Mini-Review: Is iron-mediated cell death (ferroptosis) an identical factor contributing to the pathogenesis of some neurodegenerative diseases?

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

(2020) Azhaar Ashraf et al.   Redox Biology

Ferroptotic Cell Death: New Regulatory Mechanisms for Metabolic Diseases

(2020) Yifei Le et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Fibrillar α-synuclein toxicity depends on functional lysosomes

(2020) Stephanie J Guiney et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathogenesis of Alzheimer’s disease: Multiple interacting causes against which amyloid precursor protein protects

(2020) A.F. Shah et al.   MEDICAL HYPOTHESES

In vivo imaging of chronic active lesions in multiple sclerosis

(2020) Alberto Calvi et al.   Multiple Sclerosis Journal

CMS121, a fatty acid synthase inhibitor, protects against excess lipid peroxidation and inflammation and alleviates cognitive loss in a transgenic mouse model of Alzheimer's disease

(2020) Gamze Ates et al.   Redox Biology

Supplementation with γ-glutamylcysteine (γ-GC) lessens oxidative stress, brain inflammation and amyloid pathology and improves spatial memory in a murine model of AD

(2020) Yue Liu et al.   NEUROCHEMISTRY INTERNATIONAL

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

(2019) Harald E. Möller et al.   TRENDS IN NEUROSCIENCES

Potential role of iron in repair of inflammatory demyelinating lesions

(2019) Nathanael J. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Iron Metabolism in the Peripheral Nervous System: The Role of DMT1, Ferritin, and Transferrin Receptor in Schwann Cell Maturation and Myelination

(2019) Diara A. Santiago González et al.   JOURNAL OF NEUROSCIENCE

Iron related changes in MS lesions and their validity to characterize MS lesion types and dynamics with Ultra-high field magnetic resonance imaging

(2018) Simon Hametner et al.   BRAIN PATHOLOGY

Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

(2018) Sonal Agrawal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Ferroptosis and Its Role in Diverse Brain Diseases

(2018) Abigail Weiland et al.   MOLECULAR NEUROBIOLOGY

Labile iron potentiates ascorbate-dependent reduction and mobilization of ferritin iron

(2017) Charles Badu-Boateng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence that iron accelerates Alzheimer’s pathology: a CSF biomarker study

(2017) Scott Ayton et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinson's disease

(2017) Fabio A. Zucca et al.   PROGRESS IN NEUROBIOLOGY

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Contrast mechanisms associated with neuromelanin-MRI

(2016) Paula Trujillo et al.   MAGNETIC RESONANCE IN MEDICINE

Neuromelanin Imaging and Dopaminergic Loss in Parkinson's Disease

(2016) Ioannis U. Isaias et al.   Frontiers in Aging Neuroscience

α-Synuclein Over-Expression Induces Increased Iron Accumulation and Redistribution in Iron-Exposed Neurons

(2015) Richard Ortega et al.   MOLECULAR NEUROBIOLOGY

Neurodegeneration with inflammation is accompanied by accumulation of iron and ferritin in microglia and neurons

(2015) Maj Schneider Thomsen et al.   NEUROBIOLOGY OF DISEASE

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

Multiple sclerosis deep grey matter: the relation between demyelination, neurodegeneration, inflammation and iron

(2014) Lukas Haider et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide  -amyloid (1-42)

(2014) J. Everett et al.   Journal of the Royal Society Interface

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

(2014) Dominic J. Hare et al.   Chemical Science

Labile iron in cells and body fluids: physiology, pathology, and pharmacology

(2014) Zvi Ioav Cabantchik   Frontiers in Pharmacology

Iron uptake in quiescent and inflammation-activated astrocytes: A potentially neuroprotective control of iron burden

(2013) Ilaria Pelizzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The role of iron and reactive oxygen species in cell death

(2013) Scott J Dixon et al.   Nature Chemical Biology

Genetic and biochemical markers in patients with Alzheimer's disease support a concerted systemic iron homeostasis dysregulation

(2013) Ângela C. Crespo et al.   NEUROBIOLOGY OF AGING

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Increased iron accumulation occurs in the earliest stages of demyelinating disease: an ultra-high field susceptibility mapping study in Clinically Isolated Syndrome

(2012) Ali M Al-Radaideh et al.   Multiple Sclerosis Journal

Bezafibrate for X-Linked Adrenoleukodystrophy

(2012) Marc Engelen et al.   PLoS One

Apolipoprotein E in Alzheimer's disease and other neurological disorders

(2011) Philip B Verghese et al.   LANCET NEUROLOGY

Soluble amyloid  -protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration

(2011) M. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Polarization dictates iron handling by inflammatory and alternatively activated macrophages

(2010) G. Corna et al.   HAEMATOLOGICA

Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson’s Disease

(2009) Wei Zhang et al.   NEUROTOXICITY RESEARCH