Review
Immunology
Rahul M. Dhodapkar, Diego Martell, Brian P. Hafler
Summary: Age-related macular degeneration (AMD) is a neurodegenerative disorder that leads to irreversible vision loss worldwide. Microglia-mediated neuroinflammation is identified as a key driver of neural damage in AMD, presenting potential therapeutic targets.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Juncai He, Yan Fu, Lingling Ge, Jiaman Dai, Yajie Fang, Yijian Li, Xianliang Gu, Zui Tao, Ting Zou, Minghui Li, Yong Liu, Haiwei Xu, Zheng Qin Yin
Summary: This study investigated the activation of microglia and its contribution to photoreceptor degeneration in retinitis pigmentosa (RP). The results showed that disease-associated microglia activation can suppress the degeneration of rods and cones, reducing secondary damage caused by the accumulation of dead cells and infiltrated neutrophils.
Article
Ophthalmology
Seyedeh Maryam Zekavat, Sayuri Sekimitsu, Yixuan Ye, Vineet Raghu, Hongyu Zhao, Tobias Elze, Ayellet Segre, Janey L. Wiggs, Pradeep Natarajan, Lucian Del Priore, Nazlee Zebardast, Jay C. Wang
Summary: This study investigated the changes in retinal layer thickness in AMD patients using OCT, electronic health record data, and genomic data. The study found that thinning of the photoreceptor segment was the strongest predictor of future AMD risk.
Review
Immunology
Keng Siang Lee, Shuxiao Lin, David A. Copland, Andrew D. Dick, Jian Liu
Summary: Age-related macular degeneration (AMD) is a common cause of vision loss in the elderly, with genetic, environmental, and cellular senescence factors contributing to its pathophysiology. Therapeutic strategies targeting senescent cells offer potential for treating AMD and other age-related diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Immunology
Nima Javanmehr, Kiarash Saleki, Parsa Alijanizadeh, Nima Rezaei
Summary: Microglia play a crucial role in maintaining brain homeostasis and neurorepair processes. Recent research has revealed their spatiotemporal heterogeneity and their involvement in neurodegenerative processes. Microglia have diverse phenotypes and are involved in promoting and inhibiting inflammation, as well as neurovascular unit restoration and synaptic plasticity. Further exploration is needed to understand the dynamics of microglial cells and their contribution to neurodegeneration.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Geriatrics & Gerontology
Nan Su, Uwe Hansen, Tanja Plagemann, Karin Gaeher, M. Dominik Leclaire, Jeannette Konig, Annika Hoehn, Tilman Grune, Constantin E. Uhlig, Nicole Eter, Peter Heiduschka
Summary: LF injection into the subretinal space of mice leads to activation and migration of microglial cells, increased expression of inflammatory cytokines, and gradual degradation of RPE cells. These features are consistent with those found in an aging retina, suggesting that LF injection could serve as a model for intermediate and late AMD.
Article
Food Science & Technology
Nguyen Dao, Thilini Thrimawithana, Terrence J. Piva, Danilla Grando, Huynh Tien
Summary: Age-related macular degeneration (AMD) is a chronic disease that causes blindness in older adults and has a significant economic impact on the healthcare system. Carotenoids from plants, such as lutein, zeaxanthin, and mesozeaxanthin, accumulate in the macula and protect against light exposure, oxidation, and inflammation, making them a potential preventative and therapeutic treatment for AMD. The dose and duration of treatment with carotenoids are important factors that influence their protective effects and can potentially improve visual outcomes in AMD patients. This review discusses the application of carotenoid supplementation as a non-invasive alternative for the prevention and treatment of AMD.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Geriatrics & Gerontology
Janos Feher, Agnes Elo, Lilla Istvan, Zoltan Zsolt Nagy, Zsolt Radak, Gianluca Scuderi, Marco Artico, Illes Kovacs
Summary: This review explores the role of microbiota-mitochondria disorders in age-related macular degeneration (AMD). It suggests that the dysregulation of microbiota and mitochondria may be a crucial mechanism in the development of early AMD and proposes new treatment approaches targeting these disorders.
Review
Cell Biology
Karina Ascunce, Rahul M. M. Dhodapkar, Deven Huang, Brian P. P. Hafler
Summary: Age-related macular degeneration (AMD) is a neurodegenerative disease that leads to irreversible vision loss. Recent evidence suggests that the innate immune system, including complement activation, microglial involvement, and blood-retinal-barrier disruption, plays a crucial role in the pathophysiology of AMD. This review explores the role of the innate immune system in AMD and discusses the potential therapeutic targets for AMD in the context of innate immune activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Mengmeng Sun, Tao Yu, Jianing Zhao, Xuan Zhu, Wenyu Xin, Fenglan Zhang, Leiming Zhang
Summary: Age-related macular degeneration (AMD) is a common eye disorder that leads to blindness and vision loss. The underlying causes of AMD are not well understood, but oxidative damage, inflammation, and neovascularization are believed to play a role. Flavonoids, naturally occurring bioactive substances with antioxidant, anti-inflammatory, and neovascularization inhibitory properties, have been studied in relation to AMD using in vitro and in vivo models. This article discusses the research progress and characteristics of flavonoids in treating AMD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Ophthalmology
Clement K. Chan, Wesley T. Beaulieu, Brandon J. Lujan, Maziar Lalezary, Daniella Lent-Schochet, Therlinder Lo, Glenn Yiu
Summary: The purpose of this study was to investigate the impact of prophylactic ranibizumab injections on drusen volume, macular thinning, and GA progression in eyes with intermediate AMD. The results showed that prophylactic ranibizumab did not appear to affect these parameters. Additionally, there was no difference in the conversion rate to neovascular AMD between the PR and sham injection groups.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Alexa Klettner, Johann Roider
Summary: TLR activation in the retinal pigment epithelium (RPE) can induce a pro-inflammatory response, leading to inflammation by triggering the release of pro-inflammatory cytokines, impairing RPE function, and causing RPE cell degeneration. This constant cycle of TLR activation may contribute to the development of AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Tingting Sun, Qingquan Wei, Peng Gao, Yongjie Zhang, Qing Peng
Summary: The study investigated cytokine and chemokines profiling in the aqueous humor of nAMD patients, finding lower levels of basic fibroblast growth factor and RANTES, and higher levels of VEGF-A compared to the control group. After IVR treatment, levels of Eotaxin increased while VEGF-A decreased in nAMD patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Ophthalmology
Sanjeeb Bhandari, Susan Vitale, Elvira Agron, Traci E. Clemons, Emily Y. Chew
Summary: A prospective cohort study within the AREDS2 trial evaluated the risk of late AMD development after cataract surgery, and found that cataract surgery did not increase the risk of late AMD among participants with up to 10 years of follow-up.
Article
Medicine, General & Internal
Ines Lains, Kevin M. Mendez, Joao Q. Gil, John B. Miller, Rachel S. Kelly, Patricia Barreto, Ivana K. Kim, Demetrios G. Vavvas, Joaquim Neto Murta, Liming Liang, Rufino Silva, Joan W. Miller, Jessica Lasky-Su, Deeba Husain
Summary: This study aimed to assess urinary metabolomic profiles of patients with different stages of age-related macular degeneration (AMD) and controls. Results showed no significant differences in urine metabolites when comparing patients with AMD and controls. However, when disease severity was considered as an outcome, six urinary metabolites differed significantly, supporting previous work performed with plasma.
JOURNAL OF CLINICAL MEDICINE
(2022)