Heterologous expression of cryptic biosynthetic gene cluster from Streptomyces prunicolor yields novel bicyclic peptide prunipeptin

Genome Mining Reveals High Topological Diversity of ω-Ester-Containing Peptides and Divergent Evolution of ATP-Grasp Macrocyclases

(2020) Hyunbin Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterologous expression of a cryptic gene cluster from Grimontia marina affords a novel tricyclic peptide grimoviridin

(2020) Kohta Unno et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Unlocking the Spatial Control of Secondary Metabolism Uncovers Hidden Natural Product Diversity in Nostoc punctiforme

(2019) Daniel Dehm et al.   ACS Chemical Biology

Introduction of Bifunctionality into the Multidomain Architecture of the ω-Ester-Containing Peptide Plesiocin

(2019) Chanwoo Lee et al.   BIOCHEMISTRY

A distributive peptide cyclase processes multiple microviridin core peptides within a single polypeptide substrate

(2018) Yi Zhang et al.   Nature Communications

Heterologous Production of Microbial Ribosomally Synthesized and Post-translationally Modified Peptides

(2018) Yi Zhang et al.   Frontiers in Microbiology

A topologically distinct modified peptide with multiple bicyclic core motifs expands the diversity of microviridin-like peptides

(2018) Heejin Roh et al.   CHEMBIOCHEM

Leader Peptide-Free In Vitro Reconstitution of Microviridin Biosynthesis Enables Design of Synthetic Protease-Targeted Libraries

(2016) Emmanuel Reyna-González et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combinatorial biosynthesis of RiPPs: docking with marine life

(2016) Debosmita Sardar et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Isolation of a new antibacterial peptide achromosin from Streptomyces achromogenes subsp. achromogenes based on genome mining

(2016) Issara Kaweewan et al.   JOURNAL OF ANTIBIOTICS

Isolation of a new antibacterial peptide actinokineosin fromActinokineospora spheciospongiaebased on genome mining

(2016) N. Takasaka et al.   LETTERS IN APPLIED MICROBIOLOGY

Structural basis for precursor protein–directed ribosomal peptide macrocyclization

(2016) Kunhua Li et al.   Nature Chemical Biology

Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria

(2015) Melinda L. Micallef et al.   BMC GENOMICS

Leading the way to RiPPs

(2015) A James Link   Nature Chemical Biology

Harnessing the Evolvability of Tricyclic Microviridins To Dissect Protease-Inhibitor Interactions

(2014) Annika R. Weiz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria

(2014) Anne-Catrin Letzel et al.   BMC GENOMICS

Functional Analysis of Environmental DNA-Derived Microviridins Provides New Insights into the Diversity of the Tricyclic Peptide Family

(2013) Douglas Gatte-Picchi et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Expanded genetic code for the engineering of ribosomally synthetized and post-translationally modified peptide natural products (RiPPs)

(2013) Nediljko Budisa   CURRENT OPINION IN BIOTECHNOLOGY

Leader Peptide and a Membrane Protein Scaffold Guide the Biosynthesis of the Tricyclic Peptide Microviridin

(2011) Annika R. Weiz et al.   CHEMISTRY & BIOLOGY

Exploiting the Natural Diversity of Microviridin Gene Clusters for Discovery of Novel Tricyclic Depsipeptides

(2010) N. Ziemert et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Overlap extension PCR cloning: a simple and reliable way to create recombinant plasmids

(2010) Anton Bryksin et al.   BIOTECHNIQUES

Structure-activity relationship of marinostatin, a serine protease inhibitor isolated from a marine organism

(2010) Misako Taichi et al.   JOURNAL OF PEPTIDE SCIENCE

Ribosomal Synthesis of Tricyclic Depsipeptides in Bloom-Forming Cyanobacteria

(2008) Nadine Ziemert et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Post-translational Modification in Microviridin Biosynthesis

(2008) Benjamin Philmus et al.   CHEMBIOCHEM