Article
Biotechnology & Applied Microbiology
Zhipeng Xu, Hui Chen, Jin Sun, Weipu Mao, Shuqiu Chen, Ming Chen
Summary: This study established a ten-lncRNA signature for predicting bladder cancer recurrence based on multi-omics analysis, which showed robust predictive value in training and testing sets and association with immune disorders.
Article
Immunology
Weian Zhu, Jianjie Wu, Jiongduan Huang, Dongming Xiao, Fengao Li, Chenglun Wu, Xiaojuan Li, Hengda Zeng, Jiayu Zheng, Wenjie Lai, Xingqiao Wen
Summary: This study identifies macrophage-related marker genes and evaluates their impact on prostate cancer development using single-cell sequencing data analysis. A prognostic signature based on these marker genes is constructed and shown to have excellent predictive ability. Furthermore, the study explores the relationship between the prognostic signature and the tumor immune microenvironment, therapeutic response, and drug selection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
YuanLin Sun, Bin Liu, YuJia Chen, YanPeng Xing, Yang Zhang
Summary: This study investigated the role of lipid metabolism in the prognosis of colorectal cancer (CRC) using metabonomics and transcriptomics. The study developed prognostic signatures and a composite nomogram to predict the outcome of CRC patients. The study also explored the potential relationship between tumor microenvironment and immune infiltration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Xiaodong Chen, Fen Tian, Zeyu Wu
Summary: This study investigates the prognostic value of genomic instability-derived genes in glioblastoma (GBM) patients. They identified 154 differentially expressed genes in GBM patients with high and low tumor mutation burden, and established a risk score model using 9 genes. The risk score model reliably predicted the prognosis of GBM patients, and a nomogram combining the risk score and age showed good prognostic predictive value.
WORLD NEUROSURGERY
(2022)
Article
Oncology
Qianhui Xu, Hao Xu, Rongshan Deng, Zijie Wang, Nanjun Li, Zhixuan Qi, Jiaxin Zhao, Wen Huang
Summary: This study revealed a positive correlation between TMB value and older age, male gender, and early T status in HCC. A risk score based on three hub genes significantly influenced overall survival time, immune cell infiltration, and ICB-related hub targets. The prognostic performance of the risk score was validated in an external testing group, and a risk-clinical nomogram was constructed for clinical application. HTRA3 was identified as a prognostic factor in HCC, and TP53 mutation did not interfere with the risk score-based prognostic prediction.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Xi Zhang, Yang Liu, Zhen Zhang, Juan Tan, Junjun Zhang, Hao Ou, Jie Li, Zewen Song
Summary: This study investigated the mechanism of a novel angiogenesis inhibitor, anlotinib, against pancreatic cancer cells through multi-omics analyses, and constructed an anlotinib-related gene signature to identify a subgroup of pancreatic cancer patients who might benefit from anlotinib. The results showed that anlotinib exerted significant cytotoxicity on pancreatic cancer cells and had a profound inhibitory effect on ribosome, cell cycle, RNA metabolism, and lysosome.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qing Ye, Brianne Falatovich, Salvi Singh, Alexey V. Ivanov, Timothy D. Eubank, Nancy Lan Guo
Summary: This study developed a qRT-PCR-based seven-gene microfluidic assay to predict the recurrence risk and therapeutic response in patients with early-stage NSCLC. The transcriptional regulatory network related to the seven-gene signature was identified, and multi-omics network genes were found to be associated with immune infiltration and drug response in NSCLC. The study also identified potential repositioning drugs for NSCLC treatment based on the gene expression of the multi-omics network.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Jing Liu, Zirong Li, Ting Lu, Junping Pan, Li Li, Yanwen Song, Dan Hu, Yanhong Zhuo, Ying Chen, Qin Xu
Summary: This study analyzed the genomic alteration profiles and immune characteristics of Chinese cervical cancer patients. The results showed different molecular profiles and immune characteristics between squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the cervix. Certain gene mutations were identified as independent predictors of high tumor mutational burden (TMB) in cervical cancer. Furthermore, the study proposed the prognostic value of PTEN mutations.
BMC MEDICAL GENOMICS
(2022)
Article
Genetics & Heredity
Yudong Cao, Hecheng Zhu, Weidong Liu, Lei Wang, Wen Yin, Jun Tan, Quanwei Zhou, Zhaoqi Xin, Hailong Huang, Dongcheng Xie, Ming Zhao, Xingjun Jiang, Jiahui Peng, Caiping Ren
Summary: This study identified genomic instability-related lncRNAs in lower-grade gliomas (LGGs) and established a prognostic signature model for LGG patients. The model showed a significant association with somatic mutation and outperformed other published signatures. The study also explored the relationship between risk scores and multi-omics data, including immune characteristics and stemness characteristics in LGG. The findings provide potential therapeutic targets for individualized treatment of LGG.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Guangyu Sun, Shenfei Ma, Zhiwen Zheng, Xiaohua Wang, Shuaiqi Chen, Taihao Chang, Zhengxin Liang, Yuchen Jiang, Shengxian Xu, Ranlu Liu
Summary: NSUN2 is highly expressed in prostate cancer, promoting the progression of the disease and closely associated with immune cell infiltration and chemotherapy drug sensitivity.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Dafeng Xu, Yu Wang, Yuliang Zhang, Zhehao Liu, Yonghai Chen, Jinfang Zheng
Summary: Pancreatic adenocarcinoma (PAAD) is a malignant tumor of the digestive system with poor prognosis due to its rapid progression and high invasiveness. Through RNA sequencing data, two subtypes of PAAD were identified, with one subtype showing overexpression of genes and worse prognosis. A 3-gene signature based on differentially expressed genes serves as a stable prognostic marker for patients with PAAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Libo Wang, Zaoqu Liu, Rongtao Zhu, Ruopeng Liang, Weijie Wang, Jian Li, Yuyuan Zhang, Chunguang Guo, Xinwei Han, Yuling Sun
Summary: This study reveals that a SMAD4-driven immune signature (SDIS) can predict the prognosis of pancreatic cancer and guide decision-making in chemotherapy and immunotherapy.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Medicine, Research & Experimental
Xianyu Hu, Zhenglin Wang, Qing Wang, Ke Chen, Qijun Han, Suwen Bai, Juan Du, Wei Chen
Summary: This study identified two molecular subtypes (CS1 and CS2) of gastric cancer using multi-omics data and ten clustering algorithms, revealing differences in survival time, mutation patterns, and immune cell infiltration between the two groups. The CS2 group showed higher immunocyte infiltration and potential responses to chemotherapy, suggesting potential immunotherapeutic benefits.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Oncology
Zeyu Xing, Dongcai Lin, Yuting Hong, Zihuan Ma, Hongnan Jiang, Ye Lu, Jiale Sun, Jiarui Song, Li Xie, Man Yang, Xintong Xie, Tianyu Wang, Hong Zhou, Xiaoqi Chen, Xiang Wang, Jidong Gao
Summary: This study aimed to uncover novel useful genetic biomarkers and establish a risk signature for breast cancer to aid in determining clinical strategies.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Wei Chong, Xingyu Zhu, Huicheng Ren, Chunshui Ye, Kang Xu, Zhe Wang, Shengtao Jia, Liang Shang, Leping Li, Hao Chen
Summary: This study elucidates the molecular heterogeneity of KRAS-mutant CRC and reveals new biological subtypes and therapeutic possibilities for these tumors.
Article
Pharmacology & Pharmacy
Dafeng Xu, Yu Wang, Jincai Wu, Zhensheng Zhang, Jiacheng Chen, Mingwei Xie, Rong Tang, Chen Cheng, Liang Chen, Shiyun Lin, Xiangxiang Luo, Jinfang Zheng
Summary: This study identified MTIF2 as the hub immune infiltrating gene in hepatocellular carcinoma (HCC), and found that down-regulation of MTIF2 impairs the proliferation and migration capacity of HCC cells, leading to decreased chemoresistance. Further mechanistic investigations revealed that MTIF2 interacts with AIFM1 to suppress apoptosis and impair immunogenic cell death in HCC cells.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Cell Biology
Dafeng Xu, Yu Wang, Jincai Wu, Zhensheng Zhang, Jiacheng Chen, Mingwei Xie, Rong Tang, Cheng Chen, Liang Chen, Shixun Lin, Xiangxiang Luo, Jinfang Zheng
Summary: This study identified a new candidate diagnostic and prognostic biomarker (ECT2) for HCC, and revealed its role in promoting the polarization of M2 macrophages.
CELL DEATH & DISEASE
(2021)
Review
Pediatrics
Hui Yang, Chunlan Lin, Chunyu Zhuang, Jiacheng Chen, Yanping Jia, Huiling Shi, Cong Zhuang
Summary: Serum Cystatin C has a good performance in predicting neonatal AKI and can be used as a candidate biomarker. However, large prospective studies are still needed to determine the optimal level.
JORNAL DE PEDIATRIA
(2022)
Correction
Cell Biology
Dafeng Xu, Yu Wang, Jincai Wu, Zhensheng Zhang, Jiacheng Chen, Mingwei Xie, Rong Tang, Cheng Chen, Liang Chen, Shixun Lin, Xiangxiang Luo, Jinfang Zheng
CELL DEATH & DISEASE
(2022)
Letter
Gastroenterology & Hepatology
Liang Chen, Lu-Zheng Liu, Jia-Cheng Chen, Da-Feng Xu, Cheng Chen, Shi-Xun Lin, Jin-Cai Wu
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Review
Nursing
SuFen Cao, YuQiang Zhang, BaiLang Lin, JiaCheng Chen, XiaoJing Chen, ChunYu Zhuang
Summary: Enhanced recovery after surgery protocol has a positive effect on perioperative outcomes for women undergoing gynecologic surgery, including reduced length of stay, time to first flatus and first defecation, complications, and readmission rates. However, there is heterogeneity between studies, and more research is needed to draw reliable conclusions on the favorability of enhanced recovery after surgery.
NURSING & HEALTH SCIENCES
(2023)
Article
Cell Biology
Rong Tang, Linmei Zheng, Jinfang Zheng, Jincai Wu, Pingping Chen, Jiacheng Chen, Dafeng Xu, Yongchao Zeng, Qijin Li, Zhensheng Zhang
Summary: The pharmacological antagonist secukinumab combined with starvation therapy can synergistically promote autophagic cell death in hepatocellular carcinoma (HCC) cells. The study found that secukinumab enhanced autophagy and inhibited the survival and function of HCC HepG2 cells. In addition, the combination of lenvatinib and secukinumab inhibited tumor formation in vivo.
IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
(2023)
Article
Multidisciplinary Sciences
Jiacheng Chen, Jie Chen, Xunchang J. Zhang, Peiyi Peng, Camille Risi
Summary: In this study, a 148-year precipitation oxygen isoscape in China was built by integrating observed and iGCMs-simulated isotope compositions. The Convolutional Neural Networks (CNN) fusion method performed the best among the three data fusion methods, and the generated isoscape showed reliable spatio-temporal distributions similar to observations. The isoscape can provide strong support for tracking atmospheric and hydrological processes.
Review
Biotechnology & Applied Microbiology
Xian-Wen Liang, Sheng-Zhong Wang, Bing Liu, Jia-Cheng Chen, Zhi Cao, Feng-Ran Chu, Xiong Lin, Hui Liu, Jin-Cai Wu
Summary: Ubiquitin is a small protein that can be added onto target protein to induce degradation and modulate the activity and stability of the protein. Deubiquitinases (DUBs) are a class of enzymes that can remove ubiquitin from substrate proteins, providing positive regulation at the transcriptional level, post-translational modification, protein interaction, etc. The reversible and dynamic process of ubiquitination-deubiquitination plays a critical role in maintaining protein homeostasis and is essential for almost all biological processes.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Oncology
Xian-Wen Liang, Bing- Liu, Jia-Cheng Chen, Zhi Cao, Feng-ran Chu, Xiong Lin, Sheng-Zhong Wang, Jin-Cai Wu
Summary: Drug resistance in tumors, including both primary and acquired resistance, has greatly impacted therapeutic efficacy. Recent research has shown that a significant proportion of cancer cells can develop stable drug resistance from scratch by entering a drug tolerance state (DT state) and acquiring adaptive mutations. The specific mechanisms underlying the formation of drug tolerant cells (DTCs) are not yet fully understood, although various proteins and signaling pathways have been implicated. This review provides a detailed summary of the characteristics, molecular mechanisms, and therapeutic strategies of DTCs.
FRONTIERS IN ONCOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Li Lin, Jiacheng Chen, Qiang Meng
Summary: This paper proposes a calculation method to accurately evaluate the detection capability of the infrared radiation system and establishes the calibration calculation model of the infrared radiation system using multiple integration times. The calculation function of the target radiation brightness is constructed based on the principle of constant total energy of the target in the infrared detector diffusion imaging, considering factors such as atmospheric jitter, optical system diffraction, and imaging aberration. The calculation model of the detection distance of the system is deduced based on the dispersion phenomenon of the test environment. Based on the test platform with known parameters, the correlation between the detection distance and the target radiation brightness, as well as the rationality of the detection distance calculation model, is calculated and analyzed. The obtained results provide a reference for the reliable detection of the infrared system under the condition of long-range in complex environments.
OPTOELECTRONICS AND ADVANCED MATERIALS-RAPID COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Jiacheng Chen, Xiaojing Chen, Liang Chen, Xiangxiang Luo, Chunyu Zhuang, Jincai Wu
Summary: This study investigated the mechanism of drug resistance reversal and the action of survivin in hepatocellular carcinoma cells treated with Fe3O4 magnetic nanoparticles. The results showed that Fe3O4 magnetic nanoparticles can enhance the reversal and apoptosis of multidrug resistant cells by inhibiting the expression of survivin.
Article
Oncology
Chunyu Zhuang, Huiling Shi, Yanping Jia, Jiacheng Chen, Hui Yang, Xiaojing Chen
Summary: Yoga exercise has a positive effect on reducing anxiety and promoting fetal growth in pregnant women with small gestational age fetuses.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Oncology
Yuqiang Zhang, Sufen Cao, Bailang Lin, Jiacheng Chen, Xiaojing Chen, Shengying Lin, Chunyu Zhuang
Summary: The study applied the best evidence of early active movements in mechanically ventilated patients in the ICU and found that it led to improved Barthel index and muscle strength, reduced duration of mechanical ventilation and ICU stay, lower incidence of deep vein thrombosis and ICU acquired weakness, as well as decreased anxiety and depression scores post-intervention.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)