Identification of Novel Tricyclic Benzo[1,3]oxazinyloxazolidinones as Potent Antibacterial Agents with Excellent Pharmacokinetic Profiles against Drug-Resistant Pathogens

A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide

(2020) Yong-Qi Wu et al.   SYNTHETIC COMMUNICATIONS

Discovery of a Conformationally Constrained Oxazolidinone with Improved Safety and Efficacy Profiles for the Treatment of Multidrug-Resistant Tuberculosis

(2020) Hongyi Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pretomanid: First Approval

(2019) Susan J. Keam   DRUGS

Comparison of in vitro activity and MIC distributions between the novel oxazolidinone delpazolid and linezolid against multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis in China

(2018) Zhaojing Zong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Design, Synthesis, and Antibacterial Evaluation of Oxazolidinones with Fused Heterocyclic C-Ring Substructure

(2017) Mahesh S. Deshmukh et al.   ACS Medicinal Chemistry Letters

Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis

(2017) Hongyi Zhao et al.   ACS Medicinal Chemistry Letters

Targeting Antibiotic Resistance

(2016) Mathieu F. Chellat et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Oxazolidinone antimicrobials: a patent review (2012-2015)

(2016) Oludotun A. Phillips et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies

(2015) Tao Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

New Potent Antibacterial Oxazolidinone (MRX-I) with an Improved Class Safety Profile

(2014) Mikhail F. Gordeev et al.   JOURNAL OF MEDICINAL CHEMISTRY

General synthetic approach towards annelated 3a,6-epoxyisoindoles by tandem acylation/IMDAF reaction of furylazaheterocycles. Scope and limitations

(2014) Fedor I. Zubkov et al.   TETRAHEDRON

Solubility-Driven Optimization of (Pyridin-3-yl) Benzoxazinyl-oxazolidinones Leading to a Promising Antibacterial Agent

(2013) Bin Guo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Potent Oxazolidinone Antibacterials with Heteroaromatic C-Ring Substructure

(2013) Hideyuki Suzuki et al.   ACS Medicinal Chemistry Letters

Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent

(2011) Weon Bin Im et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Structure–Activity Relationship Studies of Highly Potent Novel Benzoxazinyl-Oxazolidinone Antibacterial Agents

(2011) Qisheng Xin et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vitro and In Vivo Activities of LCB01-0371, a New Oxazolidinone

(2010) J.-W. Jeong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Pharmacokinetics and Whole‐Blood Bactericidal Activity againstMycobacterium tuberculosisof Single Doses of PNU‐100480 in Healthy Volunteers

(2010) Robert S. Wallis et al.   JOURNAL OF INFECTIOUS DISEASES