Article
Food Science & Technology
Michael D. Kendig, Kyoko Hasebe, Aynaz Tajaddini, Nadeem O. Kaakoush, R. Frederick Westbrook, Margaret J. Morris
Summary: This study examines the effects of a diet switch intervention in a rat model of maternal obesity. The results show that the intervention leads to reductions in body weight and adiposity, improvements in place recognition memory, and changes in gut microbiota composition.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Immunology
Shuyi Fan, Suyun Chen, Lin Lin
Summary: Obesity is a chronic metabolic disorder caused by an energy imbalance and is becoming increasingly prevalent, posing a global health concern. The multifactorial etiology of obesity includes genetics, high-fat diet, gut microbiota, and other factors. Among these factors, the implication of gut microbiota in the development of obesity has been widely recognized. This study aims to investigate the potential contribution of gut microbiota to high-fat diet induced obesity and the current state of probiotic intervention therapy research, providing novel insights for obesity prevention and management.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Food Science & Technology
Shijie Fu, Yanting Dang, Huilin Xu, Aimin Li, Xiaoman Zhou, Xiaodong Gao, Zijie Li
Summary: Aloe vera-fermented beverages (AFB) have been found to prevent diet-induced obesity and associated complications. They reduce lipid droplets in cells, inhibit weight gain and fat accumulation, and lower the levels of total cholesterol, alanine aminotransferase, and interleukin 10. Additionally, AFB alters the composition of gut microbiota.
Article
Microbiology
Carmen P. Ortega-Santos, Layla Al-Nakkash, Corrie M. Whisner
Summary: This study aimed to investigate the effects of genistein, exercise, and their combined effect on gut microbiota changes and obesity. The results showed that exercise and genistein could reduce weight gain and gut microbiota richness, but switching from a high-fat, high-sugar diet to chow had the greatest potential to revert these characteristics.
Article
Biochemistry & Molecular Biology
Jae-Kwon Jo, Seung-Ho Seo, Seong-Eun Park, Hyun-Woo Kim, Eun-Ju Kim, Jeong-Sang Kim, Ju-Yeon Pyo, Kwang-Moon Cho, Sun-Jae Kwon, Dae-Hun Park, Hong-Seok Son
Summary: This study aimed to identify gut microbiota-metabolomic signatures altered by a high-fat diet, revealing a significant increase in specific Firmicutes in the HFD group correlated with certain metabolites levels, impacting various metabolic pathways.
Review
Nutrition & Dietetics
Katarzyna Nabrdalik, Katarzyna Krzyzak, Weronika Hajzler, Karolina Drozdz, Hanna Kwiendacz, Janusz Gumprecht, Gregory Y. H. Lip
Summary: The incidence of cardiometabolic diseases is on the rise, and researchers are focusing on the role of nutrition in prevention. Past studies have influenced dietary guidelines recommending reduction of saturated fat and sugar intake. Low-carbohydrate diets have shown to be safe and effective in managing type 2 diabetes.
Article
Chemistry, Applied
Na Zhang, Qing Wang, Fudi Lin, Bingde Zheng, Yayan Huang, Yucheng Yang, Changhu Xue, Meitian Xiao, Jing Ye
Summary: This study shows that Neoagarotetraose (NA4) can alleviate high-fat diet-induced obesity through various mechanisms, including promoting white adipose tissue browning, regulating gut microbiota, and enhancing microbial metabolism.
CARBOHYDRATE POLYMERS
(2022)
Article
Food Science & Technology
Ju Kyoung Oh, Robie Vasquez, Sang Hoon Kim, Je Hyeon Lee, Eun Joo Kim, Soon-Kwang Hong, Dae-Kyung Kang
Summary: The study showed that supplementation of neoagarooligosaccharides (NAOs) in obese rats can reduce body weight, improve metabolism, and modulate the gut microbiome by enriching bacteria negatively associated with obesity. This suggests that the anti-obesity effect of NAOs may be linked to their regulatory effect on gut microbiota.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Nutrition & Dietetics
Ang Li, Jin Wang, Xuejiao Zhang, Ruixin Kou, Mengshan Chen, Bowei Zhang, Jingmin Liu, Bo Peng, Yan Zhang, Shuo Wang
Summary: Cold-brewed jasmine tea has been found to alleviate obesity and dysbiosis of gut microbiota. It modifies the microbial community composition, regulates gene expression related to lipid metabolism, and provides potential health benefits.
Article
Food Science & Technology
Chunxia Yu, Peng Zhang, Sujuan Liu, Yanmei Niu, Li Fu
Summary: Regular exercise can protect against dysmetabolism through the butyrate-SESN2 pathway, but this protection is weakened in the absence of SESN2. SESN2 deficiency suppresses the exercise response to microbiota composition and reduces the benefits of exercise on dysmetabolism induced by a high-fat diet.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Article
Microbiology
Ting-Ye Wang, Si-Yu Tao, Yan-Xiang Wu, Tian An, Bo-Han Lv, Jia-Xian Liu, Yu-Tong Liu, Guang-Jian Jiang
Summary: The gut microbiota plays an important role in the occurrence and development of obesity. Quinoa can effectively reduce obesity by regulating the gut microbiota, influencing metabolism, and improving obesity-related symptoms, possibly through microbiota-gut-brain-liver interaction mechanisms.
MICROBIOLOGY SPECTRUM
(2022)
Article
Pharmacology & Pharmacy
Shiyue Luo, Lixiao Zhou, Xuejun Jiang, Yinyin Xia, Lishuang Huang, Run Ling, Shixin Tang, Zhen Zou, Chengzhi Chen, Jingfu Qiu
Summary: Asparagus cochinchinensis, a traditional Chinese medicine, has shown anti-inflammatory properties and the ability to regulate gut microbiota. In a study on obese mice, it was found that the aqueous extract from Asparagus cochinchinensis root (ACE) reduced weight gain and relieved dyslipidemia induced by a high-fat diet. ACE treatment also improved glucose tolerance and insulin resistance, reduced inflammation and lipogenesis in the liver and adipose tissues, and reshaped the gut microbiota of obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Jose Alberto Molina-Tijeras, Patricia Diez-Echave, Teresa Vezza, Laura Hidalgo-Garcia, Antonio Jesus Ruiz-Malagon, Maria Jesus Rodriguez-Sojo, Miguel Romero, Inaki Robles-Vera, Federico Garcia, Julio Plaza-Diaz, Monica Olivares, Juan Duarte, Maria Elena Rodriguez-Cabezas, Alba Rodriguez-Nogales, Julio Galvez
Summary: Studies have shown that Lactobacillus fermentum CECT5716 demonstrates anti-obesity effects in a model of high fat diet-induced obesity in mice, along with improvements in anti-inflammatory properties, endothelial dysfunction, and gut dysbiosis. This probiotic modulates the microbiome by increasing beneficial bacteria abundance, reducing harmful bacterial presence, suggesting a potential use in the treatment of obesity.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dagmara Kociszewska, Jeffrey Chan, Peter R. Thorne, Srdjan M. Vlajkovic
Summary: This review focuses on the association between gut dysbiosis and hearing loss, highlighting the potential harm of a high-fat diet on auditory health. It suggests that changes in gut microbiota may lead to systemic inflammatory response, compromising the blood-labyrinth barrier permeability in the inner ear, thus inducing cochlear inflammation and hearing deficits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jiacheng Wu, Yuqi Zhu, Limian Zhou, Yang Lu, Tingting Feng, Mengyu Dai, Jiaxue Liu, Wen Xu, Wanpeng Cheng, Fenfen Sun, Hua Liu, Wei Pan, Xiaoying Yang
Summary: Parasite-derived excretory-secretory products (ESPs) were found to alleviate cognitive impairment and gut microbiota dysbiosis induced by a high-fat diet, suggesting a potential therapeutic avenue for obesity-associated neurodegenerative diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Luisa Martins Trindade, Licia Torres, Isabel David Matos, Vivian Correia Miranda, Luis Claudio Lima de Jesus, Gregorio Cavalcante, Jonathan Junio de Souza Oliveira, Geovanni Dantas Cassali, Pamela Mancha-Agresti, Vasco Ariston de Carvalho Azevedo, Tatiani Uceli Maioli, Valbert Nascimento Cardoso, Flaviano dos Santos Martins, Simone de Vasconcelos Generoso
Summary: Intestinal mucositis is a common side effect of cancer treatment, and the current management options are not very effective. Recent research suggests that the gut microbiota plays a role in the development and severity of mucositis. Therefore, the use of probiotics and paraprobiotics may have potential therapeutic effects on intestinal mucositis.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biotechnology & Applied Microbiology
Spencer S. Santos, Vivian C. Miranda, Luisa M. Trindade, Valbert N. Cardoso, Diego C. Reis, Geovanni D. Cassali, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study evaluated the probiotic effect of Bifidobacterium longum subsp. longum 5(1A) in a murine model of food allergy. The results showed that oral administration of this probiotic prevented weight loss, reduced immune reactions, and improved intestinal permeability. The dose of 10^8 CFU showed the best protective effect, and the use of live bacteria was necessary to achieve these beneficial effects.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Cell Biology
Mauro A. F. Guimaraes, Natalia Pinheiro-Rosa, Rafael P. Oliveira, Sarah L. F. Aguiar, Mariana C. G. Miranda, Luisa Lemos, Adna L. Souza, Daniela S. dos Reis, Samara R. Medeiros, William A. Goncalves, Sylvia S. Amaral, Vanessa Pinho, Anderson Miyoshi, Vasco A. Z. Azevedo, Rafael M. Rezende, Ana M. C. Faria
Summary: Multiple sclerosis (MS) is an autoimmune disease that affects the central nervous system. In this study, a protocol of oral tolerance induction using HSP65-producing Lactococcus lactis was proposed and successfully prevented and controlled MOG-induced experimental autoimmune encephalomyelitis (EAE) in mice. The treatment resulted in a reduction in EAE clinical score, higher frequencies of regulatory T cells, and reduced leukocyte adherence in the spinal cord. These findings suggest a novel therapeutic strategy for MS and other autoimmune diseases.
CELLULAR IMMUNOLOGY
(2023)
Editorial Material
Immunology
Licia Torres, Ana M. C. Faria
Summary: This study demonstrates that gut regionalization can affect microbiota and immunity through the regulation of GATA4 expression, which controls bacterial colonization, retinol metabolism, and IgA production. This metabolic-immune axis plays a crucial role in limiting intestinal Th17 responses and immunopathology.
Article
Veterinary Sciences
Maria Helena Barros Pinto, Thiago Rodrigues Cardoso Braga, Guilherme Reis Blume, Leticia Batelli De Oliveira, Nicolas Thomas Costa Das Chagas, Fernanda Rezende Souza, Geovanni Dantas Cassali, Fabiano Jose Ferreira De Sant'ana
Summary: This article describes a case of metastatic exocrine pancreatic adenocarcinoma in an 18-year-old captive giant otter. The otter presented with inappetence and apathy, and examinations revealed a neoplasm affecting the urinary bladder and hydroureter. The animal died during anesthesia recovery, and gross and microscopic examination confirmed the diagnosis of metastatic exocrine pancreatic adenocarcinoma.
ACTA VETERINARIA HUNGARICA
(2023)
Article
Behavioral Sciences
Barbara Miranda Sartori, Renato Elias Moreira Junior, Isadora Marques Paiva, Izabela Barbosa Moraes, Luis David Solis Murgas, Ana Lucia Brunialti-Godard
Summary: Alcohol consumption affects memory and learning processes in humans and animals. In this study, zebrafish were used as a model to investigate the effects of ethanol on learning and memory, as well as its relationship with behavior and gene regulation in the brain. The results showed that repeated exposure to ethanol affected the learning and memory abilities of zebrafish, altered behavior, and resulted in changes in gene transcription.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biology
Guilherme M. J. Costa, Samyra M. S. N. Lacerda, Andre F. A. Figueiredo, Natalia T. Wnuk, Marcos R. G. Brener, Lidia M. Andrade, Gabriel H. Campolina-Silva, Andrea Kauffmann-Zeh, Lucila G. G. Pacifico, Alice F. Versiani, Maisa M. Antunes, Fernanda R. Souza, Geovanni D. Cassali, Andre L. Caldeira-Brant, Helio Chiarini-Garcia, Fernanda G. de Souza, Vivian V. Costa, Flavio G. da Fonseca, Mauricio L. Nogueira, Guilherme R. F. Campos, Lucas M. Kangussu, Estefania M. N. Martins, Loudiana M. Antonio, Cintia Bittar, Paula Rahal, Renato S. Aguiar, Barbara P. Mendes, Marcela S. Procopio, Thiago P. Furtado, Yuri L. Guimaraes, Gustavo B. Menezes, Ana Martinez-Marchal, Kyle E. Orwig, Miguel Brieno-Enriquez, Marcelo H. Furtado
Summary: The SARS-CoV-2 virus has a higher affinity for the testes and can maintain its replicative and infective abilities for a prolonged period. Testicular alterations observed include angiogenesis, inflammation, and fibrosis. These findings suggest that critically ill patients may experience severe testicular pathogenesis with active viral presence.
Article
Microbiology
Juliana Lima Alves, Luisa Lemos, Nubia Morais Rodrigues, Vanessa Bastos Pereira, Patricia A. Vieira Barros, Maria Cecilia Campos Canesso, Mauro A. F. Guimaraes, Denise Carmona Cara, Anderson Miyoshi, Vasco Ariston Azevedo, Tatiani Uceli Maioli, Ana Cristina Gomes-Santos, Ana Maria Caetano Faria
Summary: Inflammatory bowel diseases (IBD) are gastrointestinal disorders characterized by a breakdown in intestinal homeostasis by inflammatory immune responses. Novel strategies for ameliorating IBD have been proposed. The study showed that different strains of Lactococcus lactis improved clinical scores and parameters of colitis, confirming their anti-inflammatory properties in this model.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Vivian C. Miranda, Ramon O. Souza, Monica F. Quintanilha, Bruno Gallotti, Helder C. Assis, Ana Maria C. Faria, Jacques R. Nicoli, Denise C. Cara, Flaviano S. Martins
Summary: This study aimed to evaluate the probiotic and postbiotic potential of Akkermansia muciniphila BAA-835 in an ovalbumin food allergy model. The results showed that treatment with viable A. muciniphila could alleviate weight loss, decrease serum levels of allergy-related antibodies, reduce intestinal injury and inflammation, and modify the gut microbiota composition. Additionally, the administration of inactivated bacteria also had a postbiotic effect by reducing allergy-related immune responses. These findings suggest that A. muciniphila BAA-835 has both probiotic and postbiotic properties in the prevention and treatment of food allergies.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Pharmacology & Pharmacy
Larissa D. Coelho, Mirna M. D. Souza, Geovanni D. Cassali, Raphaela A. Silva, Maria J. N. Paiva, Andre L. B. Barros, Eliane M. Teixeira, Josianne N. Silveira, Paulo M. Z. Coelho, Marta M. G. Aguiar, Monica C. Oliveira
Summary: Liposomes containing emetic tartar (ET) were prepared and evaluated for the treatment of leishmaniasis. The encapsulation of ET in liposomes reduced its side effects and showed antileishmanial activity in a mouse model.
Article
Pharmacology & Pharmacy
Isabela Pereira Gomes, Juliana de Oliveira Silva, Geovanni Dantas Cassali, Andre Luis Branco De Barros, Elaine Amaral Leite
Summary: A thermosensitive liposome (TSL) functionalized with hyaluronic acid (HA) containing cisplatin (CDDP) was developed to promote drug release and reduce toxicity. In vitro and in vivo experiments showed increased cytotoxicity and senescence induction by the non-coated TSL-CDDP formulation compared to free CDDP. The HA-coated TSL-CDDP eliminated drug-induced damages and showed potential as a candidate for intravenous therapy of solid tumors.
Article
Nutrition & Dietetics
Renato Elias Moreira-Junior, Mauro Andrade de Freitas Guimaraes, Miguel Etcheverria da Silva, Tatiani Uceli Maioli, Ana Maria Caetano Faria, Ana Lucia Brunialti-Godard
Summary: Mechanisms that dictate ethanol preference and addiction are not limited to the central nervous system, but also involve the immune system and gene transcription in the reward system. This study aimed to assess the impact of problematic alcohol consumption on the transcriptional profile of the Lrrk2 gene, neuroinflammation, and behavior, and investigate their interconnections.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, Research & Experimental
Juliana de Oliveira Silva, Renata Salgado Fernandes, Janaina de Alcantara Lemos, Geovanni Dantas Cassali, Adriano de Paula Sabino, Danyelle M. Townsend, Monica Cristina Oliveira, Andre Luis Branco de Barros
Summary: Recently, folate-coated pH-sensitive liposomes have been studied as a tool to enhance cellular uptake and antitumor activity of paclitaxel and doxorubicin. This study demonstrated the importance of folate functionalization in doxorubicin-loaded liposomes and showed their significant reduction in cardiac toxicity. This provides a promising drug delivery strategy for the treatment of breast tumors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Nicolle Camilla R. Da Silva, Yasmim De O. B. Silva, Jacqueline A. Takahashi, Silvia P. Andrade, Geovanni D. Cassali, Dirce R. De Oliveira
Summary: This study investigated the effect of vegetable and fish oils with different n-3 / n-6 PUFAS ratios on the lipoprotein profile and the development of murine breast cancer 4T1. The results showed that fish oil had the highest n-3 / n-6 ratio, followed by linseed, canola and soybean oils. The type of fatty acid and the high ratio of n-3 / n-6 PUFAs in the diet influenced cell proliferation and inflammation in the tumor differently, with fish oil increasing neutrophils and VEGF levels in the tumor.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)