Selective targeting of striatal parvalbumin-expressing interneurons for transgene delivery

Gene dose matters: Considerations for the use of inducible CD4‐CreER T2 mouse lines

(2020) Julia Zeiträg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Role of glial cell line‐derived neurotrophic factor in the maintenance of adult mesencephalic catecholaminergic neurons

(2020) Daniel Enterría‐Morales et al.   MOVEMENT DISORDERS

Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans

(2020) Douglas Vormstein-Schneider et al.   NATURE NEUROSCIENCE

Unique contributions of parvalbumin and cholinergic interneurons in organizing striatal networks during movement

(2019) Howard J. Gritton et al.   NATURE NEUROSCIENCE

Targeting neuronal and glial cell types with synthetic promoter AAVs in mice, non-human primates and humans

(2019) Josephine Jüttner et al.   NATURE NEUROSCIENCE

GluA4-targeted AAV vectors deliver genes selectively to interneurons while relying on the AAV receptor for entry

(2019) Jessica Hartmann et al.   Molecular Therapy-Methods & Clinical Development

Development of Efficient AAV2/DJ-Based Viral Vectors to Selectively Downregulate the Expression of Neuronal or Astrocytic Target Proteins in the Rat Central Nervous System

(2019) Charlotte Jollé et al.   Frontiers in Molecular Neuroscience

Sources of off-target expression from recombinase-dependent AAV vectors and mitigation with cross-over insensitive ATG-out vectors

(2019) Kyle B. Fischer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Viral Strategies for Targeting the Central and Peripheral Nervous Systems

(2018) Claire N. Bedbrook et al.   Annual Review of Neuroscience

A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality

(2018) Tanya L. Daigle et al.   CELL

Cre-dependent AAV vectors for highly targeted expression of disease-related proteins and neurodegeneration in the substantia nigra

(2018) Mychal S. Grames et al.   FASEB JOURNAL

Diversity of Interneurons in the Dorsal Striatum Revealed by Single-Cell RNA Sequencing and PatchSeq

(2018) Ana B. Muñoz-Manchado et al.   Cell Reports

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

(2018) Celina Monteiro Abreu et al.   Frontiers in Microbiology

Backflow-free catheters for efficient and safe convection-enhanced delivery of therapeutics

(2017) Eric Lueshen et al.   MEDICAL ENGINEERING & PHYSICS

AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors

(2017) Brian Zingg et al.   NEURON

Parvalbumin Interneurons Modulate Striatal Output and Enhance Performance during Associative Learning

(2017) Kwang Lee et al.   NEURON

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous System

(2017) Diego Pignataro et al.   Frontiers in Neuroanatomy

Dopamine Neuron-Specific Optogenetic Stimulation in Rhesus Macaques

(2016) William R. Stauffer et al.   CELL

A brain microvasculature endothelial cell‐specific viral vector with the potential to treat neurovascular and neurological diseases

(2016) Jakob Körbelin et al.   EMBO Molecular Medicine

Astrocytes are key but indirect contributors to the development of the symptomatology and pathophysiology of Huntington's disease

(2016) Cécile Meunier et al.   GLIA

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases

(2016) Michaël Hocquemiller et al.   HUMAN GENE THERAPY

A viral strategy for targeting and manipulating interneurons across vertebrate species

(2016) Jordane Dimidschstein et al.   NATURE NEUROSCIENCE

A Designer AAV Variant Permits Efficient Retrograde Access to Projection Neurons

(2016) D. Gowanlock R. Tervo et al.   NEURON

Ablation of fast-spiking interneurons in the dorsal striatum, recapitulating abnormalities seen post-mortem in Tourette syndrome, produces anxiety and elevated grooming

(2016) M. Xu et al.   NEUROSCIENCE

Tissue Specific Expression of Cre in Rat Tyrosine Hydroxylase and Dopamine Active Transporter-Positive Neurons

(2016) Zhenyi Liu et al.   PLoS One

Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq

(2016) Ozgun Gokce et al.   Cell Reports

Tailored transgene expression to specific cell types in the central nervous system after peripheral injection with AAV9

(2016) Jonathan Dashkoff et al.   Molecular Therapy-Methods & Clinical Development

Microglia-specific targeting by novel capsid-modified AAV6 vectors

(2016) Awilda M Rosario et al.   Molecular Therapy-Methods & Clinical Development

Globus Pallidus Externus Neurons Expressing parvalbumin Interconnect the Subthalamic Nucleus and Striatal Interneurons

(2016) Arpiar Saunders et al.   PLoS One

Selective transgene expression in cerebellar Purkinje cells and granule cells using adeno-associated viruses together with specific promoters

(2015) Yoonhee Kim et al.   BRAIN RESEARCH

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

Comparative analyses of adeno-associated viral vector serotypes 1, 2, 5, 8 and 9 in marmoset, mouse and macaque cerebral cortex

(2015) Akiya Watakabe et al.   NEUROSCIENCE RESEARCH

Age- and Gene-Dosage–Dependent Cre-Induced Abnormalities in the Retinal Pigment Epithelium

(2014) Lizhi He et al.   AMERICAN JOURNAL OF PATHOLOGY

Adeno-Associated Virus Serotypes 1, 8, and 9 Share Conserved Mechanisms for Anterograde and Retrograde Axonal Transport

(2014) Michael J. Castle et al.   HUMAN GENE THERAPY

A Class of GABAergic Neurons in the Prefrontal Cortex Sends Long-Range Projections to the Nucleus Accumbens and Elicits Acute Avoidance Behavior

(2014) A. T. Lee et al.   JOURNAL OF NEUROSCIENCE

A mesoscale connectome of the mouse brain

(2014) Seung Wook Oh et al.   NATURE

Effect of Needle Insertion Speed on Tissue Injury, Stress, and Backflow Distribution for Convection-Enhanced Delivery in the Rat Brain

(2014) Fernando Casanova et al.   PLoS One

A next step in adeno-associated virus-mediated gene therapy for neurological diseases: regulation and targeting

(2013) Abdelwahed Chtarto et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Intracerebroventricular Injection of Adeno-Associated Virus 6 and 9 Vectors for Cell Type–Specific Transgene Expression in the Spinal Cord

(2013) Elisabeth Dirren et al.   HUMAN GENE THERAPY

Transgene Expression in Target-Defined Neuron Populations Mediated by Retrograde Infection with Adeno-Associated Viral Vectors

(2013) M. Rothermel et al.   JOURNAL OF NEUROSCIENCE

AAV9-mediated Expression of a Non-self Protein in Nonhuman Primate Central Nervous System Triggers Widespread Neuroinflammation Driven by Antigen-presenting Cell Transduction

(2013) Lluis Samaranch et al.   MOLECULAR THERAPY

In Vivo-Directed Evolution of a New Adeno-Associated Virus for Therapeutic Outer Retinal Gene Delivery from the Vitreous

(2013) D. Dalkara et al.   Science Translational Medicine

Polymer-coated cannulas for the reduction of backflow during intraparenchymal infusions

(2012) Louis C. Vazquez et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons

(2012) Arpiar Saunders et al.   Frontiers in Neural Circuits

Universal Real-Time PCR for the Detection and Quantification of Adeno-Associated Virus Serotype 2-Derived Inverted Terminal Repeat Sequences

(2012) Christine Aurnhammer et al.   Human Gene Therapy Methods

Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery

(2011) Anja Drinkut et al.   MOLECULAR THERAPY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Differential Transgene Expression Profiles in Rat Brain, Using rAAV2/1 Vectors with Tetracycline-Inducible and Cytomegalovirus Promoters

(2008) Olivier Bockstael et al.   HUMAN GENE THERAPY

Persistent effects of mifepristone (RU-486) on cortisol levels in bipolar disorder and schizophrenia

(2008) Peter Gallagher et al.   JOURNAL OF PSYCHIATRIC RESEARCH

AAV8, 9, Rh10, Rh43 Vector Gene Transfer in the Rat Brain: Effects of Serotype, Promoter and Purification Method

(2007) Ronald L Klein et al.   MOLECULAR THERAPY