Article
Microbiology
Ines Hadrich, Nahed Khemakhem, Amin Ilahi, Houaida Trabelsi, Hayet Sellami, Fattouma Makni, Sourour Neji, Ali Ayadi
Summary: This study aimed to develop VNTR markers for genotyping Malassezia isolated from clinical and animal samples. A total of 44 M. globosa and 24 M. restricta isolates were analyzed, and 12 VNTR markers were selected. The results showed that VNTR analysis was capable of identifying the species with high accuracy and reliability, and it could be a powerful tool for monitoring Malassezia colonization in domestic animals and humans.
Article
Microbiology
Alessandra Mularoni, Elena Graziano, Alice Annalisa Medaglia, Barbara Buscemi, Taylor Eddens, Lavinia Martino, Daniele Di Carlo, Antonio Cascio, Pier Giulio Conaldi, Alessandro Bertani, Paolo Antonio Grossi
Summary: Emerging fungal infections in solid organ transplantation pose a major challenge with high morbidity and mortality rates. In this study, two cases of Malassezia restricta pneumonia in SOT recipients were successfully diagnosed and treated with antifungal therapy, leading to full recovery in both patients.
Article
Agriculture, Dairy & Animal Science
Wayne Tsang, Annika Linde, Janina A. Krumbeck, Guangxi Wu, Young J. Kim, Gerald H. Lushington, Tonatiuh Melgarejo
Summary: Oral disease in cats is a significant concern in small animal practice, with antimicrobial resistance genes being found commonly in the mouth of cats, potentially transferring to humans and making certain antibiotics less effective. Feline chronic gingivostomatitis is a severe immune-mediated inflammatory disease where antimicrobial-resistant bacteria and fungi coexist, highlighting the need for concern in both feline and human medicine.
Article
Infectious Diseases
Otomi Cho, Yasuhiko Matsumoto, Tsuyoshi Yamada, Takashi Sugita
Summary: This study established a gene transfer system for generating gene-deficient mutants of M. restricta and showed that FKB1 gene plays a key role in the sensitivity to tacrolimus.
Article
Immunology
Linda Houhamdi-Hammou, Yvonne Benito, Andre Boibieux, Damien Dupont, Francois Delahaye, Francoise Thivolet-Bejui, Martine Wallon, Francois Vandenesch, Coralie Bouchiat
Summary: This study utilized ultra-sensitive molecular techniques to detect microbial DNA in cardiac samples, revealing M. restricta as a potentially underestimated causative agent of NDIE. The serological cross-reaction between M. restricta and C. albicans could lead to misdiagnosis.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Dermatology
Roland Jourdain, Alain Moga, Prokopios Magiatis, Maxime Fontanie, Aristea Velegraki, Chrysanthi Papadimou, Valerie Rahoul, Audrey Gueniche, Tarun Chopra, George Gaitanis
Summary: Dandruff is a common scalp disorder with various microbial and host-related factors involved. Recent studies have identified specific biomarkers of dandruff-afflicted scalp, indicating the role of sebum lipoperoxidation in its onset and maintenance. The study provides evidence that the yeast Malassezia restricta mediates sebum peroxidation, leading to the production of certain compounds that affect epidermal cells and alter the skin barrier. These findings suggest that targeting the production of these lipoperoxidation products could be a potential treatment approach for dandruff.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Dermatology
Patcharin Thammasit, Angkana Laliam, Kunyaluk Chaicumpar, Kritsada Pruksaphon, Joshua D. Nosanchuk, Sirida Youngchim
Summary: This study describes different media for culturing Malassezia furfur and investigates the role of lipase enzymes in the dimorphism of this fungus. The results show that strains from healthy individuals are more likely to form mycelial growth compared to those from patients with pityriasis versicolor. The study also highlights the association between lipase and the dimorphic forms of M. furfur.
Article
Microbiology
Yong-Joon Cho, Taeyune Kim, Daniel Croll, Minji Park, Donghyeun Kim, Hye Lim Keum, Woo Jun Sul, Won Hee Jung
Summary: Malassezia is a common fungus on human skin that causes various skin diseases. This study compared the genome of the recently identified Malassezia species, M. arunalokei, with the dominant species M. restricta and found specific gene loss events during speciation. The research also revealed that M. arunalokei diverged from M. restricta approximately 7.1 million years ago, making it the most recently diverged species in the Malassezia lineage. Furthermore, analysis of the facial mycobiome showed that M. arunalokei is more abundant on the forehead and cheek than on the scalp.
MICROBIOLOGY SPECTRUM
(2022)
Article
Agricultural Engineering
Shenglan Liao, Gang Yang, Shan Huang, Bin Li, Aijun Li, Jianquan Kan
Summary: This study investigated the chemical composition, antifungal activity, and modes of action of Zanthoxylum schinifolium Siebold & Zucc. essential oil (ZSEO) against Malassezia restricta. The results showed that ZSEO had significant antifungal activity, caused damage to the cell membrane, induced lipid disorder, disrupted oxidative stress, and resulted in morphological and ultrastructural changes in M. restricta cells. These findings suggest that ZSEO has the potential to be used as an antifungal agent against M. restricta.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Yohannes Abere Ambaw, Martin P. Pagac, Antony S. Irudayaswamy, Manfred Raida, Anne K. Bendt, Federico T. Torta, Markus R. Wenk, Thomas L. Dawson
Summary: Malassezia, common components of human skin, can synthetize steroid-like lipid mediators in vitro, which may be related to metabolic pathways shared with the human skin.
Article
Biochemistry & Molecular Biology
Andrea Rios-Navarro, Mabel Gonzalez, Chiara Carazzone, Adriana Marcela Celis Ramirez
Summary: This study aimed to determine the volatile profiles of Malassezia yeasts in different growth phases. A total of 54 compounds, mainly alcohols, were identified. The volatile profiles differed between species and growth phases, with M. globosa having the highest quantity of VOCs. These findings provide important clues for understanding the pathogenic role of these yeasts.
Article
Biology
Karolina Chilicka, Iwona Dziendziora-Urbinska, Renata Szygula, Binnaz Asanova, Danuta Nowicka
Summary: Acne vulgaris is a chronic disease that affects quality of life and social interactions, and is related to the formation of skin lesions, intestinal microbiota, and the use of probiotics.
Article
Biochemistry & Molecular Biology
Xiaobin Yang, Bei Xiong, Zhuolei Yuan, Hui Liao, Xiaowei Liu, Yinan Wu, Shu Zhang, Qi Xiang
Summary: This study investigated the effects of pathogenic yeast genus Malassezia and a plant extract POL on the skin. The results showed that POL exhibited anti-inflammatory effects and promoted wound healing. However, its inhibitory effect on Malassezia activity was limited.
Article
Immunology
Kazuhiro Suzuki, Otomi Cho, Tohru Nagahama, Takashi Sugita
Summary: This study analyzed the short sequence repeats (SSRs) of the intergenic spacer (IGS) region in Malassezia globosa and Malassezia restricta, and found that the (CT)(6):(AT)(8) SSR in M. restricta is associated with the development or exacerbation of androgenetic alopecia (AGA).
MICROBIOLOGY AND IMMUNOLOGY
(2022)
Article
Immunology
Dora E. Corzo-Leon, Donna M. MacCallum, Carol A. Munro
Summary: Malassezia species are important members of the normal mycobiota, colonizing sebum-rich skin regions and causing various infections. The study observed differences in skin responses to Malassezia sympodialis under oily and non-oily skin conditions, affecting the expression of immune-related genes and protein levels in the tissue.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)