Article
Biotechnology & Applied Microbiology
Asghar Taheri-Kafrani, Hamidreza Shirzadfar, Abolghasem Abbasi Kajani, Bassam K. Kudhair, Layth Jasim Mohammed, Shima Mohammadi, Fatemeh Lotfi
Summary: The study presented a simple method for synthesizing superparamagnetic graphene oxide (SPMGO) nanocomposite using a chemical precipitation method as efficient drug carriers, functionalized with cyanuric chloride as a linker for drug loading. Characterization techniques including FTIR spectroscopy, TEM, AFM, TGA, XRD, and XPS confirmed the successful synthesis. In vitro assays demonstrated that the SPMGO/CC/MTX nanocarrier system showed high biocompatibility, enhanced drug efficiency against various cell lines, and controlled drug release, indicating great potential for targeted drug delivery in chemotherapy with methotrexate.
JOURNAL OF BIOTECHNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yuqiang Li, Yitong Jiang, Ziyan Zheng, Nan Du, Shuli Guan, Wenxuan Guo, Xiaohu Tang, Jiajunzi Cui, Lanqiong Zhang, Kunpeng Liu, Qingsong Yu, Zhihua Gan
Summary: The limited availability of anticancer drugs and drug resistance have made monotherapy-based cancer therapy challenging. Combination therapy using currently available drugs is a potential alternative, but the barrier between in vitro screening and in vivo delivery hinders its application. This study proposes a precise drug delivery strategy using engineered nanomedicine to overcome this limitation and facilitate individualized combination therapy.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Jia-Xin Cai, Ji-Hua Liu, Jun-Yong Wu, Yong-Jiang Li, Xiao-Han Qiu, Wen-Jie Xu, Ping Xu, Da-Xiong Xiang
Summary: This study developed a targeted nano-carrier and evaluated its anti-cancer efficacy both in vitro and in vivo. The results demonstrated that the nano-carrier successfully delivered the drug to osteosarcoma cells and exhibited significant anti-cancer effects, while causing minimal damage to normal tissues.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jingjing Jiang, Renxian Wang, Liang Yang, Yongjie Sha, Songsong Zhao, Jianxun Guo, Dafu Chen, Zhiyuan Zhong, Fenghua Meng
Summary: In this study, researchers modified nanodelivery of chemotherapeutics with IL-11R alpha specific peptide to enhance the specificity and anti-tumor efficacy of chemotherapy for osteosarcoma. The results showed that IL-11R alpha targeted nanodelivery could effectively inhibit the growth and metastasis of osteosarcoma and improve the survival rate of patients.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Physical
Niloufar Torabi Fard, Fariba Tadayon, Homayon Ahmad Panahi, Elham Moniri
Summary: In this study, a new type of polyester dendrimer was synthesized and used as a carrier for sustained delivery of the antidepressant drug venlafaxine hydrochloride. The attachment of polyester dendrimer onto graphene oxide was confirmed, and the adsorption and release mechanisms of the drug were investigated. The cytotoxicity of the carrier was also evaluated.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Analytical
Hui Chen, Longqiang Xing, Huiru Guo, Caixia Luo, Xuedian Zhang
Summary: The study presents a graphene oxide-based nanocarrier for dual-drug delivery to tumor cells, showing enhanced cytotoxicity against cancer cells at relatively low drug concentrations. The nanocarriers exhibit increased tumor selectivity due to the combination of active and passive targeting mechanisms, as well as the drug release in response to the acidic microenvironment within cells.
Article
Pharmacology & Pharmacy
Shangmin Yu, Xinying Wang, Linlin Lv, Tongyan Liu, Qingxiang Guan
Summary: Depression is a chronic mental disorder that poses a threat to human health and well-being. The treatment of depression is challenging due to the blood brain barrier, which limits the distribution of antidepressant drugs in the brain. This study developed a brain-targeted drug delivery system using borneol-modified PEGylated graphene oxide, which showed promising potential for the treatment of depression by efficiently penetrating the blood brain barrier and exhibiting neuroprotective effects.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Nicole Baeumer, Jessica Tiemann, Annika Scheller, Theresa Meyer, Lisa Wittmann, Matias Ezequiel Gutierrez Suburu, Lilo Greune, Matthias Peipp, Neele Kellmann, Annika Gumnior, Caroline Brand, Wolfgang Hartmann, Claudia Rossig, Carsten Muller-Tidow, Dario Neri, Cristian A. Strassert, Christian Rueter, Petra Dersch, Georg Lenz, H. Phillip Koeffler, Wolfgang E. Berdel, Sebastian Baeumer
Summary: A study found that the small arginine-rich protein protamine can condense genomic DNA into the sperm head, and its high RNA binding capacity can be utilized for the spontaneous electrostatic assembly of therapeutic nanoparticles decorated with tumor-cell-specific antibodies for efficient targeting of siRNA. These nanoparticles showed promising results in treating non-small-cell lung cancer and Ewing sarcoma models.
Article
Pharmacology & Pharmacy
Chen Zhang, Zheng Jin, Yuhong Lin, Yiyu Wang, Kai Zhao
Summary: In this study, mannosefunctionalized N-2-HACC nanoparticles loaded with doxorubicin and indocyanine green were synthesized by the ion-crosslinking method. The nanoparticles showed good dispersibility and size. Under near-infrared irradiation, these nanoparticles could significantly reduce the dosage of doxorubicin and reduce the toxic side-effects on normal tissues.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Chemistry, Physical
Zeinab Mirzaei-Kalar, Zahra Kiani Nejad, Ali Akbar Khandar
Summary: The current study focuses on the synthesis and characterization of ZnFe2O4@SiO2@GQDs nanoparticles, and evaluates their potential in targeted drug delivery. The results demonstrate the pH-sensitive release behavior of the nanoparticles, as well as their strong interaction with CT-DNA and enhanced drug loading capacity. In cell experiments, the nanoparticles exhibit concentration-dependent cytotoxicity on cancer cells, inducing apoptosis and cell cycle arrest.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Pharmacology & Pharmacy
Noyel Ghosh, Mousumi Kundu, Sumit Ghosh, Abhishek Kumar Das, Samhita De, Joydeep Das, Parames C. Sil
Summary: Cancer is a global disease and the use of phytochemicals with inherent anticancer efficacy is important. Nanotechnology is essential to enhance the bioavailability and therapeutic efficacy of these phytochemicals. In this study, folic acid conjugated polyacrylic acid capped mesoporous silica nanoparticles were used for targeted delivery of chrysin to breast cancer cells. Chrysin loaded nanoparticles showed increased cytotoxicity and induced apoptosis in the cancer cells. Furthermore, in tumor-bearing mice, the nanoparticles enhanced the anti-neoplastic effects of chrysin. This study highlights the potential of chrysin and the importance of nanotechnology in biomedical research.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Physics, Applied
Malakehsadat Seyedmousavi, Morteza Rouhani, Zohreh Mirjafary
Summary: This study investigated the potential of doped graphene nanoflakes as a carrier for the anticancer drug letrozole using density functional theory calculations. The results showed that B(OH)(2)-functionalized graphene nanoflakes could be considered as a promising nanocarrier candidate for LT delivery.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Review
Pharmacology & Pharmacy
Esinam E. Agbosu, Scott Ledger, Anthony D. Kelleher, Jing Wen, Chantelle L. Ahlenstiel
Summary: Our understanding of HIV infection has improved since its discovery in 1983, but a cure still remains elusive. The presence of a latent viral reservoir is a major barrier, and different strategies are being explored to eliminate or suppress it. RNA therapeutics, including siRNA and CRISPR gRNA, are potential options for achieving a functional cure. However, effective delivery into host cells remains a challenge for advancing RNA therapeutics to the clinic.
Article
Materials Science, Biomaterials
Kiruthiga Kaliyamoorthy, Archana Sumohan Pillai, Aleyamma Alexander, Anitha Arivarasu, Israel V. M. V. Enoch, Sivaraj Ramasamy
Summary: This study focuses on the design of biocompatible polymer-coated magnetic nanoparticles for efficient delivery of anticancer drugs, demonstrating sustained release in vitro and enhanced inhibition of cancer cell lines. The results suggest great potential for magnetic nanocarriers in drug transport.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Abbas Nezhadebrahimi, Hamid Sepehri, Mehrdad Jahanshahi, Majid Marjani, Abdoljalal Marjani
Summary: This study assessed the effect of simvastatin on gene expression in rat hepatic tissues fed with high-fat diets and its association with biochemical parameters.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Bardia Vadiati Saberi, Farouq Yousefi, Tooba Yousefi, Durdi Qujeq
Summary: This study determined the correlation between mucin and alpha-amylase protein levels in gingival crevicular fluid (GCF) with chronic periodontitis. The results showed that the levels of both markers were higher in patients with chronic periodontitis compared to successfully recovered patients, suggesting that they could be used to determine the activity of periodontal disease.
Article
Biochemistry & Molecular Biology
Fatemeh Sadeghsoltani, Iraj Mohammadzadeh, Mir-Meghdad Safari, Parisa Hassanpour, Melika Izadpanah, Durdi Qujeq, Soheila Moein, Mostafa Vaghari-Tabari
Summary: This narrative review explores the importance of zinc in the anti-viral immune response in the respiratory tract and its defense against influenza, RSV, and SARS-COV2 infections. The findings suggest that zinc plays a role in reducing viral titer, alleviating symptoms, preventing ARDS, and enhancing the effectiveness of treatments in COVID-19 patients. However, the relationship between zinc levels and the effectiveness of respiratory viruses' vaccines remains unclear and somewhat contradictory.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Review
Medical Laboratory Technology
Anvarsadat Kianmehr, Durdi Qujeq, Abouzar Bagheri, Abdolkarim Mahrooz
Summary: Vascular endothelial cells respond to physicochemical stimuli, with oxidized low-density lipoprotein contributing to atherosclerosis. MicroRNAs play a role in cellular homeostasis under stress and can serve as therapeutic targets and biomarkers.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2022)
Review
Food Science & Technology
Mostafa Vaghari-Tabari, Iraj Mohammadzadeh, Durdi Qujeq, Maryam Majidinia, Forough Alemi, Simin Younesi, Ata Mahmoodpoor, Masomeh Maleki, Bahman Yousefi, Zatollah Asemi
Summary: Respiratory viral infections are common and unregulated immune response can cause inflammation and tissue damage. Regulating the antiviral immune response in the respiratory tract is important. Recent studies highlight the importance of vitamin D in respiratory viral infections. Vitamin D, in addition to regulating phosphorus and calcium metabolism, can also regulate immune response, providing protection against respiratory viral infections and preventing excessive inflammation and tissue damage.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Seyed Mostafa Mir, Azadeh Aliarab, Golnaz Goodarzi, Moein Shirzad, Seyyed Mehdi Jafari, Durdi Qujeq, Sadra Samavarchi Tehrani, Jahanbakhsh Asadi
Summary: DNA repair is crucial for protecting DNA molecules from damage caused by various factors, and melatonin plays a role in this repair process by acting as an antioxidant. The mechanisms of DNA repair, such as homologous recombination repair and non-homologous end-joining, are important for maintaining DNA integrity.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Medicine, Research & Experimental
Roja Aghajani, Mohsen Saeidi, Taghi Amiriani, Majid Marjani, Abdoljalal Marjani
Summary: The study revealed significant correlations between IL18 levels and metabolic syndrome components in male and female Iranian Fars ethnic group, indicating the potential utility of IL18 as a biomarker for managing metabolic syndrome components and cardiovascular disease risk factors across different ages and genders.
METABOLIC SYNDROME AND RELATED DISORDERS
(2022)
Review
Oncology
Mostafa Vaghari-Tabari, Niloufar Targhazeh, Soheila Moein, Durdi Qujeq, Forough Alemi, Maryam Majidina, Simin Younesi, Zatollah Asemi, Bahman Yousefi
Summary: Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with relapse and remission periods, and it increases the risk of colorectal cancer, especially in patients with Ulcerative colitis. The importance of miRNAs in the pathophysiology of IBD and colorectal cancer has been recognized, and they may be potential therapeutic targets.
CANCER CELL INTERNATIONAL
(2022)
Review
Food Science & Technology
Lei Yan, Mostafa Vaghari-Tabari, Faezeh Malakoti, Soheila Moein, Durdi Qujeq, Bahman Yousefi, Zatollah Asemi
Summary: Various studies have shown that quercetin has beneficial therapeutic effects in various human diseases, including diabetes. Quercetin has significant anti-diabetic effects and may be helpful in lowering blood sugar and increasing insulin sensitivity. It also has positive effects in preventing and ameliorating diabetic complications, possibly due to its anti-inflammatory and anti-oxidant properties.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Pharmacology & Pharmacy
Negin Soghli, Gordon A. Ferns, Fatemeh Sadeghsoltani, Durdi Qujeq, Tooba Yousefi, Mostafa Vaghari-Tabari
Summary: This article discusses the role of various signaling pathways and associated miRNAs in the metastasis of osteosarcoma (OS), aiming to provide a comprehensive review of literature on OS metastasis and chemosensitivity. It highlights the potential of miRNA mimics and antagomiRs in inhibiting OS metastasis and increasing chemosensitivity, suggesting their potential clinical application.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Niloufar Targhazeh, Russel J. Reiter, Mahdi Rahimi, Durdi Qujeq, Tooba Youse, Mohammad Hassan Shahavi, Seyed Mostafa Mir
Summary: Melatonin, as the main secretory product of the pineal gland, not only regulates circadian rhythms, mood, and sleep, but also plays a role in the regulation of neoplastic processes. It can act as a differentiating agent in some cancer cells and reduce the invasive and metastatic status through cytosolic binding sites and nuclear receptors. Melatonin has oncostatic functions and can reduce the invasiveness of various human cancers. It exerts its effects through different biological processes such as antiproliferation, stimulation of anticancer immunity, modulation of the cell cycle, apoptosis, autophagy, modulation of oncogene expression, and antiangiogenesis.
Article
Biochemistry & Molecular Biology
Abdoljalal Marjani, Nahid Poursharifi, Mohammad Mostakhdem Hashemi, Atefe Sajedi, Mahin Tatari
Summary: The aim of this study was to evaluate the association between PON1 Q192R and L55M gene polymorphisms and its enzyme activity with the components of metabolic syndrome. The results showed that the PON1 Q192R genotypes had effects on PON1 activity and HDL-cholesterol level in patients with metabolic syndrome.
HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Ali Nosrati Andevari, Soheila Moein, Durdi Qujeq, Zoleika Moazezi, Karimollah Hajian Tilaki
Summary: This study evaluated the effect of atorvastatin on the concentrations of MGO, GLO-1, and AKR1B10 in patients with T2DM and prediabetes. The results showed that statins decreased MGO levels in patients with T2DM, but increased MGO levels in patients with prediabetes. Additionally, statins increased GLO-1 activity levels, which may help prevent diabetic complications. Assessing the impact of atorvastatin on the levels of these proteins in patients with T2DM and prediabetes is important for preventing diabetic complications.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2023)
Article
Pharmacology & Pharmacy
Hormat Alsadat Azmand Rostami, Abdoljalal Marjani, Mohammad Mojerloo, Behdad Rahimi, Majid Marjani
Summary: The study found that spirulina supplementation in new cases of type 2 diabetes can have beneficial effects on lipid profiles and malondialdehyde levels. This suggests that spirulina supplementation may help improve lipid levels and protect against certain diseases.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Orthopedics
Davood Yari, Mohammad Hosein Ebrahimzadeh, Jebrail Movaffagh, Azadeh Shahroodi, Moein Shirzad, Durdi Qujeq, Ali Moradi
Summary: Chondral defects are common causes of pain and disability, and finding ways to regenerate cartilage is crucial. Tissue engineering provides new strategies for the regeneration of functional cartilage tissue through optimized scaffold properties.
ARCHIVES OF BONE AND JOINT SURGERY-ABJS
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
