The Emergence of RNA from the Heterogeneous Products of Prebiotic Nucleotide Synthesis

A Potential Role for Aminoacylation in Primordial RNA Copying Chemistry

(2021) Aleksandar Radakovic et al.   BIOCHEMISTRY

2′/3′ Regioselectivity of Enzyme‐Free Copying of RNA Detected by NMR

(2020) Sebastian Motsch et al.   CHEMBIOCHEM

Chemistry of Abiotic Nucleotide Synthesis

(2020) Mahipal Yadav et al.   CHEMICAL REVIEWS

A Model for the Emergence of RNA from a Prebiotically Plausible Mixture of Ribonucleotides, Arabinonucleotides, and 2′-Deoxynucleotides

(2020) Seohyun Chris Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prebiotic Syntheses of Noncanonical Nucleosides and Nucleotides

(2020) David M. Fialho et al.   CHEMICAL REVIEWS

Template‐Directed Copying of RNA by Non‐enzymatic Ligation

(2020) Lijun Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selective prebiotic formation of RNA pyrimidine and DNA purine nucleosides

(2020) Jianfeng Xu et al.   NATURE

Potentially Prebiotic Activation Chemistry Compatible with Nonenzymatic RNA Copying

(2020) Stephanie J. Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing chemical energy for the activation and joining of prebiotic building blocks

(2020) Ziwei Liu et al.   Nature Chemistry

Experimental and theoretical rationalization for the base pairing abilities of inosine, guanosine, adenosine, and their corresponding 8‐oxo ‐7,8‐dihydropurine, and 8‐bromopurine analogues within A‐form duplexes of RNA

(2020) Austin Skinner et al.   BIOPOLYMERS

Structural interpretation of the effects of threo-nucleotides on nonenzymatic template-directed polymerization

(2020) Wen Zhang et al.   NUCLEIC ACIDS RESEARCH

The Origin of Biological Homochirality

(2019) Donna G. Blackmond   Cold Spring Harbor Perspectives in Biology

The mechanism of nonenzymatic template copying with imidazole-activated nucleotides

(2019) Travis Walton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Direct Prebiotic Pathway to DNA Nucleosides

(2019) Oliver Trapp et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction

(2019) Jianfeng Xu et al.   Nature Chemistry

The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA

(2019) Subhendu Bhowmik et al.   Nature Chemistry

Prebiotically Plausible “Patching” of RNA Backbone Cleavage through a 3′–5′ Pyrophosphate Linkage

(2019) Tom H. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unified prebiotically plausible synthesis of pyrimidine and purine RNA ribonucleotides

(2019) Sidney Becker et al.   SCIENCE

Non-enzymatic primer extension with strand displacement

(2019) Lijun Zhou et al.   eLife

A Light-Releasable Potentially Prebiotic Nucleotide Activating Agent

(2018) Angelica Mariani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

How nature covers its bases

(2018) Samuel Boldissar et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystallographic observation of nonenzymatic RNA primer extension

(2018) Wen Zhang et al.   eLife

Bacterial Genome Containing Chimeric DNA–RNA Sequences

(2018) Angad P. Mehta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective prebiotic conversion of pyrimidine and purine anhydronucleosides into Watson-Crick base-pairing arabino-furanosyl nucleosides in water

(2018) Samuel J. Roberts et al.   Nature Communications

Template-Directed Catalysis of a Multistep Reaction Pathway for Nonenzymatic RNA Primer Extension

(2018) Travis Walton et al.   BIOCHEMISTRY

Stability of RNA duplexes containing inosine·cytosine pairs

(2018) Daniel J Wright et al.   NUCLEIC ACIDS RESEARCH

Inosine, but none of the 8-oxo-purines, is a plausible component of a primordial version of RNA

(2018) Seohyun Chris Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prebiotic nucleic acids need space to grow

(2018) Daniel Whitaker et al.   Nature Communications

A Mechanistic Explanation for the Regioselectivity of Nonenzymatic RNA Primer Extension

(2017) Constantin Giurgiu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Common and Potentially Prebiotic Origin for Precursors of Nucleotide Synthesis and Activation

(2017) Albert C. Fahrenbach et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enhanced Nonenzymatic RNA Copying with 2-Aminoimidazole Activated Nucleotides

(2017) Li Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Prebiotic stereoselective synthesis of purine and noncanonical pyrimidine nucleotide from nucleobases and phosphorylated carbohydrates

(2017) Hyo-Joong Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

(2017) Shaun Stairs et al.   Nature Communications

RNA-DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World

(2016) Jesse V. Gavette et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Highly Reactive Imidazolium-Bridged Dinucleotide Intermediate in Nonenzymatic RNA Primer Extension

(2016) Travis Walton et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A prebiotically plausible synthesis of pyrimidine β-ribonucleosides and their phosphate derivatives involving photoanomerization

(2016) Jianfeng Xu et al.   Nature Chemistry

Biophysical properties, thermal stability and functional impact of 8-oxo-7,8-dihydroguanine on oligonucleotides of RNA—a study of duplex, hairpins and the aptamer for preQ1as models

(2016) Yu J. Choi et al.   NUCLEIC ACIDS RESEARCH

Life in the light: nucleic acid photoproperties as a legacy of chemical evolution

(2016) Ashley A. Beckstead et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The Balancing Act of Ribonucleotides in DNA

(2016) Susana M. Cerritelli et al.   TRENDS IN BIOCHEMICAL SCIENCES

Nonenzymatic copying of RNA templates containing all four letters is catalyzed by activated oligonucleotides

(2016) Noam Prywes et al.   eLife

Spontaneous Formation of RNA Strands, Peptidyl RNA, and Cofactors

(2015) Mario Jauker et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Origin of Life-Out of the Blue

(2015) John D. Sutherland   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Replacing Uridine with 2-Thiouridine Enhances the Rate and Fidelity of Nonenzymatic RNA Primer Extension

(2015) Benjamin D. Heuberger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Thermodynamic insights into 2-thiouridine-enhanced RNA hybridization

(2015) Aaron T. Larsen et al.   NUCLEIC ACIDS RESEARCH

Biophysical properties and thermal stability of oligonucleotides of RNA containing 7,8-dihydro-8-hydroxyadenosine

(2014) Ana M. Chauca-Diaz et al.   BIOPOLYMERS

Abiotic synthesis of RNA in water: a common goal of prebiotic chemistry and bottom-up synthetic biology

(2014) Brian J Cafferty et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Reevaluation of the d-Amino Acid Compatibility with the Elongation Event in Translation

(2013) Tomoshige Fujino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional RNAs exhibit tolerance for non-heritable 2′–5′ versus 3′–5′ backbone heterogeneity

(2013) Aaron E. Engelhart et al.   Nature Chemistry

Prebiotically plausible oligoribonucleotide ligation facilitated by chemoselective acetylation

(2013) Frank R. Bowler et al.   Nature Chemistry

Activated Ribonucleotides Undergo a Sugar Pucker Switch upon Binding to a Single-Stranded RNA Template

(2012) Na Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Darwinian evolution of an alternative genetic system provides support for TNA as an RNA progenitor

(2012) Hanyang Yu et al.   Nature Chemistry

The solution structure of double helical arabino nucleic acids (ANA and 2′F-ANA): effect of arabinoses in duplex-hairpin interconversion

(2012) Nerea Martín-Pintado et al.   NUCLEIC ACIDS RESEARCH

A route to enantiopure RNA precursors from nearly racemic starting materials

(2011) Jason E. Hein et al.   Nature Chemistry

The origin of biological homochirality

(2011) D. G. Blackmond   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Role of Unsatisfied Hydrogen Bond Acceptors in RNA Energetics and Specificity

(2010) Nathan A. Siegfried et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential stability of 2′F-ANA•RNA and ANA•RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility

(2010) Jonathan K. Watts et al.   NUCLEIC ACIDS RESEARCH

The Origins of the RNA World

(2010) M. P. Robertson et al.   Cold Spring Harbor Perspectives in Biology

N2′→P3′ Phosphoramidate Glycerol Nucleic Acid as a Potential Alternative Genetic System

(2009) Jesse J. Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient and Rapid Template-Directed Nucleic Acid Copying Using 2′-Amino-2′,3′-dideoxyribonucleoside−5′-Phosphorimidazolide Monomers

(2009) Jason P. Schrum et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions

(2009) Matthew W. Powner et al.   NATURE

On the origin of terrestrial homochirality for nucleosides and amino acids

(2009) R. Breslow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA