DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway

RIPK3 upregulation confers robust proliferation and collateral cystine-dependence on breast cancer recurrence

(2020) Chao-Chieh Lin et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis of epithelial ovarian cancer: genetic determinants and therapeutic potential

(2020) Chao-Chieh Lin et al.   Oncotarget

Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy

(2019) Megan M. Tu et al.   Science Advances

Randomly distributed K14+ breast tumor cells polarize to the leading edge to direct collective migration in response to chemical and mechanical environmental cues

(2019) Gregory D Longmore et al.   CANCER RESEARCH

DDR2 controls breast tumor stiffness and metastasis by regulating Integrin mediated mechanotransduction in CAFs

(2019) Samantha VH Bayer et al.   eLife

Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism

(2019) Po-Han Chen et al.   CELL DEATH AND DIFFERENTIATION

Intercellular interaction dictates cancer cell ferroptosis via NF2–YAP signalling

(2019) Jiao Wu et al.   NATURE

The Hippo Pathway Effector TAZ Regulates Ferroptosis in Renal Cell Carcinoma

(2019) Wen-Hsuan Yang et al.   Cell Reports

A TAZ–ANGPTL4–NOX2 Axis Regulates Ferroptotic Cell Death and Chemoresistance in Epithelial Ovarian Cancer

(2019) Wen-Hsuan Yang et al.   MOLECULAR CANCER RESEARCH

Induction of AP-1 by YAP/TAZ contributes to cell proliferation and organ growth

(2019) Ja Hyun Koo et al.   GENES & DEVELOPMENT

TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis

(2018) Whitney R. Grither et al.   ONCOGENE

CoA synthase regulates mitotic fidelity via CBP-mediated acetylation

(2018) Chao-Chieh Lin et al.   Nature Communications

Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer

(2018) Nathaniel W. Mabe et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain

(2018) Whitney R. Grither et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis

(2018) John M. Lamar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening

(2017) Daehwan Kim et al.   Scientific Reports

Mesenchymal Stem Cell-Induced DDR2 Mediates Stromal-Breast Cancer Interactions and Metastasis Growth

(2017) Maria E. Gonzalez et al.   Cell Reports

YAP/TAZ at the Roots of Cancer

(2016) Francesca Zanconato et al.   CANCER CELL

Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas

(2016) Xiaohu Tang et al.   CANCER RESEARCH

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

αE-catenin inhibits a Src–YAP1 oncogenic module that couples tyrosine kinases and the effector of Hippo signaling pathway

(2016) Peng Li et al.   GENES & DEVELOPMENT

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Cystine addiction of triple-negative breast cancer associated with EMT augmented death signaling

(2016) X Tang et al.   ONCOGENE

DDR2 overexpression in urothelial carcinoma indicates an unfavorable prognosis: a large cohort study

(2016) Meng-Chen Tsai et al.   Oncotarget

The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis

(2016) Callie A.S. Corsa et al.   Cell Reports

Characterization of DDR2 Inhibitors for the Treatment of DDR2 Mutated Nonsmall Cell Lung Cancer

(2015) Hideki Terai et al.   ACS Chemical Biology

Tyrosine kinase discoidin domain receptors DDR1 and DDR2 are coordinately deregulated in triple-negative breast cancer

(2015) Kathy A. Toy et al.   BREAST CANCER RESEARCH AND TREATMENT

Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

(2015) M Hayano et al.   CELL DEATH AND DIFFERENTIATION

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Clinical and molecular complexity of breast cancer metastases

(2015) Siker Kimbung et al.   SEMINARS IN CANCER BIOLOGY

Comprehensive Profiling of Amino Acid Response Uncovers Unique Methionine-Deprived Response Dependent on Intact Creatine Biosynthesis

(2015) Xiaohu Tang et al.   PLoS Genetics

PROGgeneV2: enhancements on the existing database

(2015) Chirayu Pankaj Goswami et al.   BMC CANCER

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Glutamine Sensitivity Analysis Identifies the xCT Antiporter as a Common Triple-Negative Breast Tumor Therapeutic Target

(2013) Luika A. Timmerman et al.   CANCER CELL

Epithelial-mesenchymal plasticity in carcinoma metastasis

(2013) J. H. Tsai et al.   GENES & DEVELOPMENT

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

(2013) Kun Zhang et al.   NATURE CELL BIOLOGY

Concurrent Gene Signatures for Han Chinese Breast Cancers

(2013) Chi-Cheng Huang et al.   PLoS One

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Discoidin domain receptor 2 is a critical regulator of epithelial–mesenchymal transition

(2011) Logan A. Walsh et al.   MATRIX BIOLOGY

Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway–dependent and PI3K pathway–independent mechanisms

(2011) Pixu Liu et al.   NATURE MEDICINE

miRNA-mRNA Integrated Analysis Reveals Roles for miRNAs in Primary Breast Tumors

(2011) Espen Enerly et al.   PLoS One

Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer

(2011) Peter S. Hammerman et al.   Cancer Discovery

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION