Article
Psychology, Biological
Yangmei Luo, Xi Zhang, Hongda Jiang, Xuhai Chen
Summary: The study found that neural sensitivity to repeated hedonic rewards is more prone to decrease over time compared to eudaimonic rewards. Furthermore, a decline in sensitivity to repeated eudaimonic rewards is marginally associated with longitudinal decreases in well-being. Sustained eudaimonic reward sensitivity in the short term has greater implications for changes in well-being in the long term.
Article
Psychology, Clinical
Renee J. Thompson, Natasha H. Bailen, Tammy English
Summary: The emotional experiences of individuals with remitted-major depressive disorder (MDD) mainly consist of higher intensity and variability of negative affect (NA), differing from the control group and current-MDD group. A significant group difference was found in the lower intensity of positive affect (PA) in the current-MDD group compared to the other two groups.
CLINICAL PSYCHOLOGICAL SCIENCE
(2021)
Article
Psychology, Developmental
Laura Hennefield, Kirsten Gilbert, Diana Whalen, Cristal Giorio, Laura E. Quinones Camacho, Danielle Kelly, Ethan Fleuchaus, Deanna M. Barch, Joan L. Luby, Greg Hajcak
Summary: The study found differences in latency and amplitude of reward positivity (RewP) in 4- to 6-year-old children, with RewP latency decreasing and amplitude increasing with age. These findings suggest that both amplitude and latency of RewP may function as individual difference measures of reward processing in early childhood.
DEVELOPMENTAL SCIENCE
(2022)
Article
Behavioral Sciences
Eric Rawls, Connie Lamm
Summary: The study demonstrates that mediofrontal PE signals are the mechanism underlying negative reinforcement learning, and that the increase in central delta power may contribute to the aversion positivity. PEs systematically influence future behavior in both positive and negative reinforcement conditions. In negative reinforcement conditions, cortical PE signals vary in different time windows.
Review
Clinical Neurology
Fernando C. Krause, Eftihia Linardatos, David M. Fresco, Michael T. Moore
Summary: This study conducted a meta-analysis of 23 studies on facial emotion recognition accuracy in MDD patients, showing that those in inpatient settings and with severe symptom severity were less accurate in recognizing happy facial expressions. Studies with longer stimulus durations also found lower accuracy levels in depressed participants.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Multidisciplinary
Renee J. Thompson, Daphne Y. Liu, Ella Sudit, Matt Boden
Summary: Individuals with current major depressive disorder (MDD) or in remission exhibit low levels of negative and positive emotion differentiation, indicating that diminished emotion differentiation may be a stable characteristic of depressive disorders and a potential target for future prevention efforts.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Sang-Heon Lim, Jihyun Yoon, Young Jae Kim, Chang-Ki Kang, Seo-Eun Cho, Kwang Gi Kim, Seung-Gul Kang
Summary: This study introduced an automated segmentation and volume estimation method for the habenula in 7 Tesla magnetic resonance imaging using a deep learning-based approach. The method demonstrated high precision and recall rates, as well as a strong dice similarity coefficient, indicating its potential usefulness in future psychiatric disease studies.
SCIENTIFIC REPORTS
(2021)
Article
Behavioral Sciences
Darin R. Brown, Trevor C. J. Jackson, James F. Cavanagh
Summary: The EEG feature known as the Reward Positivity (RewP) is elicited by reward receipt and appears to reflect sensitively and specifically positive prediction errors during reinforcement learning. This suggests that the RewP could serve as a possible nexus where multidimensional value is computed, reflecting both reward surprise and hedonic liking.
COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Ulrike Nowak, Katarina Krkovic, Mathias K. Kammerer, Tania M. Lincoln
Summary: This study focused on exploring the temporal affect dynamics in psychosis and found that individuals with psychotic disorders have increased affective instability. There were no significant differences in variability and inertia. These findings have important implications for emotion-focused interventions for psychosis.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Biological
Samantha Pegg, Anh Dao, Lisa Venanzi, Kaylin Hill, Autumn Kujawa
Summary: This study examines the effects of using cap compared to facial electrodes to measure eye movements for ocular correction in event-related potential (ERP) research. Findings revealed comparable data quality but some differences in overall ERP magnitude, suggesting cap electrodes may be used if needed. A consistent approach to ocular correction within a study is recommended.
Article
Neurosciences
Amir Ebneabbasi, Mostafa Mahdipour, Vahid Nejati, Meng Li, Thomas Liebe, Lejla Colic, Anna Linda Leutritz, Matthias Vogel, Mojtaba Zarei, Martin Walter, Masoud Tahmasian
Summary: Our study reveals that affective areas are regionally and/or connectively disturbed in MDD; the EP-ER interaction seems to be disrupted in MDD; and depression severity is correlated with FC of affective areas.
HUMAN BRAIN MAPPING
(2021)
Article
Psychology, Clinical
Qiang Shen, Shiguang Fu, Xiaoying Jiang, Xiaoyu Huang, Doudou Lin, Qingyan Xiao, Sitti Khadijah, Yaping Yan, Xiaoxing Xiong, Jia Jin, Richard P. Ebstein, Ting Xu, Yiquan Wang, Jun Feng
Summary: This study investigates the differences in learning behavior between adolescent depressive patients and healthy controls using an instrumental learning task. The results show that depressive patients perform worse, have slower learning rates, and exhibit pessimistic biases and counterfactual outcome biases. These biases are also linked with the severity of depressive symptoms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Cancan He, Dandan Fan, Xinyi Liu, Qing Wang, Haisan Zhang, Hongxing Zhang, Zhijun Zhang, Chunming Xie
Summary: Childhood maltreatment is a major risk factor for the development of major depressive disorder (MDD), but the underlying neurobiological mechanism is unclear. This study found specific neural connectivity abnormalities between childhood maltreatment and depressive symptoms, primarily in the frontal-limbic system and involving self-regulation and cognitive processing circuits. Furthermore, the strength of functional connectivity mediated the association between different types of childhood maltreatment, especially abuse and neglect, and depressive symptoms. These findings provide important insights into the pathological mechanism of CM-induced depressive symptoms.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Qing Wang, Cancan He, Zan Wang, Dandan Fan, Zhijun Zhang, Chunming Xie
Summary: This study investigated the dynamic alterations and dysfunction of resting-state networks (RSNs) in patients with major depressive disorder (MDD) who have suicidal ideation and behavior. The findings suggest that disrupted brain connections could serve as diagnostic biomarkers for distinguishing MDD patients with or without suicidal ideation and behavior. The study also identified specific network connections that are correlated with severity of suicidality in MDD patients.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Taylor A. James, Audrey Duarte
Summary: Age-related positivity preferences, which involve better memory for positive stimuli and reduced benefits for negative stimuli, may not be limited to older adults without depressive symptoms. This fMRI study found interactive effects between age and depressive symptoms, with reductions in positivity preferences and improvements in negative memory in older adults with higher depressive symptoms. Analyses highlighted potential underlying mechanisms, such as diminished prefrontal cortex connectivity, indicating altered emotion regulation networks.
NEUROBIOLOGY OF AGING
(2023)
Article
Psychology, Clinical
Glenn Kiekens, Penelope Hasking, Ronny Bruffaerts, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Corina Benjet, Mark Boyes, Wai Tat Chiu, Laurence Claes, Pim Cuijpers, David D. Ebert, Arthur Mak, Philippe Mortier, Siobhan O'Neill, Nancy A. Sampson, Dan J. Stein, Gemma Vilagut, Matthew K. Nock, Ronald C. Kessler
Summary: Non-suicidal self-injury (NSSI) is common among college students and is a behavioral marker of various common mental disorders.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mathilde M. Husky, Ekaterina Sadikova, Sue Lee, Jordi Alonso, Randy P. Auerbach, Jason Bantjes, Ronny Bruffaerts, Pim Cuijpers, David D. Ebert, Raul Gutierrez Garcia, Penelope Hasking, Arthur Mak, Margaret McLafferty, Nancy A. Sampson, Dan J. Stein, Ronald C. Kessler
Summary: This study examines the relationship between childhood adversities and lifetime mental disorders, 12-month disorder persistence, and impairment among incoming college students. The findings suggest that childhood adversities are associated with the onset and impairment of mental disorders, but not with disorder persistence.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Kelly A. Correa, Vivian Carrillo, Carter J. Funkhouser, Elyse R. Shenberger, Stewart A. Shankman
Summary: The study found that there are differences in attentional bias to threat and electromyography startle reactivity to threat between Hispanics/Latinx and non-Hispanic/Latinx populations. Hispanics/Latinx displayed less Slow Orientation and increased Slow Disengagement compared to non-Hispanics/Latinx, and exhibited blunted overall startle response.
JOURNAL OF ANXIETY DISORDERS
(2022)
Article
Psychiatry
Kira L. Alqueza, David Pagliaccio, Katherine Durham, Apoorva Srinivasan, Jeremy G. Stewart, Randy P. Auerbach
Summary: This study examined the correlates of suicidal thoughts and behaviors (STBs) among psychiatric inpatients. The results showed that suicidal ideation occurred during early adolescence, with more than half of the patients making a plan and one-third attempting suicide. The strongest correlates were depressive disorders, physical abuse, and non-suicidal self-injury. Knowing a peer with a history of suicide attempts also increased the likelihood of attempting suicide.
ARCHIVES OF SUICIDE RESEARCH
(2023)
Article
Psychology, Clinical
Nicholas A. Hubbard, Randy P. Auerbach, Viviana Siless, Nicole Lo, Isabelle R. Frosch, Danielle E. Clark, Robert Jones, Rebecca Kremens, Megan Pinaire, Flavia Vaz-DeSouza, Satrajit S. Ghosh, Aude Henin, Stefan G. Hofmann, Diego A. Pizzagalli, Isabelle M. Rosso, Anastasia Yendiki, Susan Whitfield-Gabrieli, John D. E. Gabrieli
Summary: Adolescents with anxiety or depression show cognitive biases towards negative emotional information processing. This study found that reduced changes in brain connectivity patterns between conditions where adolescents needed to ignore or attend to fearful faces were associated with a shared dimension of anxious and depressive symptoms. The findings suggest a failure to adapt communication patterns with sensory-representation areas in the presence of negative emotional information, which may explain the biases common to anxiety and depression in adolescents.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Clinical Neurology
Elizabeth S. S. Stevens, Carter J. J. Funkhouser, Randy P. P. Auerbach, Ardesheer Talati, Marc G. G. Gameroff, Jonathan E. E. Posner, Myrna M. M. Weissman, Stewart A. A. Shankman
Summary: Numerous theoretical models suggest that difficulties in inhibiting automatic responses contribute to the onset and/or maintenance of internalizing symptoms. Inhibition deficits and internalizing disorders have a familial and genetic association, indicating that inhibition deficits may be a significant predictor of internalizing symptoms in individuals with high familial risk. This longitudinal study examined the prospective associations between inhibition and anxiety and depressive symptoms in a sample transitioning from adolescence to early adulthood. The results showed that poor inhibition predicted higher levels of anxiety and depressive symptoms in individuals with high familial risk for major depressive disorder, supporting impaired inhibition as an indicator of risk for later internalizing symptoms in high-risk individuals.
JOURNAL OF NERVOUS AND MENTAL DISEASE
(2023)
Article
Psychology, Biological
Lilian Y. Li, James E. Glazer, Fiona Helgren, Carter J. Funkhouser, Randy P. Auerbach, Stewart A. Shankman
Summary: Identifying risk markers for persistent major depressive disorder (MDD) is important to address its high recurrence rate. Negative information processing biases, such as heightened responses to errors, may impair performance monitoring and behavioral adjustment. However, the neurophysiological correlates of post-error adaptation in depression are not well understood.
BIOLOGICAL PSYCHOLOGY
(2023)
Article
Psychology, Developmental
Randy P. Auerbach, Ranqing Lan, Hanga Galfalvy, Kira L. Alqueza, Jeffrey F. Cohn, Ryann N. Crowley, Katherine Durham, Karla J. Joyce, Lauren E. Kahn, Rahil A. Kamath, Louis-Philippe Morency, Giovanna Porta, Apoorva Srinivasan, Jamie Zelazny, David A. Brent, Nicholas B. Allen
Summary: Suicide is a leading cause of death among adolescents, but there are no clinical tools currently available to detect proximal risk for suicide. This study demonstrates that intensive longitudinal assessment through the use of personal smartphones offers a feasible method to assess variability in adolescents' emotional experiences and suicide risk.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Biochemistry & Molecular Biology
Jiahe Zhang, Jovicarole Raya, Francesca Morfini, Zoi Urban, David Pagliaccio, Anastasia Yendiki, Randy P. Auerbach, Clemens C. C. Bauer, Susan Whitfield-Gabrieli
Summary: Adolescents have alarmingly high rates of major depressive disorder (MDD), but current gold-standard treatments are only effective for about 50% of them. Therefore, there is a critical need for novel interventions that target neural mechanisms believed to potentiate depressive symptoms. This study developed a mindfulness-based fMRI neurofeedback (mbNF) for adolescents that aims to reduce default mode network (DMN) hyperconnectivity, which is implicated in the onset and maintenance of MDD. The results demonstrate that personalized mbNF can effectively and non-invasively modulate the intrinsic networks associated with the emergence and persistence of depressive symptoms during adolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychology, Clinical
Penelope A. Hasking, Kealagh Robinson, Peter Mcevoy, Glenn Melvin, Ronny Bruffaerts, Mark E. Boyes, Randy P. Auerbach, Delia Hendrie, Matthew K. Nock, David A. Preece, Clare Rees, Ronald C. Kessler
Summary: A predictive algorithm was developed to identify college students at risk of suicidal behavior, and telehealth was used to reduce subsequent risk. The algorithm effectively identified high-risk individuals and decreased their likelihood of engaging in suicidal behavior through universal screening and remote intervention.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Grace O. Allison, Rahil A. Kamath, Vivian Carrillo, Kira L. Alqueza, David Pagliaccio, George M. Slavich, Stewart A. Shankman, Randy P. Auerbach
Summary: This study found that self-referential processing biases persist during remission in adults with depression and may contribute to the occurrence of stress and depressive symptoms over time.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2023)
Article
Clinical Neurology
Sameer A. Ashaie, Carter J. Funkhouser, Roxana Jabbarinejad, Leora R. Cherney, Stewart A. Shankman
Summary: This study examined the associations between different depressive symptom dimensions among stroke survivors at three timepoints within a year following discharge, finding reciprocal within-person associations between somatic symptoms and anhedonia. These two symptom dimensions may serve as useful indicators of depression risk and intervention targets, highlighting the importance of regularly assessing depressive symptoms for early identification and intervention in stroke survivors.
NEUROREHABILITATION AND NEURAL REPAIR
(2023)
Article
Psychology, Clinical
Randy P. Auerbach, Apoorva Srinivasan, Jaclyn S. Kirshenbaum, J. John Mann, Stewart A. Shankman
Summary: Depression recurrence is a significant issue and clinical tools are needed to detect symptom reemergence. This study found that remitted depressed adults have reduced circadian routine and lower average daily distance traveled. Mobile sensing approaches hold promise for improving clinical care for depressive disorders.
JOURNAL OF PSYCHOPATHOLOGY AND CLINICAL SCIENCE
(2022)
Article
Psychology
Carter J. Funkhouser, Andrea C. Katz, Emily E. E. Meissel, Elizabeth S. Stevens, Anna Weinberg, Carver B. Nabb, Stewart A. Shankman
Summary: This study examined the association between repetitive negative thinking (RNT) and habituation. The results indicated that RNT may disrupt habituation and support the theoretical model.
Article
Psychology, Multidisciplinary
Jason Bantjes, Elsie Breet, Wylene Saal, Christine Lochner, Janine Roos, Lian Taljaard, Philippe Mortier, Randy P. Auerbach, Ronny Bruffaerts, Ronald C. Kessler, Dan J. Stein
Summary: This study used a cross-sectional web-based survey and discrete-time survival analysis to estimate the prevalence and predictors of suicidal ideation, plan, and attempt among South African university students. The results showed that the lifetime prevalence of ideation, plan, and attempt were 46.4%, 26.5%, and 8.6% respectively. Multiple primary mental disorders predicted subsequent onset of suicidality and transitions from ideation to plan and attempt. The findings highlight the importance of campus-based suicide prevention, the vulnerability of historically disadvantaged students, and the promotion of mental health in suicide prevention.
Article
Psychiatry
Yafit Levin, Rahel Bachem, Dorit Brafman, Menachem Ben-Ezra
Summary: Negative symptoms of schizophrenia have been overlooked, and this study found an association between negative symptoms and the risk of dissociative disorder, independently of depression and anxiety symptoms. It is important to consider both negative symptoms and dissociative symptoms in clinical practice to better understand their interaction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Review
Psychiatry
Roland Mergl, Sarah M. Quaatz, Vanessa Lemke, Antje-Kathrin Allgaier
Summary: Women who have had miscarriages or stillbirths have an increased risk for depressive symptoms and disorders, with a wide range of prevalence rates. However, depressive symptoms tend to diminish over time.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Hai-Yang Wang, Lin Zhang, Bei-Yan Guan, Shi-Yao Wang, Cui-Hong Zhang, Ming-Fei Ni, Yan-Wei Miao, Bing-Wei Zhang
Summary: This study investigates the association between cognitive reappraisal and panic disorder (PD), and finds that PD patients have weakened functional connectivity between the prefrontal cortex (PFC) and the amygdala, which is associated with the severity of PD symptoms. Additionally, cognitive reappraisal is negatively correlated with PD severity, and the PFC-amygdala functional connectivity plays a mediating role in this association.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Yanqiang Tao, Xinyuan Zou, Qihui Tang, Wenxin Hou, Shujian Wang, Zijuan Ma, Gang Liu, Xiangping Liu
Summary: Depression and anxiety are prevalent mental disorders among adolescents. The study utilized network analysis to examine the symptom dimension of depression and anxiety in different age groups of adolescents. The results indicated that different age groups have different key symptoms and bridging symptoms, highlighting the importance of targeting specific symptoms at different stages of adolescence in treatment to alleviate the comorbidity of anxiety and depression.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Philip J. Batterham, Aliza Werner-Seidler, Bridianne O'Dea, Alison L. Calear, Kate Maston, Andrew Mackinnon, Helen Christensen
Summary: Screening for psychological distress in adolescents is important, and the Distress Questionnaire-5 (DQ5) is a reliable measure for this purpose. The study found that DQ5 had good fit to a unidimensional construct, strong criterion and predictive validity, and sensitivity to change. The brevity and ease of interpretation of DQ5 make it suitable for screening in schools.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Xiaoli Liu, Qianqian Chen, Fang Cheng, Wenhao Zhuang, Wenwu Zhang, Yiping Tang, Dongsheng Zhou
Summary: This study found working memory defects in adolescents with major depressive disorder compared to healthy controls based on mean oxy-hemoglobin changes, which can be useful for distinguishing adolescents with MDD from healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Anders Nordahl-Hansen, Hugo Cogo-Moreira, Sareh Panjeh, Daniel S. Quintana
Summary: This article aims to determine empirically-derived effect size thresholds associated with psychotherapy for depressive disorders by calculating the effect size distribution. The findings indicate that the observed effect size thresholds are larger than the suggested guidelines, which has implications for interpreting study effects and planning future research.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Guangli Zhao, Liyong Yu, Peixin Chen, Keli Zhu, Lu Yang, Wenting Lin, Yucai Luo, Zeyang Dou, Hao Xu, Pan Zhang, Tianmin Zhu, Siyi Yu
Summary: This study investigated the neural mechanisms underlying emotional attention bias in patients with CID using ERP and rs-FC approaches. The results revealed abnormalities in attention processing and connectivity in the emotion-cognition networks of CID patients. This study provides a neural basis for understanding attention bias in CID.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Seungyeon Lee, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Major depressive disorder is a prevalent condition worldwide, but the proportion of patients receiving treatment has not increased. Biomarkers related to drug-treatment responses can be used to monitor the effectiveness of medication. Serum protein levels were compared among patients with depression who received medication, those who did not, and a control group. Eight biomarkers were identified, which can be used to monitor the effectiveness of drug treatment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Alfredo L. Sklar, Fang -Cheng Yeh, Mark Curtis, Dylan Seebold, Brian A. Coffman, Dean F. Salisbury
Summary: This study investigated semantic verbal fluency (SVF) impairments in first-episode psychosis patients within the schizophrenia spectrum. The findings revealed disruptions in both functional and structural connectivity in these patients, as well as an association between enhanced connectivity in the right hemisphere and worse SVF performance and longer disease duration.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)
Article
Psychiatry
Maksymilian Rejek, Blazej Misiak
Summary: This study investigates the association of the exposome score (ES) with psychosis risk in a non-clinical population. The results show that the ES is associated with the extended psychosis phenotype, suggesting its potential to identify individuals who may benefit from further psychosis risk assessment.
JOURNAL OF PSYCHIATRIC RESEARCH
(2024)