Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold

A site-selective amination catalyst discriminates between nearly identical C–H bonds of unsymmetrical disubstituted alkenes

(2020) Honghui Lei et al.   Nature Chemistry

Enzyme-Catalyzed Inverse-Electron Demand Diels–Alder Reaction in the Biosynthesis of Antifungal Ilicicolin H

(2019) Zhuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Directed Evolution of Protein Catalysts

(2018) Cathleen Zeymer et al.   Annual Review of Biochemistry

Receptor-Based Artificial Metalloenzymes on Living Human Cells

(2018) Wadih Ghattas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of a highly active and enantiospecific metalloenzyme from short peptides

(2018) Sabine Studer et al.   SCIENCE

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

(2017) Masao Ohashi et al.   NATURE

Natural [4 + 2]-Cyclases

(2016) Byung-sun Jeon et al.   CHEMICAL REVIEWS

Recent advances of Diels–Alderases involved in natural product biosynthesis

(2016) Atsushi Minami et al.   JOURNAL OF ANTIBIOTICS

The Catalytic Mechanism of a Natural Diels–Alderase Revealed in Molecular Detail

(2016) Matthew J. Byrne et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The coming of age of de novo protein design

(2016) Po-Ssu Huang et al.   NATURE

The structure of SpnF, a standalone enzyme that catalyzes [4 + 2] cycloaddition

(2015) Christopher D Fage et al.   Nature Chemical Biology

Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase

(2014) N. Preiswerk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Computational Enzyme Design

(2013) Gert Kiss et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective Artificial Metalloenzymes by Creation of a Novel Active Site at the Protein Dimer Interface

(2012) Jeffrey Bos et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metal-Mediated Affinity and Orientation Specificity in a Computationally Designed Protein Homodimer

(2011) Bryan S. Der et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enzyme-catalysed [4+2] cycloaddition is a key step in the biosynthesis of spinosyn A

(2011) Hak Joong Kim et al.   NATURE

De Novo Enzyme Design Using Rosetta3

(2011) Florian Richter et al.   PLoS One

An Artificial Metalloenzyme: Creation of a Designed Copper Binding Site in a Thermostable Protein

(2010) John Podtetenieff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction

(2010) J. B. Siegel et al.   SCIENCE