Three quinolinone alkaloid - phenylpropanoid adducts from Melicope pteleifolia

Preliminary in vitro cytotoxic test on different extracts of Melicope pteleifolia collected at Dak Nong province, Vietnam showed that the n-hexane one was the most potent. From this n-hexane extract, three new quinolinone alkaloid-phenylpropanoid derivatives (1-3) and three known compounds (4-6) were isolated. Based on NMR and HR-MS analysis, their chemical structures were elucidated as melicoptines A-C (1-3), flindersine (4), 3,4,5-trimethoxybenzoic acid (5) and (24S)-methylcholestan-1 alpha,3 beta-diol (6). Isolated compounds (1-4) were evaluated for their anti-bacterial and cytotoxic activities against human non-small cell lung cancer (A549), human cervical cancer (HeLa), human Burkitt's lymphoma (Raji) and normal fibroblasts (NIH-3T3). All of them were inactive.

Automated summary

The preliminary cytotoxic test on extracts of Melicope pteleifolia collected in Dak Nong province, Vietnam showed that the n-hexane extract was the most potent. Six compounds were isolated from the n-hexane extract, including three new quinolinone alkaloid-phenylpropanoid derivatives and three known compounds. These compounds were evaluated for their anti-bacterial and cytotoxic activities against various cancer cell lines and normal fibroblasts, but all showed no activity.