WDR5 facilitates EMT and metastasis of CCA by increasing HIF-1α accumulation in Myc-dependent and independent pathways

Molecular classification and therapeutic targets in extrahepatic cholangiocarcinoma

(2020) Robert Montal et al.   JOURNAL OF HEPATOLOGY

Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design

(2020) Selena Chacón Simon et al.   JOURNAL OF MEDICINAL CHEMISTRY

WD Repeat Domain 5 Promotes Invasion, Metastasis and Tumor Growth in Glioma Through Up-Regulated Zinc Finger E-Box Binding Homeobox 1 Expression

(2020) Bin Dai et al.   Cancer Management and Research

Efficient low-cost chromatin profiling with CUT&Tag

(2020) Hatice S. Kaya-Okur et al.   Nature Protocols

HIF Inhibitors: Status of Current Clinical Development

(2019) Jaleh Fallah et al.   Current Oncology Reports

CUT&Tag for efficient epigenomic profiling of small samples and single cells

(2019) Hatice S. Kaya-Okur et al.   Nature Communications

Transcription factor 7 promotes the progression of perihilar cholangiocarcinoma by inducing the transcription of c-Myc and FOS-like antigen 1

(2019) Zengli Liu et al.   EBioMedicine

Annexin10 promotes extrahepatic cholangiocarcinoma metastasis by facilitating EMT via PLA2G4A/PGE2/STAT3 pathway

(2019) Rongqi Sun et al.   EBioMedicine

Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance

(2019) Lance R. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TMPRSS4 Drives Angiogenesis in Hepatocellular Carcinoma by Promoting HB‐EGF Expression and Proteolytic Cleavage

(2019) Zhao‐Ru Dong et al.   HEPATOLOGY

Sprouty4 correlates with favorable prognosis in perihilar cholangiocarcinoma by blocking the FGFR-ERK signaling pathway and arresting the cell cycle

(2019) Bo Qiu et al.   EBioMedicine

Long noncoding RNA BLACAT2 promotes bladder cancer–associated lymphangiogenesis and lymphatic metastasis

(2018) Wang He et al.   JOURNAL OF CLINICAL INVESTIGATION

Validation Study of the American Joint Committee on Cancer Eighth Edition Prognostic Stage Compared With the Anatomic Stage in Breast Cancer

(2018) Anna Weiss et al.   JAMA Oncology

Moonlighting with WDR5: A Cellular Multitasker

(2018) Alissa Guarnaccia et al.   Journal of Clinical Medicine

Sprouty2 suppresses progression and correlates to favourable prognosis of intrahepatic cholangiocarcinoma via antagonizing FGFR2 signalling

(2018) Yun-Fei Xu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis

(2018) Sai Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

HMGB1 correlates with angiogenesis and poor prognosis of perihilar cholangiocarcinoma via elevating VEGFR2 of vessel endothelium

(2018) Yun-Fei Xu et al.   ONCOGENE

The BioGRID interaction database: 2019 update

(2018) Rose Oughtred et al.   NUCLEIC ACIDS RESEARCH

Cholangiocarcinoma: Current Knowledge and New Developments

(2017) Boris Blechacz   Gut and Liver

HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis

(2017) Hui-Huang Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Cholangiocarcinoma — evolving concepts and therapeutic strategies

(2017) Sumera Rizvi et al.   Nature Reviews Clinical Oncology

PAF1 complex component Leo1 helps recruitDrosophilaMyc to promoters

(2017) Jennifer M. Gerlach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K/AKT-mediated upregulation of WDR5 promotes colorectal cancer metastasis by directly targeting ZNF407

(2017) Xin Tan et al.   Cell Death & Disease

The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry

(2017) Gonçalo C. Vilhais-Neto et al.   Nature Communications

New molecular interactions of c-Myc in cholangiocarcinoma may open new therapeutic opportunities

(2016) Carmen Berasain et al.   HEPATOLOGY

Development and external validation of two nomograms to predict overall survival and occurrence of distant metastases in adults after surgical resection of localised soft-tissue sarcomas of the extremities: a retrospective analysis

(2016) Dario Callegaro et al.   LANCET ONCOLOGY

Hypoxic control of metastasis

(2016) E. B. Rankin et al.   SCIENCE

BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis

(2016) Laia Richart et al.   Nature Communications

In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer

(2016) Alessandro Carugo et al.   Cell Reports

The MYC-WDR5 Nexus and Cancer

(2015) L. R. Thomas et al.   CANCER RESEARCH

Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC

(2015) Lance R. Thomas et al.   MOLECULAR CELL

MYC, Metabolism, and Cancer

(2015) Z. E. Stine et al.   Cancer Discovery

Fibroblast growth factor receptor 4 promotes progression and correlates to poor prognosis in cholangiocarcinoma

(2014) Yun-Fei Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cholangiocarcinoma

(2014) Nataliya Razumilava et al.   LANCET

HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations

(2013) Gregg L. Semenza   JOURNAL OF CLINICAL INVESTIGATION

MYC, Metabolism, Cell Growth, and Tumorigenesis

(2013) C. V. Dang   Cold Spring Harbor Perspectives in Medicine

The role of WDR5 in silencing human fetal globin gene expression

(2012) Z. Xu et al.   HAEMATOLOGICA

Common genetic variants at the 11q13.3 renal cancer susceptibility locus influence binding of HIF to an enhancer of cyclin D1 expression

(2012) Johannes Schödel et al.   NATURE GENETICS

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

Hypoxia Inducible Factor Expression in Intrahepatic Cholangiocarcinoma

(2011) Yuji Morine et al.   HEPATO-GASTROENTEROLOGY

Interplay between HDAC3 and WDR5 Is Essential for Hypoxia-Induced Epithelial-Mesenchymal Transition

(2011) Min-Zu Wu et al.   MOLECULAR CELL

Hypoxia-inducible factor-1α induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition

(2009) Shiren Sun et al.   KIDNEY INTERNATIONAL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL