Review
Medicine, General & Internal
Gianvito Candita, Sara Rossi, Karolina Cwiklinska, Salvatore Claudio Fanni, Dania Cioni, Riccardo Lencioni, Emanuele Neri
Summary: Hepatocellular carcinoma (HCC) is a significant cause of oncologic mortality worldwide and poses challenges for healthcare systems. Early detection and appropriate therapy are crucial for improving patient outcomes. Imaging techniques play a vital role in the surveillance, detection, diagnosis, and post-treatment follow-up of HCC. The unique imaging characteristics of HCC lesions, especially the assessment of their vascularity using contrast-enhanced CT, MR, or CEUS, allow for accurate noninvasive diagnosis and staging. The use of imaging has expanded to include the detection of early-stage hepatocarcinogenesis using ultrasound and hepatobiliary MRI contrast agents, as well as the application of artificial intelligence for diagnostic prediction, prognosis, and treatment evaluation.
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyunho Cha, Jin-Young Choi, Young Nyun Park, Kyunghwa Han, Mi Jang, Myeong-Jin Kim, Mi-Suk Park, Hyungjin Rhee
Summary: This study investigated the imaging findings of macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) on CT and MRI. The results showed that MTM-HCC was associated with certain imaging characteristics on CT and MRI, such as arterial phase hypovascular component and non-smooth tumor margin. The MRI diagnostic criteria for MTM-HCC were applicable on CT, showing similar diagnostic performance and prognostic significance.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Choi, Rohee Park, Sang Hyun Choi, Hyeon Ji Jang, Se Jin Choi, Subin Heo
Summary: This study evaluated the added value of threshold growth for diagnosing hepatocellular carcinoma on gadoxetic acid-enhanced MRI. The results showed that when threshold growth was used as a major imaging feature, the sensitivity of the European Association for the Study of the Liver criteria was significantly higher compared to when it was not used. There was no significant difference in the sensitivities of the Asian Pacific Association for the Study of the Liver and Korean Liver Cancer Association-National Cancer Center criteria. Threshold growth had added value for improving the sensitivity of the European Association for the Study of the Liver criteria without extending washout to transitional-phase or hepatobiliary-phase images.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shu Wen Sun, Xun Xu, Qiu Ping Liu, Jie Neng Chen, Fei Peng Zhu, Xi Sheng Liu, Yu Dong Zhang, Jie Wang
Summary: An artificial intelligence (AI) tool called LiSNet was developed for scoring and interpreting hepatocellular carcinoma (HCC) aggressiveness using computed tomography (CT) imaging. LiSNet showed comparable results to subspecialists in assessing HCC aggressiveness and predicting histopathological microvascular invasion. When combined with experience-based binary diagnosis, LiSNet achieved the best predictive ability for microvascular invasion. Furthermore, LiSNet was able to predict overall survival after surgery.
Article
Gastroenterology & Hepatology
Roberto Cannella, Marco Dioguardi Burgio, Aurelie Beaufrere, Loic Trapani, Valerie Paradis, Christian Hobeika, Francois Cauchy, Mohamed Bouattour, Valerie Vilgrain, Riccardo Sartoris, Maxime Ronot
Summary: In this study, the distribution of LI-RADS major features and categories did not differ among different histological subtypes of hepatocellular carcinoma in high-risk patients. However, tumour-in-vein, LR-M features, and ancillary features can provide valuable information for the non-invasive diagnosis of hepatocellular carcinoma subtypes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Chan Park, Jin Hyoung Kim, Pyeong Hwa Kim, So Yeon Kim, Dong Il Gwon, Hee Ho Chu, Minho Park, Joonho Hur, Jin Young Kim, Dong Joon Kim
Summary: The study indicates that pre-TACE CT or MR imaging findings can predict survival outcomes in patients with small HCC undergoing TACE treatment, aiding in prognosis, identification, and selection of suitable candidates for TACE.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Medicine, General & Internal
Samuel J. Galgano, John C. Norton, Kristin K. Porter, Janelle T. West, Soroush Rais-Bahrami
Summary: Penile squamous cell carcinoma has a higher incidence worldwide, and clinical examination is crucial for initial diagnosis. Imaging plays a vital role in staging, restaging, and follow-up of penile cancer patients.
Article
Oncology
Jun-Yi Wu, Li-Ming Huang, Yan-Nan Bai, Jia-Yi Wu, Yong-Gang Wei, Zhi-Bo Zhang, Mao-Lin Yan
Summary: HCC patients with B1-B3 BDTT have more advanced tumor stages and adverse clinicopathological features. The imaging features of HCC with BDTT on CT and MRI scans, including HCC lesions and intrahepatic bile duct dilation, might facilitate the early diagnosis of B1-B3 BDTT.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pediatrics
Guillermo A. Arias, Iram Siddiqui, Oscar M. Navarro, Furqan Shaikh, Blayne A. Sayed, Govind B. Chavhan
Summary: Pediatric HCC is characterized by large heterogeneous tumors with common imaging features such as arterial phase hyperenhancement, washout, capsule, and tumor-in-vein. Fibrolamellar HCC is distinguished by central scar, normal AFP levels, and normal liver background.
PEDIATRIC RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Boryeong Jeong, Se Jin Choi, Sang Hyun Choi, Hyeon Ji Jang, Jae Ho Byun, Hyung Jin Won, Yong Moon Shin
Summary: This study compared the accuracy of LI-RADS based on original threshold growth (TG) and LI-RADS based on tumor growth rate for the diagnosis of HCC. It was found that LI-RADS based on tumor growth rate showed higher diagnostic accuracy for HCC.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Subin Heo, Hyo Jeong Kang, Sang Hyun Choi, Sehee Kim, Youngeun Yoo, Won-Mook Choi, So Yeon Kim, Seung Soo Lee
Summary: This multi-reader study demonstrated that the percentage of LR-M was significantly higher in proliferative HCCs. CT/MRI LR-M was significantly associated with poor overall survival (OS) and recurrence-free survival (RFS), regardless of the pathological classification of proliferative vs. non-proliferative HCCs.
EUROPEAN RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qishu Gong, Yusen Zhang, Tianchong Wu, Zhiyong Du, Yue Zhang
Summary: Macrotrabecular-massive hepatocellular carcinoma (MTM-HCC) is a subtype of HCC associated with worse prognosis. This study aimed to describe CT and MRI findings of MTM-HCCs and compare them with histopathological features.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qishu Gong, Yusen Zhang, Tianchong Wu, Zhiyong Du, Yue Zhang
Summary: This study analyzed the CT and MRI findings of MTM-HCCs and compared them with histopathological features. The findings showed that MTM-HCCs tend to be large in size with intratumoral artery and intratumoral necrosis, which may distinguish them from non-MTM-HCCs.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yeun-Yoon Kim, Sunyoung Lee, Jaeseung Shin, Won Jeong Son, Hyejung Shin, Ji Eun Lee, Jeong Ah Hwang, Yong Eun Chung, Jin-Young Choi, Mi-Suk Park
Summary: The study systematically compared the performance of CT/MRI LI-RADS category 5 (LR-5) for diagnosing HCC between 2017 and 2018 versions, finding no significant difference in sensitivity and specificity between the two versions. The most common underlying liver disease (hepatitis B or hepatitis C) was a significant factor contributing to the heterogeneity of sensitivities among studies for both versions.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yeun-Yoon Kim, Sunyoung Lee, Jaeseung Shin, Won Jeong Son, Yun Ho Roh, Jeong Ah Hwang, Ji Eun Lee
Summary: Comparative studies were conducted to compare the performance of Liver Imaging Reporting and Data System category 5 (LR-5) for diagnosing HCC between CT and MRI. The results showed that MRI had significantly higher sensitivity than CT in diagnosing HCC using LR-5. However, there was no significant difference in specificity between the two modalities. Subgroup analysis revealed that extracellular contrast agent-enhanced MRI had higher sensitivity than gadoxetic acid-enhanced MRI in diagnosing HCC.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Tian-yu Tang, Yun Jiao, Ying Cui, Deng-ling Zhao, Yi Zhang, Zhi Wang, Xiang-pan Meng, Xin-Dao Yin, Yun-Jun Yang, Gao-jun Teng, Sheng-hong Ju
JOURNAL OF NEUROLOGY
(2020)
Article
Oncology
Xiang-Pan Meng, Yuan-Cheng Wang, Shenghong Ju, Chun-Qiang Lu, Bin-Yan Zhong, Cai-Fang Ni, Qi Zhang, Qian Yu, Jian Xu, JianSong Ji, Xiu-Ming Zhang, Tian-Yu Tang, Guanyu Yang, Ziteng Zhao
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Hongmei Yue, Qian Yu, Chuan Liu, Yifei Huang, Zicheng Jiang, Chuxiao Shao, Hongguang Zhang, Baoyi Ma, Yuancheng Wang, Guanghang Xie, Haijun Zhang, Xiaoguo Li, Ning Kang, Xiangpan Meng, Shan Huang, Dan Xu, Junqiang Lei, Huihong Huang, Jie Yang, Jiansong Ji, Hongqiu Pan, Shengqiang Zou, Shenghong Ju, Xiaolong Qi
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Gastroenterology & Hepatology
Yifei Huang, Fangze Huang, Li Yang, Weiling Hu, Yanna Liu, Zihuai Lin, Xiangpan Meng, Manling Zeng, Chaohui He, Qing Xu, Guanghang Xie, Chuan Liu, Mingkai Liang, Xiaoguo Li, Ning Kang, Dan Xu, Jitao Wang, Liting Zhang, Xiaorong Mao, Changqing Yang, Ming Xu, Xiaolong Qi, Hua Mao
Summary: This study developed and validated radiomics signatures (rGEV and rHRV) based on noncontrast-enhanced CT images for non-invasive diagnosis of GEV and HRV in patients with cACLD. The results showed that rGEV and rHRV exhibited high discriminative abilities and could serve as satisfying auxiliary parameters for the detection of GEV and HRV with good diagnostic performance.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Neurosciences
Chun-Qiang Lu, Chu-Hui Zeng, Ying Cui, Xiang-Pan Meng, Ying Luan, Xiao-Min Xu, Shenghong Ju
Summary: This study investigated the task-fMRI and rs-fMRI results on SD and Wistar rats under different anesthetic regimens, and found differences in brain activation and functional connectivity patterns between the two rat strains.
BRAIN CONNECTIVITY
(2022)
Editorial Material
Oncology
Xiang-Pan Meng, Tian-Yu Tang, Jitao Wang, Shenghong Ju
ANNALS OF SURGICAL ONCOLOGY
(2022)
Editorial Material
Oncology
Xiang-Pan Meng, Tian-Yu Tang, Zhi-Min Ding, Jitao Wang, Chun-Qiang Lu, Qian Yu, Cong Xia, Tao Zhang, Xueying Long, Wenbo Xiao, Yuan-Cheng Wang, Shenghong Ju
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Xiang-Pan Meng, Tian-Yu Tang, Zhi-Min Ding, Jitao Wang, Chun-Qiang Lu, Qian Yu, Cong Xia, Tao Zhang, Xueying Long, Wenbo Xiao, Yuan-Cheng Wang, Shenghong Ju
Summary: This study developed two prediction models for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) using clinical factors and preoperative computed tomography images. The models were compared and it was found that the model incorporating radiomics provided a more accurate estimation of MVI. This has the potential to assist in choosing the appropriate surgical procedure for HCC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tian-Yi Xia, Zheng-Hao Zhou, Xiang-Pan Meng, Jun-Hao Zha, Qian Yu, Wei-Lang Wang, Yang Song, Yuan-Cheng Wang, Tian-Yu Tang, Jun Xu, Tao Zhang, Xue-Ying Long, Yun Liang, Wen-Bo Xiao, Sheng-Hong Ju
Summary: A radiomics approach was developed to predict the microvascular invasion (MVI) status of hepatocellular carcinoma (HCC) using preoperative CT images. Differentially expressed genes associated with MVI were identified.
Article
Geriatrics & Gerontology
Kaidong Chen, Li Zhang, Haixia Mao, Kefei Chen, Yachen Shi, Xiangpan Meng, Feng Wang, Xiaoyun Hu, Xiangming Fang
Summary: This study aimed to investigate the relationship between anxiety and brain iron deposition in Parkinson's disease patients, and found that anxiety was associated with increased brain iron deposition in the fear circuit.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Gastroenterology & Hepatology
Xiang-Pan Meng, Tian-Yu Tang, Yongping Zhou, Cong Xia, Tianyi Xia, Yibing Shi, Xueying Long, Yun Liang, Wenbo Xiao, Yuan-Cheng Wang, Xiangming Fang, Shenghong Ju
Summary: A prognostic model integrating imaging-based surrogates of distinct vascular patterns was developed to predict postoperative recurrence-free survival (RFS) in patients with hepatocellular carcinoma (HCC). The model can potentially assist in selecting the appropriate type of surgical resection and predict patients' RFS.
Article
Gastroenterology & Hepatology
Qian Yu, Chuanjun Xu, Qinyi Li, Zhimin Ding, Yan Lv, Chuan Liu, Yifei Huang, Jiaying Zhou, Shan Huang, Cong Xia, Xiangpan Meng, Chunqiang Lu, Yuefeng Li, Tianyu Tang, Yuancheng Wang, Yang Song, Xiaolong Qi, Jing Ye, Shenghong Ju
Summary: This study developed a spleen-based non-invasive model to predict hepatic decompensation in individuals with compensated cirrhosis. The proposed model showed good performance and outperformed the conventional serum-based models. It provides a non-invasive and user-friendly method in healthcare settings where liver stiffness measurements are not available.
Article
Oncology
Dongqing Wang, Zijian Zhuang, Shuting Wu, Jixiang Chen, Xin Fan, Mengsi Liu, Haitao Zhu, Ming Wang, Jinmei Zou, Qun Zhou, Peng Zhou, Jing Xue, Xiangpan Meng, Shenghong Ju, Lirong Zhang
Summary: The value of dual-energy computed tomography (DECT) radiomics in evaluating lymph node metastasis in patients with rectal cancer was explored. A predictive model based on DECT and radiomics features showed the highest diagnostic value in predicting lymph node metastasis, with the best performance found in 120kVp-like images.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhimin Ding, Yuancheng Wang, Cong Xia, Xiangpan Meng, Qian Yu, Shenghong Ju
Summary: The radiomics model and the combined model can serve as valuable imaging markers for predicting lung cancer patients at high risk of synchronous brain metastasis (SBM) at initial diagnosis. Additionally, the radiomics model can also be utilized for identifying oligometastatic or multiple brain metastases in SBM.
DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
(2022)