期刊
JOURNAL OF NEUROTRAUMA
卷 39, 期 1-2, 页码 114-121出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/neu.2020.7466
关键词
behavior; brain-derived neurotrophic factor; clinical outcomes; pediatric TBI
资金
- National Institute for Child Health and Human Development (NICHD) [K12 HD001097-16, K01 HD097030, R01 HD42729]
- National Institute of Neurological Disorders and Stroke grant [1R01NS096053]
- National Center for Advancing Translational Sciences (NCATS) [8 UL1 TR000077]
- Ronald and Irene Ward Chair in Pediatric Brain Injury - Alberta Children's Hospital Foundation
The study investigated the differential effect of BDNF Val66Met polymorphism on behavioral adjustment in children with TBI compared to children with OI. Met carriers in the TBI group showed a trend of poorer behavioral adjustment relative to Val/Val homozygotes, while the opposite trend was observed in the OI group. These within-group differences did not reach statistical significance.
The present study examined the differential effect of the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on behavioral adjustment in children with traumatic brain injury (TBI) relative to children with orthopedic injury (OI). Participants were drawn from a prospective, longitudinal study of children who sustained a TBI (n = 69) or OI (n = 72) between 3 and 7 years of age. Parents completed the Child Behavior Checklist (CBCL) at the immediate post-acute period, 6, 12, and 18 months after injury, and an average of 3.5 and 7 years after injury. Longitudinal mixed models examined the BDNF Val66Met allele status (Met carriers vs. Val/Val homozygotes) x injury group (TBI vs. OI) interaction in association with behavioral adjustment. After adjusting for continental ancestry, socioeconomic status, time post-injury, and pre-injury functioning, the allele status x injury group interaction was statistically significant for Internalizing, Externalizing, and Total Behavior problems. Post hoc within-group analysis suggested a consistent trend of poorer behavioral adjustment in Met carriers relative to Val/Val homozygotes in the TBI group; in contrast, the opposite trend was observed in the OI group. These within-group differences, however, did not reach statistical significance. The results support a differential effect of the BDNF Val66Met polymorphism on behavioral adjustment in children with early TBI relative to OI, and suggest that the Met allele associated with reduced activity-dependent secretion of BDNF may impart risk for poorer long-term behavioral adjustment in children with TBI.
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