Sustainable Four-Component Annulation for the Synthesis of 2,3,4,6-Tetraarylpyridines

A one-pot, four-component annulation of 2,3,4,6-tetraarylpyridines from aromatic aldehydes, methyl ketones, diaryl ethanones, and ammonium acetate is described. The reaction features high functional group compatibility in air under solvent-free conditions without any additive and only water as the nontoxic byproduct, providing a strategy for the facile, economical, and ecofriendly construction of multiaryl-substituted pyridines from simple and readily available reactants.

Automated summary

This method describes a one-pot, four-component annulation to synthesize 2,3,4,6-tetraarylpyridines with high functional group compatibility, solvent-free conditions, and nontoxic byproduct water, providing a simple, economical, and eco-friendly strategy for constructing multiaryl-substituted pyridines.