期刊
JOURNAL OF MOLECULAR LIQUIDS
卷 325, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.molliq.2020.115121
关键词
Charge-transfer; Azithromycin; Picric acid; Chloranilic acid; Chloranil
资金
- Taif University, Taif, Saudi Arabia [TURSP-2020/02]
Research on the charge-transfer interactions between the antibiotic azithromycin and three pi-acceptors may provide insights for improving treatment protocols for COVID-19. The synthesized CT products exhibited different morphologies from the free reactants.
Finding a vaccine or cure for the coronavirus disease (COVID-19) responsible for the worldwide pandemic and its economic, medical, and psychological burdens is one of the most pressing issues presently facing the global community. One of the current treatment protocols involves the antibiotic azithromycin (AZM) alone or in combination with other compounds. Obtaining additional insight into the charge-transfer (CT) chemistry of this antibiotic could help researchers and dinicians to improve such treatment protocols. Toward this aim, we investigated the CT interactions between AZM and three pi-acceptors: picric acid (PA), chloranilic acid (CLA), and chloranil (CHL) in MeOH solvent. AZM formed colored products at a 1:1 stoichiometry with the acceptors through intermolecular hydrogen bonding. An n -> pi* interaction was also proposed for the AZM-CHL CT product. The synthesized CT products had markedly different morphologies from the free reactants, exhibiting a semi-crystalline structure composed of spherical particles with diameters ranging from 50 to 90 nm. (C) 2020 Elsevier B.V. All rights reserved.
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