Article
Surgery
Barbara A. A. Gaines, Mark H. H. Yazer, Darrell J. J. Triulzi, Jason L. L. Sperry, Matthew D. D. Neal, Timothy R. R. Billiar, Christine M. M. Leeper
Summary: The study aimed to assess the survival impact of low-titer group O whole blood (LTOWB) in injured pediatric patients who require massive transfusion. The results showed that the use of LTOWB significantly improved the 72-hour and 28-day survival rates of pediatric patients, and the survivors in the LTOWB group had reduced hospital LOS, ICU LOS, and ventilator days.
Article
Critical Care Medicine
Christopher Cameron McCoy, Megan Brenner, Juan Duchesne, Derek Roberts, Paula Ferrada, Tal Horer, David Kauvar, Mansoor Khan, Andrew Kirkpatrick, Carlos Ordonez, Bruno Perreira, Artai Priouzram, Bryan A. Cotton
Summary: Whole blood transfusion played a significant role in treating casualties in past wars, but civilian centers have transitioned to blood component therapies. Recent studies suggest that whole blood transfusion may be more effective for treating trauma patients.
Article
Hematology
Julia R. Coleman, Hiroshi Deguchi, Taichi K. Deguchi, Mitchel J. Cohen, Ernest E. Moore, John H. Griffin
Summary: Lower levels of plasma full-SkM are associated with coagulopathy in acutely injured trauma patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Medicine, General & Internal
Nadja Weichselbaum, Daniel Oberladstaetter, Christoph J. Schlimp, Johannes Zipperle, Wolfgang Voelckel, Oliver Grottke, Georg Zimmermann, Marcin Osuchowski, Herbert Schochl
Summary: IL-6 plasma levels can effectively predict the need for massive transfusion in severely injured trauma patients, with high sensitivity and specificity. Patients with high IL-6 levels are more likely to develop coagulopathy and require MT.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Darwin Ang, Samir M. Fakhry, Dorraine D. Watts, Huazhi Liu, Jennifer L. Morse, John Armstrong, Michele Ziglar, Joseph Restivo, David Plurad, Stanley Kurek, Ernest Gonzalez, Kevin Pierre
Summary: This study aims to provide data-driven guidance for modifying massive transfusion protocols when there is a severe blood supply shortage. The study found that mortality rates significantly increase when the volume of blood transfused exceeds a certain threshold. The study suggests using relative thresholds for transfusion protocols based on age groups and key risk factors to maintain blood supply under conditions of blood shortage.
JOURNAL OF SURGICAL RESEARCH
(2023)
Article
Emergency Medicine
Andrew Robinson, Megan A. Rech, Phillip J. DeChristopher, Alex Vaughn, John Rubino, Erika Bannister, Mary E. Moore, Kevin Chang
Summary: This study aimed to determine the optimal Citrate:Ca ratio to reduce 30-day mortality caused by severe hypocalcemia in massive transfusion protocols. By comparing patients with or without severe hypocalcemia, it was found that patients with a Citrate:Ca ratio around 2 had the lowest mortality rate within 24 hours and 30 days of MTP activation.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Medicine, General & Internal
Mark Walsh, Ernest E. Moore, Hunter B. Moore, Scott Thomas, Hau C. Kwaan, Jacob Speybroeck, Mathew Marsee, Connor M. Bunch, John Stillson, Anthony V. Thomas, Annie Grisoli, John Aversa, Daniel Fulkerson, Stefani Vande Lune, Lucas Sjeklocha, Quincy K. Tran
Summary: This review examines the pathophysiology, geographic variation, and historical developments of fixed ratio versus whole blood resuscitation for hemorrhaging trauma patients. It introduces a physiologically driven and goal-directed alternative to guide blood component and factor concentrate administration to severely bleeding trauma patients, with a focus on major studies and upcoming comparative trials.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Li Li, Mark Roest, Yaqiu Sang, Jasper A. Remijn, Rob Fijnheer, Karel Smit, Dana Huskens, Jun Wan, Bas de Laat, Joke Konings
Summary: Patients with multiple myeloma have imbalanced blood cell metabolism and WB-TG profile, which may explain the paradoxically high prevalence of bleeding symptoms compared to an increased thrombosis risk. Disturbance is not observed in plasma TG, indicating that blood cells are the major determinants for the imbalanced hemostasis in multiple myeloma patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Critical Care Medicine
Jean-Stephane David, Arthur James, Maxime Orion, Agathe Selves, Melody Bonnet, Pauline Glasman, Charles-Herve Vacheron, Mathieu Raux
Summary: This retrospective study compared the outcomes of trauma-induced coagulopathy (TIC) management using viscoelastic haemostatic assays (VHA) algorithm and conventional coagulation test (CCT) algorithm. The results showed that the VHA-based strategy was associated with a higher proportion of patients alive and free of massive transfusion (MT) at 24 hours, as well as a reduced use of blood products and associated costs. However, there was no significant difference in mortality or survival between the two groups.
Article
Critical Care Medicine
Walter A. Ramsey, Christopher F. O'Neil, Aaron J. Fils, Cristina Botero-Fonnegra, Rebecca A. Saberi, Gareth P. Gilna, Louis R. Pizano, Brandon M. Parker, Kenneth G. Proctor, Carl I. Schulman, Nicholas Namias, Jonathan P. Meizoso
Summary: Previous studies have shown improved survival for severely injured patients treated at American College of Surgeons (ACS)-verified level I trauma centers compared with level II, level III, and undesignated centers. However, it is unclear whether teaching institutions provide a survival benefit for severely injured trauma patients compared with nonteaching centers. This study investigates the mortality rate in patients receiving massive transfusion (MT) at teaching hospitals versus nonteaching hospitals.
JOURNAL OF TRAUMA AND ACUTE CARE SURGERY
(2023)
Article
Emergency Medicine
Klemens Horst, Philipp Lichte, Felix Blaesius, Christian David Weber, Martin Tonglet, Philipp Kobbe, Nicole Heussen, Frank Hildebrand
Summary: The modified Trauma-Induced Coagulopathy Clinical Score (mTICCS) is a scoring system for the early detection of the need for a massive transfusion (MT). This study validated the inter-rater reliability of the mTICCS and found it to have high consistency among raters, suggesting it could be a useful tool in clinical decision-making.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Multidisciplinary Sciences
Takeshi Wada, Atsushi Shiraishi, Satoshi Gando, Kazuma Yamakawa, Seitaro Fujishima, Daizoh Saitoh, Shigeki Kushimoto, Hiroshi Ogura, Toshikazu Abe, Toshihiko Mayumi, Junichi Sasaki, Joji Kotani, Naoshi Takeyama, Ryosuke Tsuruta, Kiyotsugu Takuma, Norio Yamashita, Shin-ichiro Shiraishi, Hiroto Ikeda, Yasukazu Shiino, Takehiko Tarui, Taka-aki Nakada, Toru Hifumi, Kohji Okamoto, Yuichiro Sakamoto, Akiyoshi Hagiwara, Tomohiko Masuno, Masashi Ueyama, Satoshi Fujimi, Yutaka Umemura, Yasuhiro Otomo
Summary: Trauma patients may suffer from massive bleeding and MODS due to DIC, with a DIC diagnosis on admission associated with lower survival probability and poor outcome. DIC scores obtained immediately after trauma can effectively predict the amount of transfusion, MODS, and mortality rate in severely injured patients.
SCIENTIFIC REPORTS
(2021)
Article
Surgery
Jennifer M. Gurney, Amanda M. Staudt, Deborah J. Del Junco, Stacy A. Shackelford, Elizabeth A. Mann-Salinas, Andrew P. Cap, Philip C. Spinella, Matthew J. Martin
Summary: This study compared the early mortality rates of patients who received warm fresh whole blood with those who did not. The results showed a significant reduction in 6-hour mortality among the warm fresh whole blood group, with a dose-dependent effect. These findings support the use of warm fresh whole blood for hemorrhage control and call for further research in military and civilian trauma settings.
Article
Hematology
Francois-Xavier Ageron, Haleema Shakur-Still, Ian Roberts
Summary: TXA treatment improves survival in both severely and non-severely injured trauma patients, and its effectiveness is closely related to the time from injury to treatment.
Article
Cardiac & Cardiovascular Systems
Sandra Konrath, Reiner K. Mailer, Manu Beerens, Hanna Englert, Maike Frye, Piotr Kuta, Roger J. S. Preston, Coen Maas, Lynn M. Butler, Mark Roest, Bas de Laat, Thomas Renne
Summary: Calibrated Automated Thrombography (CAT) is a versatile and sensitive method for analyzing thrombin generation. In this study, a CAT method for analyzing thrombin generation in murine whole blood was developed, and different activators were used to stimulate thrombin generation in murine blood. The results showed that this method could be used to evaluate the process of coagulation activation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)