Article
Pharmacology & Pharmacy
Ngoc-Dung Huynh Luu, Le Hang Dang, Tuong-Van Vo Le, Thuy-Duong Ngoc Do, Thanh-Tuyen Thi Nguyen, Trang Thuy Thi Nguyen, Thi Phuong Nguyen, Le Son Hoang, Ngoc Quyen Tran
Summary: The study developed a topical cream based on the nanoformulation of ethyl acetate fraction extract of Chromolaena odorata leaf (EA.ChO NPs cream), which encapsulated phenolic compounds in Pluronic micelles before formulating in cream. The cream exhibited good homogeneity, suitable pH value, slow and sustained release of phenolics, and long-term stability. The cream showed enhanced wound healing effects by promoting fibroblast cell migration and accelerating wound closure in a deep second-degree burn mice model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Nanoscience & Nanotechnology
Shanshan Li, Cheng Yang, Junqiang Li, Chao Zhang, Liaoliao Zhu, Yang Song, Yongdong Guo, Ronglin Wang, Dongxue Gan, Jingjie Shi, Peixiang Ma, Fei Gao, Haichuan Su
Summary: Pluronic F127 hydrogel biomaterial, with its remarkable properties, has gained significant attention in wound healing and repair. This comprehensive review explores recent advances in Pluronic F127-derived hydrogels, focusing on their applications in various types of wounds and their interaction mechanisms within the wound microenvironment. By elucidating the underlying mechanisms and analyzing the current state of wound healing development, this review aims to foster the development of effective and safe wound-healing modalities.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Polymer Science
Tanikan Sangnim, Parinya Meeboon, Parinda Phongsewalak, Parichat Prasongdee, Pornsak Sriamornsak, Inderbir Singh, Suwisit Manmuan, Kampanart Huanbutta
Summary: This study developed and evaluated a liquid plaster loaded with Chromolaena odorata extract, which demonstrated antimicrobial and hemostasis effects. The extract inhibited certain bacteria at low concentrations and showed antioxidant and blood clotting activities. The optimized formulation of the liquid plaster had fast film-forming properties, high elasticity, and exhibited good antibacterial effect with low skin irritation.
Article
Biochemistry & Molecular Biology
Mansooreh Derakhshi, Mahdi Naseri, Zeinab Vafaeipour, Bizhan Malaekeh-Nikouei, Amir Hossein Jafarian, Legha Ansari
Summary: To mimic the native extracellular matrix (ECM), a novel electrospun wound dressing based on chitosan and polyethylene oxide was prepared using pluronic F127 and mesoporous rod-like hydroxyapatite nano-particles (mr-HAP NPs). F127 acted as a surface tension regulator and reduced the nanofiber size, while mr-HAP NPs accelerated cell proliferation and improved mechanical properties and water uptake capacity. The incorporation of mr-HAP NPs increased the water uptake capacity by more than 2.5 times, leading to enhanced wound healing efficacy and tissue development. This study scores 8 out of 10 in terms of importance.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell & Tissue Engineering
Yang Zhou, Xing-Liao Zhang, Shou-Tao Lu, Ning-Yan Zhang, Hai-Jun Zhang, Jing Zhang, Jun Zhang
Summary: This study explores the potential clinical application of hADSCs-Exos encapsulated in PF-127 hydrogel for wound healing. The results showed that PF-127/hADSCs-Exos complexes enhanced skin wound healing, promoted re-epithelialization, increased collagen synthesis and expression of skin barrier proteins, and reduced inflammation. Using PF-127/hADSCs-Exos complexes allows for lower doses and frequency of exosome administration while maintaining therapeutic effects.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Materials Science, Textiles
Naris Barnthip, Jarinee Paosoi, Onruthai Pinyakong
Summary: Gelatin nanofibers containing Chromolaena odorata extract were fabricated and their properties were studied. The fibers showed increased water adsorption and excellent antimicrobial activity against Staphylococcus aureus.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Review
Plant Sciences
Femi Olawale, Kolawole Olofinsan, Opeyemi Iwaloye
Summary: The review summarized the medicinal activities of Chromolaena odorata, revealing its potential bioactive compounds and the regulatory mechanisms for different health conditions. It was found that the plant contains various bioactive compounds that may act independently or synergistically in treating different diseases.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Plant Sciences
Yang Liu, Xi Zhang, Liping Yang, Shuai Zhou, Yuewei Li, Yiyu Shen, Shengli Lu, Jianda Zhou, Yu Liu
Summary: Diabetic foot ulcers (DFUs) are a serious condition and a major cause of limb amputation. This study found that a mixture of five herbal extracts has significant healing effects on DFUs by promoting angiogenesis and M2 macrophage transition. These findings provide a promising and non-surgical therapeutic strategy for accelerating wound healing in diabetic patients.
Article
Polymer Science
Alexandra Lupu, Luiza Madalina Gradinaru, Daniela Rusu, Maria Bercea
Summary: The thermoresponsive Pluronic (R) F127 (PL) gel's rheological behavior in water was investigated in different shear conditions. The gel strength was adjusted by adding 1% polysaccharide solution. The presence of xanthan gum improved the viscoelastic properties of PL-based hydrogels in aqueous environment, and PL micellar networks showed self-healing ability. The addition of 1% polysaccharide induced temperature-responsive hydrogels with shear thinning behavior, yield stress, and self-healing ability, making them versatile for injectable biomaterials or bioinks.
Article
Chemistry, Physical
R. Ganguly, G. Verma, A. Ingle, S. Kumar, H. D. Sarma, D. Dutta, B. Dutta, A. Kunwar, K. Ajish, K. C. Bhainsa, P. A. Hassan, V. K. Aswal
Summary: Lavender oil has been widely used in aromatherapy for its antimicrobial, anxiolytic, analgesic, and anti-inflammatory properties. This study investigated the healing abilities of lavender oil when applied in beeswax-oil and pluronic F127 hydrogel based ointments. The results showed that the ointments composed of lavender oil solubilized beeswax-oil and F127-water based structures exhibited suitable rheological and spreading properties for topical applications. The ointments promoted faster epithelialization and neovascularization in full thickness mice wounds.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Engineering, Chemical
Faridah Aminullah Lubis, Nik Ahmad Nizam Nik Malek, Nor Suriani Sani, Khairunadwa Jemon
Summary: This study successfully synthesized silver nanoparticles using plant extract and evaluated their potential applications in antibacterial, cytocompatibility, and wound healing activities. The results showed that these silver nanoparticles exhibited antibacterial effects against common bacteria and were non-toxic to normal cells. They also enhanced cell migration and facilitated wound healing.
Article
Plant Sciences
Aaliya Ali, Prakrati Garg, Rohit Goyal, Gurjot Kaur, Xiangkai Li, Poonam Negi, Martin Valis, Kamil Kuca, Saurabh Kulshrestha
Summary: The study evaluated the wound healing efficacy of n-hexane extract and hydrogels of Moringa oleifera seeds, demonstrating their significant effectiveness in wound healing.
Article
Pharmacology & Pharmacy
Bapi Gorain, Manisha Pandey, Ng Hui Leng, Cho Wei Yan, Kuek Wee Nie, Simran Jeet Kaur, Vincent Marshall, Sreenivas Patro Sisinthy, Jithendra Panneerselvam, Nagashekhara Molugulu, Prashant Kesharwani, Hira Choudhury
Summary: Management of chronic wounds has significant social and economic implications, and traditional medicines combined with nanotechnology offer new opportunities for wound healing.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Materials Science, Textiles
G. Resmi, S. Amsamani
Summary: This paper reports on the characteristics and potential applications of viscose fabric treated with extracts of Chromolaena odorata for antibacterial and wound healing purposes. The study found that the treated dressings showed good wound healing efficiency and antibacterial competence against S. aureus and E. coli. The research also revealed that the phytochemicals can be imparted on the fabric for a certain period of time, providing antibacterial and wound healing properties.
INDIAN JOURNAL OF FIBRE & TEXTILE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Hui Zhang, Xinyu Sun, Jiao Wang, Yalan Zhang, Mengna Dong, Tong Bu, Lihua Li, Yingnan Liu, Li Wang
Summary: In this study, Gel-DA was used as a biotemplate to synthesize Gel-DA@Ag NPs with antioxidant activity and NIR laser irradiation synergistic antibacterial behavior for the first time. These NPs were then incorporated into guar gum based hydrogels to achieve remolding, injectable, and self-healing properties. The multifunctional hydrogels demonstrated the ability to completely cover irregular wound shapes and accelerate wound healing under NIR, with the appearance of skin appendages like hair follicles and blood vessels.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Ngoc Hoa Nguyen, Le Hang Dang, Phuong Doan, Chan Khon Huynh, Cuu Khoa Nguyen, Bich Tram Nguyen, Ngoc Tung Nguyen, Ngoc Quyen Tran
Summary: Platinum complexes are being explored for cancer therapy, with PAMAM G4.0 modified to improve delivery effectiveness and reduce toxicity. The PAA-conjugated PAMAM G4.0 showed enhanced cytocompatibility and higher affinity with aquated cisplatin, leading to reduced toxicity against cancer cells.
BULLETIN OF MATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Van Toan Nguyen, Thi Phuong Le, Le Hang Dang, Tan Phuoc Ton, Dinh Trung Nguyen, Nam Nguyen Dang, Bich Tram Nguyen, Vu Van Van, Thi Hiep Nguyen, Ngoc Quyen Tran
Summary: The study introduces a nanosized biomimetic catalyst, hematin-decorated polyamidoamine dendrimer (G3.0-He), which effectively catalyzes the in situ hydrogelation of phenol-conjugated polymers under neutral pH conditions. The catalyst exhibits excellent enzyme mimetic functions and remains active even at high H2O2 concentration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Tan Phuoc Ton, Thi Yen Nhi Tran, Le Hang Dang, Kim Thi Hoang Nguyen, Phuong Doan, Van Toan Nguyen, Dinh Trung Nguyen, Bao Huy Le, Ngoc Quyen Tran, Bich Tram Nguyen
Summary: The study successfully fabricated an enzyme-mimicking biocatalyst G2.0-He, which showed higher stability than HRP enzyme at high H2O2 concentrations and excellent cytocompatibility, making it a potential scaffold for fibroblast cell adhesion and proliferation in biomedical applications.
INTERNATIONAL JOURNAL OF POLYMER SCIENCE
(2021)
Article
Crystallography
Van Khiem Nguyen, Duy Khanh Pham, Ngoc Quyen Tran, Le Hang Dang, Ngoc Hoa Nguyen, Thanh Viet Nguyen, Thi Hiep Nguyen, Thi Bich Luong
Summary: Blue-emitting Ag(+)-, Cu(2+)-, and Mg(2+)-doped ZnSe nanoparticles were successfully synthesized using mercaptopropionic acid as a stabilizer. The nanoparticles showed different diameters based on the dopant metal, with Ag-doped ZnSe being the smallest at about 13 nm. Photoluminescence occurred within the wavelength range of 400-550 nm, with intensity and quantum yields related to the ionic radii of the dopant metals.
Article
Pharmacology & Pharmacy
Hung Quach, Tuong-Vi Le, Thanh-Thuy Nguyen, Phuong Nguyen, Cuu Khoa Nguyen, Le Hang Dang
Summary: In this study, the researchers demonstrated the modification of lecithin-based nano-lipids by incorporating ginger oil, resulting in improved stability, biocompatibility, antibacterial activity, and pH-dependent drug release. The findings suggest the potential of these ginger oil-modified nano-lipids for drug delivery systems.
Article
Polymer Science
Tien Thinh Nguyen, Le Hang Dang, Phuong Nguyen, Truc Le-Buu Pham, Hai Khoa Le, Minh-Ty Nguyen, Tran Thi Yen Nhi, Sijia Feng, Jun Chen, Ngoc Quyen Tran
Summary: Hydrogels with bone biomimetic microenvironment are prepared using biopolymer and biphasic calcium phosphate nanoparticles, which have great potential for bone-graft materials development.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Ngoc-Dung Huynh Luu, Le Hang Dang, Tuong-Van Vo Le, Thuy-Duong Ngoc Do, Thanh-Tuyen Thi Nguyen, Trang Thuy Thi Nguyen, Thi Phuong Nguyen, Le Son Hoang, Ngoc Quyen Tran
Summary: The study developed a topical cream based on the nanoformulation of ethyl acetate fraction extract of Chromolaena odorata leaf (EA.ChO NPs cream), which encapsulated phenolic compounds in Pluronic micelles before formulating in cream. The cream exhibited good homogeneity, suitable pH value, slow and sustained release of phenolics, and long-term stability. The cream showed enhanced wound healing effects by promoting fibroblast cell migration and accelerating wound closure in a deep second-degree burn mice model.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dinh Trung Nguyen, Thi Phuong Nguyen, Van Thoai Dinh, Ngoc Hao Nguyen, Kim Thi Hoang Nguyen, Thi Hiep Nguyen, Tang Tuan Ngan, Tran Thi Yen Nhi, Bao Ha Tran Le, Phuong Le Thi, Le Hang Dang, Ngoc Quyen Tran
Summary: Dual-drug delivery systems using FA-GP-P123 nanogels show great potential in targeted chemotherapy by simultaneously delivering QU and PTX to tumors, overcoming drug resistance and improving therapeutic efficacy. The nanogels have high drug loading capacity and the release of drugs follows Fickian diffusion and swelling behavior. The FA-GP-P123/QU/PTX system exhibits synergistic effects and FA positive targeting effect, leading to reduced tumor volume and minimized side effects in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Dinh Trung Nguyen, Hai Phuong Doan, Thi Kim Ngan Tran, Chan Khon Huynh, Ngoc Quyen Tran, Le Hang Dang
Summary: In recent years, nanomaterials have been extensively studied and applied in various fields, including pharmaceutical applications. Researchers successfully embedded an anticancer drug, methotrexate, into a nano-sized carrier and increased its stability and prolongation of effect by adding a sulfated polysaccharide fucoidan. The synthesized nanoparticle complex showed enhanced drug release activity and high cytocompatibility.
ADVANCES IN NATURAL SCIENCES-NANOSCIENCE AND NANOTECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Ngoc Hao Nguyen, Quynh Anh Bui, Le Hang Dang, Dinh Trung Nguyen, Ngoc Quyen Tran
Summary: Approaches of synthesizing injectable hydrogels have attracted attention in various fields, and injectable horseradish peroxidase-mediated hydrogels have emerged as a promising candidate in biomedical material development. In this study, we prepared a HGT polymer that could form an injectable hydrogel without the need for HRP. The HGT hydrogel exhibited rapid gelation in the presence of a small amount of H2O2 and showed enzyme-like catalytic activity. The biocompatibility of the hydrogel will be further investigated for tissue regeneration applications.
VIETNAM JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Van Khiem Nguyen, Duy Khanh Pham, Ngoc Quyen Tran, Le Hang Dang, Ngoc Hoa Nguyen, Thanh Mien Nguyen, Nguyen Thanh Viet, Jin-Woo Oh, Thi-Diem Bui, Bich Thi Luong
Summary: The effect of three types of capping polymers (MPA, PEG, and starch) on the photoluminescence of Mn(2+)-doped ZnSe nanoparticles was investigated. The nanoparticles with different capping polymers had identical optical properties, but the photoluminescence quantum yields (PLQY) and lifetimes varied. Starch-capped nanoparticles had the largest size and highest photoluminescence intensity.
GREEN PROCESSING AND SYNTHESIS
(2022)
Article
Chemistry, Multidisciplinary
Tan Phuoc Ton, Van Toan Nguyen, Phuong Doan, Dinh Trung Nguyen, Thi Phuong Nguyen, Chan Khon Huynh, Thi Cam Quyen Ngo, Le Hang Dang, Ngoc Quyen Tran
Summary: The newly designed Ge-He compound, created by conjugating a molecule onto gelatin, effectively improves the catalytic effectiveness of hematin in neutral conditions, exhibiting better catalytic efficiency and stability than free hematin. Additionally, the Ge-He biocatalyst demonstrates rapid gelation similar to HRP-mediated hydrogels in the preparation of hydrogels, while also showing good compatibility with cells, with 100% viability of human fibroblast cells in vitro.
NEW JOURNAL OF CHEMISTRY
(2021)
