Article
Plant Sciences
Valerija Krizhanovska, Inga Sile, Arta Kronberga, Ilva Nakurte, Ieva Mezaka, Maija Dambrova, Osvalds Pugovics, Solveiga Grinberga
Summary: The study found significant differences in the phytochemical composition and cytotoxic activity of Chelidonium majus extracts between wild-grown and organically cultivated specimens. Cultivation resulted in a significant increase in alkaloid content and enhanced cytotoxicity of the extracts.
Article
Food Science & Technology
Shivraj Hariram Nile, Hui Wang, Arti Nile, Xianmin Lin, Huilin Dong, Baskar Venkidasamy, Elwira Sieniawska, Gansukh Enkhtaivan, Guoyin Kai
Summary: Metabolic variations, antioxidant potential and cytotoxic effects were investigated in different parts of C. majus L. using spectroscopic and chromatographic methods. The results revealed that the flower extract showed higher antioxidant activity, while the pod and leaf extracts exhibited higher cytotoxic effects in the in vitro SRB assay. These findings suggest promising potential for the development of high value products for phytomedicine applications.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Oskar Musidlak, Alicja Warowicka, Justyna Broniarczyk, Damian Adamczyk, Anna Gozdzicka-Jozefiak, Robert Nawrot
Summary: Latex of Chelidonium majus L. has antiviral and antitumor properties, with alkaloids and proteins playing important roles in its pharmacological activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Alicja Warowicka, Badr Qasem, Anna Dera-Szymanowska, Maria Wolun-Cholewa, Patryk Florczak, Nikodem Horst, Marta Napierala, Krzysztof Szymanowski, Lukasz Popenda, Grazyna Bartkowiak, Ewa Florek, Anna Gozdzicka-Jozefiak, Piotr Mlynarz
Summary: The study found that protoberberine compounds from Chelidonium majus effectively prevent the recurrence of endometriosis in rats. Metabolomics analysis revealed significant changes in metabolite concentrations related to energy homeostasis after treatment. This suggests that natural protoberberine plant compounds have pharmaceutical activity and further research should focus on understanding their mechanisms of action.
Article
Chemistry, Medicinal
Nilo E. Gardin, Anne Jacqueline Braga
Summary: A study on the use of greater celandine in treating COVID-19 outpatients revealed that most patients experienced complete or near complete clinical improvement within 1-9 days of treatment, with symptoms such as fever, fatigue, cough, sore throat, coryza, anosmia, ageusia, and headache. This small case series may inspire further research on Chelidonium majus as a potential therapeutic option for COVID-19.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maciej Strzemski, Slawomir Dresler, Beata Podkoscielna, Kamil Skic, Ireneusz Sowa, Daniel Zaluski, Rob Verpoorte, Sylwia Zielinska, Pawel Krawczyk, Magdalena Wojciak
Summary: This study evaluated the potential of using volatile natural deep eutectic solvents (VNADESs) for the efficient and environmentally friendly extraction of Chelidonium alkaloids. The results showed that the use of appropriate VNADESs formulations led to higher extraction yields compared to traditional methods.
Article
Chemistry, Physical
Sylwia Zielinska, Adam Matkowski, Karolina Dydak, Monika Ewa Czerwinska, Magdalena Dziagwa-Becker, Mariusz Kucharski, Magdalena Wojciak, Ireneusz Sowa, Stanislawa Plinska, Karol Fijalkowski, Daria Ciecholewska-Jusko, Michal Broda, Damian Gorczyca, Adam Junka
Summary: In this study, a bi-functional bacterial-nano-cellulose (BNC) carrier system was developed for cell cultures of Chelidonium majus, a medicinal plant producing antimicrobial compounds. The unpurified BNC synthesized for 3 days exhibited the highest content and most complex composition of pharmacologically active substances, showing anti-inflammatory and antimicrobial activities. This modified composite material has potential applications in combating microbial pathogens.
Article
Agricultural Engineering
Maria Stasinska-Jakubas, Barbara Hawrylak-Nowak, Slawomir Dresler, Magdalena Wojciak, Katarzyna Rubinowska
Summary: Plant elicitors, such as chitosan lactate and salicylic acid, have been extensively used to increase the production of secondary metabolites in vitro. In vivo studies are still needed to fully understand the biological basis of elicitation. Among the compounds studied, chitosan lactate and salicylic acid showed the strongest elicitation effects on phenolic metabolites in lemon balm, while a mixture of elicitors did not significantly change metabolite levels. Additionally, the highest concentrations of metabolites were observed on the 8th day of elicitation, and the elicitors also increased antioxidant activity in plant extracts.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Robert Nawrot, Alicja Warowicka, Piotr Jozef Rudzki, Oskar Musidlak, Katarzyna Magdalena Dolata, Jacek Musijowski, Elzbieta Urszula Stolarczyk, Anna Gozdzicka-Jozefiak
Summary: The study on the interaction between latex protein and alkaloids in Chelidonium majus L. revealed their ability to reduce the viability of cervical cancer cells. This novel approach provides insights into plant defense mechanisms and can contribute to pharmacological research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sadra Hesami, Shahabeddin Safi, Kambiz Larijani, Hassanali Naghdi Badi, Vahid Abdossi, Milad Hadidi
Summary: Essential oils from greater celandine roots and leaves were extracted and loaded into chitosan nanoparticles, with good encapsulation efficiency confirmed. These nanoparticles showed a dose-dependent effect on MCF-7 cell line, with CNPs-GCLEO displaying the highest rate of apoptosis. Encapsulation of GCREO and GCLEO in CNPs proved to be an efficient technique for enhancing their anti-cancer activity against MCF-7 cell line.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Plant Sciences
Ramaraj Sathasivam, Hyeon Ji Yeo, Chang Ha Park, Minsol Choi, Haejin Kwon, Ji Eun Sim, Sang Un Park, Jae Kwang Kim
Summary: This study identified and analyzed the carotenoid biosynthesis pathway genes of Chelidonium majus. The genes showed tissue-specific expression, with the highest levels in flowers. The study provides insights for optimizing carotenoid production in C. majus and lays a foundation for further molecular genetics and functional analysis studies.
Review
Biochemistry & Molecular Biology
Avantika Pandey, Madhoolika Agrawal, Shashi Bhushan Agrawal
Summary: Despite a rich history and economic importance, the potential of medicinal plants has not been fully explored under different abiotic stress conditions. The penetration of UV-B radiation and contamination of heavy metals have a significant impact on the defense-related and pharmaceutically important secondary metabolites of medicinal plants, which can affect both the quality and quantity of these metabolites. Understanding the effects of UV-B and heavy metal contamination on the biosynthesis and accumulation of secondary metabolites is important for the comprehensive study of medicinal plants.
Article
Biochemistry & Molecular Biology
Redouan Elboutachfaiti, Roland Molinie, David Mathiron, Yannis Maillot, Jean-Xavier Fontaine, Serge Pilard, Anthony Quero, Clement Brasselet, Marguerite Dols-Lafargue, Cedric Delattre, Emmanuel Petit
Summary: In this study, it was found that high dose treatment of COS oligosaccharides can indirectly trigger metabolic response modifications in flax plants, especially inducing the accumulation of (neo)lignans in the roots and flavones luteolin C-glycosides, and chlorogenic acid in the shoots.
Article
Biotechnology & Applied Microbiology
Lei Shen, Soon Lee, Jong Cheon Joo, Eunmi Hong, Zhen Yang Cui, Eunbi Jo, Soo Jung Park, Hyun-Jin Jang
Summary: Chelidonium majus induces apoptosis in ovarian cancer cells by regulating the expression levels of ATF3, Tip60, and Foxo3a. This provides evidence for the potential therapeutic role of Chelidonium majus in ovarian cancer.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Plant Sciences
Mohini Kajla, Amit Roy, Indrakant K. Singh, Archana Singh
Summary: Biotic stresses pose a threat to global food security and crop yield worldwide. Plants respond to these stresses by triggering various adaptive changes, including the synthesis and accumulation of plant secondary metabolites. Transcription factors and miRNAs play crucial roles in regulating the production of these metabolites during stress conditions. This review summarizes the role of stress-inducible TFs in synthesizing and accumulating secondary metabolites and highlights how miRNAs fine-tune the expression of stress-responsive transcription factors during biotic stress.
FRONTIERS IN PLANT SCIENCE
(2023)
Review
Engineering, Environmental
Peiman Zandi, Jianjun Yang, Aminu Darma, Elke Bloem, Xing Xia, Yaosheng Wang, Qian Li, Ewald Schnug
Summary: The persistent bioavailability of toxic metals is the leading source of serious environmental problems, and the formation of iron oxyhydroxide plaque on the root surface of hydrophytes significantly affects plant physiology and biomass production.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Plant Sciences
Agnieszka Tatoj, Katarzyna Mozdzen, Beata Barabasz-Krasny, Anna Soltys-Lelek, Wojciech Gruszka, Peiman Zandi
Summary: This study investigates the allelopathic potential of Rosa gorenkensis by examining the germination reactions of mono-and dicotyledonous plant seeds to its aqueous extracts. The results show that the extracts have a negative influence on seed germination and seedling growth, with the extracts from leaves and flowers exhibiting the greatest allelopathic potential.
NOTULAE BOTANICAE HORTI AGROBOTANICI CLUJ-NAPOCA
(2022)
Article
Biology
Aminu Darma, Jianjun Yang, Peiman Zandi, Jin Liu, Katarzyna Mozdzen, Xing Xia, Ali Sani, Yihao Wang, Ewald Schnug
Summary: The article proposes a microbial approach using a group of bacteria to reduce the negative consequences of toxic heavy metal availability in the environment, specifically focusing on arsenic. This innovative strategy can decrease the mobility and uptake of arsenic by plants, and it offers the advantages of low cost and minimal impact on the environment.
Correction
Biochemistry & Molecular Biology
Seyed Mohammad Hashemi, Mohammad Reza Naghavi, Esmaeil Bakhshandeh, Mehdi Ghorbani, Chanditha Priyanatha, Peiman Zandi
Article
Environmental Sciences
Sajjad Hussain, Jianjun Yang, Jamshad Hussain, Abdul Sattar, Subhan Ullah, Imran Hussain, Shafeeq Ur Rahman, Peiman Zandi, Xing Xia, Liandong Zhang
Summary: The study found that different forms of soil mercury can affect the absorption and accumulation of mercury in wheat, with crystalline aluminum and crystalline manganese significantly impacting the transfer of mercury.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Engineering, Environmental
Peiman Zandi, Xing Xia, Jianjun Yang, Jin Liu, Laurent Remusat, Cornelia Rumpel, Elke Bloem, Beata Barabasz Krasny, Ewald Schnug
Summary: This study investigated the distribution of iron plaque and metabolites in rice roots and found some results regarding the uptake and bioavailability of chromium. The results showed that root regions with different maturity levels play an important role in the formation of chromium compounds and the exudation of metabolites.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Green & Sustainable Science & Technology
Angelika Kliszcz, Joanna Pula, Katarzyna Mozdzen, Agnieszka Tatoj, Peiman Zandi, Alina Stachurska-Swakon, Beata Barabasz-Krasny
Summary: In this experiment, the allelopathic potential of Phacelia tanacetifolia was investigated. The water extracts from its roots, stems, leaves, and flowers significantly inhibited the germination and growth of triticale.
Review
Microbiology
Zahra Aghaali, Mohammad Reza Naghavi
Summary: The benefits of biotechnology go beyond genetic engineering and have a great impact on the industrial uses of crops. The production of Polyhydroxyalkanoates (PHAs), a bio-based and biodegradable polymer, can be achieved through genetic engineering of microorganisms and plants. This review summarizes the biotechnological mechanisms used to increase PHAs production in bacteria and plants, and discusses new methods that have not been applied in the field of bioplastics.
CURRENT MICROBIOLOGY
(2023)
Article
Polymer Science
Ferdows Saeedi, Mohammad Reza Naghavi, Manijeh Sabokdast, Parisa Jariani
Summary: The effect of MeJA on the quantity and quality of NR extracted from TKS roots was investigated. It was found that treating TKS with 600 mu M MeJA for 12 h resulted in the highest impact on the relative expression of key genes involved in rubber biosynthesis. This treatment led to a significant increase in the total rubber content extracted from TKS roots.
IRANIAN POLYMER JOURNAL
(2023)
Article
Agriculture, Multidisciplinary
Sadegh Asadi, Hosein Moghaddam, Hassanali Naghdi Badi, Mohammad Reza Naghavi, Seyed Alireza Salami
Summary: The aim of this study was to identify drought-tolerant ecotypes and medicinal and industrial populations of cannabis. 12 cannabis ecotypes were evaluated under different soil moisture conditions, and it was found that they had different responses to soil moisture. Some ecotypes were valuable in terms of pharmaceutical metabolite production, while others were valuable for fibre production. Therefore, tolerant and sensitive ecotypes should be considered in production and breeding programs.
CROP & PASTURE SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Roghayeh Fatemi, Mehrdad Yarnia, Soleman Mohammadi, Ebrahim Khalil Vand, Bahram Mirashkari
Summary: This study evaluated promising lines and commercial barley cultivars in terms of their quantitative and qualitative characteristics under normal and water deficit conditions. Water deficiency significantly reduced various traits and increased certain enzyme activity and protein content. The M-88-2 line showed potential for drought resistance and desirable characteristics. Grain yield had positive correlations with different traits in different environmental conditions.
ASIAN JOURNAL OF AGRICULTURE AND BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zahra Aghaali, Mohammad Reza Naghavi
Summary: Protein engineering plays a crucial role in overcoming challenges related to enzyme function and can be applied to improve the properties of CYP82Y1, an enzyme involved in the biosynthesis of noscapine. This article reviews the methods used to enhance the activity of CYP82Y1 and discusses potential strategies, including substitution of substrate recognition site residues, construction of fusion proteins, and creation of an artificial lipid-based scaffold. These approaches have the potential to accelerate the rate of noscapine synthesis by improving the properties of CYP82Y1.
BIOCHEMICAL JOURNAL
(2023)
Article
Agricultural Engineering
Hamid Ahadi, Majid Shokrpour, Reza Fatahi, Mohammad Reza Naghavi, Mohammad Hossein Mirjalili
Summary: The metabolic diversity of 24 Iranian Rosa damascena genotypes was studied, and major compounds and phytochemical markers were identified. This study provides valuable information for further commercial cultivation and production of essential oils, flavonoids, and anthocyanins.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Agriculture, Multidisciplinary
A. A. Karimi, M. R. Naghavi, S. A. Peighambari, A. Sobhani, A. Rasoulnia
Summary: This study identified 970 miRNAs in Taraxacum spp., with miR5021 being the most frequent one. miR5021 and miR838 play important roles in rubber production in Taraxacum by regulating the expression of HMGCR gene.
JOURNAL OF AGRICULTURAL SCIENCE AND TECHNOLOGY
(2022)
Article
Food Science & Technology
Negin Samadi, Mohammad Reza Naghavi, Natalia Moratalla-Lopez, Gonzalo L. Alonso, Majid Shokrpour
Summary: The study investigated the effects of colchicine and ethyl methanesulfonate (EMS) mutagens on inducing new variations in Crocus sativus L. The results suggest the potential of mutagens in creating new variations in the plant.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2022)