Plum, Heike Loeser, Philipp Lohneis, Monique Meuschke, Daniel Pinto dos Santos, Florian Gebauer, Alexander Quaas, Axel Walch, Christiane J. Bruns, Kai Lawonn, Felix C. Popp, Katarzyna Bozek
Summary: This study presents a deep-learning method based on convolutional neural networks (CNNs) for scoring microscopy images of gastroesophageal adenocarcinoma (GEA) patients. The method accurately detects HER2 overexpression and offers automated detection without the need for manual assessment and costly in situ hybridisation (ISH) tests. The approach shows high accuracy, precision, and recall, and exhibits superior performance in cases that require additional ISH testing.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Xin Xiao, Chao Cheng, Liang Cheng, Qi-Xin Shang, Yu-Shang Yang, Xiao-Xi Zeng, Yang Hu, Long-Qi Chen, Yong Yuan
Summary: The optimal interval between neoadjuvant therapy and oesophagectomy for oesophageal cancer remains controversial. This study found that for patients with clinical complete response (cCR) to neoadjuvant chemoradiation, the time interval to surgery can be safely prolonged for at least 10 weeks. However, for patients without cCR, delayed surgery is associated with poor survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Surgery
Boris Janssen, Stijn van Roessel, Susan van Dieren, Onno de Boer, Volkan Adsay, Olca Basturk, Lodewijk Brosens, Fiona Campbell, Deyali Chatterjee, Angela Chou, Claudio Doglioni, Irene Esposito, Roger Feakins, Talia L. Fuchs, Noriyoshi Fukushima, Anthony J. Gill, Seung-Mo Hong, Ralph H. Hruban, Jeffrey Kaplan, Alyssa Krasinkas, Claudio Luchini, Chanjuan Shi, Aatur Singhi, Elizabeth Thompson, Marie-Louise F. Velthuysen, Marc G. Besselink, Joanne Verheij, Huamin Wang, Caroline Verbeke, Arantza Farina
Summary: The ISGPP-1 study found that it is unreliable to identify the effect of neoadjuvant therapy in resected pancreatic cancer, and the interobserver agreement for current tumour response scoring systems is suboptimal.
BRITISH JOURNAL OF SURGERY
(2022)
Article
Oncology
M. Redegalli, M. Schiavo Lena, M. G. Cangi, C. E. Smart, M. Mori, C. Fiorino, P. G. Arcidiacono, G. Balzano, M. Falconi, M. Reni, C. Doglioni
Summary: This study aimed to identify a new quantitative prognostic index based on tumor morphology to predict the prognosis of patients with PDAC undergoing neoadjuvant chemotherapy followed by surgery. The results showed that perineural invasion and lymph node ratio were associated with shorter overall survival and disease-free survival, while high stroma to neoplasia ratio predicted longer overall survival and disease-free survival. These variables were combined to generate a semi-quantitative prognostic index that significantly distinguished patients with poor outcomes from those with a good outcome.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
J. F. Huisman, I. J. H. Schoenaker, R. M. Brohet, O. Reerink, H. van der Sluis, F. C. P. Moll, E. de Boer, J. C. de Graaf, W. H. de Vos tot Nederveen Cappel, G. L. Beets, H. L. van Westreenen
Summary: The study demonstrates that the introduction of structured multidisciplinary response evaluation leads to a significant decrease in patients with locally advanced rectal cancer achieving complete response after nCRT, reducing the need for surgery and improving stoma-free survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Oncology
Jen-Hao Yeh, Yung-Sung Yeh, Hsiang-Lin Tsai, Ching-Wen Huang, Tsung-Kun Chang, Wei-Chih Su, Jaw-Yuan Wang
Summary: For locally advanced gastric cancer (LAGC), a multimodal approach, including neoadjuvant chemoradiotherapy (NCRT), leads to better long-term prognosis compared to mere surgical resection. NCRT has shown superior disease control and reduced local recurrence, but optimal chemotherapy regimen, patient selection, technical consideration, and potential biomarkers are still under investigation. The comparison of NCRT with neoadjuvant/perioperative chemotherapy is also an important issue to be answered.
Article
Oncology
Floor Piqeur, Britt J. P. Hupkens, Stefi Nordkamp, Marnix G. Witte, Philip Meijnen, Heleen M. Ceha, Maaike Berbee, Margriet Dieters, Sofia Heyman, Alexander Valdman, Martin P. Nilsson, Joost Nederend, Harm J. T. Rutten, Jacobus W. A. Burger, Corrie A. M. Marijnen, Heike M. U. Peulen
Summary: This study presents the first consensus-based delineation guideline for locally recurrent rectal cancer (LRRC). Multidisciplinary evaluation is beneficial in determining target volumes. Further analysis of re-recurrences is needed to optimize the delineation guidelines.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xin Xiao, Yu-Shang Yang, Xiao-Xi Zeng, Qi-Xin Shang, Si-Yuan Luan, Jian-Feng Zhou, Xiao-Kun Li, Pin-Hao Fang, Yang Hu, Long-Qi Chen, Yong Yuan
Summary: This study evaluated the short-term outcomes of neoadjuvant chemoimmunotherapy (NACI) followed by oesophagectomy for locally advanced oesophageal squamous carcinoma. The results showed that NACI was associated with lower pneumonia rate and was safe and feasible for locally advanced oesophageal squamous cancer. However, the tumour regression score and pathological complete response rate were lower in the NACI group compared to the neoadjuvant chemoradiotherapy group.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Xin Xiao, Yu-Shang Yang, Xiao-Xi Zeng, Qi-Xin Shang, Si-Yuan Luan, Jian-Feng Zhou, Xiao-Kun Li, Pin-Hao Fang, Yang Hu, Long-Qi Chen, Yong Yuan
Summary: The study found that NACI was associated with a lower pneumonia rate compared to NACR and was considered safe and feasible for locally advanced esophageal squamous cancer. However, patients treated with neoadjuvant immunotherapy had lower tumor regression scores and pathological complete response rates than those treated with NACR. The short-term follow-up results were similar between the two treatment modalities.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Oncology
A. I. Damanakis, F. Gebauer, A. Stapper, H. A. Schloesser, M. Ghadimi, T. Schmidt, L. M. Schiffmann, H. Fuchs, T. Zander, A. Quaas, C. J. Bruns, W. Schroeder
Summary: By analyzing 715 patients with oesophageal squamous cell carcinoma (SCC) or adenocarcinoma (AC) who received neoadjuvant treatment, it was found that combining histopathologic regression and nodal status can improve the prediction of survival after treatment.
BRITISH JOURNAL OF CANCER
(2023)
Review
Oncology
Hollie A. Clements, Tim J. Underwood, Russell D. Petty
Summary: Adenocarcinoma of the oesophagus and gastro-oesophageal junction is a major cause of cancer death in the Western World, with increasing incidence. The overall survival of patients on a potentially curative treatment pathway has significantly improved by adding perioperative oncological therapies to surgery. However, patients often have poor response to oncological treatment or struggle to complete their treatment after surgery.
BRITISH JOURNAL OF CANCER
(2023)
Article
Geriatrics & Gerontology
Han Gyul Yoon, Dongryul Oh, Jae Myoung Noh, Won Kyung Cho, Jong-Mu Sun, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Kyunga Kim
Summary: This study successfully predicted excessive muscle loss following NACRT in esophageal cancer patients using machine learning models based on body mass index and blood laboratory test results, without the need for CT images.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Oncology
Tiuri E. Kroese, Peter S. N. van Rossum, Magnus Nilsson, Florian Lordick, Elizabeth C. Smyth, Riccardo Rosati, Philippe Nafteux, Domenico D'Ugo, M. Asif Chaudry, Wojciech Polkowkski, Franco Roviello, Ines Gockel, Piotr Kolodziejczyk, Karin Haustermans, Matthias Guckenberger, Marianne Nordsmark, Maria A. Hawkins, Andres Cervantes, Tania Fleitas, Eric van Cutsem, Markus Moehler, Anna D. Wagner, Hanneke W. M. van Laarhoven, Richard van Hillegersberg
Summary: Currently, there is a lack of uniform definition and treatment for oligometastatic esophagogastric cancer. The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to develop a multidisciplinary European consensus statement to improve outcomes for these patients.
Article
Oncology
Lien van Walle, Geert Silversmit, Lieven Depypere, Philippe Nafteux, Hans Van Veer, Elke Van Daele, Yannick Deswysen, Jerome Xicluna, Annelies Debucquoy, Liesbet Van Eycken, Karin Haustermans
Summary: This population-based study supports the association between hospital volume and outcomes of esophageal cancer surgery. The findings suggest the need for centralization of esophageal resections in Belgium, in line with national health policy measures.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Simon K. B. Spohn, Cederic Draulans, Amar U. Kishan, Daniel Spratt, Ashley Ross, Tobias Maurer, Derya Tilki, Alejandro Berlin, Pierre Blanchard, Sean Collins, Peter Bronsert, Ronald Chen, Alan Dal Pra, Gert de Meerleer, Thomas Eade, Karin Haustermans, Tobias Holscher, Stefan Hocht, Pirus Ghadjar, Elai Davicioni, Matthias Heck, Linda G. W. Kerkmeijer, Simon Kirste, Nikolaos Tselis, Phuoc T. Tran, Michael Pinkawa, Pascal Pommier, Constantinos Deltas, Nina-Sophie Schmidt-Hegemann, Thomas Wiegel, Thomas Zilli, Alison C. Tree, Xuefeng Qiu, Vedang Murthy, Jonathan I. Epstein, Christian Graztke, Xin Gao, Anca L. Grosu, Sophia C. Kamran, Constantinos Zamboglou
Summary: Current risk-stratification systems for prostate cancer do not adequately reflect the disease heterogeneity. Genomic classifiers show promise in improving risk stratification after surgery, but limited data exist for patients treated with radiation therapy or in advanced stages of the disease. A systematic review and expert survey were conducted to evaluate the role of genomic classifiers in radiation therapy and identify future research areas for personalized treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Editorial Material
Oncology
Birgitte Vrou Offersen, Marianne C. Aznar, Carol Bacchus, Rob P. Coppes, Eric Deutsch, Dieter Georg, Karin Haustermans, Peter Hoskin, Mechthild Krause, Eric F. Lartigau, Anne W. M. Lee, Steffen Loeck, David I. Thwaites, Albert J. van der Kogel, Uulke van der Heide, Vincenzo Valentini, Jens Overgaard, Michael Baumann
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Lien Smets, Annelies Debucquoy, Eva Oldenburger, Chantal Van Audenhove, Lynn Debrun, Jeroen Dekervel, Gabriele Bislenghi, Andre D'Hoore, Albert Wolthuis, Karin Haustermans
Summary: This study developed a patient decision aid (PtDA) for rectal cancer patients with a clinical complete response after neo-adjuvant treatment, aiming to facilitate shared decision making. The results of the survey showed that most patients believed using a PtDA in clinical practice would be of added value in decision making.
Review
Cardiac & Cardiovascular Systems
Melanie Grehn, Stefano Mandija, Marcin Miszczyk, David Krug, Bartlomiej Tomasik, Kristine E. Stickney, Pino Alcantara, Filippo Alongi, Matteo Anselmino, Ricardo Salgado Aranda, Brian Balgobind, Judit Boda-Heggemann, Leif-Hendrik Boldt, Nicola Bottoni, Jakub Cvek, Olgun Elicin, Gaetano Maria De Ferrari, Rutger J. Hassink, Colien Hazelaar, Gerhard Hindricks, Coen Hurkmans, Cinzia Iotti, Tomasz Jadczyk, Otakar Jiravsky, Raphaël Jumeau, Steen Buus Kristiansen, Mario Levis, Manuel Algara Lopez, Julio Marti-Almor, Felix Mehrhof, Ditte Sloth Moller, Giulio Molon, Alexandre Ouss, Petr Peichl, Jiri Plasek, Pieter G. Postema, Aurelio Quesada, Tobias Reichlin, Roberto Rordorf, Boris Rudic, Ardan M. Saguner, Rachel M. A. ter Bekke, Jose Lopez Torrecilla, Esther G. C. Troost, Viviana Vitolo, Nicolaus Andratschke, Katja Zeppenfeld, Slawomir Blamek, Martin Fast, Ludovica de Panfilis, Oliver Blanck, Etienne Pruvot, Joost J. C. Verhoeff
Summary: The STOPSTORM consortium, funded by the EU Horizon 2020 Framework, aims to establish a standardized treatment and outcome platform for investigating STAR in ventricular tachycardia. The consortium consists of 31 clinical and research institutions and is divided into nine work packages. A comprehensive questionnaire was conducted to review the current clinical practice of STAR in Europe, highlighting potential areas of optimization and harmonization.
Article
Oncology
Tiuri E. Kroese, Hanneke W. M. van Laarhoven, Sebastian F. Schoppman, Pieter R. A. J. Deseyne, Eric van Cutsem., Karin Haustermans., Philippe. Nafteux, Melissa Thomas, Radka Obermannova, Hanna R. Mortensen, Marianne Nordsmark, Per Pfeiffer, Anneli Elme, Antoine Adenis, Guillaume Piessen, Christiane J. Bruns, Florian Lordick, Ines Gockel, Markus Moehler, Cihan Gani, Theodore Liakakos, John Reynolds, Alessio G. Morganti, Riccardo Rosati, Carlo Castoro, Francesco Cellini, Domenico D'Ugo, Franco Roviello, Maria Bencivenga, Giovanni de Manzoni, Mark I. van Berge Henegouwen, Maarten C. C. M. Hulshof, Jolanda van Dieren, Marieke Vollebergh, Johanna W. van Sandick, Paul Jeene, Christel T. Muijs, Marije Slingerland, Francine E. M. Voncken, Henk Hartgrink, Geert-Jan Creemers, Maurice J. C. van der Sangen, Grard Nieuwenhuijzen, Maaike Berbee, Marcel Verheij, Bas Wijnhoven, Laurens V. Beerepoot, Nadia H. Mohammad, Stella Mook, Jelle P. Ruurda, Piotr Kolodziejczyk, Wojciech P. Polkowski, Lucjan Wyrwicz, Maria Alsina, Manuel Pera, Tania F. Kanonnikoff, Andres Cervantes, Magnus Nilsson, Stefan Monig, Anna D. Wagner, Matthias Guckenberger, Ewen A. Griffiths, Elizabeth Smyth, George B. Hanna, Sheraz Markar, M. Asif Chaudry, Maria A. Hawkins, Edward Cheong, Richard van Hillegersberg, Peter S. N. van Rossum
Summary: This study aimed to develop a multidisciplinary European consensus statement on the definition, diagnosis and treatment of oligometastatic oesophago-gastric cancer. Through a series of discussions and expert evaluations, a consensus was reached, which can be used for future research in clinical trials.
EUROPEAN JOURNAL OF CANCER
(2023)
Review
Oncology
M. Ducreux, G. K. Abou-Alfa, T. Bekaii-Saab, J. Berlin, A. Cervantes, T. de Baere, C. Eng, P. Galle, S. Gill, T. Gruenberger, K. Haustermans, A. Lamarca, P. Laurent-Puig, J. M. Llovet, F. Lordick, T. Macarulla, D. Mukherji, K. Muro, R. Obermannova, J. -M. O'Connor, E. M. O'Reilly, P. Osterlund, P. Philip, G. Prager, E. Ruiz-Garcia, B. Sangro, T. Seufferlein, J. Tabernero, C. Verslype, H. Wasan, E. Van Cutsem
Summary: This article summarises expert discussion on the management of patients with hepatocellular carcinoma (HCC), which took place during the 24th World Gastrointestinal Cancer Congress (WGICC) in Barcelona, July 2022. A multidisciplinary approach is essential for optimal diagnosis, staging, and planning of curative and therapeutic options for HCC, considering factors such as liver cirrhosis.
Article
Oncology
Gaelle Saade, Eva Bogaerts, Sophie Chiavassa, Guillaume Blain, Gregory Delpon, Manon Evin, Youssef Ghannam, Ferid Haddad, Karin Haustermans, Charbel Koumeir, Ellina Macaeva, Lydia Maigne, Quentin Mouchard, Noel Servagent, Edmond Sterpin, Stephane Supiot, Vincent Potiron
Summary: Recently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. However, the differential effect on healthy and tumor tissue is only observable in in vivo models, which limits the amount of work that can be done in a timely manner.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Pieter Populaire, Gilles Defraene, Philippe Nafteux, Lieven Depypere, Johnny Moons, Sofie Isebaert, Karin Haustermans
Summary: This study aimed to investigate the relationship between dose to functional lung volumes (FLV) and treatment-related lung toxicity in locally advanced esophageal cancer (EC) patients. The results showed that an increase in FLV dose between 10 and 20 Gy and a decrease in anatomical lung volume (ALV) were associated with postoperative pulmonary complications.
Article
Oncology
Lisa De Cock, Cedric Draulans, Floris J. Pos, Sofie Isebaert, Robin De Roover, Uulke A. van der Heide, Robert J. Smeenk, Martina Kunze-Busch, Jochem van der Voort van Zyp, Hans de Boer, Linda G. W. Kerkmeijer, Karin Haustermans
Summary: The study aimed to investigate the safety of reducing the overall treatment time for focal boosted prostate stereotactic body radiotherapy. Results showed that the semi-weekly treatment schedule was associated with acceptable acute genitourinary and gastrointestinal toxicity. Compared to the once-weekly schedule, the semi-weekly treatment resulted in lower genitourinary toxicity and improved quality of life for the patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Eva Oldenburger, Robin De Roover, Kenneth Poels, Tom Depuydt, Sofie Isebaert, Karin Haustermans
Summary: The study aims to report on the accuracy of an automated delineation, treatment plan quality, and duration for vertebral bone metastases using a 1£ 8 Gy regimen in an in-silico scan-(pre)plan-treat (SPT) workflow. The cloud-based emulator system of the Ethos therapy system was utilized to adapt a preplan created on the diagnostic CT to the anatomy-of-the-day using the cone beam CT prior to treatment. The SPT workflow resulted in good coverage of the target volume and acceptable dose to the organs at risk, with the best delivery time and plan homogeneity achieved using a 7-field IMRT plan template.
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Nuclear Science & Technology
Isabelle Thierry-Chef, Beate Timmermann, Neige Journy, Marie-Odile Bernier, Richard McNally, Jeremie Dabin, Lorenzo Brualla, Siamak Haghdoost, Adelaida Sarukhan, Karin Haustermans, Inge De Wit, Sofie Isebaert, Yasmin Lassen-Ramshad, Louise Tram Henriksen, Morten Hoyer, Laura Toussaint, Guillaume Boissonnat, Juliette Thariat, Charlotte Demoor-Goldschmidt, Nadia Haddy, Stephanie Bolle, Brice Fresneau, Amel Belhout, Steffen Dreger, Hajo Zeeb, Maria Grazia Andreassi, Jonica Campolo, Eugenio Picano, Andreas Jahnen, Cecile Ronckers, John H. Maduro, Kristina Kjaerheim, Gaute Dohlen, Trude Eid Robsahm, Hilde M. Olerud, Utheya Salini Thevathas, Susmita Afroz, Bjorn Helge Osteras, Uwe Schneider, Linda Walsh, Agnes Dumas, Angela Jackson, Estelle Rage, Marijke De Saint-Hubert, Richard Hardy, Christian Baeumer, Theresa Steinmeier, Suzan Botzenhardt, Martina Wette, Rodney Ortiz, Vadim Chumak
Summary: The use of ionising radiation in medical procedures has greatly benefited paediatric patients, but the long-term health effects need to be evaluated. The HARMONIC project aims to understand the increased risk of cancer and non-cancer effects after exposure to radiation in children with cancer and cardiac defects. It investigates potential endocrine dysfunction, cardiovascular and neurovascular damage, health-related quality of life, and risks of second primary cancers. The project also develops software tools for dose reconstruction and builds a biobank to identify biomarkers of radiation-induced adverse health effects.
EPJ NUCLEAR SCIENCES & TECHNOLOGIES
(2023)
Article
Oncology
Lien van Walle, Geert Silversmit, Lieven Depypere, Philippe Nafteux, Hans Van Veer, Elke Van Daele, Yannick Deswysen, Jerome Xicluna, Annelies Debucquoy, Liesbet Van Eycken, Karin Haustermans
Summary: This study aimed to evaluate the association between surgical volume and outcomes of esophageal cancer surgery. The results showed that higher annual surgical volume was associated with lower 90-day mortality and better 5-year overall survival. Therefore, the study supported the centralization of esophageal cancer surgery in hospitals with higher surgical volumes.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Derek A. Mumaw, Allison J. Hazy, Aleksander Vayntraub, Thomas J. Quinn, Kamran Salari, John H. Chang, Noah Kalman, Sanford Katz, James Urbanic, Robert H. Press, Arpi Thukral, Henry Tsai, George E. Laramore, Jason Molitoris, Carlos Vargas, Samir H. Patel, Craig Stevens, Rohan L. Deraniyagala
Summary: This study evaluated contralateral recurrences in patients with oropharyngeal squamous cell carcinoma who received unilateral proton beam therapy. The results showed a favorable contralateral neck failure rate that was comparable to photon irradiation.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Kangpyo Kim, Dongryul Oh, Jae Myoung Noh, Yang Won Min, Hong Kwan Kim, Yong Chan Ahn
Summary: This study suggests that hypofractionated radiation therapy alone is a feasible option for early stage esophageal squamous cell carcinoma patients. Particularly, in patients with tumor length < 3 cm, this treatment scheme shows favorable local control rates with low incidence of esophageal toxicities.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Lin Chen, Jing Li, Kunpeng Li, Jiang Hu, Qingjie Li, Chenglong Huang, Gaoyuan Wang, Na Liu, Linglong Tang
Summary: This study analyzed the probability of hearing impairment after radiotherapy for nasopharyngeal carcinoma and developed a predictive model, providing dose limitation suggestions to improve patients' quality of life.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yiwei Yang, Jianxin Wang, Feng Gao, Zhen Liu, Tangzhi Dai, Haowen Zhang, Hongyu Zhu, Tingting Wang, Dexin Xiao, Kui Zhou, Zheng Zhou, Dai Wu, Xiaobo Du, Sen Bai
Summary: This paper provides a comprehensive description of the current status of PARTER, which is the first experimental FLASH platform utilizing megavoltage X-rays. It showcases the reliable performance and stability of the dosimeters and monitors used in PARTER, as well as the satisfactory dose distribution and characteristics of the FLASH X-rays. The platform effectively meets the requirements of preclinical research on megavoltage X-ray FLASH and undergoes continuous upgrades.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Maria Thor, Kelly Fitzgerald, Aditya Apte, Jung Hun Oh, Aditi Iyer, Otasowie Odiase, Saad Nadeem, Ellen D. Yorke, Jamie Chaft, Abraham J. Wu, Michael Offin, Charles B. Simone Ii, Isabel Preeshagul, Daphna Y. Gelblum, Daniel Gomez, Joseph O. Deasy, Andreas Rimner
Summary: The purpose of this study was to identify predictors of disease progression in early-stage non-small cell lung cancer (NSCLC) patients after receiving definitive stereotactic body radiation therapy (SBRT). The results showed that tumor diameter and SUVmax were the most frequently reported features associated with progression/survival, and a re-fitted model including these two features had the best performance.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Yong-Qiao He, Tong-Min Wang, Da-Wei Yang, Wen-Qiong Xue, Chang-Mi Deng, Dan-Hua Li, Wen-Li Zhang, Ying Liao, Ruo-Wen Xiao, Lu-Ting Luo, Hua Diao, Xia-Ting Tong, Yan-Xia Wu, Xue-Yin Chen, Jiang-Bo Zhang, Ting Zhou, Xi-Zhao Li, Pei-Fen Zhang, Xiao-Hui Zheng, Shao-Dan Zhang, Ye-Zhu Hu, Guan-Qun Zhou, Jun Ma, Ying Sun, Wei-Hua Jia
Summary: In this study, researchers aimed to establish a predictive model for radiation-induced brain injury (RBI) in nasopharyngeal carcinoma (NPC) patients by incorporating clinical factors and newly developed genetic variants. They conducted a large-scale retrospective study and a genome-wide association study to develop a polygenic risk score (PRS) for RBI risk prediction. The results showed that the PRS, combined with clinical factors, improved the accuracy of RBI risk stratification and suggested personalized radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2024)
Review
Oncology
Xiaoyong Xiang, Zhe Ji, Jing Jin
Summary: A review of studies suggests that brachytherapy as a salvage therapy for recurrent glioblastoma shows acceptable safety and good post-treatment clinical efficacy for selected patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
M. Berbee, C. T. Muijs, F. E. M. Voncken, L. Wee, M. Sosef, B. van Etten, J. W. van Sandick, F. A. R. M. Warmerdam, J. J. de Haan, E. Oldehinkel, J. M. van Dieren, L. Boersma, J. A. Langendijk, A. van der Schaaf, J. B. Reitsma, E. Schuit
Summary: This study externally validated a model for predicting 2-year total mortality in lung cancer patients in esophageal cancer patients. The intercept and/or slope of the original model needed adjustment to achieve good performance in esophageal cancer patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominique Reijtenbagh, Jeremy Godart, Joan Penninkhof, Sandra Quint, Andras Zolnay, Jan-Willem Mens, Mischa Hoogeman
Summary: This study compared the performance of the current PotD strategy with non-adaptive and fully online-adaptive techniques in the treatment of cervical cancer patients. The findings show that the PotD protocol is effective in improving normal tissue sparing compared to no adaptation, while fully online-adaptive approaches can further reduce target volume but come with a more complex workflow.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Albrecht Weiss, Steffen Loeck, Ting Xu, Zhongxing Liao, Aswin L. Hoffmann, Esther G. C. Troost
Summary: Traditional models for predicting radiation pneumonitis may not be applicable to non-small cell lung cancer patients treated with passively-scattered proton therapy. The use of effective alpha/beta parameter can predict the occurrence of radiation pneumonitis in these patients.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Z. A. R. Gouw, J. Jeong, A. Rimner, N. Y. Lee, A. Jackson, A. Fu, J-j. Sonke, J. O. Deasy
Summary: This study investigates the effectiveness of non-uniform fractionation schedules in radiotherapy for early-stage non-small cell lung cancer. Through modeling, optimized schedules are proposed to minimize local failures and toxicity risk. The results suggest that non-standard primer shot fractionation can reduce hypoxia-induced radioresistance and improve treatment outcomes.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Sara Ronchi, Alessandro Cicchetti, Maria Bonora, Rossana Ingargiola, Anna Maria Camarda, Stefania Russo, Sara Imparato, Paolo Castelnuovo, Ernesto Pasquini, Piero Nicolai, Mohssen Ansarin, Michele Del Vecchio, Marco Benazzo, Ester Orlandi, Barbara Vischioni
Summary: This study evaluates the efficacy and toxicity of carbon ion radiotherapy (CIRT) in locally advanced head and neck mucosal melanoma patients. The results show that CIRT is safe and effective in treating the local region, and immunotherapy after relapse can improve overall survival. However, further prospective trials are needed to assess the role of targeted/immune- systemic therapy in this disease.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Dominik Wawrzuta, Justyna Klejdysz, Marzanna Chojnacka
Summary: This study analyzed articles about radiation oncology published in The New York Times since its inception in 1851, and identified changes in media sentiment and prevalent themes related to radiotherapy. The findings suggest an increasing negative sentiment in media coverage towards radiotherapy, with a shift towards reporting treatment errors, toxicity, and ineffectiveness.
RADIOTHERAPY AND ONCOLOGY
(2024)
Article
Oncology
Elaine Limkin, Pierre Blanchard, Benjamin Lacas, Jean Bourhis, Mahesh Parmar, Lisa Licitra, Quynh-Thu Le, Sue S. Yom, Catherine Fortpied, Johannes Langendijk, Jan B. Vermorken, Jacques Bernier, Jens Overgaard, Jonathan Harris, Jean-Pierre Pignon, Anne Auperin
Summary: This study investigated the impact of season of radiotherapy on the outcomes of head and neck squamous cell cancer patients. The results showed that the season of radiotherapy did not have any significant effect on patient outcomes.
RADIOTHERAPY AND ONCOLOGY
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Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)