Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism

Structural basis for the recognition of the SARS-CoV-2 by full-length human ACE2

(2020) Renhong Yan et al.   SCIENCE

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

(2020) Xintian Xu et al.   Science China-Life Sciences

Cloroquina y sus derivados en el manejo de la COVID-19: una revisión exploratoria

(2020) Juan Pimentel et al.   Biomedica

COVID-19 infections are also affected by human ACE1 D/I polymorphism

(2020) Joris R. Delanghe et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

(2020) Jacques Fantini et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

In silico study the inhibition of angiotensin converting enzyme 2 receptor of COVID-19 by Ammoides verticillata components harvested from Western Algeria

(2020) Imane Abdelli et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structural variations in human ACE2 may influence its binding with SARS-CoV-2 spike protein

(2020) Mushtaq Hussain et al.   JOURNAL OF MEDICAL VIROLOGY

Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

(2020) Xin Zou et al.   Frontiers of Medicine

Acute chloroquine and hydroxychloroquine toxicity: A review for emergency clinicians

(2020) Alessandra Della Porta et al.   AMERICAN JOURNAL OF EMERGENCY MEDICINE

Remdesivir improved time to recovery in adults hospitalized with COVID-19 and lower respiratory tract involvement

(2020) Susmita Paladugu et al.   ANNALS OF INTERNAL MEDICINE

The host’s angiotensin-converting enzyme polymorphism may explain epidemiological findings in COVID-19 infections

(2020) Joris R. Delanghe et al.   CLINICA CHIMICA ACTA

Acute respiratory distress syndrome: a life threatening associated complication of SARS-CoV-2 infection inducing COVID-19

(2020) Riadh Badraoui et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Beyond Anti-viral Effects of Chloroquine/Hydroxychloroquine

(2020) Vincent Gies et al.   Frontiers in Immunology

Early Hydroxychloroquine but not Chloroquine use reduces ICU admission in COVID-19 patients

(2020) A.J.J. Lammers et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

(2020) Xingyi Guo et al.   Journal of Translational Medicine

Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome-Induced Cell Death in Head and Neck Squamous Cell Carcinoma

(2020) Jeremy JP Shaw et al.   MOLECULAR CANCER THERAPEUTICS

Conceptual DFT-Based Computational Peptidology of Marine Natural Compounds: Discodermins A–H

(2020) Norma Flores-Holguín et al.   MOLECULES

Prospects for mucosal vaccine: shutting the door on SARS-CoV-2

(2020) Rajat Mudgal et al.   Human Vaccines & Immunotherapeutics

Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome

(2020) Anton E. Shikov et al.   Frontiers in Genetics

Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study

(2020) Riadh Badraoui et al.   Antioxidants

Repurposing Drugs for COVID-19: Pharmacokinetics and Pharmacogenomics of Chloroquine and Hydroxychloroquine

(2020) Mariana Babayeva et al.   Pharmacogenomics & Personalized Medicine

Plants-Derived Biomolecules as Potent Antiviral Phytomedicines: New Insights on Ethnobotanical Evidences against Coronaviruses

(2020) Arif Jamal Siddiqui et al.   Plants-Basel

microRNA-based autophagy inhibition as targeted therapy in pancreatic cancer

(2020) Sanhong Liang et al.   BIOMEDICINE & PHARMACOTHERAPY

Effect of Opuntia ficus indica extract on methotrexate-induced testicular injury: a biochemical, docking and histological study

(2020) Amira Akacha et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Oxford–AstraZeneca COVID-19 vaccine efficacy

(2020) Maria Deloria Knoll et al.   LANCET

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chloroquine and hydroxychloroquine as ACE2 blockers to inhibit viropexis of 2019-nCoV Spike pseudotyped virus

(2020) Nan Wang et al.   PHYTOMEDICINE

Stapled Peptides Based on Human Angiotensin-Converting Enzyme 2 (ACE2) Potently Inhibit SARS-CoV-2 Infection In Vitro

(2020) Francesca Curreli et al.   mBio

Novel poly(2-oxazoline) block copolymer with aromatic heterocyclic side chains as a drug delivery platform

(2019) Duhyeong Hwang et al.   JOURNAL OF CONTROLLED RELEASE

RCSB Protein Data Bank: Enabling biomedical research and drug discovery

(2019) David S. Goodsell et al.   PROTEIN SCIENCE

Ensembl 2020

(2019) Andrew D Yates et al.   NUCLEIC ACIDS RESEARCH

Cardiac Complications Attributed to Chloroquine and Hydroxychloroquine: A Systematic Review of the Literature

(2018) Clotilde Chatre et al.   DRUG SAFETY

The clinical value of using chloroquine or hydroxychloroquine as autophagy inhibitors in the treatment of cancers

(2018) Ran Xu et al.   MEDICINE

Hydroxychloroquine retinopathy — implications of research advances for rheumatology care

(2018) April Jorge et al.   Nature Reviews Rheumatology

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Synthesis of chiral chloroquine and its analogues as antimalarial agents

(2014) Manish Sinha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quinolines and structurally related heterocycles as antimalarials

(2010) Kirandeep Kaur et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading

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