Review
Dermatology
Yufei He, Ruoyu Tang, Jie Deng, Tongkai Cai, Ping He, Jianhua Wu, Yongbing Cao
Summary: Vulvovaginal candidosis (VVC) is a frequently occurring infectious disease caused mainly by Candida albicans, affecting over 100 million women worldwide annually. High levels of circulating oestrogen due to pregnancy, the use of oral contraceptives, and hormone replacement therapy are factors influencing C. albicans colonisation and the incidence of VVC.
Review
Mycology
Paula Faria-Goncalves, Joana Rolo, Carlos Gaspar, Rita Palmeira-de-Oliveira, Jose Martinez-de-Oliveira, Ana Palmeira-de-Oliveira
Summary: The study highlights important factors contributing to chronic vulvovaginal candidosis, including molecular epidemiology and the expression of virulence factors, while clarifying terminology related to these infections.
Article
Microbiology
Philipp Foessleitner, Herbert Kiss, Julia Deinsberger, Julia Ott, Lorenz Zierhut, Alex Farr
Summary: Pregnant women are at increased risk of vulvovaginal candidosis, and a point-of-care vaginal yeast detection assay shows high sensitivity and specificity in asymptomatic pregnant women, suggesting its potential role as a screening tool in early gestation.
Review
Medicine, General & Internal
G. Cooke, C. Watson, L. Deckx, M. Pirotta, J. Smith, M. L. van Driel
Summary: Treatment of RVVC with oral or topical antifungal drugs may effectively reduce clinical recurrence. Further research is needed to determine the differences between different treatment options.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Microbiology
Marina Randelovic, Marina Dimitrijevic, Suzana Otasevic, Ljiljana Stanojevic, Milica Isljamovic, Aleksandra Ignjatovic, Valentina Arsic-Arsenijevic, Zorica Stojanovic-Radic, Richard D. Cannon
Summary: This study found that Melissa officinalis essential oil (MOEO) has a good antibiofilm effect on candida biofilms. However, the combined effect of MOEO with antifungal drugs depends on the choice of drugs and their concentrations.
Review
Immunology
Gilbert Donders, Istvan Oszkar Sziller, Jorma Paavonen, Phillip Hay, Francesco de Seta, Jean Marc Bohbot, Jan Kotarski, Jordi Antoni Vives, Bela Szabo, Ramona Cepuliene, Werner Mendling
Summary: Recurrent vulvovaginal candidosis (RVVC) is a chronic and difficult to treat vaginal infection caused by Candida species. Fluconazole resistance and the rising prevalence of non-albicans Candida species pose challenges in treatment. Innovative strategies and research into new drugs and the impact of RVVC on patients' quality of life and sex life are needed.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Microbiology
Jian Miao, Jessica Regan, Chun Cai, Glen E. Palmer, David L. Williams, Michael D. Kruppa, Brian M. Peters
Summary: This study characterizes the glycogen metabolism pathways in Candida albicans and shows that glycogen metabolism is important for the long-term survival and virulence of the fungus.
Review
Microbiology
Jack D. Sobel, Paul Nyirjesy
Summary: RVVC presents significant burdens on women in terms of disease, financial impact, and quality of life, and currently lacks an approved treatment. Fluconazole is a widely accepted first-line treatment for RVVC, but has limitations such as resistance development and high recurrence rates. Oteseconazole, a novel treatment option, has shown impressive efficacy and a promising profile for superior RVVC management.
FUTURE MICROBIOLOGY
(2021)
Article
Obstetrics & Gynecology
Alex Farr, Isaak Effendy, Brigitte Frey Tirri, Herbert Hof, Peter Mayser, Ljubomir Petricevic, Markus Ruhnke, Martin Schaller, Axel P. A. Schaefer, Birgit Willinger, Werner Mendling
Summary: This official guideline, coordinated by multiple gynecological and obstetrical societies in Germany, Austria, and Switzerland, aims to provide consensus-based recommendations for the diagnosis, treatment, and management of women with vulvovaginal candidosis. The structured consensus was obtained by evaluating relevant literature and represents the expertise of a panel of experts with diverse professional backgrounds. The guideline offers recommendations for diagnosis, management, counseling, prophylaxis, and screening of vulvovaginal candidosis.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Article
Pharmacology & Pharmacy
Mariana Tomas, Joana Rolo, Carlos Gaspar, Ana Palmeira-de-Oliveira, Sergio Simoes, David F. Katz, Jose Martinez-de-Oliveira, Rita Palmeira-de-Oliveira
Summary: The study aimed to develop and characterize sodium bicarbonate gels to treat VVC, with formulation C showing the most effective inhibition of Candida albicans' growth and other VVC etiological agents. Gel C exhibited physicochemical characteristics suitable for short term treatments and was deemed biocompatible, making it suitable for further development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Fiama Martins, Daniella L. Morgado, Bruno Sarmento, Emerson R. de Camargo, Jose das Neves
Summary: Vulvovaginal candidiasis is a concerning issue in women's healthcare, and better treatment options are needed. The chitosan sponge formulations developed in this study show promise as alternative antifungal products, with improved safety and effectiveness.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Editorial Material
Microbiology
Nicolas Papon, Patrick Van Dijck
Summary: A recent study sheds light on the complex interactions between Candida and Lactobacillus in recurrent vulvovaginal candidiasis, suggesting that probiotic Lactobacillus-based therapies could be effective in combating these problematic fungal infections.
Article
Infectious Diseases
Paula Faria-Goncalves, Carlos Gaspar, Ana Sofia Oliveira, Rita Palmeira-de-Oliveira, Teresa Goncalves, Jose Martinez-de-Oliveira, Ana Palmeira-de-Oliveira, Joana Rolo
Summary: This study aimed to assess the mechanisms leading to Candida spp persistence in women with chronic vulvovaginal candidosis, focusing on strains genotypes, azole resistance, and ability to form biofilms. The results showed that related strains with increased fluconazole resistance and enhanced biofilm formation capacity were correlated with recurrent cases caused by C. glabrata, highlighting the importance of these factors in enhancing persistence in the vaginal mucosa for this particular species.
Article
Immunology
Jingyun Zhang, Jingwen Peng, Dongmei Li, Huan Mei, Yu Yu, Xiaofang Li, Xiaodong She, Weida Liu
Summary: Vulvovaginal candidiasis is characterized by inflammatory responses in the vagina caused by Candida albicans and non-albicans Candida species. This study found that different Candida strains and species induce different host immune responses and epithelial damage. The EGFR-MAPK signaling pathway plays an important role in the pathogenesis of vulvovaginal candidiasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Zhixia Chen, Jing Jin, Huichao Chen, Ying Chen, Shuyi Feng
Summary: The incidence of vaginal infection caused by Candida species has increased over the past two decades. Candida albicans is the main cause of vulvovaginal candidiasis (VVC), but non-albicans Candida (NAC) species are now frequently identified in VVC patients. The fungal influence on bacterial communities and potential microbial interaction contributing to VVC pathology in NAC species-associated VVC remain unclear. Taxonomic analysis revealed that the vaginal microbiome in C. glabrata-associated VVC women is different from that of other Candida species-associated VVC women, suggesting a different pathogenesis.
MICROBIAL PATHOGENESIS
(2023)
Article
Nursing
Karin Windsperger, Herbert Kiss, Wilhelm Oberaigner, Hermann Leitner, Franz Binder, Dana A. Muin, Philipp Foessleitner, Peter W. Husslein, Alex Farr
Summary: A large nationwide cohort study in Austria over an 8-year period found that exposure to high and medium light pollution during night-time is associated with increased odds of prolonged labor and adverse neonatal outcomes. The study suggests that the negative impact of light pollution on obstetric outcomes needs to be re-evaluated to minimize associated health risks.
BIRTH-ISSUES IN PERINATAL CARE
(2022)
Article
Nursing
Michael Wagner, Veronica Falcone, Sabrina B. Neururer, Hermann Leitner, Irmgard Delmarko, Herbert Kiss, Angelika Berger, Alex Farr
Summary: During the first wave of the COVID-19 pandemic, perinatal and postpartum care significantly differed from that provided before, with increased rates of adverse events highlighting the importance of ensuring access to high-quality obstetric care.
BIRTH-ISSUES IN PERINATAL CARE
(2022)
Article
Dermatology
Elke Weisshaar, Philipp Bentz, Christian Apfelbacher, Eva Haufe, Luise Heinrich, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Julia Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Sung-Hei Hong-Weldemann, Bernhard Homey, Jens-Joachim Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
Summary: TREATgermany is a disease registry that investigates the severity, symptoms, treatment, and quality of life in patients with moderate to severe atopic dermatitis. The results show that 97.2% of patients experienced itch, and the severity of itch is correlated with the patient's self-reported disease severity.
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Dermatology
Elke Weisshaar, Philipp Bentz, Eva Haufe, Luise Heinrich, Christian Apfelbacher, Annice Heratizadeh, Susanne Abraham, Inken Harder, Andreas Kleinheinz, Andreas Wollenberg, Knut Schaekel, Franca Wiemers, Konstantin Ertner, Matthias Augustin, Julia Wildberger, Ralph von Kiedrowski, Margitta Worm, Alexander Zink, Isaak Effendy, Andrea Asmussen, Mario Pawlak, Michael Sticherling, Melanie Hilgers, Christiane Handrick, Sven Quist, Beate Schwarz, Magnus Bell, Petra Staubach-Renz, Su-Hei Hong-Weldemann, Bernhard Homey, Jens Bruecher, Stephan Weidinger, Thomas Werfel, Jochen Schmitt
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Pietro Nenoff, Dieter Reinel, Peter Mayser, Dietrich Abeck, Guntram Bezold, Philipp P. Bosshard, Jochen Brasch, Georg Daeschlein, Isaak Effendy, Gabriele Ginter-Hanselmayer, Yvonne Graeser, Gudrun Hamm, Ulrich Hengge, Uta-Christina Hipler, Peter Hoeger, Alexandra Kargl, Annette Kolb-Maeurer, Constanze Krueger, Bartosz Malisiewicz, Johannes Mayer, Hagen Ott, Uwe Paasch, Martin Schaller, Silke Uhrlass, Miriam Zidane
Summary: Onychomycosis is a fungal infection of the fingernails and toenails. The updated German S1 guideline aims to simplify the selection and implementation of appropriate diagnostics and treatment for this condition. It is based on current international guidelines and a literature review conducted by a multidisciplinary committee.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Pietro Nenoff, Dieter Reinel, Peter Mayser, Dietrich Abeck, Guntram Bezold, Philipp P. Bosshard, Jochen Brasch, Georg Daeschlein, Isaak Effendy, Gabriele Ginter-Hanselmayer, Yvonne Graeser, Gudrun Hamm, Ulrich Hengge, Uta-Christina Hipler, Peter Hoeger, Alexandra Kargl, Annette Kolb-Maeurer, Constanze Krueger, Bartosz Malisiewicz, Johannes Mayer, Hagen Ott, Uwe Paasch, Martin Schaller, Silke Uhrlass, Miriam Zidane
Summary: Onychomycosis is a common fungal infection of the nails. The German S1-guideline provides updated recommendations for the diagnosis and treatment of onychomycosis based on current international guidelines and expert literature review. The guideline was developed by a multidisciplinary committee and approved by participating medical societies following comprehensive internal and external reviews.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Andrea Lietz, Fanny Eckel, Herbert Kiss, Marion Noe-Letschnig, Alex Farr
Summary: The study aimed to assess the health-related quality of life (QoL) in women with recurrent vulvovaginal candidosis (RVVC) using validated questionnaires and analyze the impact of RVVC on sexual health. The results showed that after a 6-months maintenance treatment, the QoL and sexual health of the patients significantly improved.
Article
Multidisciplinary Sciences
Ljubomir Petricevic, Ingo Rosicky, Herbet Kiss, Nina Janjic, Ulrike Kaufmann, Iris Holzer, Alex Farr
Summary: This study aimed to treat pregnant women in the first trimester with intermediate bacterial microbiota imbalance by using a vaginally applied lactobacilli preparation to restore the normal microbiota and delay preterm delivery. The results showed that among women without lactobacilli, those who received treatment had a significant decrease in Nugent score and higher gestational age at delivery and neonatal birthweight compared to the untreated group.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Melissa Amyx, Marianne Philibert, Alex Farr, Serena Donati, Alexander K. Smarason, Vlad Tica, Petr Velebil, Sophie Alexander, Melanie Durox, Maria Fernandez Elorriaga, Guenther Heller, Theopisti Kyprianou, Ewa Mierzejewska, Ivan Verdenik, Irisa Zile-Velika, Jennifer Zeitlin
Summary: The study assessed changes in caesarean section (CS) rates in Europe from 2015 to 2019, and used the Robson Ten Group Classification System (TGCS) to evaluate the contribution of different obstetric populations to overall CS rates and trends. The findings showed that CS rates and trends varied among the 28 European countries. The TGCS analysis revealed that labour induction increased in most countries, while multiple pregnancies decreased. Countries with decreasing CS rates tended to see decreases across all TGCS groups, whereas countries with increasing rates tended to see increases in most groups. In countries with the greatest increase in CS rates, the absolute contribution of certain TGCS groups to the overall CS rate tended to increase.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Dermatology
Stephan Traidl, Luise Heinrich, Doreen Siegels, Lennart Roesner, Eva Haufe, Inken Harder, Susanne Abraham, Konstantin Ertner, Andreas Kleinheinz, Knut Schaekel, Andreas Wollenberg, Isaak Effendy, Sven Quist, Andrea Asmussen, Julia Wildberger, Elke Weisshaar, Franka Wiemers, Jens-Joachim Bruecher, Stephan Weidinger, Jochen Schmitt, Thomas Werfel, TREATgermany Study Grp
Summary: The study investigated the frequency and clinical features of patients with eczema herpeticum (EH) in a German cohort of atopic dermatitis (AD) patients. The results showed a high prevalence and recurrence rate of EH, with an increase in allergies as a common characteristic among EH patients.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Dermatology
Thomas Birkner, Doreen Siegels, Luise Heinrich, Eva Haufe, Susanne Abraham, Annice Heratizadeh, Inken Harder, Magnus Bell, Isabell Fell, Margitta Worm, Christiane Handrick, Isaak Effendy, Andrea Asmussen, Andreas Kleinheinz, Bernhard Homey, Michael Sticherling, Sung-Hei Hong-Weldemann, Matthias Augustin, Elke Weisshaar, Knut Schaekel, Thomas Schaefer, Beate Schwarz, Franca Wiemers, Jens-Joachim Bruecher, Sven Quist, Andreas Wollenberg, Tilo Biedermann, Konstantin Ertner, Ralph von Kiedrowski, Thomas Werfel, Stephan Weidinger, Jochen Schmitt, TREATgermany Study Group
Summary: TREATgermany is a multicenter registry study conducted in Germany, involving patients with moderate-to-severe atopic dermatitis (AD). The study found that AD has a negative impact on the work productivity of patients, and there are significant associations between work productivity and itch, sleep loss, depressive symptoms, and fatigue.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)
Article
Medicine, General & Internal
Philipp Foessleitner, Marie-Christin Budil, Stefanie Mayer, Felix Kraft, Mira Stephanie Zeilberger, Julia Deinsberger, Alex Farr
Summary: Peripartum maternal admission to the intensive care unit poses challenges and requires understanding of altered maternal physiology, fetal considerations, and acute emergencies. This study analyzed data of peripartum admissions to the intensive care unit to identify trends over 15 years. The study found consistent patient characteristics and admission diagnoses, with an increase in postpartum hemorrhage and cesarean hysterectomy, but a reduction in preterm births and neonatal intensive care unit admission.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Fanny Eckel, Katrin Klebermass-Schrehof, Zsuzsanna Bago-Horvath, Alex Farr
Summary: Delayed interval delivery is an important approach to prolonging pregnancy and improving outcomes in multiple pregnancies, particularly in cases of preterm birth or stillbirth of the first fetus.
Article
Medicine, General & Internal
Eva Karner, Gregor J. Kasprian, Alex Farr, Elisabeth Krampl-Bettelheim
Summary: This case report presents a patient with a monochorionic twin pregnancy, development of twin-twin transfusion-syndrome (TTTS) and polymicrogyria (PMG) of one fetus. The patient underwent fetoscopic laser ablation at gestational week 16+1 due to TTTS grade 3. Sonographic follow-up revealed a cortical malformation in the former donor, identified as PMG through MRI scans. The report describes the course of the pregnancy and the clinical development of the child over 3 years, highlighting the power of neuroplasticity for a good neurological outcome despite extensive cortical malformation. Additionally, it stresses the importance of thorough prenatal imaging characterization for optimal prenatal counseling in cases of cortical developmental malformations.
Meeting Abstract
Dermatology
Beate Schwarz, Isaak Effendy, Christian Kors, Konstantinos Fotiou, Teodora Festini, Lara Spina, Christian Machacek, Andreas Pinter, Diamant Thaci
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2023)