期刊
ENVIRONMENT INTERNATIONAL
卷 95, 期 -, 页码 30-35出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2016.07.013
关键词
Parabens; Occurrence; Pharmaceutical; Implication; Human exposure
资金
- Open Project of State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology [ES201601-02]
- Heilong Jiang Postdoctoral Funds for Scientific Research Initiation [LBH-Q15047]
- National Natural Science Foundation of China [21277038]
Parabens are widely used as antimicrobial preservatives during pharmaceutical production. However, little information is available regarding the occurrence of parabens in commercial pharmaceuticals and their implications for human exposure. In this study, six commonly used parabens were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry with 100 commercial pharmaceuticals collected from China. Almost all of the pharmaceutical samples contained at least one kind. of parabens with the detection frequency of 97%. The concentrations of Sigma(6)parabens (sum of the six parabens) ranged from below MDL to 1256 ng/g, with mean and median values of 94.8 and 119 ng/g, respectively. Methyl paraben (MeP), ethyl paraben (EtP) and propyl paraben (PrP) were the predominant compounds. Significant positive correlation was observed between concentrations of MeP and PrP, indicating their co-applications in pharmaceuticals. Levels of Sigma(6)parabens varied in different categories of pharmaceuticals and increased with their shelf lives. Based on the measured concentrations and daily ingestion rates of pharmaceuticals, the estimated daily intake (EDI) of parabens was calculated. The median values of EDIpharmaceutical for male adults, female adults and children were 4.05, 4.75 and 9.73 ng/kg-bw/day, respectively, which were three orders of magnitude lower than those from foodstuffs and personal care products (PCPs). It was firstly reported that the total exposure dose was 0326 mg/kg-bw/day via foodstuffs, PCPs, and pharmaceuticals for Chinese female adults. (C) 2016 Elsevier Ltd. All rights reserved.
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