Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity

First-in-Human, First-in-Child Trial of Autologous MSCs Carrying the Oncolytic Virus Icovir-5 in Patients with Advanced Tumors

(2020) David Ruano et al.   MOLECULAR THERAPY

Oncolytic Adenovirus Armed with BiTE, Cytokine, and Checkpoint Inhibitor Enables CAR T Cells to Control the Growth of Heterogeneous Tumors

(2020) Caroline E. Porter et al.   MOLECULAR THERAPY

Systemic oncolytic adenovirus delivered in mesenchymal carrier cells modulate tumor infiltrating immune cells and tumor microenvironment in mice with neuroblastoma

(2020) Lidia Franco-Luzón et al.   Oncotarget

Mesenchymal stem cells as carriers for systemic delivery of oncolytic viruses

(2020) Agata Hadryś et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

(2020) Alireza Labani-Motlagh et al.   Frontiers in Immunology

Modeling the Efficacy of Oncolytic Adenoviruses In Vitro and In Vivo: Current and Future Perspectives

(2020) Mary K. McKenna et al.   Cancers

Engineered off-the-shelf therapeutic T cells resist host immune rejection

(2020) Feiyan Mo et al.   NATURE BIOTECHNOLOGY

Tumor response and endogenous immune reactivity after administration of HER2 CAR T cells in a child with metastatic rhabdomyosarcoma

(2020) Meenakshi Hegde et al.   Nature Communications

Mesenchymal stem cells in suppression or progression of hematologic malignancy: current status and challenges

(2019) Myoung Woo Lee et al.   LEUKEMIA

Killing Mechanisms of Chimeric Antigen Receptor (CAR) T Cells

(2019) Mohamed-Reda Benmebarek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesenchymal stem cell-mediated delivery of an oncolytic adenovirus enhances antitumor efficacy in hepatocellular carcinoma

(2019) A-Rum Yoon et al.   CANCER RESEARCH

Mesenchymal stem cell-mediated delivery of therapeutic adenoviral vectors to prostate cancer

(2019) Tahir Muhammad et al.   Stem Cell Research & Therapy

Correction for Yang et al., “Granzyme B Is an Essential Mediator in CD8+ T Cell Killing of Theileria parva-Infected Cells”

(2019) Jie Yang et al.   INFECTION AND IMMUNITY

Polyfunctional tumor-reactive T cells are effectively expanded from non-small cell lung cancers, and correlate with an immune-engaged T cell profile

(2019) Rosa De Groot et al.   OncoImmunology

Tumor-Infiltrating Immunosuppressive Cells in Cancer-Cell Plasticity, Tumor Progression and Therapy Response

(2019) Laura Lorenzo-Sanz et al.   Cancer Microenvironment

Halfway between 2D and Animal Models: Are 3D Cultures the Ideal Tool to Study Cancer-Microenvironment Interactions?

(2018) Jessica Hoarau-Véchot et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A deep conical agarose microwell array for adhesion independent three-dimensional cell culture and dynamic volume measurement

(2018) Andreas R. Thomsen et al.   LAB ON A CHIP

Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies

(2018) Shashi Gujar et al.   TRENDS IN IMMUNOLOGY

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

Recent Advances in Targeting CD8 T-Cell Immunity for More Effective Cancer Immunotherapy

(2018) Aurélie Durgeau et al.   Frontiers in Immunology

How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive

(2018) Alessandro Poggi et al.   Frontiers in Immunology

CAR-T Cells and Oncolytic Viruses: Joining Forces to Overcome the Solid Tumor Challenge

(2018) Sonia Guedan et al.   Frontiers in Immunology

Adenovirotherapy Delivering Cytokine and Checkpoint Inhibitor Augments CAR T Cells against Metastatic Head and Neck Cancer

(2017) Amanda Rosewell Shaw et al.   MOLECULAR THERAPY

Systemically Infused Mesenchymal Stem Cells Show Different Homing Profiles in Healthy and Tumor Mouse Models

(2017) Chengying Xie et al.   Stem Cells Translational Medicine

Mesenchymal Stromal/Stem Cells: A New Era in the Cell-Based Targeted Gene Therapy of Cancer

(2017) Faroogh Marofi et al.   Frontiers in Immunology

HER2-Specific Chimeric Antigen Receptor–Modified Virus-Specific T Cells for Progressive Glioblastoma

(2017) Nabil Ahmed et al.   JAMA Oncology

Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response

(2017) Qiong Xue et al.   Journal for ImmunoTherapy of Cancer

CCL11, a novel mediator of inflammatory bone resorption

(2017) Elin Kindstedt et al.   Scientific Reports

3D modeling of human cancer: A PEG-fibrin hydrogel system to study the role of tumor microenvironment and recapitulate the in vivo effect of oncolytic adenovirus

(2016) Francesca Del Bufalo et al.   BIOMATERIALS

Darwinian Dynamics of Intratumoral Heterogeneity: Not Solely Random Mutations but Also Variable Environmental Selection Forces

(2016) M. C. Lloyd et al.   CANCER RESEARCH

Biodistribution, migration and homing of systemically applied mesenchymal stem/stromal cells

(2016) Johannes Leibacher et al.   Stem Cell Research & Therapy

Exposure of Human CD4 T Cells to IL-12 Results in Enhanced TCR-Induced Cytokine Production, Altered TCR Signaling, and Increased Oxidative Metabolism

(2016) Aldo Vacaflores et al.   PLoS One

A T-cell-directed chimeric antigen receptor for the selective treatment of T-cell malignancies

(2015) M. Mamonkin et al.   BLOOD

The Antitumor Efficacy of IL2/IL21-Cultured Polyfunctional Neu-Specific T Cells Is TNF /IL17 Dependent

(2015) V. Phan-Lai et al.   CLINICAL CANCER RESEARCH

Clinical development of talimogene laherparepvec (T-VEC): a modified herpes simplex virus type-1–derived oncolytic immunotherapy

(2015) Kevin J Harrington et al.   Expert Review of Anticancer Therapy

Human Epidermal Growth Factor Receptor 2 (HER2) –Specific Chimeric Antigen Receptor–Modified T Cells for the Immunotherapy of HER2-Positive Sarcoma

(2015) Nabil Ahmed et al.   JOURNAL OF CLINICAL ONCOLOGY

Mesenchymal Stromal Cells for Linked Delivery of Oncolytic and Apoptotic Adenoviruses to Non-small-cell Lung Cancers

(2015) Valentina Hoyos et al.   MOLECULAR THERAPY

The challenges and promises of allogeneic mesenchymal stem cells for use as a cell-based therapy

(2015) Jun Zhang et al.   Stem Cell Research & Therapy

Individual Motile CD4 + T Cells Can Participate in Efficient Multikilling through Conjugation to Multiple Tumor Cells

(2015) Ivan Liadi et al.   Cancer Immunology Research

Bortezomib sensitizes non-small cell lung cancer to mesenchymal stromal cell-delivered inducible caspase-9-mediated cytotoxicity

(2014) M Ando et al.   CANCER GENE THERAPY

Eosinophils and Cancer

(2014) B. P. Davis et al.   Cancer Immunology Research

Combinatorial treatment with oncolytic adenovirus and helper-dependent adenovirus augments adenoviral cancer gene therapy

(2014) Lisa Farzad et al.   Molecular Therapy-Oncolytics

Thunder and Lightning: Immunotherapy and Oncolytic Viruses Collide

(2011) Alan Melcher et al.   MOLECULAR THERAPY

Secretion of MIP-1β and MIP-1α by CD8+ T-lymphocytes correlates with HIV-1 inhibition independent of coreceptor usage

(2010) Kevin O. Saunders et al.   CELLULAR IMMUNOLOGY

Concise Review: Dissecting a Discrepancy in the Literature: Do Mesenchymal Stem Cells Support or Suppress Tumor Growth?

(2010) Ann H. Klopp et al.   STEM CELLS

Adenovirus-specific human T cells are pervasive, polyfunctional, and cross-reactive

(2010) Natalie A. Hutnick et al.   VACCINE

The Interleukin-8 Pathway in Cancer

(2008) D. J.J. Waugh et al.   CLINICAL CANCER RESEARCH

Pulmonary Passage is a Major Obstacle for Intravenous Stem Cell Delivery: The Pulmonary First-Pass Effect

(2008) Uwe M. Fischer et al.   STEM CELLS AND DEVELOPMENT